發癌物質과 DNA-鹽基雙과의 配向結定

朴潤烈,金鎬順,朴柄珏 嶺南大學校附設 基礎科學硏究所 1981 基礎科學硏究 Vol.1 No.-

The interactions of various carcinogens, such as polyaromatic hydrocarbons, dimethylaminoazobenzene(DAB) and its derivatives and benzacridines with deoxyribonucleic acid(DNA) were investigated by means of second-order perturbation method. The most probable orientations of molecular complex between DNA-base pairs and carcinogen were defermined by the quantity of charge transfer from adenine-thymine pair (A=T pair) to carcinogen and from Guanine-Cytosine pair (G≡C) to carcinogen. It was found that the quantity of charge transfer from thymine part of A=T pair to carcinogen was considerably larger than that from guanine part of G≡C pair to carcinogen. A good parallelism was alos found between the quantity of charge transfer and experimenental carcinogenic activity.

環境이 體育學習에 미치는 영향에 관한 연구

尹炳烈 弘益大學校 1975 弘大論叢 Vol.7 No.-

In this paper 1. attempted to clarify the concept of learning in terms of physical education and studied the effects of environment on physical education by a documentary research. I have come to a conclusion that in physical education motivation and repetitive practice matter most and that physical capability and function of a person ara much affected by environmental elements by exertion, while such outer physical aspects and bodily constitution and type are mainly dependent upon heredity.

事務所建物 空調設備의 豫防保全 最適點檢周期가 信賴性向上 및 期待利益에 미치는 영향

곽노열,박병윤,손장열 대한건축학회 2003 대한건축학회논문집 Vol.19 No.5

In this study, using Monte Carlo simulation about inspection model applied practically in air-conditioning facilities of office building, the optimal preventive maintenance inspection period is suggested to improve the reliability of the units, and effect on expected profit of optimal preventive maintenance inspection period is computed. The main results of this study are summarized as follows: 1) Simulation program for sensitivity analysis and optimal preventive maintenance inspection period is made, in order to execute precisely sensitivity analysis of maintenance factors, by using Monte Carlo simulation's flow chart and compute optimal preventive maintenance inspection period. 2) Using models for the relationship between reliability and inspection frequency per unit time and model between inspection and expected profit of preventive maintenance by CBM, the optimal preventive maintenance inspection period of air-conditioning facilities is computed, and it is revealed that the range of that is 90∼175 hr and, correlation curve of the original MTBF and optimal preventive maintenance inspection period by CBM is derived. 3) And effect on expected profit of preventive maintenance's activity by optimal preventive maintenance inspection period is computed. It is found that the larger the original MTBF, like MTBF of centrifugal compression chiller and AHU is, and the smaller the expected profit increased, and the smaller the original MTBF, like MTBF of boiler, absorption chiller and turbo case cooling tower is, and larger the expected profit increased.

최대산소섭취량, 환기역치, 환기역치 이하의 운동강도에서 지속적 운동시 혈중 지질 및 지단백 농도의 특성

안병근,손태열 龍仁大學校 1998 용인대학교 논문집 Vol.16 No.-

The aim of this paper was to evaluate a characteristics of serum lipids and lipoproteins concentration during acute exercise at graded exercise for VO2max test, at ventilatory threshold and below ventilatory threshold. The results and conclusion of this study is obtained as follows. 1. No significant difference followed exercise intensities of three types in serum total cholesterol. Also, it was not a significant difference following time course of continuous exercise at ventilatory threshold and below ventilatory threshold. However, it was shown a significant difference(p<.05) between resting value and exhaustion value at graded exercise test. 2. Serum triglycerides concentration was not significantly altered as compared to three types exercise intensities. Also, Serum TG concentration did not differ follows time course of continuous exercise at ventilatory threshold and below ventilatory threshold. However, significant difference in traded exercise test was found between resting value and exhaustion value(p<.01), and between exhaustion value and recovery 30 minute(p<.05). 3. Serum HDL-C concentration did not differ significantly from the corresponding value at graded exercise test, at ventilatory threshold and below ventilatory threshold. It was not shown a significant difference follows time course of continuous exercise at graded exercise test and below ventilatory threshold. However, significant difference was found between resting value and exercise after 30 min. (p<.01), and between resting value and exercise after 60 min. (p<.05) at ventilatory threshold intensity. 4. Serum LDL-C concentration showed no change at the graded exercise test, at ventilatory threshold and below ventilatory threshold. Also, it was not shown a significant difference followed time course as exercise continued for all intensity.

