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- 저자 : ( Yan Huang ) (검색결과 587 건)
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Lu, Yan-Yan,Huang, Xin-En,Xu, Lin,Liu, De-Gan,Cao, Jie,Wu, Xue-Yan,Liu, Jin,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Background: Pemetrexed (PEM) is effective in first-line treatment for patients with non-squamous non-small cell lung cancer (NSCLC). However there are currently no definitive determinants to certify which patients could benefit from PEM. To improve the efficacy of PEM combined with platinum as first-line therapy for advanced non-squamous NSCLC, we conducted this retrospective study to detect potential determinants of this regimen. Methods: We recruited 109 patients with advanced non-squamous NSCLC who received PEM with a platinum as first-line therapy from June 2006 to February 2013 in Jiangsu Cancer Hospital. Multiple variables (age, sex, smoking, degree of cell differentiation, hemoglobin, platinum drugs combined, positions of metastasis) were selected. Logistic regression analysis was used to analyse relationships between these variables and tumor response. Result: In univariate analysis, we found that age and platinum significantly influenced the results of PEM therapy (P<0.05). In multivariable analysis, no factors were independently significant. Conclusion: Our analysis did not suggest that the age, sex, metastasis of liver or other organs, hemoglobin, smoking history and pathological differentiation are associated with the response of PEM. We should conduct further analyses with larger sample size to reconfirm this issue.
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Clinical Observations on Associations Between the UGT1A1 Genotype and Severe Toxicity of Irinotecan
Lu, Yan-Yan,Huang, Xin-En,Wu, Xue-Yan,Cao, Jie,Liu, Jin,Wang, Lin,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Background: Severe toxicity is commonly observed in cancer patients receiving irinotecan (CPT-11) UDPglucuronosyltransferase1A1 (UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38 but the relationship between UGT1A1 and severe toxicity remains unclear. Our study aimed to assess this point to guide clinical use of CPT-11. Materials and Methods: 89 cancer patients with advanced disease received CPT-11-based chemotherapy for at least two cycles. Toxicity, including GI and hematologic toxicity was recorded in detail and UGT1A1 variants were genotyped. Regression analysis was used to analyse relationships between these variables and tumor response. Results: The prevalence of grade III-IV diarrhea was 10.1%, this being more common in patients with the TA 6/7 genotype (5 of 22 patients, 22.7%) (p<0.05). The prevalence of grade III-IV neutropenia was 13.4%and also highest in patients with the TA 6/7 genotype (4 of 22 patients; 18.2%) but without significance (p>0.05). The retreatment total bilirubin levels were significantly higher in TA6/7 patients (mean, $12.75{\mu}mol/L$) with compared to TA6/6 (mean, $9.92{\mu}mol/L$) with p<0.05. Conclusions: Our study support the conclusion that patients with a $UGT1A1^*28$ allele (s) will suffer an increased risk of severe irinotecan-induced diarrhea, whether with mid-or low-dosage. However, the $UGT1A1^*28$ allele (s) did not increase severe neutropenia. Higher serum total bilirubin is an indication that patients UGT1A1 genotype is not wild-type, with significance for clinic usage of CPT-11.
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Lu, Yan-Yan,Huang, Xin-En,Cao, Jie,Xu, Xia,Wu, Xue-Yan,Liu, Jin,Xiang, Jin,Xu, Lin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8
Purpose: To investigate the efficacy and safety of Javanica oil emulsion injection (Yadanzi$^{(R)}$) combined with pemetrexed and platinum (PP) for treating patients with advanced lung cancer. Patients and Methods: From June 2011 to June 2013, we recruited 58 patients with advanced lung cancer, and divided them into two groups. Twenty eight patients received Yadanzi$^{(R)}$ (from ZheJiang Jiuxu Pharmaceutical Co., Ltd.) together with PP chemotherapy (combined group), while the others were given only PP chemotherapy (control group). After two cycles of treatment, efficacy and safety of treatment were evaluated. Results: The overall respnse rate [(CR+PR+SD)/(CR+PR+SD+PD)] of the combined group was higher than that of control group (89.7% vs. 86.2%, p>0.05). Regarding rate of life improvement, it was 82.8% in combined group, and 51.7% in the control group (p<0.05). In terms of side effects, leukopenia in combined group was less frequent than that in control group (p<0.05). More patients in the control group were found to suffer liver toxicity. Conclusions: Javanica oil emulsion injection combined with chemotherapy could be considered as a safe and effective regimen in treating patients with advanced lung adenocarcinoma. It can improve the quality of life and reduce the possibility of leukopenia. Further clinical trials with a large sample size should be conducted to confirm whether addition of Yadanzi$^{(R)}$ to chemotherapy could increase the response rate, reduce toxicity, enhance tolerability and improve quality of life for patients with advanced lung cancer.
