간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

Gilbert 증후군에서 열량 제한 시험과 Phenobarbital 자극 시험의 의의(14예)

이헌영,채경훈,정재훈,강윤세,김연수,문희석,박기오,이엄석,김선문,김석현,성재규,이병석,이강욱 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Gilbert 증후군은 인구의 7%에서까지 나타날 수 있는 매우 흔한 증후군으로서 비진행성인 양성의 만성적 경과를 치하며, 간질환의 증상과 징후가 없는 경한 비포합형 고빌리루빈혈증이 특징인 일종의 체질적인 증상으로서 혈장 빌리루빈 농도에 대한 사춘기의 영향 때문에 10대와 20대에 자주 진단이 된다. 따라서 임상적인 중요성은 미약하지만 높은 빈도가 예상되는 점에 그 중요성이 부여되어야 할 것이다. 따라서 적정한 임상적 진단법으로 기왕에 소개된 열량제한 시험과 phenobarbital 유도 시험을 시행하고 이들의 진단적 가치를 알아보기 위하여 본 연구를 시행하였다. 1990년 7월부터 1999년 4월까지 충남대학교병원에 내원하여 HBsAg, IgG anti-HBc 및 anti-HCV가 음성이고, 간 초음파 스캔에서 이상이 없으며, 혈청 AST, ALT 및 AP가 정상인 비음주자에서 경한 비포합형 고빌리루빈혈증이 있는 14예의 환자들을 대상으로 ^(99m)Tc-DISID 스캔을 시행하였으며, 기저 치 총빌리루빈 및 포합형 빌리루빈 치를 측정한 다음에 하루에 400Kcal로 48시간동안 제한한 열량 제한 시험을 시행하였고, phenobarbital을 하루 60mg씩 5일간 투여한 후에도 각각 총빌리루빈과 포합형 빌리루빈 치를 검사하여 비포합형을 구하였다. 대상 환자들은 모두 14예로서 남자가 11예(78.6%)였고 여자가 3예(21.4%)여서 3.7:1로 남자에서 많았으며, 20대가 6예(42.9%), 30대가 역시 6예(42.9%) 및 40대가 2예(14.2%)로서 2,30대가 대부분(85.8%)이었다. 열량 제한 시험 후의 총빌리루빈 치, 비포합형 및 포합형 빌리루빈 치들은 평균 각각 5.5±2.7, 4.2±2.3 및 1.3±10mg/dL 로서, 시험 전 치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg/dL 보다 유의하게(p=0.001, p=0.001, p=0.023) 상승하였다. 포합형 빌리루빈 치도 유의하게 상승하였으나 비포합형의 상승보다는 훨씬 낮아서 주로 비포합형이 증가하였다. phenobarbital 투여 중 설사가 발생하여 중단한 1예를 제외한 13예에서 열량 제한 시험 후에 상승하였던 총, 비포합형 및 포합형 빌리루빈 치가 phenobarbital 유도 시험후에는 2.0±1.1, 1.5±0.8 및 0.5±0.4mg/dL로서 열량 제한 시험 결과보다 유의하게 낮아졌고(p=0.00, p=0.000, p=0.001), 열량 제한 시험 전의 기초치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg.dL 보다도 더욱 낮아졌으며 유의한 차이(p=0.001, p=0.02, p=0.005)를 나타내었다. 14예에서 시행한 ^(99m)-Tc DISIDA 스캔에서 9예(64.3%)가 정상이었고, 5예(35.7%)에서는 심장 및 신장으로의 간외 섭취가 3예였고, 60분까지 소장 배출이 없는 배설 지연 예와 담낭 수축 불량 예가 각각 1예 씩 발견되었다. Phenobarbital 투여시험에서 민감도가 열량제한시험에 비해 더 높았다(92.3%와 50.0%). Gilbert 증후군에서 1일 400 Kcal로 48시간의 열량제한 시험과 1일 60mg의 phenobarbital을 5일간 투여하는 유도 시험은 편리하고 유용한 임상적인 진단법으로 이용할 수 있다고 생각된다. 그러나 열량 제한 시험에서는 증가 기준의 통일이 필요하다고 유추되며 phenobarbital 유도 시험이 민감도가 더 높은 것으로 생각된다. Gilbert's syndrome is very frequent and benign chronic process characterized by mild, intermittent, unconjugated hyperbilirubinemia without any symptom and sign of liver disease. Previously intoduced caloric restriction test and phenobarbital stimulation test as two appropriate clinical tests had been examined and their diagnostic values were reevaluated. Fourteen patients with mild, persistent, unconjugated hyperbilirubinemia were included. Subsequently caloric restriction has been applicated by 400 Kcal/day for 48 hours and phenobarbital has been prescribed by 60 mg/day for 5 days. Therafter serum levels of total and direct bilirubin were measured. Most of the patients were third and fourth decade(85.8%) and male predominant. Each basal serum levels of total, indirect and direct bilirubin were 3.0±0.8, 2.2±0.8 and 0.7±0.4 mg/dL. After caloric restriction test, each levels were increased significantly to 5.5±2.7, 4.2±2.3 and 1.3±1.0 mg/dL(p=0.001, p=0.001, p=0.023). After phenobarbital stimulation test for 13 patients had been practiced, increased levels of each bilirubin after caloric restriction test were decreased significantly to 2.0±1.0, 1.5±0.8 and 0.5±0.4 mg/dL(p=0.000, p=0.000, p=0.001) and these levels were significantly lower than basal levels(p=0.001, p=0.02, p=0.005). The sensitivities of caloric restriction test were 85.7%, 50.0%, and 71.4%, 35.7%(1.0, 1.5 mg increase of total bilirubin and 1.0, 1.5 mg/dL increase of indirect bilirubin). The sensitivities of phenobarbital stimulation test were 93.2% and 92.3% at criteria of 1.5 mg/dL increase of total bilirubin and indirect bilirubin. On the diagnosis of Gilbert syndrome, caloric restriction test and phenobarbital stimulation test are convenient and useful diagnostic tools in clinical face. And also phenobarbital stimulation test has higher sensitivity than caloric restriction test. Furthermore, standardization of bilirubin increment would be necessary in caloric restriction test.

