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Research Collaborations for Better Predictions of Aviation Weather Hazards
Chun, Hye-Yeong,Kim, Jung-Hoon,Lee, Dan-Bi,Kim, Soo-Hyun,Strahan, Matt,Pettegrew, Brian,Gill, Philip,Williams, Paul D.,Schumann, Ulrich,Tenenbaum, Joel,Lee, Young-Gon,Choi, Hee-Wook,Song, In-Sul,Park, American Meteorological Society 2017 Bulletin of the American Meteorological Society Vol.98 No.5
Yuan, Chun-Hui,Yang, Xue-Qin,Zhu, Cheng-Liang,Liu, Shao-Ping,Wang, Bi-Cheng,Wang, Fu-Bing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Interleukin-7 (IL-7) is a potent anti-apoptotic cytokine that enhances immune effector cell functions and is essential for lymphocyte survival. While it known to induce differentiation and proliferation in some haematological malignancies, including certain types of leukaemias and lymphomas, little is known about its role in solid tumours, including breast cancer. In the current study, we investigated whether IL-7 could enhance the in vivo antitumor activity of tumor-reactive $CD8^+$ T cells with induction of IFN-${\gamma}$ in a murine breast cancer model. Human IL-7 cDNA was constructed into the eukaryotic expression plasmid pcDNA3.1, and then the recombinational pcDNA3.1-IL-7 was intratumorally injected in the TM40D BALB/C mouse graft model. Serum and intracellular IFN-${\gamma}$ levels were measured by ELISA and flow cytometry, respectively. $CD8^+$ T cell-mediated cytotoxicity was analyzed using the MTT method. Our results showed that IL-7 administration significantly inhibited tumor growth from day 15 after direct intratumoral injection of pcDNA3.1-IL-7. The anti-tumor effect correlated with a marked increase in the level of IFN-${\gamma}$ and breast cancer cells-specific CTL cytotoxicity. In vitro cytotoxicity assays showed that IL-7-treatment could augment cytolytic activity of $CD8^+$ T cells from tumor bearing mice, while anti-IFN-${\gamma}$ blocked the function of $CD8^+$ T cells, suggesting that IFN-${\gamma}$ mediated the cytolytic activity of $CD8^+$ T cells. Furthermore, in vivo neutralization of $CD8^+$ T lymphocytes by CD8 antibodies reversed the antitumor benefit of IL-7. Thus, we demonstrated that IL-7 exerts anti-tumor activity mainly through activating $CD8^+$ T cells and stimulating them to secrete IFN-${\gamma}$ in a murine breast tumor model. Based on these results, our study points to a potential novel way to treat breast cancer and may have important implications for clinical immunotherapy.
( Han-bi Kim ),( Jin Cheol Kim ),( Ji-young Um ),( Seok Young Kang ),( Bo Young Chung ),( Chun Wook Park ),( Hye One Kim ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.-
Background: Previous studies have identified differences in skin surface and intestinal microbiota between healthy humans and patients with atopic dermatitis. However, the microbiome of the skin has very different characteristics depending on the dry, wet, and oily areas. Objectives: This study was purposed to identify whether the skin microflora and tryptophan metabolites are different between atopic dermatitis patients group and normal control group. Methods: Skin samples of 60 volunteers were collected from the nose, abdomen, antecubital fossa by swabs and tapping, and stool samples were collected with cotton swabs. Results: In the atopic dermatitis patients, the Kocuria, Megamonas, Unassigned, Enterocloster, Tyzzerella, Veillonella, and Rhodospirillum are increased in the fecal samples. The Comamonas, Finegoldia, Haemophilus, Porphyromonas, Staphylococcus, Neisseria, Thermodesulfobacterium, and Prevotella are increased in skin samples of the atopic dermatitis group. Indole-3-lactic acid, a tryptophan metabolite, was significantly decreased in skin of the atopic dermatitis patients group. Conclusion: This study showed the skin microflora and tryptophan metabolites are different between atopic dermatitis patients group and normal control group.