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Yan-Hua Huang,Sheng-Qi Yang,Guo-Qing Chen,Bo Meng 한국지질과학협의회 2022 Geosciences Journal Vol.26 No.1
It is important to analyze the rock crack initiation, propagation and coalescence in fractured rock mass. At present, the 3D crack evolution process of pre-flawed rock has not been comprehensively studied during the deformation. In this study, uniaxial compression tests were carried out on cylindrical sandstone specimens with two pre-existing flaws with various ligament inclination angles. The crack evolution process at the front surface of the specimen was analyzed by photographic and AE monitoring. In addition, a 3D discrete element modelling was conducted to explore the spatial crack evolution behaviors during compressive loading. Both the numerical strength and final failure modes of specimens were consistent with those obtained in the laboratory experiment. The numerical simulation results revealed that the internal crack distribution was not always identical along the thickness direction. Two types of crack coalescence were identified. The experimental and numerical results enhance the understanding of 3D crack evolution mechanism of fractured rock under external loading.
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A Strategy of Subsea Pipeline Identification with Sidescan Sonar based on YOLOV5 Model
Yan Li,Meiyan Wu,Jiahong Guo,Yan Huang 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
Accurate identification of pipelines is the basis and prerequisite for tracking and inspection of subsea pipelines with the help of autonomous unmanned vehicles. In this paper, we proposed a strategy based on a deep learning model YOLOV5 to extract the subsea pipeline from acoustic images acquired by a Side scan sonar (SSS). Considering the imaging mechanisms of SSS, the formed bar image by SSS in a short certain period is segmented into many sub-images. Subsequently, these sub-images are fed into a pre-trained identification model based on YOLOV5 to extract the subsea pipelines. This strategy ensures the subsea pipeline could be detected with low time consumption and satisfactory accuracy. The average precision (AP) of our proposed subsea pipeline identification strategy achieved 97.62% with 304ms time consumption for the bar image formed in the 10s period. The experimental results demonstrate that the performance of the proposed subsea pipeline identification strategy is superior comparing with other state-of-the-art models in the performance of both identification and real-time.
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Kinetic Models of Controllable Pore Growth of Anodic Aluminum Oxide Membrane
Yan Huang,Hong-yan Zeng,Ce Zhao,Ye-qing Qu,Pin Zhang 대한금속·재료학회 2012 METALS AND MATERIALS International Vol.18 No.3
An anodized Al2O3 (AAO) membrane with apertures about 72 nm in diameter was prepared by two-step anodic oxidation. The appearance and pore arrangement of the AAO membrane were characterized by energy dispersive x-ray spectroscopy and scanning electron microscopy. It was confirmed that the pores with high pore aspect ratio were parallel, well-ordered, and uniform. The kinetics of pores growth in the AAO membrane was derived, and the kinetic models showed that pores stopped developing when the pressure (σ) trended to equal the surface tension at the end of anodic oxidation. During pore expansion,the effects of the oxalic acid concentration and expansion time on the pore size were investigated, and the kinetic behaviors were explained with two kinetic models derived in this study. They showed that the pore size increased with extended time (r=G·t+G’), but decreased with increased concentration (r=−K·lnc -K’)through the derived mathematic formula. Also, the values of G, G’,K, and K’ were derived from our experimental data.