고혈압 관리를 위한 의사지원결정시스템의 데이터 마이닝 접근

강석민,조승연,채영문,김태수,호승희 대한간질학회 2003 대한간질학회지 Vol.9 No.2

慢性 氣管支喘息 患者에 있어서의 N-(3',4'-dimethoxycinnamoyl) anthranilic acid의 臨床的 效果

康晳榮,金有瑩,文熙範 최신의학사 1985 最新醫學 Vol.28 No.1

Corynebacterium hofmannii에 依한 전신감염 1예

문대혁,최강원,박석건,이광호 대한감염학회 1984 감염 Vol.16 No.1

Corynebacterium of hoffmannii is a part of normal pharyngeal flora. Human infection caused by C. hofmannii is very rare. All reported cases involve prosthetic or native cardiac valve. This patient sufered from chronic alcohlism, diabetes mellitus, and acute suppurative inflammation of brain, meninges and soft tissue. And he failed to show any clinical response to various antimicrobial therapy and died after discharge.

정수처리용 응집제 주입율 및 경제성에 관한 연구

박성천,문병석,김강석 東新大學校 工業技術硏究所 1997 工業技術硏究 Vol.3 No.-

The purpose of this study was to compare the characteristics of coagulant LAS (Liquid Aluminum Sulfate) with PAC (Poly Aluminum Chloride) and to determine their injection rate for the water treatment. LAS have been used as a coagulant for the water treatment in the city of Kwangju. PAC is considered as an alternation of LAS. The injection rate of the coagulant in water treatment is one of main factors affecting the whole water treatment process. The injection rate have been adjusted based on the jar test results obtained daily. There are a number of factors affecting the flocculation such as turbidity, pH, temperature, alkalinity. If we relate somehow these factors as well as jar test results, more scientific and theoretical approach for adjusting the injection rate of coagulant is possible. Therefore, two flocculants, LAS and PAC, were examined in this study in water drawn from the Ju-am dam. The comparison between LAS and PAC was accomplished with the Jar-Test results and other factors involved in coagulation and settling such as pH, turbidity, water temperature, and alkalinity. The data were gathered and subjected to multivariate regression analysis. Analysis of the subordinate and independent correlation variables were conducted to determine which factor in the model supported the best correlation. As a results of analysis, it was found that PAC is more suitable than LAS and that the statistical formula for the injection rate was found to be suitable for practical application in real water purification plants

Maillard 反應에 관한 연구 : Ⅰ. 아미노산과 6炭糖의 Maillard 反應 Ⅰ. Study on the Mailard Browning of Amino Acids and Hexoses

