사과 추출물과 phloretin에 의한 항염증 활성

김근호(Geun-Ho Kim),이은주(Eun-Joo Lee),류승민(Seung-Min Ryu),손호용(Ho-Yong Sohn),김종식(Jong-Sik Kim) 한국생명과학회 2021 생명과학회지 Vol.31 No.2

본 연구에서는 풋사과의 열수추출물(GAHW)과 에탄올추출물(GAE), 그리고 애사과 열수추출물(UAHW)을 제조하고 LPS로 활성화된 RAW264.7세포주를 이용하여 이들의 항염증 활성을 연구하였다. 모든 추출물이 세포생존율에는 영향을 미치지 않고 nitric oxide (NO) 생산을 저해하였으며, iNOS의 발현도 감소시켰다. 반면, UAHW만이 COX-2의 발현을 저해하였다. 또한 모든 추출물이 모든 MAPKs의 인산화를 감소시켰다. 모든 추출물이 ROS의 생산을 농도의존적으로 감소시켰으며, GAHW와 GAE에 의해 HO-1의 발현이 증가됨을 확인하였다. 또한, 사과 flavonoid인 phloretin과 phloridzin의 항염증 활성을 연구하였다. Phloretin은 농도의존적으로 NO의 생산을 저해하였으나, phloridzin은 NO 생산에 아무 영향이 없었다. 또한, phloretin은 iNOS와 COX-2 단백질의 발현을 감소시킨 반면, phloridzin은 두 단백질 발현에 영향을 주지 못하였다. 따라서, 이러한 연구결과는 사과 추출물은 MAPK 경로와 HO-1 경로를 조절함으로써 항염증 활성을 가지며, phloretin이 사과의 항염증 활성을 담당하는 파이토케미칼의 하나가 될 수 있음을 제시한다. In the present study, we prepared hot water extracts of green apple (GAHW) and unripe apple (UAHW), and ethanol extract of green apple (GAE), and investigated their anti-inflammatory activities in LPS-activated RAW264.7 cells. All extracts dramatically suppressed nitric oxide (NO) production in a dose-dependent manner in LPS-stimulated RAW264.7 cells without affecting cell viability. In addition, all extracts decreased the expression of iNOS, whereas UAHW only reduced the expression of COX-2. All extracts suppressed the phosphorylation of MAPKs (p38, ERK, and JNK) indicating all extracts show their anti-inflammatory activities via regulating MAPK pathway. Furthermore, all extracts reduced the production of reactive oxygen species in a dose-dependent manner and they increased the expression of heme oxygenase-I (HO-I) whereas UAHW could not. We also investigated whether apple flavonoids phloretin and phloridzin can have their anti-inflammatory activities in same in vitro model. Phloretin dramatically decreased NO production in a dose dependent manner without affecting cell viability, whereas phloridzin have no effects. Phloretin also reduced the expression of iNOS as well as COX-2, whereas phloridzin could not. Overall, these results suggest that apple extracts have their anti-inflammatory activities via regulating MAPKs and HO-1 pathways, and apple flavonoid phloretin can be one of phytochemicals responsible for anti-inflammatory effect of apple.

