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Acute Hydronephrosis owing to A Giant Fecaloma in an Older Patient
Narae Joo,Hyung Seok Lee 대한노인병학회 2020 Annals of geriatric medicine and research Vol.24 No.3
Hydroureteronephrosis with acute urinary tract obstruction can lead to serious complications such as obstructive nephropathy or pyelonephritis. We report the first case of hydroureteronephrosis caused by a giant fecaloma in an 83-year-old woman accompanied with chronic constipation in Korea. The patient with a fever presented to the emergency room and was diagnosed with right hydronephrosis. Computed tomography revealed a markedly dilated rectum with a giant fecaloma compressing the right vesicoureteric junction. Hydroureteronephrosis was resolved through manual disimpaction of the fecaloma and simultaneous lavage with rectal tubes, which improved the acute pyelonephritis and renal function. Chronic constipation can lead to giant fecaloma threatening urinary tract patency, especially in older patients with immobility or dehydration. Therefore, clinicians should consider this condition as a rare but possible cause of hydronephrosis in older adult patients with chronic constipation.
Hak-Jae Chung,NaRae Son,Joo-Hee Han,Chun-Gyu Park,Kyung-Woon Kim,Mi-Ryung Park,In-Sul Hwang,Jin-Ki Park,Gi-Sun Im 한국수정란이식학회 2015 한국동물생명공학회지 Vol.30 No.3
Understanding the behavior of transgenes introduced into oocyte or embryos is essential for evaluating the methodologies for transgenic animal production. To date, many studies have reported the production of transgenic pig embryos with, however, low efficiency in environment of blastocyst production. The aim of present study was to determine the expression and duration of transgene transferred by intracytoplasmic sperm injection-mediated gene transfer (ICSI-MGT). Embryos obtained from the ICSI-MGT procedure were analysed for the expression of GFP and then for the transmission of the transgene. Briefly, fresh spermatozoa were bound to exogenous DNA after treatment by Triton X-100 and Lipofectin. When ICSI-MGT was performed using sperm heads with tails removed, the yield of blastocyst (25.3%), treated with Lipofectin (18.8%) and Triton X-100 (19.2%) were observed. Treatments of Lipofectin or Triton X-100 did not further improve the rates of blastocysts. Moreover, the apoptosis rates of embryos were obtained from the control and LIpofectin groups (8.7%, 9.7%, respectively), but were significantly higher in the Triton X-100 group (13.0%). Our results demonstrated that ICSI-MGT caused minimal damage to oocytes that could develop to full term. Moreover, the embryos derived by ICSI-MGT have shown prolonged exogenous DNA expression during preimplantation stage in vivo. However, more efforts will be required to improve the procedures of both sperm treatments cause of high frequency of mosaicisms.
국내산 귀리의 유리아미노산, 페놀산 함량 및 효소 저해 활성
한나래(Narae Han),이유영(Yu-Young Lee),이진영(Jin Young Lee),김미향(Mihyang Kim),강문석(Moon Seok Kang),김현주(Hyun-Joo Kim) 한국식품과학회 2022 한국식품과학회지 Vol.54 No.5
본 연구는 국내 육성 귀리의 이용 다양화를 위한 기초자료를 마련하고자 ‘대양’ 및 ‘조양’의 유용성분 함량 및 효소 저해 활성을 비교 분석하였다. 총 유리아미노산 및 페놀산 함량은 ‘대양’이 각각 375.10mg/g 및 86.81 μg/g으로 ‘조양’(각각 330.96 mg/g 및 10.40 μg/g)보다 높았다. 항당뇨, 항고혈압 및 미백 활성의 지표인 α-glucosidase, ACE 및 tyrosinase 저해 활성 모두 ‘대양’이 ‘조양’보다 약 2배 이상 우수하였다. 향후 후속 연구를 통해 효소 저해활성에 관여하는 기능성분 함량 및 조성을 구명하고 효소 활성과 성분 간 상관관계 분석을 수행하고자 한다. This study investigated the functional compounds (free amino acid and phenolic acid) and enzyme inhibitory activities (anti-diabetic, anti-hypertension, and skin-lightening) of the domestic oat cultivars ‘Daeyang’ and ‘Choyang’. Total free amino acid and phenolic acid contents in the ‘Daeyang’ cultivar were significantly higher at 375.10 mg/g and 86.84 μg/g, respectively, compared to those in the ‘Choyang’ cultivar (330.96 mg/g and 10.40 μg/g, respectively). In addition, α-glucosidase, angiotensin-converting enzyme, and tyrosinase inhibitory activities were approximately 2-times higher in the Daeyang’ cultivar than in the Choyang’ cultivar. This report provides basic information on the utilization of domestic oats as industrial materials and functional foods.
Congenital Internal Hernia Presented with Life Threatening Extensive Small Bowel Strangulation
Lee, Narae,Kim, Su-Gon,Lee, Yeoun Joo,Park, Jae-Hong,Son, Seung-Kook,Kim, Soo-Hong,Hwang, Jae-Yeon The Korean Society of Pediatric Gastroenterology 2013 Pediatric gastroenterology, hepatology & nutrition Vol.16 No.3
Internal hernia (IH) is a rare cause of small bowel obstruction occurs when there is protrusion of an internal organ into a retroperitoneal fossa or a foramen in the abdominal cavity. IH can be presented with acute or chronic abdominal symptom and discovered by accident in operation field. However, various kinds of imaging modalities often do not provide the assistance to diagnose IH preoperatively, but computed tomography (CT) scan has a high diagnostic accuracy. We report a case of congenital IH in a 6-year-old boy who experienced life threatening shock. CT scan showed large amount of ascites, bowel wall thickening with poor or absent enhancement of the strangulated bowel segment. Surgical exploration was performed immediately and had to undergo over two meters excision of strangulated small bowel. To prevent the delay in the diagnosis of IH, we should early use of the CT scan and take urgent operation.
A Case of Microcephaly with Congenital Retinal Detachment
( Donghoon Joo ),( Mun Hui Jeong ),( Seong Hee Jeong ),( Narae Lee ),( Mi Hye Bae ),( Young Mi Han ),( Kyung Hee Park ),( Shin Yun Byun ) 대한주산의학회 2021 Perinatology Vol.32 No.2
Microcephaly can occur with autosomal dominant or autosomal recessive inherited pattern in a family, but more commonly it is a form of many syndromes that lead to intellectual impairment. Several reports of ocular anomalies accompanied with microcephaly vary from microphthalmia, nystagmus, cataracts, falciform retinal folds, retinal dysplasia, optic disc coloboma and optic atrophy to chorioretinal degeneration have been documented. In this report, the patient hospitalized for intrauterine growth restriction and microcephaly was diagnosed with congenital retinal detachment on fundus examination incidentally and whose result of chromosomal microarray analysis revealed about 1.4 Mb of duplication at Yq11.23 that is irrelevant with clinical symptom. The result of whole exome sequencing was not significant, either. So by enrolling the patient’s genetic information obtained through whole genome sequencing and clinical feature to the national bio big data, we plan to research on genetic disease in comparison with genetic information of similar cases continuously. The authors experienced a case of congenital retinal detachment accompanied by microcephaly without family history and regardless of congenital viral infection, this has not been reported until now.