Current Concepts in Non-Gastrointestinal Stromal Tumor Soft Tissue Sarcomas: A Primer for Radiologists

Akshay D. Baheti,Jyothi P. Jagannathan,Ailbhe O’Neill,Harika Tirumani,Sree Harsha Tirumani 대한영상의학회 2017 Korean Journal of Radiology Vol.18 No.1

Non-gastrointestinal stromal tumor (GIST) soft tissue sarcomas (STSs) are a heterogeneous group of neoplasms whose classification and management continues to evolve with better understanding of their biologic behavior. The 2013 World Health Organization (WHO) has revised their classification based on new immunohistochemical and cytogenetic data. In this article, we will provide a brief overview of the revised WHO classification of soft tissue tumors, discuss in detail the radiology and management of the two most common adult non-GIST STS, namely liposarcoma and leiomyosarcoma, and review some of the emerging histology-driven targeted therapies in non-GIST STS, focusing on the role of the radiologist.

Investigating the structural, magnetic and magnetocaloric properties in B-site Mo-doped La<SUB>1.4</SUB>Ca<SUB>1.6</SUB>Mn<SUB>2-x</SUB>Mo<SUB>x</SUB>O<SUB>7</SUB> (0 ≤ x ≤ 0.3) bilayer manganites

Akshay Kumar,Kavita Kumari,Minji Shin,Seok Hwan Huh,Bon Heun Koo 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.1

Magnetic refrigeration has attracted significant research interest because of having considerable advantages over the conventional gas compression refrigeration. Unlike the conventional gas compression refrigeration, the magnetic refrigeration is a green cooling technology which does not produce the harmful gases. In the present work, controlled substitution of molybdenum (Mo) in place of Manganese (Mn) was performed in La_1.4Ca_1.6Mn_2-xMo_xO₇ (x = 0.0, 0.1, 0.2 and 0.3) to modify the magnetic and magnetocaloric behavior of the material. All samples were prepared through the conventional ceramic heating route. XRD profiles of the synthesized compounds revealed the tetragonal structure (I4/mmm) of bilayer Ruddlesden-Popper (R-P) Phase. However, some MoO₃ oxide and/or unidentified peaks in x ≥ 0.2 doped samples emerged along with the R-P phase which suggest the dilution limit on B-Site doping for Mo. Temperature dependent magnetization measurements exhibit ferromagnetic to paramagnetic transitions above the respective transition temperature (TC) of individual compounds. The parent compound displayed second order magnetic phase transition, while the first order transition was observed in the Mo-doped compositions. The maximum change in magnetic entropy (∆S_M^max) values achieved for x = 0.0, 0.1, 0.2 and 0.3 samples are 2.98 J/kgK, 2.71 J/kgK, 2.64 J/kgK, 2.37 J/kgK respectively at 2.5 T applied field. Among the doped samples highest ∆S_M^max value was achieved for x = 0.1 sample. For the these compounds the relative cooling power (RCP) slightly increased to 102 J/kg for x = 0.1 sample compared to the parent compound 98 J/kg. RCP values decreased for high Mo-concentrations and reached a lowest value 68 J/kg for x = 0.3 sample. Sufficient structural analysis carried out here suggest that the tetragonal symmetry in the B-site doped bilayer manganites reduced to simple perovskite symmetry above the dilution limit (x ≥ 0.2) thereby rigorously affecting the magnetic and magnetocaloric properties.

Evaluation of Outcome of Posterior Decompression and Instrumented Fusion in Lumbar and Lumbosacral Tuberculosis

Akshay Jain,Ravikant Jain,Vivek Kiyawat 대한정형외과학회 2016 Clinics in Orthopedic Surgery Vol.8 No.3