당뇨합병증-단백뇨로 알아보는 당뇨병환자의 신장질환 위험도

김근호,Kim, Geun-Ho 사단법인 한국당뇨협회 2005 당뇨 Vol.182 No.-

딥 러닝 기반 대학 이수학점 및 활동에 의한 교원임용 후보자 경쟁 시험 합격여부 예측

김근호,김의정,Kim, Geun-Ho,Kim, Eui-Jeong 한국정보통신학회 2019 한국정보통신학회논문지 Vol.23 No.8

최근 교사 직업에 대한 선호도가 높아짐에 따라 사범대학 및 교육대학의 선호도가 높아지고 있다. 모든 학생들이 교사에 진출 할 수 있는 것이 아니라 졸업 후 교원임용 후보자 경쟁시험이라는 시험을 통과하여야한다. 그러나 인구수 감소에 따른 임용T.O는 매년 줄어들고 있고 경쟁률은 가파르게 오르고 있는 사정이다. 때문에 입학하면서 임용시험에 매진하고자 대학교가 학문을 연구하고 배우는 곳이 아닌 시험을 위한 거대한 학원이 되어가는 중이다. 이에 본 연구에서는 학점뿐이 아니라 학생들의 전반적인 학교생활 및 스터디그룹 활용 여부 등을 종합하여 딥 러닝을 이용한 교원임용 후보자 경쟁시험 합격여부의 연관성을 파악하였다. 합격에 대하여 학과활동 등이 크게 영향을 미치지는 않았고 합격률 예측에 대한 정확도는 대체적으로 70%의 정확성을 보였다. The recent increase in preference for teacher jobs has led to a rise in preference for education colleges. Not all students can enter teachers, but they must pass the test called the competitive examination for teacher appointment candidates after graduation. However, due to the declining population, the and employment T.O.s are decreasing every year and the competition rate is rising steeply. Therefore, in order to concentrate on the recruitment exam upon entering the university, the university is becoming a huge academy for the exam, not a place to study and learn. We found a connection between students' overall school life and their use of study groups as well as their grades and whether they passed the competition test for teachers using deep running. The academic activities did not significantly affect the acceptance process, and the accuracy of the prediction of the acceptance rate was generally 70% accurate.

진로교육을 위한 희망진로 예측프로그램 설계

김근호,김의정,Kim, Geun-Ho,Kim, Eui-Jeong 한국정보통신학회 2018 한국정보통신학회논문지 Vol.22 No.8

In the wake of the 4th Industrial Revolution, the problem of career education in schools has become a big issue. While various studies are being conducted on services or technologies to effectively handle artificial intelligence and big data, in the field of education, data on students is simply processed. Therefore, in this paper, we are going to design and present career prediction programs for students using artificial intelligence and big data. Using observational data from students at the institute, the decision tree is constructed with the C4.5 algorithm known to be most intelligent and effective in the decision tree and is used to predict students' path of hope. As a result, the coefficient of kappa exceeded 0.7 and showed a fairly low average error of 0.1 degrees. As shown in this study, a number of studies and data will be deployed to help guide students in their consultation and to provide them with classroom attitudes and directions. 4차 산업혁명을 맞이하여 학교 교육에 있어서 진로교육의 문제가 크게 대두되고 있다. 일선 현장에서도 인공지능 및 빅 데이터들을 효과적으로 처리하기 위한 서비스 또는 기술에 대하여 다양한 연구가 진행되고 있으나, 교육분야에 있어서는 학생들에 대한 데이터들을 단순처리과정을 거칠 뿐이다. 이에 본 논문에서는 인공지능 및 빅데이터를 활용한 학생들의 진로교육을 위한 진로 예측 프로그램을 설계 제시하고자 한다. 영재교육원 학생들의 관찰데이터를 이용하여 의사결정 트리중 가장 인공지능에 가깝고 효과적이라고 알려진 C4.5알고리즘으로 의사결정 트리를 구성하고 학생들의 희망 진로를 예측하는 것이다. 판별결과 카파계수는 0.7을 넘어 상당한 일치도를 보였고 평균절대오차도 0.1정도로 상당히 낮은 수치를 보였다. 이에 따라서 본 연구에서 보이듯이 많은 연구 및 데이터를 구축하여 학생들의 상담에 활용 진로를 제시하고 수업태도 및 방향을 제시하는데 도움이 될 것으로 사료된다.

