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보조호르몬요법을 받는 여성 유방암 환자의 모발 변화와 치료 실태에 대한 기초 연구
이재경 ( Jae Kyung Lee ),김창현 ( Chang-hyun Kim ),홍동균 ( Dongkyun Hong ),정경은 ( Kyung Eun Jung ),서영준 ( Young-joon Seo ),김창덕 ( Chang-deok Kim ),이진선 ( Jin Sun Lee ),권인선 ( In Sun Kwon ),박상현 ( Sanghyun Park ),이영 대한피부과학회 2021 대한피부과학회지 Vol.59 No.7
Background: Hormone therapy, which includes tamoxifen and aromatase inhibitors, is the most common adjuvant therapy used for breast cancer. However, only a few studies have reported endocrine therapy induced alopecia. Objective: We investigated the effects of long-term adjuvant hormone therapy on hair in patients with breast cancer, in addition to patients’ concerns and current treatment for hair loss. Methods: Patients completed a questionnaire that included information on self-perceived hair changes after each adjuvant therapy session, distress, and current treatment for hair loss. Using a folliscope, we measured hair density and thickness in each patient and in healthy controls. Results: The study included 93 patients with breast cancer (mean age 51.9±9.8 years). The density and hair thickness were 106.36±21.85 hairs/cm2 and 0.07±0.01 mm in the patient group and 147.86±30.67 hairs/cm2 and 0.07±0.01 mm in the control group (n=98, mean age 52.10±8.40 years), respectively. The mean hair density was significantly lower in the patient group than in the control group; however, no statistically significant intergroup difference was observed in hair thickness. Among 76 patients who perceived hair changes after adjuvant therapy, 71.1% (n=54) were distressed with regard to hair changes. However, only 7.8% of the patients, including two who were treated by dermatologists, currently received treatment for hair changes. Conclusion: Dermatologists should be familiar with hair changes in patients with breast cancer and provide appropriate education to encourage patients to consult dermatologists for hair loss and thinning after breast cancer treatment. (Korean J Dermatol 2021;59(7):521∼526)
Sports and Culture: Exploration for the Thought of Diversity and Historical Approach
Deok Seon CHANG,Hae Yu KIM,Hyuk Jin LEE 한국스포츠과학회 2020 스포츠과학연구(JSAS) Vol.4 No.4
Purpose: This study started with interest in sport culture and is meaningful as an exploratory study to help with the basic understanding of sport culture research. Research design, data, and methodology: The approach of this study is the exploratory approach by literature reviews. This study carried out exploratory research on thinking about diversity of sports culture and the development process of sports culture by human history periods. Results: First, in thinking about cultural diversity, cultural absolutism and cultural relativism were identified. The characteristics of sports culture can identify universality, individuality and diffusion, and the attributes of sports culture included sharing, learning, accumulation, whole systematic relationship and change. Second, the characteristics of sports culture were identified by the approach of each historical era. The historical stages were divided into ancient civilizations, ancient Greece and Rome, middle ages and early modern period, and late modern period. Sports have historically been found to have a British-centered European origin or popularized in the United States. Conclusions: with the characteristics of modern sports culture, the globalization of sports culture, the prominence of sports industry and sports space marketing, and the symbiotic influence relationship of sports and mass media were examined and future directions were discussed.
Polyimide계 배향막의 합성과 그 입체구조가 액정분자의 프리틸트 각에 미치는 영향
김재창,이상진,허노성,권덕용,이진국 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.53 No.-
Polyimide계 배향막은 고온처리 등 디스플레이 제조공정을 거치면서도 액정 배향특성이 유지되며 장시간 사용에도 물리·화학적 안정성이 좋은 장점을 가지고 있어 널리 사용되고 있다. 이 배향막을 연구하는데 있어서 합성기술과 러빙처리에 따른 배향막 표면의 특성분석이 필수적이며, 본 연구에서는 Diamine과 Dianhydride를 NMP용매하에서 용액중합하여 polyamic acid를 합성한 후, ITO코팅된 유리표면위에 스핀개스팅하여 박막을 입히고 열적처리를 하여 이미드화시켰다. 배향막의 배향을 위해서 러빙처리를 하고, 러빙처리 전후의 접촉각 측정을 통한 배향막 표면장력변화를 harmonic-mean 방법으로 구했고 2차 고조파 신호 (SHG) 분석을 통한 배향막 표면분자들의 방향성 분포를 검토해 보았다. Polyimide의 반복단위구조를 컴퓨터 그래픽 프로그램 (CS Chem3D Pro)을 사용하여 3차원적으로 시뮬레이션함으로서 polyimide의 입체구조를 알아보았다. 그리고 그 입체구조와 프리틸트 각과의 상관관계를 분자간 상호 작용설을 근거로 하여 살펴보았다. Polyimide has been widely used as the alignment film for liquid crystal displays because of their excellent properties, such as thermal can chemical stability. In this experiment, polyamic acid is rapidly formed at ambient temperatures when a diamine and a dianhydride are added into NMP. Polyimide films were fabricated by spin-coating solution on ITO-coated glass substrates. Polyimide films were baked at 80oC and then cured at 150oC 250oC for 30min at each temperature. The polyimide-coated substrates were rubbed by a rubbing machine with a roller. We measured the contact angles and the second-harmonic signals on the surface of samples to know the surface tension and the surface orientation of samples. and We also measured the pretilt angle of liquid crystal molecules in order to find the effect of the rubbing strength and the steric structure of polyimides on it.
