벌자상 후에 발생한 급성심근경색증 2례

민영기,정윤석,박인철,조준필,탁승제 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Acute myocardial infarction after a bee sting is a very rare process. Among proposed mechanisms, vasospasm of the coronary artery ㅑs the most probable mechanism. Many mediators are included in the venom of wasps, and those mediators have vasoconstrictive properties and may constrict the coronary artery. Furthemore, those mediators have thrombogenic properties that lead to thrombogenesis in the coronary artery and aggravate myocardial ischemia. Epinephrine, commonly used in the management of anaphylactic shock, may further aggravate myocardial ischemia, We experienced two cases of acute myocardial infarction after a bee sting. In the first case, we could find no underlying abnormalities of the coronary vessel because the patient died during coronary angiography. In the second case, the electrocardiogram showed inferior wall myocardial infarction, but only mild stenosis of the right coronary artery was seen in coronary angiography.

STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice.

Cho, Mi-La,Kang, Jung-Won,Moon, Young-Mee,Nam, Hyo-Jung,Jhun, Joo-Yeon,Heo, Seong-Beom,Jin, Hyun-Tak,Min, So-Youn,Ju, Ji-Hyeon,Park, Kyung-Su,Cho, Young-Gyu,Yoon, Chong-Hyeon,Park, Sung-Hwan,Sung, You American Association of Immunologists 2006 Journal of Immunology Vol.176 No.9

<P>IL-23 is a heterodimeric cytokine composed of a p19 subunit and the p40 subunit of IL-12. IL-23 has proinflammatory activity, inducing IL-17 secretion from activated CD4(+) T cells and stimulating the proliferation of memory CD4(+) T cells. We investigated the pathogenic role of IL-23 in CD4(+) T cells in mice lacking the IL-1R antagonist (IL-1Ra(-/-)), an animal model of spontaneous arthritis. IL-23 was strongly expressed in the inflamed joints of IL-1Ra(-/-) mice. Recombinant adenovirus expressing mouse IL-23 (rAd/mIL-23) significantly accelerated this joint inflammation and joint destruction. IL-1beta further increased the production of IL-23, which induced IL-17 production and OX40 expression in splenic CD4(+) T cells of IL-1Ra(-/-) mice. Blocking IL-23 with anti-p19 Ab abolished the IL-17 production induced by IL-1 in splenocyte cultures. The process of IL-23-induced IL-17 production in CD4(+) T cells was mediated via the activation of Jak2, PI3K/Akt, STAT3, and NF-kappaB, whereas p38 MAPK and AP-1 did not participate in the process. Our data suggest that IL-23 is a link between IL-1 and IL-17. IL-23 seems to be a central proinflammatory cytokine in the pathogenesis of this IL-1Ra(-/-) model of spontaneous arthritis. Its intracellular signaling pathway could be useful therapeutic targets in the treatment of autoimmune arthritis.</P>

혈청 총 콜레스테롤과 관련된 인자들

탁양주,유선미,조비룡,송윤미,유태우,허봉렬 대한가정의학회 1992 Korean Journal of Family Medicine Vol.13 No.12

