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( Christina Stefanidou ),( Efterpi Bogia ),( Christina Botziori ),( Eleftheria Nakou ),( Asimoula Koteli ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The correlation between vitamin D, parathormone (PTH), Calcium (Ca), Phosphorus (P), Magnesium (Mg) and osteopenia or osteoporosis in patients with Thalassemia major. Methods: 43 thalassaemics patients 24-63 years old were included in the study. 31 of them were female and 12 male. 3 females were in menopause. 25 females were treated with oestogens and 3 diagnosed with hypogonadism. 3 males were diagnosed with hypogonadism, 5 were treated with testosterone and 4 had no treatment. The levels of Ca, P, Mg and 25(OH)D were measured with the method of Chemiluminescent Immunoassay (Architect c8000 ABBOTT Laboratories) where PTH with the method of radioimmunoassay RIA. The osseous density of COCCYX and trochanter femoral neck were both recorded via DEXA method. Results: All patients were diagnosed with osseous metabolism disorder either with osteopenia (Tscore from -1 to -2,5) or osteoporosis (Tscore = -2,5).18 of them were recorded with osteoporosis and 25 with osteopenia. In osteoporosis: the average range of 25(OH)D was 27,93 in men/16,3 in women (normal range:20-60,3 ng/ml), of PTH was15,0/23,2 (normal range:10-65 pg/ml), of Ca 8,83/9,0 (normal: 8,4-10,2 mg/dl). In osteopenia the average range of 25(OH)D was respectively 20,56 in men /20,36 in women, of PTH was 39,63 in men /38,33 in women, of Ca 8,71 in men /8,74 in women. Measurements of P and Mg were monitored within normal range. Conclusions: Females with osteoporosis or osteopenia were diagnosed with insuffi cient Vit.D and high levels of PTH. The inverse correlation of Vit.D with PTH occurs when levels of Vit.D were < 20.
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Endometrial cancer risk and survival by tumor MMR status
Christina M. Nagle,Christina M. Nagle,Tracy A. O'Mara,Yen Tan,Daniel D. Buchanan,Andreas Obermair,Penny Blomfield,Michael A. Quinn,Penelope M. Webb,Amanda B. Spurdle,Australian Endometrial Cancer Stud 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.3
Objective: The risk of developing endometrial cancer (EC) and/or survival following a diagnosis of EC might differ by tumor DNA mismatch repair (MMR) status. We assessed the association between tumor MMR status (classified as MMR-proficient, somatic MMR-deficient, germline MMR-deficient) and the risk of developing EC and survival following a diagnosis of EC. Methods: We analyzed data from women who participated in the Australian National Endometrial Cancer Study (ANECS) conducted between 2005 and 2007. Risk analyses (698 cases/691 population controls) utilized sociodemographic and lifestyle information obtained from telephone interviews at recruitment. For survival analyses (728 cases), patients' clinical data was abstracted from medical records, and survival data were obtained via linkage with the Australian National Death Index. We used logistic regression analysis to evaluate the associations between tumor MMR status and EC risk, and proportional hazards models to perform survival analyses with adjustment of known prognostic factors. Results: Established risk factors for EC did not differ significantly by tumor MMR status. In analyses including all EC subtypes, overall and EC-specific survival did not differ by tumor MMR status. Among women with the most common endometrioid subtype, EC-specific survival was worse for women with somatic MMR-deficient EC compared to women with MMR-proficient EC (hazard ratio [HR]=2.18; 95% confidence interval [CI]=1.19–4.01). Conclusion: The risk of EC is not associated with MMR status. Accurate separation of germline from somatic causes of MMR deficiency suggests that patients with endometrioid subtype somatic MMR-deficient tumors have poorer EC-specific survival than those with MMR-proficient tumors, after accounting for other prognostic factors.
