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Zhu, Zhen-Li,Zhang, Jun,Chen, Mei-Lan,Li, Ke Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Introduction: Trastuzumab, an HER2-targeting agents, has shown efficacy in metastatic HER2-positive breast cancer patients. Single-agent clinical trials have evaluated therapeutic regimens using trastuzumab for metastatic breast cancer patients. The aim of our study is to evaluate the efficacy and safety of trastuzumab in combination with chemotherapy or hormone therapy in HER2-positive metastatic breast cancer patients. Methods: A literature research was conducted in PubMed and to identify appropriate studies from relevant reviews. Randomized controlled trials comparing chemotherapy or hormone therapy regimens in combination with trastuzumab were eligible. Dadta on clinical outcomes, including safety, efficacy, and patient characteristics were collected. Results: Seven articles describing five trials were included in our systematic review and meta-analysis. Partners of trastuzumab included in trials were anthracycline, paclitaxel, docetaxel, anastrozole and letrozole. The addition of trastuzumab to chemotherapy improved the overall survival (HR=0.79, 95%CI 0.65-0.96), while to hormone therapy did not (HR=0.85 95%CI 0.56-1.30). All trastuzumab-containing regimens increased cardiac toxicity (RR=3.37, 95%CI 1.26-9.02) and grade III-IV adverse events. Conclusions: Our study supports the addition of trastuzumab to chemotherapy which is effective and tolerated for metastatic breast cancer with HER2+ patients. Of note, more adverse events will occur followed the use of trastuzumab, especially cardiac toxicity, with two treatment regimens.
Zhen-Jian Lin,Xiao-Ming Lu,Tian-Jiao Zhu,Yu-Chun Fang,Qian-Qun Gu,Weiming Zhu 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9
An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y.C.Ma..Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.
Preparation and activity evaluation of chrysin-b-Dgalactopyranoside
Zhen-Yuan Zhu,Ling Chen,Fei Liu,Li-Jing Chen,Meng Meng,Hui-Qing Sun,Yong-Min Zhang 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.10
Chrysin-b-D-galactopyranoside was efficiently synthesized, evaluated for its inhibitory activities against H22 cell lines compared with chrysin, the scavenging of hydroxyl radical, DPPH radical and superoxide anion, inhibitory effect against bacteria and fungi. The structures of all compounds were fully characterized by spectroscopic data (NMR, MS). The anti-tumor, antioxidant and antimicrobial activities of chrysin-b-D-galactopyranoside were proved to be enhanced significantly compared with chrysin.
RVA Property analysis of rice varieties under different ecological condition of Yunnan Plateau
Zhen-Hua Zhu,Ki-Young Kim,Bo-Kyeong Kim,Lu-Yuan Dai,Jae-Kwon Ko 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10
Starch RVA profile parameters serve as important indices in the estimation of rice cooking and eating quality. Four cold- tolerant and five cold-sensitive japonica rice varieties grown at 3 different altitudes in Yunnan plateau were used in this experiments. RVA parameters including peak viscosity(PKV), hot viscosity(HTV), final viscosity(FLV), breakdown viscosity(BDV), setback viscosity(SBV) and pasting temperature(PaT) were investigated. SBV and PaT of cold tolerant varieties and PKV, BDV and SBV of cold-sensitive varieties were significantly influenced by environments. The variances of RVA parameters were affected by genotype×environment interactions in cold tolerant and sensitive varieties. The coefficients of variation of RVA parameters except for SBV in cold tolerant varieties were lower than those in cold sensitive varieties. HTV, FLV and SBV of cold tolerant varieties were significantly lower, while PKV, BDV and PaT were significantly higher than those of cold sensitive varieties. With altitude increasing, SBV and PaT of cold sensitive varieties increased significantly, whereas PKV, HTV, FLV and BDV decreased significantly. However, PKV, BDV and PaT of cold tolerant varieties gradually increased while HTV, FLV and SBV increased and then gradually decreased with altitude rising. These results suggested that cooking and eating quality would be improved by improving cold tolerance of rice varieties in breeding program.
Stock Prices and the Exchange Rate in a Structural Model with an Application to the Case of France
Zhu, Zhen 세종대학교 국제경제연구소 1998 Journal of Economic Integration Vol.13 No.1
This paper investigates the relationship between stock prices and the real exchange rate suggested by some structural macroeconomic models such as Gavin [1989]. Adding stock prices to a conventional macroeconomic model allows us to examine the stock price-exchange rate relationship, and empirically investigate the dynamics of the variables in the system more precisely than a bi-variate system. French data are used to study the long run as well as short run relationships. The results suggest the usefulness of incorporating stock markets into such studies. (JEL Classification: E44, G15, F31)
Lin, Zhen-Jian,Lu, Xiao-Ming,Zhu, Tian-Jiao,Fang, Yu-Chun,Gu, Qian-Qun,Zhu, Weiming 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9
An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y.C.Ma.. Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.