이호진(Ho Jin Lee)(李昊振),장창덕(Chang Deok Jang)(張昌德),전계원(Kye Won Jun)(全桂元) 위기관리 이론과 실천 2011 Crisisonomy Vol.7 No.2
최근 세계 곳곳에서 기후변화에 따른 자연재해의 발생확률이 점점 높아지고 있다. 우리나라도 예외가 될 수 없으며 특히 강원도 지역의 경우 태풍과 홍수의 피해가 가장 빈번히 발생하는 지역 중의 하나이다. 지난 2002년 태풍 루사와 2003년 태풍 매미로 많은 인명과 재산피해가 발생하였으며 이로 인해 재해위험지구 또한 증가 하였다. 따라서 본 연구에서는 침수해석을 위해 XP-SWMM을 적용하여 강원도 삼척시 자원동 지역을 대상으로 강우 자료와 지형자료를 분석하고 하천범람과 내수침수 범위를 수치모의 하였다. 모의결과 삼척시에서 제작한 침수흔적도와 비교하여 모의된 침수범위가 조사된 침수범위 보다 넓게 분포하는 경향을 나타내었다. 이는 모형에 사용된 지형자료의 정밀도에 기인한 결과로 분석되었다. 추후 연구에서는 주요지점에 대해 보다 해상도 높은 지형자료를 이용한 침수범위를 산정이 수행되어야 한다고 판단된다. Recently the possibility of the natural disaster has been increased around the world due to the climate change. Especially, Gangwon-do is one of the areas that the damage by storm and flood is most frequent. In 2002 and 2003, the typhoon Rusa and Maemi had generated huge losses of both life and property, resulted in increased number of natural hazard area. In this study, we analyzed the rainfall and geographical data of the Jawon-dong area, Samcheok City of Gangwon-do during the hit of typhoon Rusa, and XP-SWMM(Numerical Model) was applied to calculate the natural hazard area’s river flooding and inundation range.
( Chang-wook Kim ),( Jin-deok Joo ),( Young-hoon Kim ),( Jung Ho Han ),( Chae-yong Kim ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2016 Brain Tumor Research and Treatment Vol.4 No.2
Background Alongside the extent of removal and patients’ survival in the management of brain tumors, health-related quality of life (HRQOL) has become an important consideration. The purpose of this study is to evaluate the change of HRQOL in brain tumor patients before and after surgery and to assess the associated factors that contribute to the change of HRQOL. Methods A total of 258 patients who underwent surgical treatment were enrolled in this study. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC QLQ-C30) and the 20-item EORTC QLQ-Brain Neoplasm (QLQ-BN20) were used to assess HRQOL. Patients were asked to fill out the questionnaires before and 3-6 months after surgery. Results Global QOL (p<0.001) and emotional function (p<0.018) were significantly improved after surgery. Physical function (p=0.015) was significantly aggravated. Among the symptoms, headache, pain and nausea and vomiting were significantly decreased (p<0.01, p=0.041, p<0.001, respectively), while dyspnea, communication deficit and weakness of the legs were increased (p=0.005, p=0.040, and p=0.014, respectively). Preoperative neurologic deficit (p=0.019) and tumor diameter (p=0.016) were significantly related to the patients who showed aggravation of global QOL after brain tumor surgery. In the aggravated global QOL group, common complaints and concerns included role function, appetite loss, financial difficulty and future uncertainty. Conclusion In brain tumor patients, HRQOL has improved after surgery. Role function, appetite loss, financial difficulty and future uncertainty were important factors for HRQOL in brain tumor patients treated with surgery. Although there is National Health Insurance and Medical Aid program in Korea, financial difficulty and future uncertainty are much more important in influencing QOL than previously thought. The results of this short-term follow up preliminary study suggest that several factors were related to HRQOL, Further research is needed to evaluate the long term change of HRQOL and enhance the global QOL by analyze related factors.