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Hesperidin 대사에 의한 대금음자(對金飮子)와 평위산(平胃散)의 처방해석
김남재,배은아,한명주,김동현,Kim, Nam-Jae,Bae, Eun-Ah,Han, Myung-Joo,Kim, Dong-Hyun 한국생약학회 1998 생약학회지 Vol.29 No.2
To analyze scientifically the polyprescription principle of Daekumeumja(對金飮子), which has been used for alcoholic damage, and Pyungwesan(平胃散), which has been used for indigestion, the transforming rate of hesperidin of these polyprescriptions to hesperetin was investigated. The transforming rate of the former was higher 3 times than that of the latter. The transforming rate of hesperidin of Aurantii nobilis Pericarpium was inhibited by Magnoliae Cortex, but was activated by Glycyrrhizae Radix. The activity of trypsin was inhibited by Glycyrrhizae Radix and Daekumeuja. However, Aurantii nobilis Pericarpium, Atractylodis Rhizoma, Magnoliae Cortex and Pyungwesan did not inhibited it. When human intestinal microflora were cultured with the media containing Daekumeumja, Pyungwesan and herbal medicines consisting of them, Aurantii nobilis Pericarpium and Magnoliae Cortex inhibited the activity of ${\beta}$-glucosidase. These results suggests that the therapeutic effect of Daekumeumja may be better than that of Pyungwesan on alcoholic damage and the therapeutic effect of Pyungwesan may be better than that of Daekumeumja on indigestion, although these prescriptions are consisted of the same herbal medicines.
감초 함유 처방의 글리치리진 대사와 몇가지 효소저해효과
김남재,배은아,한명주,김동현,Kim, Nam-Jae,Bae, Eun-Ah,Han, Myung-Joo,Kim, Dong-Hyun 한국생약학회 1999 생약학회지 Vol.30 No.3
To analyze scientifically the prescription principle of polyprescriptions (Gamchotang, Daewhanggamchotang, Jakyakgamchotang, Gamchogungangtang and Gilkyungtang) containing Glycyrrhizae Radix, the transforming rate of glycyrrhizin in these polyprescriptions to 18 ${\beta}-glycyrrhetinic$ acid and their inhibitory effect on ${\beta}-glucuronidase$, hyaluronidase, phosphodiesterase and trypsin were investigated. When Glycyrrhizae Radix containing polyprescriptions were extracted with water, the contents of glycyrrhizin in water extract of Glycyrrhizae Radix with Rhei Rhizoma or with Zingiberis Rhizoma were higher than that of Glycyrrhizae Radix only, but that in water extract of Glycyrrhizae Radix with Platicodi Radix was lower than that of Glycyrrhizae Radix only. By human intestinal bacteria, glycyrrhizin was metabolized to 18 ${\beta}-glycyrrhetinic$ acid. These metabolism of glycyrrhizin in polyprescriptions containing Glycyrrhizae Radix was inhibited by Rhei Rhizoma, Paeoniae Radix and Platicodi Radix, but was not affected by Zingiberis Rhizoma. The inhibitory activity of Glycyrrhizae Radix on hyaluronidase and ${\beta}-glucuronidase$, was synergistic with Rhei Rhizoma or Zingiberis Rhizoma, but was antagonistic by Platicodi Radix.
생약복합제제중 보기제(補氣劑)의 혈청성분 및 장내미생물에 대한 작용
김남재,김동현,박종백,홍남두,Kim, Nam-Jae,Kim, Dong-Hyun,Park, Jong-Baek,Hong, Nam-Doo 한국생약학회 1993 생약학회지 Vol.24 No.3
We have concerned the action of traditional herbal medicine (THM) to relate with longevity, aging and immune, etc. Espically, we have studied on the role of intestinal bacteria on THM such as Nokyongdaebo-Tang, Bojungikgi-Tang, Ikgibohyul-Tang, Bobyulansin-Tang and Bojanggunbi-Tang. Samples of the p.o. administration of 2 g/kg for 2 weeks did not find the change transaminase activities in mice. But, Nokyongdaebo-Tang and Bojanggunbi-Tang elevated the serum glucose levels and Bojungikgi-Tang elevated the total cholesterol levels in mice. ${\beta}-Glucuronidase$ activities in mice faeces are decreased by the treatment of Nokyongdaebo-Tang, Bojungikgi-Tang, Ikgibohyul-Tang and Bojanggunbi-Tang, but increased by the treatment of Bohyulansin-Tang. Number of lactic acid bacteria in mice faeces are increased by the treatment of Nokyongdaebo-Tang, Bojungikgi-Tang, lkgibohyul-Tang, Bohyulansin-Tang and Bojanggunbi-Tang. We recognized that ${\beta}-glucuronidase$ activities and the number of lactic acid bacteria were remarkably decreased by the pretreatment of antibiotics in mice. Nokyongdaebo-Tang and Ikgibohyul-Tang at the p.o. administration of 2 g/kg significantly increased the ${\beta}-glucuronidase$ activities and Bojungikgi-Tang and Bohyulansin-Tang remarkably increased the number of lactic acid bacteria in antibiotics pretreated mice.
