학교 음악수업에서 대중음악의 영향과 적용방안 연구

지혜미(Hye Mi Ji) 한국청소년문화연구소 2009 청소년 문화포럼 Vol.- No.22

서울 송파지역 초등학생에서 알레르기비염 유병률과 항원 감작과의 관련성

권지원 ( Ji Won Kwon ),서주희 ( Ju Hee Seo ),유진호 ( Jin Ho Yu ),김병주 ( Byoung Ju Kim ),김효빈 ( Hyo Bin Kim ),이소연 ( So Yeon Lee ),김우경 ( Woo Kyung Kim ),김경원 ( Kyung Won Kim ),지혜미 ( Hye Mi Ji ),김규언 ( Kyu Earn Kim 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.1

목적: 본 연구는 서울지역 초등학생 알레르기비염 유병률 및 위험인자를 확인하기 위해 시행되었다. 방법: 연구대상은 서울 송파지역 1개 초등학교 학생 1,376명 (남아 740명, 여아 636명) 이었고, 개량된 ISAAC설문지를 통해 알레르기비염의 유병률 분석을 시행하였고, 알레르기 피부반응검사 및 혈액 내 총 IgE, 호산구 분율 검사를 시행하여 생체지표에 따른 현증 알레르기비염의 위험도를 분석하였다. 결과: 설문지의 회수율은 98.3%였고, 대상군의 연령은 9.43±1.76세였고 남아가 746명, 여아가 636명으로 남녀의 비율은 53.8%, 46.2%였다. 최근 12개월 내 알레르기비염 증상 유병률은 39.0%, 알레르기비결막염 증상 유병률은 13.1%였으며, 평생 동안 의사에게 진단받은 알레르기비염의 유병률은 38.5%, 최근 12개월 내에 알레르기비염 치료 유병률은 29.5% 였다. 현증 알레르기비염의 유병률은 24.2%였다. 현증 알레르기비염의 위험인자로는 아토피피부염 진단 병력 (aOR=1.47, 95% CI 1.05-2.04), 천식 진단 병력 (aOR=3.48, 95% CI 2.15-5.61), 부모의 알레르기질환(aOR=3.78, 2.76-5.18), 어머니의 대졸이상 학력(aOR=1.42, 95% CI 1.02-1.99) 등이 있었다. 또한 호산구 분율이 높을수록(P value for trend =0.001), 혈청 IgE가 높을수록(P value for trend <0.001), 알레르겐 감작수가 많을수록(P value for trend <0.001) 위험도가 증가하였다. 집먼지진드기(1.54, 1.10-2.15), 개 항원(2.95, 1.38-6.28), 고양이 항원(1.85, 1.02-3.34), 오리나무 (2.71, 1.09-6.71), Alternaria 감작(2.37, 1.06-5.32)은 현증 알레르기비염의 독립적인 위험인자였다. 결론: 서울 초등학교 알레르기비염 유병률은 과거 자료와 비교하여 증가하고 있으며, 아토피피부염과 천식의 병력,부모의 알레르기질환력, 모의 높은 교육수준 등의 경우에 그위험도가 높았다. 혈액 내 호산구 분율, 혈청 IgE, 알레르겐 감작수는 현증알레르기비염과 용량반응관계의 위험도를 보였으며, 집먼지진드기, 개, 고양이 항원, 오리나무, Alterna-ria는 서울 송파지역 초등학생 알레르기비염의 주요 원인 항원이었다. Purpose: We investigated the relationship between allergic rhinitis (AR) and allergen sensitization in students at an elementary school in Seoul. Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire survey was administered to 1,376 elementary school children in the Songpa area of Seoul. Serum total IgE, blood eosinophils, and skin prick tests for 18 common allergens were performed. Results: The prevalence of AR symptoms during the last 12 months and the current AR, defined as having AR symptoms during last 12 months with a history of AR diagnosis from the doctor, were 39.0% and 24.2%, respectively. Males were more likely to have current AR than females (26.6% vs. 21.5%, P=0.04). Independent risk factors for current AR were parental allergic disease (adjusted odds ratio [aOR], 3.78, 95% CI, 2.76-5.18), history of atopic dermatitis (AD; aOR, 1.47; 95% CI, 1.05-2.04), history of asthma (aOR, 3.48; 95% CI, 2.15-5.61), and higher maternal education (aOR, 1.42; 95% CI, 1.02-1.99). The subjects with higher quartiles of serum total IgE (P value for trend <0.001), more than 4% of eosinophil fraction (aOR 1.76; 95% CI, 1.24-2.48), and allergen sensitization house dust mites [aOR, 1.54; 95% CI, 1.10-2.15], dog [aOR, 2.95; 95% CI, 1.38-6.28], cat [1.85; 95% CI, 1.02-3.34], Alternaria[aOR, 2.37; 95% CI, 1.06-5.32] and lateblooming tree pollen mixture [aOR 2.26; 95% CI, 1.12-4.57] were more likely to have current AR. Conclusion: The prevalence of AR in children has increased during the last decade. The sensitization to common allergens and increased sensitization were associated with the development of current AR. House dust mites, dog, cat, alder, and Alternaria were the important allergens for current AR. [Pediatr Allergy Respir Dis(Korea) 2011;21:47-55]