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Huang, Xin-En,Wei, Guo-Li,Huo, Jie-Ge,Wang, Xiao-Ning,Lu, Yan-Yan,Wu, Xue-Yan,Liu, Jin,Xiang, Jin,Feng, Ji-Feng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
Aims: To explore efficacy and side effects of intrapleural or intraperitoneal lobaplatin for treating patients with malignant pleural or peritoneal effusions. Methods: Patients in Jiangsu Cancer Hospital and Research Institute with cytologically confirmed solid tumors complicated with malignant pleural effusion or ascites were enrolled into this study. Lobaplatin (20-30 $mg/m^2$) was intrapleurally or intraperitoneally infused for patients with malignant pleural effusion or ascites. Results: From 2012 to 2013, intrapleural or intraperitonea lobaplatin was administered for patients with colorectal or uterus cancer who were previous treated for malignant pleural effusion or ascites. Partial response was achieved for them. Main side effects were nausea/vomiting, and bone marrow suppression. No treatment related deaths occurred. Conclusion: Intrapleural or intraperitoneal infusion of lobaplatin is a safe treatment for patients with malignant pleural effusion or ascites, and the treatment efficacy is encouraging.
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( Yan-sheng Huang ),( Ding-jun Hao ),( Yong-ai Zhang ) 한국감성과학회 2017 한국감성과학회 국제학술대회(ICES) Vol.2017 No.-
Purpose : The purpose of this study was to compare the efficacy of percutaneous kyphoplasty (PKP) and bone cement-augmented short segmental fixation (BCA+SSF) for treating Kummell disease. Methods : Between June 2013 and December 2015, 60 patients were treated with PKP or BCA+SSF. All patients were followed up for 12-36 months. We retrospectively reviewed outcomes, including Oswestry Disability Index (ODI), visual analogue scale (VAS), and kyphotic Cobb angle. Results : VAS, ODI, and Cobb angle, measured postoperatively and at the final follow-up, were lower than those measured preoperatively in both groups (P< 0.05). VAS, ODI, and Cobb angle measured postoperatively demonstrated no significant differences when compared with those measured at the final follow-up in the PKP group (P >0.05). In the BCA+SSF group, VAS and ODI at the final follow-up were lower than those measured postoperatively (P< 0.05), but no significant difference was found in the Cobb angle (P >0.05). The PKP group had better VAS and ODI than the BCA+SSF group, postoperatively (P< 0.05). No significant difference was found in VAS and ODI at the final follow-up (P >0.05) or the Cobb angle measured postoperatively and at the final follow-up (P>0.05) between the two groups. Operative time, blood loss, and hospital stay in the PKP group were lower than those in the BCA+SSF group (P< 0. 05). No significant difference was found in complications (P >0.05). Conclusions : PKP patients had better early clinical outcomes, shorter operation and hospital admission times, and decreased blood loss, but similar complications, radiographic results, and long-term clinical outcomes compared with BCA+SSF patients.
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Huang, Yan,Liu, Qingluan,Wang, Yunqing,He, Na,Zhao, Rongfang,Choo, Jaebum,Chen, Lingxin The Royal Society of Chemistry 2019 Nanoscale Vol.11 No.25
<P>Theranostics nanoplatforms offer opportunities for imaging-guided precision therapy and hold great potential for clinical applications. In most reported works, the imaging unit has a lack of site selectivity, and is always kept in the “on” modality regardless of whether it is in normal tissues or tumor sites, increasing the risk of unsafe treatment. Herein, we designed a near-infrared (NIR) fluorescence-guided theranostics nanoplatform by integrating the functions of tumor-response and photodynamic therapy (PDT)/photothermal therapy (PTT). A novel NIR fluorescent dye, CyPT, with excellent optical and PDT/PTT properties, was synthesized and linked onto the gold nanorods (AuNRs) to form CyPT-AuNRs nanohybrids<I>via</I>a sulfur-sulfur bond that can be broken by glutathione (GSH) with high selectivity and sensitivity. In normal cells where the concentration of GSH is low, the fluorescence of CyPT is quenched by the AuNRs. By contrast, the high level of GSH in tumor cells leads to the breaking of the sulfur-sulfur bond, resulting in the release of CyPT and the accomplishment of a “off-on” fluorescence response. Followed by precise NIR tumor-imaging diagnosis, the PDT and PTT treatment which rely on the released CyPT and AuNRs, respectively, can be effectively performed. The CyPT-AuNRs nanoplatform has been successfully applied to the treatment of tumor xenograft models and no distinct damage has been observed in the nearby normal tissues. This versatile nanoplatform has potential for use in targeted tumor imaging and precision therapy.</P>
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