The Effects of Negative Carbon Ion Beam Energy on the Properties of DLC Film
Choi Bi Kong,Choi Dae Han,Kim Yu Sung,Jang Ho Sung,Lee Jin Hee,Yoon Ki Sung,Chun Hui Gon,You Young Zoo,Kim Dae Il 한국표면공학회 2006 한국표면공학회지 Vol.39 No.3
The effects of negative carbon ion beam energy on the bonding configuration, hardness and surface roughness of DLC film prepared by a direct metal ion beam deposition system were investigated. As the negative carbon ion beam energy increased from 25 to 150 eV, the sp³ fraction of DLC films was increased from 32 to 67%, while the surface roughness was decreased. The films prepared at 150 eV showed the more flat surface morphology of the film than that of the film prepared under another ion beam energy conditions. Surface roughness of DLC film varied from 0.62 to 0.22 ㎚ with depositing carbon ion beam energy. Surface nanohardness increased from 12 to 57 Gpa when increasing the negative carbon ion beam energy from 25 to 150 eV, and then decreased when increasing the ion beam energy from 150 to 200 eV.
( Han-bi Kim ),( Jin Cheol Kim ),( Ji-young Um ),( Seok Young Kang ),( Bo Young Chung ),( Chun Wook Park ),( Hye One Kim ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.1
Background: Previous studies have identified differences in skin surface and intestinal microbiota between healthy humans and patients with atopic dermatitis. However, the microbiome of the skin has very different characteristics depending on the dry, wet, and oily areas. Objectives: This study was purposed to identify whether the skin microflora and tryptophan metabolites are different between atopic dermatitis patients group and normal control group. Methods: Skin samples of 60 volunteers were collected from the nose, abdomen, antecubital fossa by swabs and tapping, and stool samples were collected with cotton swabs. Results: In the atopic dermatitis patients, the Kocuria, Megamonas, Unassigned, Enterocloster, Tyzzerella, Veillonella, and Rhodospirillum are increased in the fecal samples. The Comamonas, Finegoldia, Haemophilus, Porphyromonas, Staphylococcus, Neisseria, Thermodesulfobacterium, and Prevotella are increased in skin samples of the atopic dermatitis group. Indole-3-lactic acid, a tryptophan metabolite, was significantly decreased in skin of the atopic dermatitis patients group. Conclusion: This study showed the skin microflora and tryptophan metabolites are different between atopic dermatitis patients group and normal control group.
Impact of Chemotherapy-Related Hyperglycemia on Prognosis of Child Acute Lymphocytic Leukemia
Zhang, Bi-Hong,Wang, Jian,Xue, Hong-Man,Chen, Chun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20
Purpose: To investigate the impact of hyperglycemia during inductive treatment on the prognosis of acute lymphocytic leukemia (ALL) in children. Materials and Methods: Clinical data of 159 ALL childhood cases were reviewed. The patients were divided into the hyperglycemia group (fasting $glucose{\geq}126mg/dl$ and/or random blood $glucose{\geq}200mg/dl$) and the euglycemia group according to the blood glucose values. The X2 test was performed to compare the complete remission rates of the two groups, and Kaplan-Meier and log-rank tests were performed to compare the 5-year overall and relapse-free survival. Results: The incidence of hyperglycemia in the $age{\geq}10-year-old$ group was higher than the younger-age group (P=0.009). Values in the interim- and high-risk groups were higher than the standard-risk group (P=0.028), while there was no significant difference between genders (P=0.056). The complete remission rates of the 2 groups demonstrated no significant difference (P=0.134), while the 5-year OS of the hyperglycemia group was lower than in the euglycemia group ($83.8{\pm}6.0%$ vs $94.9{\pm}2.4%$, P=0.014). The 5 -year RFS was significantly lower than the euglycemia group ($62.9{\pm}8.7%$) vs $80.2{\pm}9.1%$, P<0.001). Conclusions: Children with $age{\geq}10year$ old, and in the middle- and high-risk groups appear prone to complicating hyperglycemia during inductive chemotherapy, associated with lower 5-year OS and RFS.