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윤현정 ( Hyun Jung Yoon ),조석 ( Seok Jo ),홍서나 ( Seo Na Hong ),이신석 ( Shin Seok Lee ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.4
Benign Joint Hypermobility Syndrome (BJHS) is characterized by generalized ligamentous laxity, with associated tendency to recurrent sprain and dislocation. Whereas ankylosing spondylitis (AS) is characterized by ankylosis and loss of mobility of the affected joints by fibrosis and ossification of cartilage and enthesis. The association of these two pathologies is rare. We report on a 18-year old man with a joint hypermobility and laxity as well as accompanying 18-month history of back pain at the lumbar spine, both knee and left buttock pain. At physical examination the patient presented 5 points of Nine-Point Beighton hypermobility score and limitation of movement in the lumbar spine due to back pain. Magnetic resonance imaging of the pelvis showed bilateral sacroiliitis and erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were elevated and HLA B27 was positive. Transthoracic echocardiography and opthalmologic examination excluded other cause of joint hypermobility. We diagnosed co-existent BJHS and AS.
관상동맥 중재술을 받은 급성 심근경색증 환자에서 체질량 지수의 영향
정선영 ( Seon Young Jeong ),이정애 ( Jung Ae Rhee ),정명호 ( Myung Ho Jeong ),황선호 ( Seon Ho Hwang ),윤남식 ( Nam Sik Yoon ),홍서나 ( Seo Na Hong ),이상록 ( Sang Rok Lee ),김계훈 ( Kye Hun Kim ),문재연 ( Jae Youn Moon ),홍영준 ( 대한내과학회 2007 대한내과학회지 Vol.73 No.6
목적: 비만은 관상동맥 질환의 위험인자로 알려져 있으나, 급성 심근경색증 환자에서 비만이 미치는 영향이나 관상동맥 중재술 후 장기 예후에 대한 영향은 잘 알려져 있지 않다. 본 연구를 통해 급성 심근경색증 환자에서 비만이 미치는 영향과 관상동맥 중재술 후 장기 예후에 미치는 영향을 알아보고자 하였다. 방법: 2002년 2월 1일부터 2006년 6월 30일까지 전남대학교 심장센터에서 급성 심근경색증으로 진단되어 관상동맥 중재술을 시행한 309예(60.5±11.3세, 남:여=243:66)를 대상으로 하였다. 체질량 지수가 25 kg/m2미만인 194예의 환자를 I 군(61.7±11.1세, 남:여=151:43), 체질량 지수가 25 kg/m2 이상인 115예의 환자를 II 군(58.6±11.5세, 남:여=92:23)으로 하여 두 군 간의 임상적 특성이나 위험인자들을 비교하였고, 6개월간 추적 경과관찰 동안 발생한 주요 심장 사건을 분석하였다. 결과: I 군에서 II 군에 비하여 나이가 많았고(61.7±11.1세 vs. 58.6±11.5세, p=0.017), II 군에서 고혈압(59/115 vs. 75/194예, p=0.033)과 고지혈증(60/115 vs. 75/194예, p=0.024)의 빈도가 높았다. 고지혈증의 경우 II 군이 I 군에 비해 혈중 총 콜레스테롤(201.4±42.6 mg/dL vs. 184.3±39.9 mg/dL, p=0.001), 중성지방(147.1±96.2 mg/dL vs. 121.2±61.6 mg/dL, p=0.005), 저밀도 콜레스테롤(134.1±37.8 mg/dL vs. 120.3±35.1 mg/dL, p=0.002)이 높았으나, 고밀도 콜레스테롤(42.3±10.2 mg/dL vs. 44.5±12.1mg/dL, p=0.109)은 차이가 없었다. 관상동맥 조영술이나 중재술과 연관된 인자는 두 군에서 차이가 없었다. 178예(I 군 109예, II 군 69예)의 환자에서 6개월 추적 관상동맥 조영술이 시행되었다. 재협착은 I 군에서 14예(12.8%), II 군에서 18예(26.1%)가 발생하여 II 군이 I 군에 비해 재협착율이 유의하게 높았다(p=0.025). 결론: 비만을 동반한 급성 심근경색증 환자에서는 고지혈증과 고혈압이 동반되는 경우가 많았으며, 관상동맥 중재술 후 재협착이 유의하게 많이 발생함을 알 수 있었다. 따라서 비만에 대한 적극적인 치료가 심근경색증 환자에서 중재술 후 재협착 예방에 중요할 것으로 생각되었다. Background: Obesity is one of the major risk factors for coronary artery disease. However, the long-term clinical effects of obesity after percutaneus coronary intervention (PCI) in Korean patients with acute myocardial infarction (AMI) have not been sufficiently evaluated. Methods: A total of 309 patients (mean age 60.5±11.3 years, M:F=243:66) that underwent PCI with a diagnosis of AMI between February 2002 and June 2006. Thepatients were divided into two groups according to the body mass index (BMI): group I (n=194; BMI<25 kg/m2; mean age 61.7±11.1 years, M:F=151:43) and group II (n=115; BMI≥25 kg/m2, mean age 58.2±11.3 years, M:F=92:23). Clinical characteristics and risk factors, and major adverse cardiac events during a six-month follow-up were compared between patients in the two gropus. Results: The mean age of group I patients was older than that of group II patients (61.7±11.1 years vs. 58.6±11.5 years, p=0.017). The prevalence of hypertension was higher in group II patients (75/194, 38.7% vs.59/115, 51.3%, p=0.033) and hyperlipidemia was more prevalent in group II patients (75/194, 38.7% vs. 60/115, 52.2%, p=0.024). The levels of total cholesterol (184.3±39.9 mg/dL vs. 201.4±42.6 mg/dL, p=0.001), triglycerides (121.2±61.6 mg/dL vs. 147.1±96.2 mg/dL, p=0.005), low-density lipoprotein-cholesterol (120.3±35.1 mg/dL vs. 134.1±37.8 mg/dL, p=0.002) were lower in group I patients than in group II patients. The restenosis rate on a follow-up coronary angiogram was higher in group II patients (18/69, 26.1%) than in group I patients (14/109, 12.8%, p=0.025). Conclusions: Obesity is associated with hyperlipidemia and hypertension in patients with AMI. The restenosis rate after PCI was higher in obese AMI patients. (Korean J Med 73:603-610, 2007)
김정기,홍서나,양보라,박정호,명보현,신종희,김세종,신동현 대한감염학회 2001 감염 Vol.33 No.5
Pylephlebitis is defined as an inflammation of the portal system, which is a rare but dreaded complication of intra-abdominal inflammatory processes. In the past it was observed as a sequela of neglected or complicated appendicitis. With earlier diagnosis, modern surgical technique and antibiotics, the incidence has declined even further. In addition, thrombosis in portal system (pylethrombosis) can complicate the pylephlebitis, followed by obstruction of the portal system, leading to portal hypertension in the late stage. Proper recognition of early thrombosis and an accompanying intra-abdominal inflammatory process should arouse the suspicion of septic thrombophlebitis and lead to the early institution of adequate therapy to prevent the almost universally fatal outcome. We report the case of woman who had pylephlebitis and presented with fever of unknown origin, probably associated with acute appendicitis. (Korean J Infect Dis 33:346∼349, 2001)