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Christina-Maria Kastorini,Christina Chrysohoou,Demosthenes Panagiotakos,Panagiotis Aggelopoulos,Catherine Liontou,Christos Pitsavos,Christodoulos Stefanadis 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.1
The aim of the present work was to evaluate the association between coffee consumption and the development of left ventricular systolic dysfunction (LVSD) in patients who had had an acute coronary syndrome. During 2006–2007, 144 male (65 ± 14 years) and 50 female (71 ± 12 years) post-acute coronary syndrome patients who developed LVSD (ejection fraction <40%) after the cardiac event and 129 male (64 ± 12 years) and 51 female (67 ± 10 years) post-acute coronary syndrome patients without LVSD (ejection fraction >50%) were included in the study. Participants were consequently selected. Detailed information regarding their medical records, sociodemographic and anthropometric data, and various psychological and lifestyle characteristics (physical activity, smoking habits, etc.) were recorded. In particular, nutritional habits, including coffee consumption, were evaluated using a semiquantitative food-frequency questionnaire. Multi-adjusted analysis revealed that in normotensive patients coffee consumption of 1–2 cups/day was associated with 88% (95% confidence interval, 0.02–0.84) lower likelihood of developing LVSD and consumption of >3 cups/day with 90% (95% confidence interval, 0.01–0.88) lower likelihood for LVSD, compared with no history of consumption of coffee and after adjusting for various confounders. In contrast, in hypertensive patients coffee consumption of >3 cups/day was associated with 4.5-fold higher likelihood for developing LVSD (95% confidence interval, 0.89–22.58) as compared with no history of coffee consumption. Coffee consumption has opposite effects on the likelihood of developing LVSD in post-acute coronary syndrome patients depending on their blood pressure levels.
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Issues in Hiriong People with Disabilities Expressed by Employers
Christina Kim,Heidi Paul 국립특수교육원 2007 특수교육연구 Vol.14 No.1
고용주의 장애인 고용에 대한 현안사항 탐색-미국 캘리포니아 지역을 중심으로 -Christina Kimm* Heidi Paul**이 연구는 장애인을 고용할 때 고용주가 갖는 기대와 문제점을 주목적으로 장애인의 고용률을 증가시킬 수 있는 요소가 무엇인지를 알아보고자 하는 연구이다 . 연구의 참가자는 미국 캘리포니아주 남부(남가주)에 사업체를 가지고 있는 2,000여 명의 고용주들에게 설문지를 보내어 약 665명으로부터 얻은 결과를 기록했다 . 참가자는 남가주 지역사회의 구성인원의 비율보다는 동양인과 히스패닉
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Kastorini, Christina-Maria,Chrysohoou, Christina,Panagiotakos, Demosthenes,Aggelopoulos, Panagiotis,Liontou, Catherine,Pitsavos, Christos,Stefanadis, Christodoulos The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.1
The aim of the present work was to evaluate the association between coffee consumption and the development of left ventricular systolic dysfunction (LVSD) in patients who had had an acute coronary syndrome. During 2006.2007, 144 male ($65\;{\times}\;14$ years) and 50 female ($71\;{\times}\;12$ years) post-acute coronary syndrome patients who developed LVSD (ejecti fraction 40%) after the cardiac event and 129 male ($64\;{\times}\;12$ years) and 51 female ($67\;{\times}\;10$ years) post-acute coronary syndrome patients without LVSD (ejection fraction >50%) were included in the study. Participants were consequently selected. Detailed information regarding their medical records, sociodemographic and anthropometric data, and various psychological and lifestyle characteristics (physical activity, smoking habits, etc.) were recorded. In particular, nutritional habits, including coffee consumption, were evaluated using a semiquantitative food-frequency questionnaire. Multi-adjusted analysis revealed that in normotensive patients coffee consumption of 1-2 cups/day was associated with 88% (95% confidence interval, 0.02-0.84) lower likelihood of developing LVSD and consumption of >3 cups/day with 90% (95% confidence interval, 0.01-0.88) lower likelihood for LVSD, compared with no history of consumption of coffee and after adjusting for various confounders. In contrast, in hypertensive patients coffee consumption of >3 cups/day was associated with 4.5-fold higher likelihood for developing LVSD (95% confidence interval, 0.89-22.58) as compared with no history of coffee consumption. Coffee consumption has opposite effects on the likelihood of developing LVSD in post-acute coronary syndrome patients depending on their blood pressure levels.