식도섬책에 대한 외과적 치료

김근호,김영학,Kim, Geun-Ho,Kim, Yeong-Hak 대한흉부심장혈관외과학회 1989 Journal of Chest Surgery (J Chest Surg) Vol.22 No.1

A clinical evaluation was made on total 207 cases of corrosive esophageal stricture after ingestion of various corrosive substances and 173 cases of neoplasms in the esophagus and the cardia. The various complications associated with esophageal corrosion were observed on 28 cases [13.5%] in a total of 207 cases. Pathoanatomic findings of complication may be classified to the five category as follow; [1] stenosis in the pharynx due to adhesion of the epiglottis, [2] esophagobronchial fistula, [3] esophageal perforation with bougienation, [4] necrotic rupture of the esophagus and the stomach, and [5] so-called chronic corrosive gastritis. The comparative studies were done on a total of 165 cases of the various procedures of esophagoplasty to the reconstruction of the esophagus, which consists of antethoracal esophagoplasty with jejunum, retrosternal esophagoplasty with jejunum, retrosternal esophagoplasty with right colon, and retrosternal esophagoplasty with left colon. There is no hard and fast rule in selection of jejunum, right colon or left colon as the transplanting bowel and an operative method either antethoracal or retrosternal approach. When there was no possibility of the complication and no any defect of the anatomical states, one stage retrosternal esophagoplasty using right colon was better in various points of view. The 173 patients of the neoplasm of the esophagus consist of 28 cases of benign tumors and 145 cases of malignant tumors in the esophagus and cardia. 28 cases of benign tumors in the esophagus received the surgical treatment and they obtained with excellent results postoperatively. Of the 145 patients of esophageal carcinoma who received surgical managements, 101 cases [69.6%] were found to be operable and 44 cases [30.3%] were inoperable. Due to the various level of carcinoma in the esophagus, the following different surgical procedure was properly used case by case to get the best results in each case. Esophageal carcinoma in the upper and middle third segment received the total esophagectomy and the reconstruction of the esophagus using right colon by substernal procedure. Esophageal carcinoma in the lower third segment received an esophagojejunostomy in the mediastinum after the resection of lower third segment of the esophagus. Carcinoma in the esophago cardia and the stomach received also an esophagojejunostomy after the resection of the lower third segment of the esophagus and subtotal gastrectomy. For the 44 patients with inoperable carcinoma, the several palliative surgical managements such as gastrostomy or jejunostomy for feeding and esophagojejunostomy for bypass of the lower esophagus and the stomach were properly performed case by case for their maximum improvement.

식도게실의 외과적 치료에 대한 임상적 고찰

김근호,김영학,Kim, Geun-Ho,Kim, Yeong-Hak 대한흉부심장혈관외과학회 1989 Journal of Chest Surgery (J Chest Surg) Vol.22 No.1

This is a report of 12 cases of esophageal diverticulum treated surgically at the Department of Thoracic and Cardiovascular Surgery, Hanyang University Hospital during the 16 years. 10 patients were female and 2 were male and the age distribution was between 31 and 61 years. Various subjective symptoms were noticed preoperatively. Diagnosis was confirmed by esophagography. The type of esophageal diverticulum were pulsion type in 11 cases and traction type in one case, and they were all located on the mid-thoracic esophagus, but one case was associated with epiphrenic pulsion diverticulum After diverticulectomy with or without myotomy, subjective symptoms disappeared and there were no operative complications and mortality. Indication of myotomy evaluated with motilities status by fluoroscopic finding of X-ray barium study. Recurrence of symptoms was not noticed during follow-up.

시뮬레이션을 통한 APV 모듈 cell string 최적화

김근호(Geun Ho Gim),김덕성(Deok Sung Kim),김우람(Woo Ram Kim),임철현(Cheol hyun Lim) 한국태양에너지학회 2020 한국태양에너지학회 학술대회논문집 Vol.2020 No.10

딥 러닝을 이용한 교원 임용후보자 경쟁시험 합격 여부 예측 적중률을 높이기 위한 방안 연구

김근호(Geun-Ho, Kim),정종인(Chong-In, Jeong),김창석(Chang-Seok, Kim),강신천(Shin-Chun, Kang),김의정(Eui-Jeong, Kim) 한국정보통신학회 2020 한국정보통신학회 종합학술대회 논문집 Vol.24 No.2