왕대잎(Phyllostachys bambusoides S. et Z.)의 지질과산화억제활성
김남재,이석주,권창호,홍남두,Kim, Nam-Jae,Lee, Suk-Joo,Kwon, Chang-Ho,Hong, Nam-Doo 한국생약학회 1995 생약학회지 Vol.26 No.4
The leaf of Phyllostachys bambusoides S. et Z. (Gramineae) has been used in traditional herbal medicine as a antipyretics, antitussives and antidiuretcs, etc, in Korea, China and Japan. In order to investigate the effects on antilipoperoxidation and liver protective effect, the leaf of Phyllostachys bambusoides S. et Z. was extracted by water and then fractionated with butanol. The water extract and BuOH soluble fraction strongly exhibited antilipoperoxidatant effect in rat liver homogenate intoxicated with $CCl_4$. The BuOH fraction significantly suppressed the increases of s-GOT, s-GPT and s-LDH activities in injuried rats induced by $CCl_4$. And the BuOH fraction inhibited significantly the decrease of the body weight and showed the antilipoperoxidatant effect in liver and kidney in $CCl_4$ intoxicated rats.
김남재,윤황금,홍남두,Kim, Nam-Jae,Youn, Whang-Geum,Hong, Nam-Doo 한국생약학회 1994 생약학회지 Vol.25 No.3
Pharmacological effects of water extracts of Lycii Fructus, Lycii Folium and Lycii Cortex Radicis from Lycium chinensis were investigated. Lycii Folium significantly protected the hepatic function from damages orally caused by $CCl_4 $administration in mice and had a strong hypoglycemic effect in hyperglycemic mice induced by streptozotocin. Lycii Fructus decreased the blood pressure rise associated with the growth of normal rats. Lycii Cortex Radicis had a strong hypoglycemic effect in hyrerglycemic mice induced by streptozotocin. Also, hypolipidemic effects in hyperlipidemic rats induced by 1% cholesterol fed-diet and 75% fructose were significantly observed by oral administration of water extracts of Lycii Fructus, Lycii Folium and Lycii Cortex Radicis.
