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서용준(Seo Yong-Jun),서선덕(Suh Sunduck),김한영(Kim Hanyoung),서상교(Suh Sangkyo) 한국철도학회 2007 한국철도학회 학술발표대회논문집 Vol.- No.-
Number of highway lanes and level of service are based on the 30th, 60th or 100th highest hour volume of the target year. On the other hand, railroad design volume is generally expressed in average annual daily traffic (AADT). This procedure ignores attributes of railroad demand"s concentration on peak days and hours. Actual data analysis represents railroad"s peaking characteristics very similar to those of highways. Therefore it is necessary to set a procedure in selecting design volume for railroad planning. This study presents a concept and the calculating procedure for railroad design hourly volume to analyze effect of railroad investment.
GC/MS를 이용한 소변 중 대마 대사체 분석의 측정불확도 평가
김진영,정재철,서승일,서용준,이정직,김종상,인문교,Kim, Jin-Young,Jeong, Jae-Chul,Suh, Sung-Ill,Suh, Yong-Jun,Lee, Jeong-Jik,Kim, Jong-Sang,In, Moon-Kyo 대한약학회 2008 약학회지 Vol.52 No.6
We described an estimation of measurement uncertainty in quantitative analysis of 11-nor-9-carboxy-${\Delta}^9$-tetrahydrocannabinol (THCCOOH), the major metabolite of ${\Delta}^9$-tetrahydrocannabinol, in urine sample by solid-phase extraction (SPE) and GC/MS detection. The analytical results were compared and the different contributions to the uncertainty were evaluated. Inter-day and inter-person validation were performed using statistical analysis of several indicative factors. Measurement uncertainty associated with target analyte in real forensic samples was estimated using quality control (QC) data. Traceability of measurement was established through traceable standards, calibrated volumetric glassware and volume measuring device. The major factors of contribution to combined standard uncertainty, were calibration linearity, inter-day repeatability and inter-person reproducibility, while those associated with preparation of analytical standards and sampling volume were not so important considering the degree of contribution. Relative combined standard uncertainties associated with the described method was 12.05% for THCCOOH.
GC/MS를 이용한 모발 중 메스암페타민 및 암페타민 분석의 측정불확도 평가
김진영,김종상,김민경,이재일,서용준,인문교,Kim, Jin-Young,Kim, Jong-Sang,Kim, Min-Kyoung,Lee, Jae-Il,Suh, Yong-Jun,In, Moon-kyo 대한약학회 2007 약학회지 Vol.51 No.3
Recently estimating the uncertainty of an analytical result has become an essential part of quantitative analysis. This study describes the uncertainty of the measurement for the determination of methamphetamine and its major metabolite amphetamine in human hair, The method consists of washing, drying, weighing, incubation and extraction with methanolic HCI solution, clean-up, trifluoroacetyl derivatization, and qualification/quantification of residues by gas chromatography/mass spectrometry (GC/MS). Traceability of measurement was established through traceable standards and calibrated volumetric equipment and measuring instruments. Measurement uncertainty associated with each analyte in real samples was estimated using quality control (QC) data. The main source of combined standard uncertainty comprised two components, which are uncertainties associated with calibration linearity and variations in QC, while those associated with preparation of analytical standards and sample weighing were not so important considering the degree of contribution. Relative combined standard uncertainties associated with the described method ranged for individual analytes from 4.99 to5.03%.
신유진(Yu-Jin Shin),김봉선(Bong-Sun Kim),서용준(Yong-Jun Suh),조덕제(Duck-Jae Cho),최원일(Won-Eil Choi),이용규(Yong-Kyu Lee) 한국식품영양과학회 2004 한국식품영양과학회지 Vol.33 No.6
저령의 에틸아세테이트 추출물에서 4개의 분획을 제조한 후 백혈병 세포인 K-562, L-1210, HL-60와 U-937 세포의 세포생존 억제효능을 관찰하였다. Fr. 2는 L-1210, HL-60세포 억제효능이 미비하였고, fr. 3은 4종의 백혈병 세포주에 대하여 세포생존 억제효능이 있었다. 이 효능은 L-1210 세포에 대하여 가장 강하게 나타났다. 세포사멸 작용을 증명하는 DNA분절 현상을 L-1210 세포에서 관찰하였을 때, fr. 3을 30 ㎍/mL, 100 ㎍/mL로 처리한 군에서만 DNA분절 현상이 관찰되었다. Fr. 3에 대한 DNA합성 억제능을 [³H]thymidine incorporation test로 관찰하였을 때 50 ㎍/mL, 100 ㎍/mL로 처리한 군에서만 [³H]thymidine incorporation이 저하되었다. 결론적으로 저령에는 백혈병세포인 L-1210과 HL-60의 세포생존 억제성분이 포함되어 있으며, 억제작용은 L-1210에 가장 뚜렷이 나타내었다. Fr. 3은 L-1210 세포에 대하여 DNA 합성능을 저해시켰고, fr. 3가 L-1210 세포에 대하여 세포생존 억제작용을 나타내는 것은 계획된 세포사멸현상인 apoptosis에 의한 것으로 사료된다. 따라서 fr. 3에 대한 성분 연구가 요구되어진다. The effect of gradient eluted fractions from Et2O extracts of Polyporus umbellatus screlotium was investigated on the viability of leukemia cell lines, K-562, L-1210, HL-60 and U-937 cells. Among those fractions, fraction 2 showed mild cytotoxic effect on L-1210 and HL-60 cells. Fraction 3 showed cytotoxic effect on 4 cell lines, and cytotoxic effect was the most potent on L-1210. The hallmark of apoptosis, DNA fragmentation, also appeared by fraction 3 on L-1210 after 48 hr treatment. Furthermore, this fraction was shown to be able to induce cell death on L-1210 cells by the inhibition of DNA synthesis in [³H]thymidine incorporation test. From these results, P. umbellatus involves a potent chemical component that inhibits the viability of leukemia cell lines, L-1210. Further studies about the components of fraction 3 to function as a apoptosis inducer are necessary.