최근 4차 산업혁명 시대를 맞이하여 다양한 분야에서 인공지능 및 딥 러닝 머신러닝 등을 이용하여 예측 및 추천시스템을 개발 활용하고 있다. 따라서 본 연구는 사범대학 재학생들 및 교육대학원 재학생들의 가장 고민인 국내 대학생들의 가장 큰 고민인 진로 문제 즉 임용후보자 경쟁시험의 합격여부에 대한 예측을 하고 적중률을 높이기 위한 연구를 통하여 학생들의 지도 및 공부에 도움이 되고자 한다. 국·공립 중긍 교사가 되기 위해서는 사범대 및 교육대학에 진학하여 교원 자격증을 취득한 뒤 교원임용 후보자 경쟁시험이라는 일명 임용고사라는 시험을 통과하여야한다. 그러나 점차 인구수감소와 맞물려서 교육부에서 발표되는 임용T.O는 매년 줄어들고 있고 그에 비해 입학학생 수 및 재수생숫자는 늘어나 경쟁률은 가파르게 오르고 있는 사정이다. 이에 본 연구에서는 딥 러닝을 이용하여 교원 임용 후보자 경쟁시험 합격 여부 예측 모델을 구상하고 이에 예측 적중률을 높이기 위한 연구를 하고자 한다. 데이터 분석 및 딥 러닝과 같은 정보기술을 활용하여 학생들의 합격여부를 예측 하고 이에 따른 조언과 학습을 위한 방안을 제시하여 임용 후보자 경쟁시험 합격률 상승을 사료할 수 있을 것 이다. In the wake of the recent 4th Industrial Revolution, it has developed and utilized prediction and recommendation systems using artificial intelligence and deep running machine learning in various fields. Therefore, this study aims to help students guide and study through a study to predict whether they will pass the competitive examination for appointment candidates, which is the biggest concern for Korean university students, who are enrolled in the College of Education and students who are enrolled in the Graduate School of Education. In order to become a national and public-oriented teacher, he/she must go to a college of education or an education university, obtain a teacher"s license, and pass a test called a competitive examination for teachers" appointment candidates. However, the Ministry of Education"s employment T.O., which is announced by the Ministry of Education in line with the decrease in population, is decreasing every year, while the number of students enrolled and re-entered is increasing rapidly. In this study, we are going to use deep learning to devise a model for predicting whether or not a teacher candidate will pass the competitive examination and to increase the predicted hit rate. Information technology, such as data analysis and deep learning, will be used to predict whether students will pass the examination and to provide advice and learning measures accordingly to feed the increase in the rate of passing the competitive examination for appointment candidates. future.

관통형 필로티 내부 외장재의 풍압계수 분포특성 분석

김근호(Kim, Geun-Ho),유장열(You, Jang-Youl),유기표(You, Ki-Pyo),김영문(Kim, Young-Moon) 대한건축학회 2018 대한건축학회 학술발표대회 논문집 Vol.38 No.1

Various pilotis are installed in the lower part of high rise buildings. Strong winds can generate sudden airflow around the pilotis, which can cause unexpected internal airflow changes and may cause damage to the exterior of the piloti ceiling. The present study investigates the characteristics of peak wind pressure coefficient for the design of piloti exteriors by conducting wind pressure tests on high rise buildings equipped with penetration-type in urban areas. Peak wind-pressure coefficient increases with taller pilotis. On the other hand, when piloti height decreases, the absolute value of the minimum peak wind pressure coefficient increases.

과수용 Y 지주 일체형 영농형 태양광 구조물 개발

김근호(Geun Ho Gim),김우람(Woo Ram Kim),김창한(Chang Han Kim),남재우(Jaewoo Nam),임철현(Cheolhyun Lim) 한국태양에너지학회 2019 한국태양에너지학회 학술대회논문집 Vol.2019 No.10