공공부조 수급자의 생활실태와 소득활동에 관한 연구 : 광주광역시 서구 영구임대주택 거주 국민기초 생활보장 수급자를 중심으로

조원탁,이형하,윤종성 한국사회복지정책학회 2004 사회복지정책 Vol.19 No.-

본 연구에서는 소득활동에 참여하는 국민기초생활보장제도 수급자의 일과 생활에서 나타나는 급여수 행태와 욕구를 확인하고 소득획득금액이라는 변수를 활용하여 욕구별 차이를 살펴보았다. 먼저 일하는 수급자의 일반적 특성을 사회복지전담공무원이 활용하는 보건복지종합행정시스템의 자료를 활용하여 기초통계 분석을 실시하였으며 다음으로 가족특성과 근로형태를 고려하여 선정된 44사례에 대해 귀납적 방법으로 욕구 분석을 하였다. 또한 욕구별 소득획득금액의 차이를 복지급여액과 기타 지원내용을 현금화한 자료와 빈곤을 구성하는 지수를 통해 분석하였다. 분석결과를 요약하면 첫째, 일하는 수급자의 특성에서 여성가구주는 자녀교육과 양육에 대한 부담이 크고 남성가구주는 질병과 장애가 있는 가구원 보호에 대한 부담이 큰 것으로 나타났다. 20대에서는 양육과 보호에 대한 욕구, 30~40대에서는 교육비지원에 대한 욕구, 50대에서는 일자리 유지와 질병에 대한 욕구가 강한 것으로 나타났다. 둘째, 일하는 수급자의 생활에서 파악된 급여 수급형태는 일반 장기관에 신고되지 않는 소득활동에 참여하는 형식으로 나타났다. 주된 욕구문제는 질병문제 교육비 부담, 가사부담, 아동보육, 불안정한 소득기반, 빈곤생활의 지속, 부채 등으로 나타났다. 셋째, 복지급여액과 기타 지원내용을 현금화한 소득획득금액을 산출을 통한 분석 결과 일하는 수급자들은 국가가 정한 최저생계비 대비 130%의 수입효과를 얻는 것으로 나타났다. 따라서 향후 차상위계층의 소득획득금액의 분석을 통해 비교연구를 하는 것이 필요하다. This study intends to examine the behaviours within daily lives of recipients of national basic livelihood protection, who participate in economic activities, and get the bottom of the efficiency of their needs. First, I conducted fundamental statistics analysis on general data of working recipients by using materials from health and welfare general administration system, which is used by governmental employees in social welfare department. Then I selected 44 cases considering their family career and type of business they are engaged in, and conducted analysis on their needs inductively. In addition, I conducted this analysis by converting welfare allowance and other support into money to determine the result of behaviours for their needs. The result can be summarized as follows. First, it is found out that female householders worry about the educational expenditure of their children and the cost of bringing up their children the most and that male householders family members who suffer from illnesses or disorders the most. It is shown that the recipients in their 20s are interested in the bringing up and protection of their children, in their 30s to 40s meeting the educational expenditure of their children, and in their 50s keeping being employed and maintaining their health. Second, they avoid getting usual jobs, prefer self-support jobs provided by the government to usual ones and work close to their home, and mostly participate in economic activities, which are not registered in social security institutes, as I examined their strategies by conducting intensive interview on their life and job. They mostly worry about their health, educational expenditure, household duties, bringing up their children, unstable income, continuation of poverty and debt. Third, they earn 130% of minimum cost of living, which is determined by the government, according to the analysis on their needs and efficiency. Especially, the efficiency was found high in cases where recipients seem to worry about education, protection of their children and debt. This study has significance as it intends to examine the recipients who live in permanent rental apartments and evaluate their needs and efficiency of the allowance in a situation where their residential space and health care are insured. Second, this study proved the adequacy of implementing separate allowance system in areas such as residence, health care and education, by clarifying strategies by needs and conducting analysis on efficiency.

역전파 학습 알고리즘의 최적화에 관한 연구

탁형근,홍봉화,윤현식,조원경 慶熙大學校 레이저 工學硏究所 1992 레이저공학 Vol.3 No.-

In this paper, the back-propagation algorithm through change learning parameter nita(η) has been proposed to improve learning speed. The proposed algorithm has been applied to consonants pattern learning of Hangul. The learning speed in pattern traning of consonants of Hangul is improved more than 18 percentage. According to the region of conversions, it is remoted to the effect.

Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension.

Cho, Yu Ji,Han, Jae Yoon,Lee, Sang Gab,Jeon, Byeong Tak,Choi, Wan Sung,Hwang, Young Sil,Roh, Gu Seob,Lee, Jong Deog American Association for Laboratory Animal Science 2009 Comparative medicine Vol.59 No.4

<P>Angiogenic factors such as vascular endothelial growth factor (VEGF) are implicated in pulmonary hypertension (PH). However, the pathway of angiogenic factor-mediated pathologic angiogenesis in PH remains unclear. In this study, we evaluated the temporal expression of angiopoietin (Ang) 1, Ang2, and their receptor (Tie2) as well as VEGF, endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), and heme oxygenase 1 (HO1) in the monocrotaline-induced PH model. Histologic evaluation showed pathologic vascular remodeling in the arteries of lung sections 1 wk after monocrotaline treatment. Protein levels of Ang1, Ang2, eNOS, iNOS, HO1, and VEGF were increased 1 wk after monocrotaline treatment but Tie2 protein levels were decreased 2 wk afterward. These results suggest that Ang2 mediates vascular remodeling in PH by decreasing Tie2 expression. Therefore, the Ang-Tie2 system may play a role in the pathophysiology of PH.</P>

Col1a1-cre mediated activation of β-catenin leads to aberrant dento-alveolar complex formation

Tak-Heun Kim,Cheol-Hyeon Bae,Eun-Ha Jang,Chi-Young Yoon,Young Bae,Seung-O Ko,Makoto M,Taketo,Eui-Sic Cho 대한해부학회 2012 Anatomy & Cell Biology Vol.45 No.3

Wnt/β-catenin signaling plays a critical role in bone formation and regeneration. Dentin and cementum share many similarities with bone in their biochemical compositions and biomechanical properties. Whether Wnt/β-catenin signaling is involved in the dento-alveolar complex formation is unknown. To understand the roles of Wnt/β-catenin signaling in the dento-alveolar complex formation, we generated conditional β-catenin activation mice through intercross of Catnb+/lox(ex3) mice with Col1a1-cre mice. In mutant mice, tooth formation and eruption was disturbed. Lower incisors and molars did not erupt. Bone formation was increased in the mandible but tooth formation was severely disturbed. Hypomineralized dentin was deposited in the crown but roots of molars were extremely short and distorted. In the odontoblasts of mutant molars, expression of dentin matrix proteins was obviously downregulated following the activation of β-catenin whereas that of mineralization inhibitor was increased. Cementum and periodontal ligament were hypoplastic but periodontal space was narrow due to increased alveolar bone formation. While cementum matrix proteins were decreased, bone matrix proteins were increased in the cementum and alveolar bone of mutant mice. These results indicate that local activation of β-catenin in the osteoblasts and odontoblasts leads to aberrant dento-alveolar complex formation. Therefore, appropriate inhibition of Wnt/β-catenin signaling is important for the dento-alveolar complex formation.