기관지확장제 반응 검사에서 속효성 기관지확장제 투여 용량의 차이가 소기도 반응도에 영향을 줄까?

백지현 ( Ji Hyeon Baek ),장호민 ( Homin Jang ),전유훈 ( You Hoon Jeon ),서보선 ( Bo Seon Seo ),이승진 ( Seung Jin Lee ),지혜미 ( Hye Mi Jee ),이경석 ( Kyung Suk Lee ),정영호 ( Young-ho Jung ),신윤호 ( Youn Ho Sheen ),한만용 ( Man 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.4

Purpose: It is recommended to use 200 (2 puffs) or 400 (4 puffs) μg of salbutamol in the bronchodilator response (BDR) test. We aimed to compare the difference between these 2 doses with regard to small airway dysfunction.Methods: One hundred sixteen subjects who visited the hospital for diagnosis or follow-up of asthma were consecutively enrolled between June 1 and November 31, 2013. The subjects were randomly assigned to the BDR test at the 2 doses (200 or 400 μg of salbutamol), with physicians blinded to the group each subject was assigned to and undertook the BDR test using the spirometry and impulse oscillometry system (IOS).Results: A total of 116 subjects participated in this study; the mean age was 7.8±3.6 years. The number of participants who were assigned to 2 and 4 puffs groups was 59 and 57, respectively. The mean age was older in the 4 puffs group than in the 2 puffs group (P=0.008). There were no significant difference in spirometric and oscillometric parameters between the 2 and 4 puffs groups. However, in subgroup analysis of asthmatic patients on maintenance therapy (n=21), there was a significant difference in relative changes in Rrs5 between the 2 and 4 puffs groups (16.4%±9.6% vs. 28.7%±8.8%, P=0.035). The forced expiratory volume of 1 second showed a significant correlation with resistance in the 2 puffs group and with reactance in the 4 puffs group.Conclusion: There was a significant relationship between the amounts of bronchodilators administered and the small airway dysfunction in children with asthma on maintenance therapy. Further research is warranted to delineate changes in spirometric and IOS measures in accordance with the different amounts of bronchodilators administered. (Allergy Asthma Respir Dis 2016:4:284-289)

소아 천식 환자에서 비염과 천식과의 관계: 알레르기비염과 비알레르기비염 비교

권은별 ( Eun Byul Kwon ),백지현 ( Ji Hyeon Baek ),김형윤 ( Hyeong Yun Kim ),윤정원 ( Jung Won Yoon ),신윤호 ( Youn Ho Shin ),지혜미 ( Hye Mi Jee ),최선희 ( Sun Hee Choi ),한만용 ( Man Yong Han ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1991 소아알레르기 및 호흡기학회지 Vol.1 No.3

