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김성엽,설용건,이태희,노용우 연세대학교 산업기술연구소 1991 논문집 Vol.23 No.2
Pore structure and acid absorbancy of carbon electrode of phosphoric acid fuel cell were studied by varying carbon black, PTFE loading, and fabricating method for Denka black. Results showed that the primary pore(micro pore) of the carbon electrode included the micro space formed around the carbon particles regardless of the carbon black(Vulcan XC-72 and Denka black) used, and that addition of PTFE and pressing of electrode influenced mainly the secondary proe. The acid absorbancy of electrode was decreased as PTFE loading was increased and Denka black showed more hydrophobic than Vulcan XC-72 with three times in saturation time and one-half in acid absorbancy.
Kim, Seong Hwan,Cho, Goo-Yeong,Kim, Min-Kyu,Park, Woo-Jung,Kim, Jong-Hyun,Lim, Hong Euy,Lim, Sang Yup,Shin, Chol by the Society of Critical CarE Medicine and Lippi 2009 Critical care medicine Vol.37 No.4
OBJECTIVE:: There has been limited study regarding the effects of high-voltage electrical injury on left ventricular (LV) function, as well as the clinical utility of using cardiac troponin I (cTnI) to assess such injuries. We investigated changes in LV function by using two-dimensional speckle tracking imaging, and we also studied the clinical utility of cTnI for predicting myocardial damage in survivors of high-voltage electrical injury. DESIGN:: Prospective clinical study. SETTING:: Burn care unit and echocardiography laboratory of a university hospital. PATIENTS:: Twenty male patients surviving a high-voltage electrical injury. INTERVENTIONS:: From July 2006 to October 2007, 20 patients suffering from high-voltage electrical injury were prospectively evaluated. A serial echocardiogram was obtained from each patient on hospital days 1, 3, and 7. Serum cTnI levels were drawn at baseline and every 6 hours for the first 24 hours. All parameters of the study patients were compared with age-, sex-, and body mass index-matched healthy controls. MEASUREMENTS AND MAIN RESULTS:: On the day of admission and during follow-up, there were no significant differences in LV dimension, stroke volume index, LV fractional shortening, LV ejection fraction, or peak systolic strain as compared with the controls. In contrast to the peak systolic strain, the peak systolic strain rate was significantly increased at baseline and during follow-up for the patient group. There were no significant differences in LV systolic function parameters between the two groups according to the level of cTnI. CONCLUSION:: The current study demonstrates that LV dysfunction after high-voltage electrical injury is uncommon, and that the serum cTnI level does not seem to be a useful diagnostic test for predicting impairment of LV contractility in patients who did not experience cardiac arrest or fatal arrhythmia.
Annual Case Volume and One-Year Mortality for Endovascular Treatment in Acute Ischemic Stroke
Kim Jun Yup,Kang Jihoon,Kim Beom Joon,Kim Seong-Eun,Kim Do Yeon,Lee Keon-Joo,Park Hong-Kyun,Cho Yong-Jin,박종무,Lee Kyung Bok,Cha Jae-Kwan,Lee Ji Sung,Lee Juneyoung,Yang Ki Hwa,Hong Ock Ran,Shin Ji Hyeon 대한의학회 2022 Journal of Korean medical science Vol.37 No.36
Background: The association between endovascular treatment (EVT) case volume per hospital and clinical outcomes has been reported, but the exact volume threshold has not been determined. This study aimed to examine the case volume threshold in this context. Methods: National audit data on the quality of acute stroke care in patients admitted via emergency department, within 7 days of onset, in hospitals that treated ≥ 10 stroke cases during the audit period were analyzed. Ischemic stroke cases treated with EVT during the last three audits (2013, 2014, and 2016) were selected for the analysis. Annual EVT case volume per hospital was estimated and analyzed as a continuous and a categorical variable (in quartiles). The primary outcome measure was 1-year mortality as a surrogate of 3-month functional outcome. As post-hoc sensitivity analysis, replication of the study results was examined using the 2018 audit data. Results: We analyzed 1,746 ischemic stroke cases treated with EVT in 120 acute care hospitals. The median annual EVT case volume was 12.0 cases per hospital, and mortality rates at 1 month, 3 months, and 1 year were 12.7%, 16.6%, and 23.3%, respectively. Q3 and Q4 had 33% lower odds of 1-year mortality than Q1. Adjustments were made for predetermined confounders. Annual EVT case volume cut-off value for 1-year mortality was 15 cases per year (P < 0.02). The same cut-off value was replicated in the sensitivity analysis. Conclusion: Annual EVT case volume was associated with 1-year mortality. The volume threshold per hospital was 15 cases per year.