도시계획의 시가화구역 설정에서 토지적합성분석의 적용 : 경산시 사례 A Case of Kyung-san city

김타열,김병관 영남대학교 지역발전연구소 2001 영남지역발전연구 Vol.27 No.-

The main purpose of this paper is to propose the applicability of land suitability analysis to making the future urbanized area policy of Kyoung-san city and evaluating urban spatial structure of those. The major results can be summarized as follow; 1. The furture population is taken through Kyoung-san urban comprehensive plan. The space requirement is divided into three periods until 2016, by adapting planning density. 2. On applying to land suitability analysis, variables and weight are picked up from the pre-studied papers. Variables for analysis are classisied with topological, geographical and institution factor. 3. Political alternatives for land use policies was formulated from feasibility of up-zoning ordinances. The up-zoning was supposed from urban planning area to whole planning area, from the urbanized zone to semi-agri-forest zone. 4. The urbanized areas of each alternative are resulted in applying land suitability analysis with using GIS, then the utban spatial structures are derived from those form and evaluated for the good utban fotm. In results of analysis, the summaries of urban spatial structures are following; 1) the alternative Ⅰ of linear form, 2) the alternative Ⅱ of circular form, 3) the alternative Ⅲ of combine with linear from and separated urban area. For evaluating each of urban spatial structure, the alternative Ⅰ was proved to be the best of three, and the alternative Ⅱ was proved to be the worst, in side of the conservation of agricultural land. Second, the alternative Ⅱ was proved to have the highest access, in side of the access to the arterial road. Third, the alternative Ⅲ was proved to be the best, in side of the distance to the CBD.

運動類型別 男大生選手의 性格에 關한 硏究(Ⅰ)

尹炳烈 弘益大學校 1974 弘大論叢 Vol.6 No.-

The purpose of this study is to find out the expressed personal characteristics of male students players when they are engaged in various kind of sports. To achieve this aim, 200 male students were tested chiefly through masculine sports, using the standardized test papers that were devised to fit the Koreans. Mental characters that were revealed by the test are as follows: 1. peaceful, active and very ready in cooperating, 2. medial in leadership, calmness, subjectiveness and kindness, 3. low in thoughtfulness and emotional stability.

大學 肢體不自由學生들의 體育實技指導方法

尹炳烈 弘益大學校 1976 弘大論叢 Vol.8 No.-

In order to work out a more effective method of guiding those physically-handicapped students whose practical physical traning has been neglected in their regular courses so far, I conducted an investigation, through questionnaires and interviews, into the training situation of 33 college students who are physically handicapped, and the guiding conditions of those professors who are leading their respective physical education department in 26 universities and colleges sellected for this study. I combined and analized the data which have resulted from my investigation, such as those about how the physically-handicapped students are actually trained and dealt with, and what are their requirements, etc. The results attained are as follows. 1. The physically-handicapped students should in no way be excluded from their regular activities of developing their physical abilities. 2. They should be given an ample recognition that the effect of rehabilitation is possible by means of physical activities. 3. The professors in charge of those students should be careful enough not to deal with them with prejudice and any fixed idea. 4. The most effective exerdise available for them is thought to be the individual one which mainly calls for the use of the upper half of their bodies. 5. The practical physical training, aiming at developing the physical abilities of the handicapped students, should be given to them in close consideration of their individual circumstances, to ave them adjusted and accustomed to one or two types of physical exercise as their daily activities. 6. they may as well be given individual training, although it is desirable to let them equally join their regular classes.