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Ivabradine for the Therapy of Chronic Stable Angina Pectoris: a Systematic Review and Meta-Analysis
Christina Kalvelage,Christian Stoppe,Nikolaus Marx,Gernot Marx,Carina Benstoem 대한심장학회 2020 Korean Circulation Journal Vol.50 No.9
Background and Objectives: Coronary artery disease (CAD) is the number one cause of death worldwide. The If channel inhibitor ivabradine serves as second line medication for the CAD leading symptom angina pectoris. This systematic review and meta-analysis assess the existing evidence of ivabradine in angina pectoris. Methods: We systematically searched MEDLINE, Embase, CENTRAL, and Web of Science (September 2019) for randomized controlled trials (RCTs) that compared ivabradine versus placebo, standard therapy (ST) or other anti-anginal drugs. Two review authors independently assessed trials for inclusion and performed data extraction. We completed a ‘risk of bias’ assessment for all studies and assessed quality of the trial evidence using the Grading of Recommendations Assessment, Development and Evaluation methodology. We meta-analysed data were applicable and calculated mean differences (MDs) and risk ratios using a random-effects model. Results: A total of 11 RCTs (n=16,039) were included. Compared to placebo/ST, we found significant effects on the frequency of hospitalisation in a small cohort (n=90; hazard ratio [HR], 0.19; 95% confidence interval [CI], 0.04, −0.92; p=0.04), but no effects on cardiovascular mortality (n=19,102; HR, 1.10; 95% CI, 0.94, 1.28; p=0.25) or the frequency of angina pectoris episodes (n=167; weighted MD, −1.06; 95% CI, −2.74, −0.61; p=0.21). Conclusions: The present work makes an important contribution to optimal patient care in angina pectoris by complementing the current European Society of Cardiology guideline—recommending class IIa with evidence level B—decisively with 8 further studies.
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Christina Alexandris 세종대학교 언어연구소 2010 Journal of Universal Language Vol.11 No.2
The present approach targets the facilitation of translation and the correct transfer of opinions, style and overall spirit of written and spoken online journalistic texts. Here, we present the integration of an annotation strategy for written and spoken journalistic texts, detecting elements with explicit and implicit connotative features. The proposed annotation strategy is morphologically based, functioning as a checklist and targeting to address re-occurring problems encountered mainly by “semi-professional” translators, namely journalists, economists and other professionals working with multilingual written and transcribed journalistic texts available from the media and the Internet. Most of these professionals, usually having an above-average fluency of one or more foreign languages, often lack the necessary exposure to the culture(s) related to the concerned foreign language(s), especially due to distance or frequent changes of location. Thus, essential information is presented either in a subtle form or in an indirect way, constituting emotionally and socio-culturally “marked” elements, often going undetected. The present user-oriented design is aimed to be integrated into an annotation tool targeting the indication of the largest possible percentage of the points in the texts signalizing “marked” information, alerting the user-translator to evaluate these expressions and, in the case of transcribed spoken journalistic texts, to allow a comparison of “marked” elements with prosodic and paralinguistic features in the respective multimedia files.
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Dermatoses of Pregnancy -Clues to Diagnosis, Fetal Risk and Therapy
( Christina M. Ambros Rudolph ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.3
The specific dermatoses of pregnancy represent a heterogeneous group of pruritic skin diseases that have been recently reclassified and include pemphigoid (herpes) gestationis, polymorphic eruption of pregnancy (syn. pruritic urticarial papules and plaques of pregnancy), intrahepatic cholestasis of pregnancy, and atopic eruption of pregnancy. They are associated with severe pruritus that should never be neglected in pregnancy but always lead to an exact work-up of the patient. Clinical characteristics, in particular timing of onset, morphology and localization of skin lesions are crucial for diagnosis which, in case of pemphigoid gestationis and intrahepatic cholestasis of pregnancy, will be confirmed by specific immunofluorescence and laboratory findings. While polymorphic and atopic eruptions of pregnancy are distressing only to the mother because of pruritus, pemphigoid gestationis may be associated with prematurity and small-for-date babies and intrahepatic cholestasis of pregnancy poses an increased risk for fetal distress, prematurity, and stillbirth. Corticosteroids and antihistamines control pemphigoid gestationis, polymorphic and atopic eruptions of pregnancy; intrahepatic cholestasis of pregnancy, in contrast, should be treated with ursodeoxycholic acid. This review will focus on the new classification of pregnancy dermatoses, discuss them in detail, and present a practical algorithm to facilitate the management of the pregnant patient with skin lesions.
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