Kim Tae Jung,Lee Hak Seung,Kim Seong-Eun,Park Jinju,Kim Jun Yup,Lee Ji Yoon,Song Ji Eun,Hong Jin-Hyuk,Lee Joongyub,Chung Joong-Hwa,Kim Hyeon Chang,Shin Dong-Ho,Lee Hae-Young,Kim Bum Joon,Seo Woo-Keun 질병관리청 2024 Osong Public Health and Research Persptectives Vol.15 No.1
Objectives: Limited information is available concerning the epidemiology of stroke and acute myocardial infarction (AMI) in the Republic of Korea. This study aimed to develop a national surveillance system to monitor the incidence of stroke and AMI using national claims data.Methods: We developed and validated identification algorithms for stroke and AMI using claims data. This validation involved a 2-stage stratified sampling method with a review of medical records for sampled cases. The weighted positive predictive value (PPV) and negative predictive value (NPV) were calculated based on the sampling structure and the corresponding sampling rates. Incident cases and the incidence rates of stroke and AMI in the Republic of Korea were estimated by applying the algorithms and weighted PPV and NPV to the 2018 National Health Insurance Service claims data.Results: In total, 2,200 cases (1,086 stroke cases and 1,114 AMI cases) were sampled from the 2018 claims database. The sensitivity and specificity of the algorithms were 94.3% and 88.6% for stroke and 97.9% and 90.1% for AMI, respectively. The estimated number of cases, including recurrent events, was 150,837 for stroke and 40,529 for AMI in 2018. The age- and sex-standardized incidence rate for stroke and AMI was 180.2 and 46.1 cases per 100,000 person-years, respectively, in 2018.Conclusion: This study demonstrates the feasibility of developing a national surveillance system based on claims data and identification algorithms for stroke and AMI to monitor their incidence rates.
Sun-Yup Shim,Yun Jae Kim,Kap Seong Choi,Taisun Shin,Jiyeon Chun,Ginnae Ahn,Eui Jeong Han,Min- Jong Kim,Sang-Hyun Kim,Jung-Beom Kim,Kang-Hee Kho,Dae Heon Kim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Basophils and mast cells are characteristic effector cells in allergic reaction. Sargahydorquinoic acid (SHQA), potent antioxidant compound, isolated from S. serratifolium with various biochemical properties. In the present study, we investigated the inhibitory effects of SHQA in basophils activation and allergic mouse model. SHQA reduced PMACI- induced intracellular ROS and calcium levels. Western blot analysis revealed that SHQA down-regulated activation of ERK, p38 and translocation of NF-κB in a dose-dependent manner. Moreover, SHQA suppressed the production and gene expression of IL-1β, IL-4, IL-6 and IL-8 in PMACI-induced KU812F cells and IL-4 and TNF-α in compound 48/80-induced RBL-2H3 cells. It inhibited degranulation by reducing α-hexosaminidase release in PMACI-stimulated KU812F and compound 48/80-stimulated RBL-2H3 cells. Furthermore, it attenuated the IgE-mediated passive cutaneous anaphylactic reaction (PCA) in the ear of BALB/c mice. These results suggest that S. seratifolium containing SHQA is a marine-derived potential therapeutic functional materials for the inhibition of effector cell activation and allergic mouse model in allergic disorders.