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Yim, Se-Jeong,Lee, Yong-Seok,Lee, Jin-A,Chang, Deok-Jin,Han, Jin-Hee,Kim, Hyoung,Park, Hyungju,Jun, Heejung,Kim, V. Narry,Kaang, Bong-Kiun Raven Press [etc.] 2006 Journal of neurochemistry Vol.98 No.2
<P>Abstract</P><P><I>Aplysia</I> CCAAT enhancer-binding protein (ApC/EBP), a key molecular switch in 5-hydroxytryptamine (5-HT)-induced long-term facilitation of <I>Aplysia</I>, is quickly and transiently expressed in response to a 5-HT stimulus, but the mechanism underlying this dynamic expression profile remains obscure. Here, we report that the dynamic expression of ApC/EBP during long-term facilitation is regulated at the post-transcriptional level by AU-rich element (ARE)-binding proteins. We found that the 3′UTR of ApC/EBP mRNA contains putative sequences for ARE, which is a representative post-transcriptional <I>cis</I>-acting regulatory element that modulates the stability and/or the translatability of a distinct subset of labile mRNAs. We cloned the <I>Aplysia</I> homologue of embryonic lethal abnormal visual system homologue (ELAV/Hu) protein, one of the best-studied RNA-binding proteins that associate with ARE, and elucidated the involvement of <I>Aplysia</I> ELAV/Hu protein in ApC/EBP gene expressional regulation. Cloned <I>Aplysia</I> ELAV/Hu protein, <I>Aplysia</I> embryonic lethal abnormal visual system (ApELAV), bound to an AU-rich region within the 3′UTR of ApC/EBP mRNA. Additionally, ApELAV controlled the expression of ApC/EBP 3′UTR-containing reporter gene by functioning as a stability-enhancing factor. In particular, 5-HT-induced long-term facilitation was impaired when the AU-rich region within the 3′UTR of ApC/EBP was over-expressed, which suggests the significance of this region in 5-HT-induced ApC/EBP expression, and in the resultant formation of long-term facilitation. Our results imply that the <I>Aplysia</I> ARE-binding protein, ApELAV, can regulate ApC/EBP gene expression at the mRNA level, and accordingly, ARE-mediated post-transcriptional mechanism may serve a crucial function in regulating the expression of ApC/EBP in response to a 5-HT stimulus.</P>
A Study of Ice - Formation Phenomena on Freezing of Flowing Water in a Stenotic Tube
Jeong-Se Suh,Moo-Geun Kim,Sung Tack Ro,Chang Soon Yim 대한설비공학회 1999 International Journal Of Air-Conditioning and Refr Vol.7 No.-
In this study, a numerical analysis is made on the ice-formation for laminar water flow inside a stenotic tube. The study takes into account the interaction between the laminar flow and the stenotic port in the circular tube. The purpose of the present numerical investigation is to assess the effect of a stenotic shape on the instantaneous shape of the flow passage during freezing upstream/downstream of the stenotic channel. In the solution strategy, the present study is substantially distinguished from the existing works in that the complete set of governing equations in both the solid and liquid regions are resolved. In a channel flow between parallel plates, the agreement befween the of predictions and the available experimental data is very good. Numerical analyses are performed for parametric variations of the position and heights of stenotic shape and flow rate. The results show that the stenotic shape has the great effect on the thickness of the solidification layer inside the tube. As the height of a stenosis grows and the length of a stenosis decreases, the ice layer thickness near the stenotic port is thinner, due to backward flow caused by the sudden expansion of a water tunnel. It is found that the flow passage has a slight uniform taper up to the stenotic channel, at which a sudden expansion is observed. It is also shown that the ice layer becomes more fat in accordance with its Reynolds number.