李乙熙,姜奉泰,金基元,文点東,吳錫斗 진주산업대학교 농업기술연구소 1989 農業技術硏究所報 Vol.2 No.-

아미노산과 7炭糖溶液을 121℃에서 15분간 열처리하였을 때 Maillard 反應의 發色强度를 비교한 결과는 다음과 같다. 1. 아미노산은 종류에 따라 갈변화 현상의 강도가 높은 것, 중간 것 및 낮은 것으로 대별되었다. 2. Ketose인 L-sorbose와 D-fructose가 aldose인 D-galactose, D-mannose 및 D-glucose 보다 갈변화현상이 높게 나타났다. 3. 반응액의 pH가 높아질 수록 반응성은 증가되었다. 4. D-glucose 및 D-fructose의 농도가 증가될 수록 반응성은 증가되었다. Common amino acids and hexoses have been ranked according to the intensity of Maillard Browning formed when heated in an autoclave for 15min, at 121℃. The results obtained as follows : 1. The amino acid compounds have been grouped into high, intermediate and low browning groups. 2. L-sorbose and D-fructose of ketose form showed higher velocity in this reaction than D-galactose, D-manose and D-glucose of aldose form. 3. As the pH values of reaction solutions increased, the color intensities of Maillard reaction increased. 4. As the concentrations of D-glucose and D-fructose increased, the color intensities of Maillard reaction increased.

개인 및 환경적 조건과 스키상해의 관련성 연구

전종귀,강문석 忠南大學校體育科學硏究所 2002 體育科學硏究誌 Vol.20 No.1

The purpose of this study was to investigate during the period of 1999-2001 winter season in M ski resort. This study is analysis on related ski injury in personal and environmental condition on records of 1,105 people. The resuits study were as follows; First, Along with increased numbers of beginners, there are too many people in beginner's highly sex, age, level and cause of injured people. There were three causes that worked upon and affected on developing injuries. A personal factor was that beginners, without being properly taught, imitated skilled skiers or rode on an advanced course that which was beyond their ability and lost their power of control. Second, An environmental factor was that the slopes and the lift were not sufficiently facilitated for beginners and so forth made them utilize facilities for more advanced skiers where it was less crowded. Most ski accidents occur, when skiers chose higher level course than their ability with over estimation of their ability. The finding of these results implied that sufficient preseason preparation in terms of fitness and knowledge of skiing skill is the ski injury prevention.

熱處理에 의한 양배추 시들음병 防除

張田益,秦石天,文英仁,姜榮吉 제주대학교 아열대농업연구소 2000 亞熱帶農業硏究 Vol.17 No.-

This study was conducted to evaluate the efficacy of soil heating treatment for the control of cabbage yellows. The results obtained are summarized as follows ; 1.The density of Fusarium oxysporum was not changed with time at room temperature while it was not isolated 25 and 5 days after the heating treatment of 35 and 40℃, respectively. However any of it was not detected above 45℃. 2.When cabbage was grown in the soil inoculated with the pathogen after the inoculated soil was incubated for 1, 3, 5 and 7 days at 45℃, Fusarium oxysporum wilt was not observed for cabbage grown in the soil incubated for more than 3 days. 3.Pseudomonas sp. and Bacilus sp. antagonists that show antifungal activity to were Fusarium oxysporum in petri dish assays were isolated. The growth temperature of Bacillus sp. was higher than that of Fusarium oxysporum.

太陽熱 消毒에 의한 양배추 시들음병 防除 效果

張田益,秦石天,文英仁,姜榮吉 제주대학교 아열대농업연구소 2000 亞熱帶農業硏究 Vol.17 No.-

This study was conducted to evaluate the efficacy of soil solarization, alone and combined with various treatments for the control of soil-borne diseases of cabbage at Cheju from 1988∼ 1999. The results obtained are summarized as follows ; 1.The average of maximum soil temperature at the l0cm depth under soil sruface from Aug. 4 to Sept. 3, 1998 were 6.5℃ higher under polyethylene(P.E.) film mulch compared with 35.4℃ of control. The maximum soil temperatures of above 40℃ at the 10cm depth were recorded for 23 days in the P.E. film mulch. 2.The infection rate of F. oxysporum wilt of cabbages grown after the treatment of disinfector dazomet+P.E. film mulch, was lowest, followed by manure+P.E. film mulch, and alone P.E. film mulch. 3.The leaf length of cabbages grown after P.E. film mulch were greater compared with untreated control but head weight showed no difference between P.E. film mulch and control.