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이종심 ( Jong Sim Lee ),윤재원 ( Jae Won Yoon ),이경희 ( Kyong Hee Lee ),정성호 ( Sung Ho Jung ),류영준 ( Young Joon Ryu ),박정열 ( Jeong Yeol Park ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.1
Intravascular leiomyomatosis is a rare entity of benign smooth muscle tumor invading into the lumen of veins. Although these tumors are histologically benign they sometimes extend into the cardiac cavity and can cause sudden death due to their incarceration into the artrioventricular orifice. We present a case of the intravascular leiomyomatosis originating from huge leiomyoma in the pelvic cavity and extending to the ovarian veins, the inferior vena cava, the right atrium, the right ventricle and the pulmonary artery. She underwent surgery by a single-stage o including laparotomy and venotomy without thoracotomy, and the tumor was successfully removed. Therefore, we report this case with a brief review of the literature.
난소 갑상선종에서 기원한 유두상 갑상선암종 증례 보고 및 문헌 고찰
김주연 ( Joo Yuen Kim ),임유진 ( You Jin Lim ),이종심 ( Jong Sim Lee ),이선주 ( Sun Joo Lee ),박정열 ( Jeong Yeol Park ),남주현 ( Joo Hyun Nam ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.9
About 15-20% of ovarian tumors are teratomas. Struma ovarii is a highly specialized form of ovarian teratoma, in which thyroid tissue is the predominant element. It is rare, comprising about 2% of all teratomas, and malignant transformation occurs in less than 5% of struma ovarii. Among the malignant struma ovarii, papillary type is the most common histologic type. However, because of the rarity of malignant struma ovarii, there is considerable confusion concerning management. Recently, the authors experienced a case of papillary thyroid carcinoma arising in struma ovarii found in a postmenopausal woman who presented with adnexal mass and underwent laparoscopic unilateral salpingoophorectomy. Therefore, we report this rare case with a brief review of the literature.
조대현,박창원,김준규,이윤숙,서경원,이종심,김정구,문화회,김진석,조태순 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-
실험동물 랫드(SD계)의 수컷게 rnetharnphetamin(METH)을 Smg/kg/day의 용량으로 8일간 복강툰여하고, MK-801 (0.35mg/kg/day, ip ) , N- nitro- L- arginine ( NA,2smg/kg/day, j.p ) 및 sodium nitroprusside(SNP,4.7smg/kg/day, ip)를 MET였투여 30분전에 병용투여하였을 태 나타나는 신·경독성을 관찰하였다. 투여기간 중 임 상증상, 사망률, 조건회피반응을 측정하였으며, 부검일에 채취한 뇌조직을 이용하여 조직염색(nissl stain), 조직화학염색 (NADPH-diaphorase hi:;tocheinisty) 및 면역조직화학염색 (tyrosine hydroxylase(T보), glutamine synthetase(GS))를 실시하였다. 실험결과, M료70의 투여는 VTA에서 TH면역반응을 감소시키고. 선조체에서 NOS면역양성 중간신경세포의 구적감소, 잔존 중간신경세포의 형태학적 손상을 유발 및 해마에서 성상교세포의 재표인 GS의 면역반응을 증가시켰으며, METH 처치군에 MK-801을 전처치한 군에서는 MET보 단독처치군에 비해 그 독성정포가 경감됨을 관찰하였다. NA 전처치군에서는 임상증상 및 사망를은 악화되었으나, 조직학적인 면에서는 독성경감작용이 관찰되었다. 이상의 소견들이 MK-8()1의 전처치예 의하여 차단되는 것으로 미루어 보아 METH의 신경독성이 NMDA수용체의 매개에 의한 것으로 사료되며, NA웨 전처치로 임상증상 및 사망률은 악화되었으나, 조작 학적으로는 실결독성을 경감시켜 신경독성에 NO가 METH에 의한 신경독성에 팎여함을 추측할 수 있었다. The purpose of this siudy is te determine whether methamphetamine (METH )-induced neurotoxicities are related to NMDA - mediated excitatory toxicity. In addition, we also examined the effects of nitric oxide(NO) which is known to modulate NMDA receptor activity. In animal experiment, MK -801 (9.3smg/kg/day, ip, NMIIA antagonist), N-nitro-L-arginine(NA, 25mg/kg/day, ip, nitric of oxide synthetase inhibitor) and sodillm nitroprusside(SNP, 4.75mg/kg/day, ip, NO donor) were daily treated 30min before METH injection(Smg/1tg/day) for 8 days in SD rats. Waobsefred clinical signs, changes of body weight and carried out active avoidance test during the treatmeat period. After the final treatment, neurotoxicities were characterized by Missl stain, NADPH-diaphorase histochemistry, immunohistochemistry {tyroxine hydroxylase(TH), glutamine synthetase(GS)}. The results of this study were as follows; METH-induced neurotoxicities such as decrement of TH immunoactivity in Ventral Tegmental Area and increment of GS immunoactivity in hippocampus were observed in doparninergic neuron, interneuron and astrocyte. These neurotoxicities of METH were attenuated by pretreatment of MK-801. In NA pretreatmnent group, increment of the mortality and severity of clinical signs were shown, but the changes of histological alterations were similar to MK-801 pretreatment group. Based on these findings, we suggest that NMDA receptor and NO play an important role in the neurotoxic process of METH.