자산처리 연구개발비와 비용처리 연구개발비가 신용등급에 미치는 영향
정세진(Se-Jin Jung),김석진(Seok-Chin Kim),임정대(Jeong-Dae Yim) 한국무역연구원 2018 무역연구 Vol.14 No.1
We investigate the relationship between research and development (R&D) expenditures and credit ratings for firms listed on the Korea Exchange from 2000 to 2016 using an ordered probit model. For the United States, Germany, and the United Kingdom firms, R&D expenditures are not allowed to be capitalized. Korean firms, however, may adopt two accounting methods for R&D expenditures: asset-counted or cost-counted R&D expenditures. Our empirical results are as follows. First, the R&D expenditures have a significantly positive impact on credit ratings. Second, interestingly, the asset-counted R&D expenditures positively affect credit ratings but cost-counted R&D expenditures do not. Overall, our empirical results provide a hint for the debate on capitalization of R&D expenditures. In particular, the finding that only asset-counted R&D expenditures related to future growth for firms have an impact on credit ratings suggests implications for properly reflecting R&D expenditures when credit agencies calculate credit ratings of firms.
A Study of Ice-Formation Phenomena on Freezing of Flowing Water in a Stenotic Tube
Suh, Jeong-Se,Kim, Moo-Geun,Ro, Sung-Tack,Yim, Chang-Soon The Society of Air-Conditioning and Refrigerating 1999 International Journal Of Air-Conditioning and Refr Vol.7 No.-
In this study, a numerical analysis is made on the ice-formation for laminar water flow inside a stenotic tube. The study takes into account the interaction between the laminar flow and the stenotic port in the circular tube. The purpose of the present numerical investigation is to assess the effect of a stenotic shape on the instantaneous shape of the flow passage during freezing upstream/downstream of the stenotic channel. In the solution strategy, the present study is substantially distinguished from the existing works in that the complete set of governing equations in both the solid and liquid regions are resolved. In a channel flow between parallel plates, the agreement between the of predictions and the available experimental data is very good. Numerical analyses are performed for parametric variations of the position and heights of stenotic shape and flow rate. The results show that the stenotic shape has the great effect on the thickness of the solidification layer inside the tube. As the height of a stenosis grows and the length of a stenosis decreases, the ice layer thickness near the stenotic port is thinner, due to backward flow caused by the sudden expansion of a water tunnel. It is found that the flow passage has a slight uniform taper up to the stenotic channel, at which a sudden expansion is observed. It is also shown that the ice layer becomes more fat in accordance with its Reynolds number.
Peritoneal dialysis-related peritonitis due to <i>Halomonas hamiltonii</i> : A first case report
Yeo, Se Hwan,Kwak, Jae Hoon,Kim, Yeo Un,Lee, Jin Suk,Kim, Hyo Jin,Park, Kyoung Hwa,Lee, Jung Sook,Ha, Gyoung Yim,Lee, Jeong Ho,Lee, Jun Yeop,Yoo, Kyung Don Williams & Wilkins Co 2016 Medicine Vol.95 No.47
<P><B>Abstract</B></P><P><B>Introduction:</B></P><P><I>Halomonas hamiltonii</I> is a Gram-negative, halophilic, motile, and nonspore-forming rod bacterium. Although most <I>Halomonas</I> sp. are commonly found in saline environments, it has rarely been implicated as a cause of human infection. Herein, the authors present a case report of continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis attributed to <I>H hamiltonii</I>.</P><P><B>Case presentation:</B></P><P>An 82-year-old male patient who had been receiving CAPD therapy presented to an emergency department with complaints of abdominal pain and cloudy dialysate that had persisted for 2 days. The peritoneal dialysate was compatible with CAPD peritonitis, with white blood cell count of peritoneal effluent of 810/mm<SUP>3</SUP> and neutrophils predominated (60%). Two days after culture on blood agar medium, nonhemolytic pink mucoid colonies showed, with cells showing Gram-negative, nonspore-forming rods with a few longer and larger bacilli than usual were found. We also performed biochemical tests and found negative responses in K/K on the triple sugar iron test and H<SUB>2</SUB>S and equivocal (very weak) response in the motility test, but positive responses to catalase, oxidase, and urease tests. The partial sequence of the 16S rRNA gene of a bacterium detected by peritoneal fluid culture was utilized for a Basic Local Alignment Search Tool search, which revealed that the organism was <I>H hamiltonii</I>. Intraperitoneal antibiotics were administered for 21 days, and the patient was discharged without clinical problems.</P><P><B>Conclusion:</B></P><P>We present here the first case report of CAPD-related peritonitis caused by <I>H hamiltonii</I>, which was identified using molecular biological techniques. Although guidelines do not exist for the treatment of infections caused by this organism, conventional treatment for Gram-negative organisms could be effective.</P>