현장측정에 의한 공기조화기 에어필터의 성능 평가

정용호,박병윤,손장열 대한건축학회 2004 대한건축학회논문집 Vol.20 No.7

Air filters of air conditioning system play a main role in improving indoor air quality. However there is not enough information about air filters and any official maintenance standards or guidelines for air filters in Korea. The aims of this study are proposal for air filter test methods after installation and basic data about air filter maintenance guidelines or standards. In this study, arrestances, pressure losses and microorganisms between the upstream and the downstream of air filters were measured with digital dust indicators, a micro manometer and blood agar plates. Measurements were conducted before and after washing out pre filters and outdoor air untake ratio varied between 10%, 20% and 30% under actual operating conditions. The results of this study is as follows. Arrestance increased depending on whether the input of outdoor air was added. However some cases did not follow the trend. Pressure loss decreased depending on whether the input of outdoor air was added to AHUs which have built-out type return fans and vice versa in the built-in type. In contrast, the colony counts of microorganisms increased in the downstream of air filters. The rates of increase dropped depending on the addition of the input of OA. Arrestance increased, pressure loss decreased and the rates of increase of microorganisms dropped after washing out prefilters. Medium filter replacement is the main factor for arrestance, prefilter replacement or washing is the main factor for microorganisms but the range of fluctuation in differential pressure was hard to recognize as 1∼4mmAq. As for the results, proper maintenance for air filters, periodical washing out prefilters are important and development air filter performance test methods, standards or guidelines of dust concentration and microorganisms in AHUs after installation are required.

HBx형질전환 생쥐에서 발생한 간세포암종에서 H-ras 및 c-myc의 발현에 관한 연구

문형배,소병준,김학철,윤기중,한원철,조향정,유대열,정영진 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2

<연구목적> HBx형질전환 생쥐에서 발생한 간세포암종의 발암과정에 종양유전자(H-rgs, c-myc)의 발현 정도를 조사하고자 하였다. <연구방법> 정상생쥐 12마리(4-18개월) 및 HBx 형질전환 생쥐 44마리(4-18개월)를 대상으로 포르말린에 고정하고 파라핀에 포매한 간 조직을 이용하여 면역조직화학적염색을 실시하였다. 실험군은 정상 부위, 이형성 부위 및 종양 부위로 구분하였으며, 종양 부위는 소결절성병변 부위와 간세 포암종 부위로 구분하였고, 이형성병변 부위는 이형성병변만 발견되는 부위, 소결절성병변과 동반된 이형성병변 부위 및 간세포암종과 동반된 이형성병변 부위로 구분하였다. <연구결과> H-rgs의 발현은 정상 간조직에 비하여 이형성병변 부위(P<0.05) 및 종양 부위(P<0.01)에서 증가하였으며, 소결절성병변 부위과 간세포암종 부위 사이에서는 간세포암종 부위에서 증가된 경향이었으나 통계학적으로 유의한 차이가 없었으며, 각 이형성병변 부위 사이에서도 유의한 차이는 없었다. c-myc의 발현은 정상 간조직 및 이형성병변 부위에 비해 종양 부위에서 증가하였으며(P<0.001), 소결절성병변 부위와 간세포암종 부위에서는 비슷하였고, 각 이형성병변부위 사이에서도 비슷하였다. <결론> HBx형질전환 생쥐에서 발생하는 간세포암종의 발생에 H-rgs는 이형성 변화를 일으키는 시기에 관여하며, c-myc은 이형성병변에서 암으로 이행하는 시기에 관여할 것으로 생각한다. Background: This experiment was designed for the expression of H-ras and c-myc in hepatocarcinogenesis of the HBx transgenic mice. Methods: Immunohistochemical stains in the paraffin embedded tissue of the liver were used for the detection of H-ras and c-myc in the 12 normal mice and 44 HBx transgenic mice of the 4-18 month old. Results: Expression of the H-ras was significantly increased in the dysplastic area (P<0.05) and tumor area (P<0.01) than in the normal liver. But there were no differences of H-ras expression between areas of microscopically identified hepatocellular carcinoma (MI-HCC) and grossly identified hepatocellular carcinoma (GI-HCC) and dysplastic areas among the only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Expression of the c-myc was significantly increased in the tumor area (P<0.001) than in the normal liver and dysplastic area. But there were no differences of c-myc expression between areas of MI-HCC and GI-HCC, and dysplastic areas among only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Conclusions: Our study suggests that H-ras is related to the dysplastic change and c-myc is related to the neoplastic change in the hepatocarcinogenesis of the HBx transgenic mice.