Background: For surgical treatment of lumbar and lumbosacral tuberculosis, the anterior approach has been the most popular approach because it allows direct access to the infected tissue, thereby providing good decompression. However, anterior fixation is not strong, and graft failure and loss of correction are frequent complications. The posterior approach allows circumferential decompression of neural elements along with three-column fixation attained via pedicle screws by the same approach. The purpose of this study was to evaluate the outcome (functional, neurological, and radiological) in patients with lumbar and lumbosacral tuberculosis operated through the posterior approach. Methods: Twenty-eight patients were diagnosed with tuberculosis of the lumbar and lumbosacral region from August 2012 to August 2013. Of these, 13 patients had progressive neurological deterioration or increasing back pain despite conservative measures and underwent posterior decompression and pedicle screw fixation with posterolateral fusion. Antitubercular therapy was given till signs of radiological healing were evident (9 to 16 months). Functional outcome (visual analogue scale [VAS] score for back pain), neurological recovery (Frankel grading), and radiological improvement were evaluated preoperatively, immediately postoperatively and 3 months, 6 months, and 1 year postoperatively. Results: The mean VAS score for back pain improved from 7.89 (range, 9 to 7) preoperatively to 2.2 (range, 3 to 1) at 1-year followup. Frankel grading was grade B in 3, grade C in 7, and grade D in 3 patients preoperatively, which improved to grade D in 7 and grade E in 6 patients at the last follow-up. Radiological healing was evident in the form of reappearance of trabeculae formation, resolution of pus, fatty marrow replacement, and bony fusion in all patients. The mean correction of segmental kyphosis was 9.85° postoperatively. The mean loss of correction at final follow-up was 3.15°. Conclusions: Posterior decompression with instrumented fusion is a safe and effective approach for management of patients with lumbar and lumbosacral tuberculosis.

Robotic Control using Hand Gesture Recognition baesd on FFT Analysis

Akshay Agarwal,Neha Singh,G. C. Nandi 보안공학연구지원센터(IJSIP) 2014 International Journal of Signal Processing, Image Vol.7 No.2

In silico exploration of inhibition potency of maslinic acid, a plant based triterpene, against Helicoverpa armigera serine protease

Akshay P. Ware,Faiyaz K. Shaikh,Archana N. Panche,Sanjay N. Harke 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.1

Gut proteases are accountable for survival of Helicoverpa armigera on protein rich parts of plant devastating many important agricultural crops. The aim of present study was to identify potential natural compounds having inhibitory potency against Helicoverpa armigera gut proteases. We have modeled structure of H. armigera serine protease (UniProt ID: O18447) and analyzed its interactions with maslinic acid (Zinc ID: ZINC38140521). A 3D model was generated using bovine trypsin in complex with analogues of sunflower inhibitor 1 as template with the help of Chimera Modeler 1.11. The PROCHECK and Modfold analysis have revealed 81.8% of residue in favored region. The POOL and COACH analysis have revealed 18 amino acids in the active site. In the 10 ns MD simulations of modeled structure, the RMSD of the protein backbone increased slightly and later stabilized from 7 ns to 10 ns. The modeled structure was stabilized at gyration distance of about 1.65 nm at 7 ns. Potential hit compounds from the ZINC database identified in this study showed good inhibitory bindings with modeled structure. Among these compounds maslinic acid, a plant based pentacyclic triterpenes was found to be potent lead compound with good binding affinity (−9.5 kcal/mol). RMSD profile was < 0.45 nm for complex with stabilization at about 18,000 ps (18 nm) suggesting stable interaction. This work demonstrates reasonable in silico inhibitory action of maslinic acid against H. armigera serine protease and depicts utility of in silico methodologies for designing competent strategies against dreaded insect pests like H. armigera.

Emergence of Three-Dimensional Printing Technology and Its Utility in Spine Surgery

Akshay Gadia,Kunal Shah,Abhay Nene 대한척추외과학회 2018 Asian Spine Journal Vol.12 No.2

In the last decade, spine surgery has advanced tremendously. Tissue engineering and three-dimensional (3D) printing/additive manufacturing have provided promising new research avenues in the fields of medicine and orthopedics in recent literature, and their emergent role in spine surgery is encouraging. We reviewed recent articles that highlighted the role of 3D printing in medicine, orthopedics, and spine surgery and summarized the utility of 3D printing. 3D printing has shown promising results in various aspects of spine surgery and can be a useful tool for spine surgeons. The growing research on tissue bioengineering and its application in conjunction with additive manufacturing has revealed great potential for tissue bioengineering in the treatment of spinal ailments.