양측성 신우신염에 동반된 급성 신부전 1 예

윤성철,김병하,조종태,탁우택,최유식 대한내과학회 2002 대한내과학회지 Vol.62 No.3

Acute renal failure is a rare complication of acute pyelonephritis. Therefore, acute pyelonephritis is not usually considered in the differential diagnosis of acute renal failure. However, it is import ant to consider this entity because of potential for recovery of renal function if appropriate early antibiotics are instituted. We report a case of biopsy pr oven acute pyelonephritis which was manifested as acute renal failure. A 38-year-old women was admitted to this hospital owing to abdominal distension and generalized edema. On admission she was started on hemodialysis because of severe hyperkalemia and marked uremic symptoms. She had pyuria and hematuria, but no organism was isolated at urine. We initially don't know the cause of renal failure. She was improved with antimicrobial therapy and hemodialysis. A kidney biopsy was performed on the 26th hospital day because of persistent proteinuria. Microscopic examination revealed focal tubular atrophy, necrosis or loss wit h heavy infilteration of leukocytes and histocytes in interstitium. Atrophic tubules contain pus casts. The patient was treated with ciprofloxacin for 4 weeks. At about 2 month follow up, proteinuria completely disappeared and serum creatinine level decreased to 1.0 mg/dL. (Korean J Med62:297- 301, 2002)

Outcome of ABO-incompatible adult living-donor liver transplantation for patients with hepatocellular carcinoma

Yoon, Young-In,Song, Gi-Won,Lee, Sung-Gyu,Hwang, Shin,Kim, Ki-Hun,Kim, Seok-Hwan,Kang, Woo-Hyoung,Cho, Hwui-Dong,Jwa, Eun-Kyoung,Kwon, Jae-Hyun,Tak, Eun-Young,Kirchner, Varvara A. Elsevier 2018 Journal of hepatology Vol.68 No.6

<P>Lay summary: Despite hypothetical immunological concerns that the desensitization protocol for breaking through the ABO blood group barrier might have a negative impact on the recurrence of hepatocellular carcinoma, our experience demonstrated no significant differences in the long-term overall survival and recurrence-free survival rates between patients receiving ABO-compatible or ABO-incompatible liver transplantation. In conclusion, results from our institution indicated that ABO-incompatible living-donor liver transplantation constitutes a potentially feasible option for patients with hepatocellular carcinoma, especially those with compensated cirrhosis with hepatocellular carcinoma within conventional Milan criteria. (C) 2018 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</P>

<i>Col1a1-cre</i> mediated activation of β-catenin leads to aberrant dento-alveolar complex formation

Kim, Tak-Heun,Bae, Cheol-Hyeon,Jang, Eun-Ha,Yoon, Chi-Young,Bae, Young,Ko, Seung-O,Taketo, Makoto M.,Cho, Eui-Sic Korean Association of Anatomists 2012 Anatomy & Cell Biology Vol.45 No.3

<P>Wnt/β-catenin signaling plays a critical role in bone formation and regeneration. Dentin and cementum share many similarities with bone in their biochemical compositions and biomechanical properties. Whether Wnt/β-catenin signaling is involved in the dento-alveolar complex formation is unknown. To understand the roles of Wnt/β-catenin signaling in the dento-alveolar complex formation, we generated conditional β-catenin activation mice through intercross of <I>Catnb<SUP>+/lox(ex3)</SUP></I> mice with <I>Col1a1-cre</I> mice. In mutant mice, tooth formation and eruption was disturbed. Lower incisors and molars did not erupt. Bone formation was increased in the mandible but tooth formation was severely disturbed. Hypomineralized dentin was deposited in the crown but roots of molars were extremely short and distorted. In the odontoblasts of mutant molars, expression of dentin matrix proteins was obviously downregulated following the activation of β-catenin whereas that of mineralization inhibitor was increased. Cementum and periodontal ligament were hypoplastic but periodontal space was narrow due to increased alveolar bone formation. While cementum matrix proteins were decreased, bone matrix proteins were increased in the cementum and alveolar bone of mutant mice. These results indicate that local activation of β-catenin in the osteoblasts and odontoblasts leads to aberrant dento-alveolar complex formation. Therefore, appropriate inhibition of Wnt/β-catenin signaling is important for the dento-alveolar complex formation.</P>