Purpose: We aimed to determine the prevalence of allergic rhinitis and nonallergic rhinitis, difference in symptoms between allergic rhinitis and nonallergic rhinitis, and the association between lung function and the degree of asthma control in children with asthma. Methods: One hundred seventy patients who were followed-up for asthma treatment at the department of pediatrics of CHA Bundang Medical Center were enrolled in this study. We conducted the questionnaire regarding coexistence of rhinitis, childhood asthma control test (C-ACT), and the basic lung function test. The patients were classified as allergic rhinitis group and nonallergic rhinitis group according to the response to 11 common inhalation and food allergens, and assessed the degree of asthma control and the severity of rhinitis. Results: One hundred thirty patients (73%) were found to have rhinitis. Of these, 79 patients (53%) had allergic rhinitis and 34 patients (20%) had nonallergic rhinitis. The allergic rhinitis group was older than the nonallergic rhinitis group or the nonrhinitis group (7.73±2.85 vs. 5.97±2.48 vs. 6.12±2.70, P<0.001). Nasal itching sense was more prevalent in the allergic-rhinitis group than in the nonallergic rhinitis group (3.23±1.90 vs. 2.44±1.56, P=0.036). There was an inverse correlation between the rhinitis and C-ACT (r= .0.329, P<0.05). Of note, nasal obstruction symptom was highly correlated with C-ACT (r=.0.334, P<0.001). Conclusion: Allergic rhinitis and nonallergic rhinitis were highly prevalent in the pediatric patients with asthma and both of them had a significantly adverse impact on asthma control by rhinitis-itself. Therefore, regardless of atopic status, clinicians should focus on relieving rhinitis symptoms. (Allergy Asthma Respir Dis 2013;1:241-247)

소아 천식 환자에서 비염과 천식과의 관계: 알레르기비염과 비알레르기비염 비교

권은별 ( Eun Byul Kwon ),백지현 ( Ji Hyeon Baek ),김형윤 ( Hyeong Yun Kim ),윤정원 ( Jung Won Yoon ),신윤호 ( Youn Ho Shin ),지혜미 ( Hye Mi Jee ),최선희 ( Sun Hee Choi ),한만용 ( Man Yong Han ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3

Purpose: We aimed to determine the prevalence of allergic rhinitis and nonallergic rhinitis, difference in symptoms between allergic rhinitis and nonallergic rhinitis, and the association between lung function and the degree of asthma control in children with asthma. Methods: One hundred seventy patients who were followed-up for asthma treatment at the department of pediatrics of CHA Bundang Medical Center were enrolled in this study. We conducted the questionnaire regarding coexistence of rhinitis, childhood asthma control test (C-ACT), and the basic lung function test. The patients were classified as allergic rhinitis group and nonallergic rhinitis group according to the response to 11 common inhalation and food allergens, and assessed the degree of asthma control and the severity of rhinitis. Results: One hundred thirty patients (73%) were found to have rhinitis. Of these, 79 patients (53%) had allergic rhinitis and 34 patients (20%) had nonallergic rhinitis. The allergic rhinitis group was older than the nonallergic rhinitis group or the nonrhinitis group (7.73±2.85 vs. 5.97±2.48 vs. 6.12±2.70, P<0.001). Nasal itching sense was more prevalent in the allergic-rhinitis group than in the nonallergic rhinitis group (3.23±1.90 vs. 2.44±1.56, P=0.036). There was an inverse correlation between the rhinitis and C-ACT (r= -0.329, P<0.05). Of note, nasal obstruction symptom was highly correlated with C-ACT (r=-0.334, P<0.001). Conclusion: Allergic rhinitis and nonallergic rhinitis were highly prevalent in the pediatric patients with asthma and both of them had a significantly adverse impact on asthma control by rhinitis-itself. Therefore, regardless of atopic status, clinicians should focus on relieving rhinitis symptoms. (Allergy Asthma Respir Dis 2013;1:241-247)

소아천식 환자에서 충격진동법과 폐활량기로 측정한 소기도 장애와 호기산화질소와의 관계

서보선 ( Bo Seon Seo ),이정민 ( Jeong Min Lee ),조은혜 ( Eunhae Cho ),백지현 ( Ji Hyeon Baek ),이경석 ( Geong Suk Lee ),신윤호 ( Youn Ho Shin ),지혜미 ( Hye Mi Jee ),정영호 ( Yong Ho Jung ),한만용 ( Man Yong Han ) 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.4