Lightweight image classifier for CIFAR-10

( Akshay Kumar Sharma ),( Amrita Rana ),( Kyung Ki Kim ) 한국센서학회 2021 센서학회지 Vol.30 No.5

Image classification is one of the fundamental applications of computer vision. It enables a system to identify an object in an image. Recently, image classification applications have broadened their scope from computer applications to edge devices. The convolutional neural network (CNN) is the main class of deep learning neural networks that are widely used in computer tasks, and it delivers high accuracy. However, CNN algorithms use a large number of parameters and incur high computational costs, which hinder their implementation in edge hardware devices. To address this issue, this paper proposes a lightweight image classifier that provides good accuracy while using fewer parameters. The proposed image classifier diverts the input into three paths and utilizes different scales of receptive fields to extract more feature maps while using fewer parameters at the time of training. This results in the development of a model of small size. This model is tested on the CIFAR-10 dataset and achieves an accuracy of 90% using .26M parameters. This is better than the state-of-the-art models, and it can be implemented on edge devices.

An overview of SnO2 based Z scheme heterojuctions: Fabrication, mechanism and advanced photocatalytic applications

Akshay Chawla,Anita Sudhaik,Pankaj Raizada,Aftab Aslam Parwaz Khan,Archana Singh,Quyet Van Le,Van Huy Nguyen,Adem Sreedhar,Saad M. Alshehri,Abdullah M. Asiri,Pardeep Singh 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.116 No.-

Not just people, but all living species, desire a clean and green environment to live a happy and healthylife. However, in our ever-increasingly congested world, it is quite challenging. Excessive deforestation,factory smoke, various chemical compounds, agricultural chemicals, etc. all pollute our environmentseverely. Some of its adverse consequences include water contamination and a shortage of energy supplies. In recent times, photocatalysts have sparked tremendous attention as a means of addressing energydemands as well as environmental challenges (water pollution). For this, SnO2 and SnO2 based photocatalystshave gained a great attention due to its good photocatalytic ability. In the same way, SnO2-based Zschemephotocatalysts has extended significant interest to address these concerns due to its strong photocatalyticcharacteristics, energy savings, eco-friendliness, and lack of adverse health effects. Though, thephotocatalytic effectiveness of conventional SnO2 semiconductors, with their shortcomings, falls wellshort of the real requirements. The current review emphasizes on admirable properties and several synthesisprocesses of SnO2 which make it an ideal photocatalyst. This study also stresses the fundamentalshortcomings of SnO2 that restrict its utilization. The central section of this review is concentrated onSnO2-based Z-scheme photocatalysts and most recent significant research modification of Z-schemeSnO2-based photocatalysts. The photocatalytic applications of Z-scheme SnO2-based photocatalysts forpollutants removal, energy conversion, and water splitting are also summarized. In conclusion, we haveaddressed the challenges and future exploration of SnO2-based photocatalysts with a Z-scheme heterojunctiontype for pollutant degradation and energy conversion.

Real -Time ECG Signal Acquisition and Processing Using LabVIEW

( Akshay Kumar Sharma ),( Kyung Ki Kim ) 한국센서학회 2020 센서학회지 Vol.29 No.3

The incidences of cardiovascular diseases are rapidly increasing worldwide. The electrocardiogram (ECG) is a test to detect and monitor heart issues via electric signals in the heart. Presently, detecting heart disease in real time is not only possible but also easy using the myDAQ data acquisition device and LabVIEW. Hence, this paper proposes a system that can acquire ECG signals in real time, as well as detect heart abnormalities, and through light-emitting diodes (LEDs) it can simultaneously reveal whether a particular waveform is in range or otherwise. The main hardware components used in the system are the myDAQ device, Vernier adapter, and ECG sensor, which are connected to ECG monitoring electrodes for data acquisition from the human body, while further processing is accomplished using the LabVIEW software. In the Results section, the proposed system is compared with some other studies based on the features detected. This system is tested on 10 randomly selected people, and the results are presented in the Simulation Results section.

Peristaltic Recovery After Peroral Endoscopic Myotomy for Achalasia: Dream or Reality?

( Akshay Kulkarni ),( Anshuman Elhence ),( Uday C Ghoshal ) 대한소화기기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.1