급성 백혈병 환자에서 감염증의 양상 및 예후인자에 관한 연구 : 1988년∼1995년까지

정희진,김병수,신상원,김열홍,김우주,김민자,김준석,박승철,김권범 대한감염학회 1998 감염 Vol.30 No.3

목적 : 급성 백혈병의 경우 골수기능이 억제되고 항암화학요법에 따른 골수기능 저하로 감염의 위험이 증가하며 감염의 치료가 환자의 생존에 큰 영향을 미치게 된다. 이에 저자들은 1988년부터 1995년까지 고대 구로병원에 급성 백혈병으로 입원했던 환자들 중 입원 기간 내 감염이 있었던 경우를 대상으로 하여 감염의 위험인자 및 감염증의 예후를 후향적으로 분석함으로써 향후 급성 백혈병환자의 감염의 치료에 대한 지침을 얻고자 하였다. 방법 : 급성 백혈병으로 확진된 환자들 중 감염병에 이환된 경우를 대상으로 하여 각각을 미생물학적 확인감염, 임상적 확인감염, 그리고 설명 불가열로 구분하였다. 각각의 경우에서 감염 당시의 호중구 수, 호중구 감소 기간, 항암화학요법과의 연관성, 감염 병소, 배양된 검체 및 원인균, 선택적 소화관 살균법의 사용여부 및 골수회복 여부 등을 조사한 후 환자의 예후와 어떤 관계가 있는 지 조사하였다. 결과 : 연구 대상은 총 113예로 남녀비는 46:67 이었고 평균연령은 34±13세, 진단은 급성 골수성 백혈병 (AML)이 84예, 급성 림프구성 백혈병(ALL)이 29예였으며, 감염시 평균 호중구수는 663±1678/㎣이었고, 호중구 감소 기간은 평균 18±13일이었다. 감염양상은 항암화학요법과 연관된 감염이 84예로 대부분이었고 미생물학적 확인 감염이 40예로서 35%였으며, 폐렴과 원발성 패혈증이 각각 20예와 19예로 가장 많았고, 카테터 연관 감염이 7예로 나타났다. 배양된 균주는 E. coli가 10예(25%)로서 가장 많았으며, 전체적으로 E. coli, P. aeruginosa, K. pneumoniae 등의 그람음성균이 63%로 대부분을 차지하였으나 최근 그람양성구군 및 진균의 분리율이 증가하는 양상을 보였다. 감염증의 예후를 분석한 결과 진균 감염인 경우나 호중구 감소 기간이 긴 경우 사망률이 높았으며 그 중에서도 골수 기능이 회복 여부가 환자들의 생존과 통계적으로 유의한 연관이 있었다.(P=0.01). 결론 : 급성 백혈병 환자들에서의 감염은 관해유도화학요법 후 초래되는 호중구 감소와 유의한 관계가 있으며, 폐렴 및 패혈증의 임상양상을 보이는 경우가 흔하고, 원인균별로는 그람 음성균이 주류를 이루나 최근 그람 양성균 감염이 증가하는 추세를 보였다. 감염의 예후 인자로는 진균 감염인 경우나 호중구 감소 기간이 긴 경우 사망률이 높았으나 골수 기능의 회복여부가 결정적인 역할을 하는 것으로 나타나, 향후 급성 백혈병 환자의 치료에 있어 감염 빈도의 감소와 감염에서의 조속한 회복을 위해서는 골수 기능의 회복에 중점을 두어야 할 것으로 사료된다. Background : Infection is one of the most important and fatal complications in patients with acute leukemia. The characteristics of infection in acute leukemic patients are different from those in other diseases by the lack of normal inflammatory responses or distinct clinical evidence except fever. To improve the outcome of acute leukemia, it is very important to recognize the risk factors, patterns and prognostic factors of acute leukemia. Methods : We analyzed retrospectively the patterns of infection from 113 febrile patients with acute leukemia from January, 1988 to December, 1995. To determine the prognostic factors and the outcome of infection, the following variables were analyzed: the presence of neutropenia, use of chemotherapeutic agents, type and site of infections, isolated organisms, gastrointestinal decontamination, duration of neutropenia, and bone marrow recovery. Results : Out of 113 febrile patients with acute leukemia, 84 infection episodes(74%) occurred after chemotherapy. The mean duration of neutropenia was 18±13 days. The incidence of microbiologically-documented infection(MDI) was 35%(40/113). Pneumonia was the most common infection(26%), followed by primary sepsis(24%), catheter-related infection(9%). In cases of MDI, 63% were caused by gram-negative bacteria, followed by gram-positive bacteria(28%), and fungi(10%). Escherichia coli(25%) was the most common isolated in MDI. Regarding the prognostic factors in cases with infections, the recovery of bone marrow function was the only statistically significant factor(P=0.01). Conclusion : Infection has been a major cause of morbidity and mortality in acute in acute leukemic patients. To prevent infection and thereby improve the prognosis of acute leukemia, restoration of bone marrow function at early stage is important.