Purpose: Fractional exhaled nitric oxide (FeNO) is a maker of airway inflammation, and impedance of low frequency in the impulse oscillometry system (IOS) reflects small-airway obstruction. We investigated the association of the FeNO level with IOS parameters and spirometry results in asthma patients. Methods: Fifty-eight children with asthma (60.3%, male), mean age 8.3 years (range, 4.5.16.0 years), were enrolled in the study. Reactance and resistance at 5 Hz with IOS, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and forced expiratory flow 25%.75% of the vital capacity (FEF25%-75%) with spirometry and FeNO were measured in all patients. The Z-score of spirometry and IOS parameters and the mean level of FeNO were used for correlation and regression analysis. Results: FeNO was not significantly associated with height, age, or other demographic parameters. There was a statistically significant correlation between spirometry results and IOS measurements. The FeNO level was not significantly correlated with IOS variables. After adjusting for height, sex, atopic status, and the use of inhaled corticosteroid, the FeNO level showed significant correlations with Z-score of FEV1/FVC (P=0.037, adjusted R2=0.234). Conclusion: FeNO was significantly correlated with Z-scores of FEV1/FVC, but not with IOS variables. Therefore, FeNO may be used to detect whole airway obstruction, but not small-airway obstruction. (Allergy Asthma Respir Dis 2015;3:267-271)

전형적인 알레르기 증상으로 내원한 6세 미만 소아 환자에서 항원 감작 패턴: 단일 기관 연구

윤정원 ( Jung Won Yoon ),이상민 ( Sang Min Lee ),김준환 ( Joon Hwan Kim ),김나연 ( Na Yeon Kim ),백지현 ( Ji Hyeon Baek ),백혜성 ( Hey Sung Baek ),지혜미 ( Hye Mi Jee ),김형윤 ( Hyeung Yoon Kim ),최선희 ( Sun Hee Choi ),김기은 ( K 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.4

Purpose: Population studies have reported that sensitization to inhalant allergens is rare in young children; however, most subjects in those studies had little or no symptoms or signs highly suggestive of allergic diseases. The aim of the present study was to assess the prevalence of sensitization to inhalant allergens in young children with symptoms and/or signs of allergic disease. Methods: We analyzed the results of all specific IgE tests performed at our hospital laboratory in children younger than 6 years presenting with symptoms and/or signs highly suggestive of allergic diseases between 2008 and 2013. Specific IgE tests for Dermatophagoides pteronyssinus, Dermatophagoides farinae, Alternaria alternata, German cockroach, cat dander, egg white or egg yolk, milk, peanut, and soybean were performed on 295 children; a specific IgE concentration ≥0.35 or ≥0.2 IU/mL was considered positive. We also compared allergen sensitization rates using the two cutoff values. Results: One hundred eighty-one children (61.4%) were positive to at least 1 allergen tested and 53 children (18.9%) were positive to at least 1 inhalant allergen when a specific IgE concentration ≥0.35 IU/mL was considered positive. The children were more likely to have asthma or allergic rhinitis when they were sensitized to any inhalant allergen, particularly house dust mites. The prevalence of sensitization to inhalant allergens increased with age (P<0.001). There was no significant difference in the prevalence of polysensitization among different age groups, but sensitization to both inhalant and food allergens significantly increased with age. Conclusion: Our results suggest that specific IgE tests to common inhalant allergens, particularly the house dust mites, may be considered when performing blood screening tests for young children presenting with symptoms and/or signs of allergic diseases

역류식 충진탑에서 수력학적인 분석과 이산화탄소의 탈착에 관한 연구

楊善惠,崔東勳,지혜미,金恩貞,金彰昊 동아대학교 환경문제연구소 1996 硏究報告 Vol.19 No.1

This study was carried out to interpret hydraulic behavior and CO₂gas desorption in countercurrent packing tower which packed 50 mm plastic Hiflow-ring. The results are as follows: 1. To compare with conventional packing, 50mm Hiflow-ring could save energy because of low pressure drop under high load. 2. As relative error between calculated value and investigated value was less than 6% in the loading point and flooding point we found that we can predict results mathematically which occurres in the packing tower. 3. The unique magnituteds of packing which was used are as follows. C_(L) = 2.1×10^(-4), n = 0.787 so we can predict efficency which occurres.