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배영훈,안태훈,임성철,박석천,이재창,강남현,배춘식,Bai, Young-Hoon,An, Tae-Hun,Lim, Sung-Chul,Pak, Sok-Cheon,Lee, Jae-Chang,Kang, Nam-Hyun,Bae, Chun-Sik 대한수의학회 2002 大韓獸醫學會誌 Vol.42 No.2
For the induction of arthropathy, 5% hydrogen peroxide($H_2O_2$) was injected for 5 weeks into the intraarticular space of the New Zealand white rabbits to damage articular cartilage. Alginic acid of low molecular weight (2%) made from macromolecular alginate treated with enzyme was administered into articular space at the dose of 5 mg/kg twice a week for 3 and 6 weeks using 1 ml syringe and 26 G needle. Saline was injected for the control. Tissues surrounding the articulation were obtained for the measurements of superoxide dismutase(SOD) activity as a major antioxidant enzyme and malondialdehyde (MDA) as a lipid peroxidation level. Histopathologic examination on the surface of articular cartilage was carried out. Data showed that injection of hydrogen peroxide for 5 weeks had led to the induction of free radical damage and of articular cartilage change as confirmed by microscopic observation. The application of hydrogen peroxide caused a gradual increase in the SODs and MDA. These patterns were similar after 3 and 6 weeks of alginate treatment. Furthermore, microscopic examinations revealed that hydrogen peroxide caused flaking, fibrillation, fissuring, denudation, and hypocellularity in the articular surfaces. In conclusion, lipid peroxidation was demonstrated in the articular cartilage by the administration of hydrogen peroxide in the rabbit model. This lipid peroxidation could be caused by oxygen free radicals. The histologic and enzymatic correlations on lipid peroxidation in the articulation have provided a better understanding of arthropathy. It is possible to take advantage of these findings to evaluate effective alginate dosage more efficiently.
Thiopental이 백서 자궁 평활근의 수축에 미치는 영향
안태훈,이세정,송창훈 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2
Background and Objectives: Thiopental has been used as an intravenous induction agent for cesarean section. The aim of the present study was to investigate the effects of thiopental on the isolated rat uterine smooth muscle. Materials and Methods: Uterine smooth muscle tissues were obtained from non-pregnant rats(n=20). The muscle strips were suspended in tissue baths and the isometric tension was recorded. After spontaneous uterine activity had been accomplished, thiopental in various concentrations was applied cummulatively to the bath and the effects were continuously monitored. Results: Thiopental induced a dose-dependent inhibition of spontaneous myometrial contractile activity, Complete muscular relaxation on the spontaneous uterine contractility was obtained at in a dose of 10_(-3)M of thiopental. Conclusions: The spontaneous contractile activity of the uterine smooth muscle is inhibited by thiopental.