고 위험군 급성 담낭염 환자에서 경피적 담낭배액술의 치료 효과
김남재(Nam Jae Kim),이경태(Kyung Tae Lee),이승민(Seung Min Lee),김석현(Seok Hyun Kim),이병석(Byung Seok Lee),서광식(Kwang Sik Seo),김진희(Jin Hee Kim),김성걸(Seong Gul Kim),이헌영(Heon Young Lee) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.4
N/A Background/Aims: Percutaneous cholecystostomy for decompression and drainage of the gallbladder is indicated when the patient is elderly or suffers from an inflatnmatory process of the gallbladder and is unable to tolerate an operation. To evaluate the role of percutaneous cholecystostomy in the management of acute cholecystitis in the high risk patients, we reviewed our experiences. Methods: Fourteen high risk critically ill patients with acute cholecystitis underwent percutaneous cholecystostomy from January, 1994 to July, 1995 using 8.'7 Fr pigtail catheter under real-time ultrasound and fluoroscopic guidance. Results: The clinical conditions of 14 patients improved after percutaneous cholecystostomy without technical complications. Eight patients subsequently underwent successful elective cholecystectomy after improvement in their medical condition, but one patient who underwent surgery died 10 days after surgery due to gastric varix bleeding which was not related to the gallbladder catheter. The remaining six patients had resolution of acute cholecystitis but did not undergo elective operation because of their poor medical conditions (three in calculous disease) and restoration of gallbladder function(three in acalculous disease). Conclusions: Percutaneous cholecystostomy may be used as an initial life saving procedure for critically I]1 patients with acute cholecystitis, and serves as a definitive procedure for patients considered to be at high operative risk and who have no residual stones. (Korean J Gastroenterol 1997; 29:515-521)
김선영(Sun Young Kim),김진희(Jin Hee Kim),이경태(Kyung Tae Lee),이승민(Seung Min Lee),김석현(Seok Hyun Kim),이병석(Byung Seok Lee),김남재(Nam Jae Kim),정현용(Heon Young Jeong),이헌영(Heon Young Lee),김영건(Young Kun Kim) 대한내과학회 1999 대한내과학회지 Vol.56 No.5
N/A Objective : Eradication of H. pylori not only results in ulcer healing, but reduces recurrences essentially curing peptic ulcer disease. The purpose of this study was to evaluate the eradication rate of H. pylori and side effects with regard to three drug regimens. Methods : 96 patients were included and divided into three groups: 14 patients(group 1: OA) received omeprazole(20 mg b.i.d.) and amoxicillin(1.0 gm b.i.d.) for 14 days ; 12 patients (group 2: BAM) received colloidal bismuth subcitrate(CBS)(120 mg b.i.d.), amoxicillin(500 mg q.i.d.) and metronidazole(250 mg q.i.d.) for 14 days. ; 70 patients(group 3: OAC) received omeprazole(20 mg b.i.d.), amoxicillin(500 mg q.i.d.) and clarithromycin(250 mg q.i.d.) for 10 days. The diagnosis of the status of H. pylori was made by histology or culture or rapid urease test(CLO test). Results : 1) The eradication rate of H. pylori was higher group 2(91.7%) and group 3(91.4%) than group 1(57.1%). 2) The total failure rate regardless of the regimens (n=96) was 13.5%(13 patients). 10 patients whose treatment failed were randomly assigned to receive retreatment with the alternative regimen of BAM or OAC. In retreatment group(n=10), the eradication rate of H. pylori infection was achieved in 100 %. 3) The side effects were oral burning sensation, odynophagia, nausea, epigastric pain, diarrhea, constipation, gas bloating. The side effects were negligible. Conclusions : 10-day therapy with omeprazole, amoxicillin and clarithromycin(OAC) achieved eradication rate of 91.4 %. The side effects were few and negligible. 10-day therapy with OAC was a safe and very effective regimen for the eradication of H. pylori infection.
우리나라 담석증의 역학에 관한 연구 ; 전국적 다기관 협동 조사 성적
김명환 ( Myung Hwan Kim ),오희철 ( Hee Choul Ohrr ),정재복 ( Jae Bock Chung ),김창덕 ( Chang Duck Kim ),강진경 ( Jin Kyung Kang ),고문수 ( Moon Soo Koh ),김남재 ( Nam Jae Kim ),김대곤 ( Dae Ghon Kim ),김성국 ( Sung Kook Kim ),김 대한소화기학회 1999 대한소화기학회지 Vol.32 No.5
Background/Aims: To understand the epidemiologic characteristics of gallstone disease in Korea and to evaluate the chronological changes of gallstone disease, the authors performed this prospective nationwide cooperative study. Methods: The subjects were 1,263 patients with gallstone. They were hospitalized at 19 hospitals in Korea from February to July, 1997. The study protocals were recorded on 1,263 patients and gallstones were removed from 1,133 patients and their chemical compositions were analyzed. Results: Among total patients with gallstone, the proportions of patients with gallbladder, common bile duct (CBD) and intrahepatic duct (IHD) stones were 64.0%, 21.9%, and 14.1%, respectively. Male to female ratio was 1 versus 1.3. The gallbladder stones were categorized as cholesterol (58.1%), black pigment (25.2%) and brown pigment (12.1%) stones. The CBD stones were classified into brown pigment (76.1% ), cholesterol (18.4%) and black pigment (3.5%) stones.