Delayed bilateral facet dislocation at L4-5 : A case report

Park, Hyung-Youl,Ha, Kee-Yong,Kim, Young-Hoon,Kim, Sang-Il,Min, Hyung-Ki,Oh, In-Soo,Seo, Jun-Yeong,Chang, Dong-Gune,Alhazmi, Mohammed Ali,Cho, Joon-Hyung Williams & Wilkins Co 2018 Medicine Vol.97 No.38

<P><B>Abstract</B></P><P><B>Rationale:</B></P><P>Traumatic bilateral facet dislocation in the lumbar (L) spine has rarely been reported. All reported cases were presented with acute facet dislocation. However, we present the first case of delayed bilateral facet dislocation at L4-5.</P><P><B>Patient concerns:</B></P><P>A 34-year-old woman presented with back pain after a head-on collision. The patient was treated conservatively for 3 months with rigid orthosis and activity restriction. Even after this conservative treatment, she continued to suffer from persistent back pain that radiated down her left leg and a progressively kyphotic posture.</P><P><B>Diagnoses:</B></P><P>Initial imaging studies revealed a fracture of the left L5 superior articular process with a posterior ligament complex (PLC) injury. Subsequent radiographs showed the locked facet dislocation with kyphotic changes.</P><P><B>Interventions:</B></P><P>The patient underwent surgical reduction and fusion, and the operative findings revealed the L4-5 bilateral facet dislocation and rupture of the PLC at the index level.</P><P><B>Outcomes:</B></P><P>After surgical reduction and fusion at L4-5 by posterior interbody fusion, we achieved a satisfactory clinical outcome.</P><P><B>Lessons:</B></P><P>Injury of the PLC in the lower lumbar region deserves careful attention for the development of sequelae. The anatomic transition from lordosis to kyphosis, in the lumbosacral region may be related to this type of injury.</P>

Nutrikinetics of Isoflavone Metabolites After Fermented Soybean Product (Cheonggukjang) Ingestion in Ovariectomized Mice

Lee, Da‐,Hye,Kim, Min Jung,Ahn, Jiyun,Lee, Sang Hee,Lee, Hyunjung,Kim, Jin Hee,Park, So‐,Hyun,Jang, Young‐,Jin,Ha, Tae‐,Youl,Jung, Chang Hwa John Wiley and Sons Inc. 2017 Molecular Nutrition & Food Research (Print) Vol.61 No.12

<P><B>Scope</B></P><P>Cheonggukjang (CGJ) is a soybean‐based quick‐fermented food popular in Korea that contains a variety of biologically active compounds including isoflavones and saponins. Isoflavone bioavailability may be important for the bone health of postmenopausal women; therefore, the aim of this study is to evaluate the influence of fermentation on the isoflavone metabolite nutrikinetic profile after single dose CGJ or unfermented soybean administration in ovariectomized (OVX) and sham mice.</P><P><B>Methods and results</B></P><P>We identify 34 isoflavone metabolites using UPLC–QTOF‐MS and analyze their nutrikinetics at different time points (0.25, 0.5, 1, 2, 4, 8, 16, and 24 h) to understand their fermentation‐ and OVX‐mediated time‐dependent concentration changes. Nutrikinetics analysis shows that genistein, daidzein, genistein 4′‐sulfate, dihydrodaidzein sulfate, equol 4′‐sulfate, and equol‐7‐glucuronide are present at high concentrations in all groups based on area‐under‐the‐curve analysis. OVX mice appear to show lower isoflavone bioavailability than mice in the sham group. CGJ enhances various isoflavone metabolite bioavailability including genistein, 3‐hydroxygenistein, and equol 7‐glucuronide, compared to the unfermented soybean‐treated group. Among these metabolites, intact isoflavones, 3‐hydroxygenistein, genistein 4′‐sulfate, and equol 7‐glucuronide promote osteoblastogenesis and inhibit osteoclast formation.</P><P><B>Conclusions</B></P><P>CGJ has good isoflavone bioavailability and may be beneficial for the bone health of postmenopausal women.</P>

Korean physician prescription patterns for home oxygen therapy in chronic obstructive pulmonary disease patients

( Youlim Kim ),( Hwan Il Kim ),( Ji Young Park ),( Ji Young Hong ),( Joo-hee Kim ),( Kyung Hoon Min ),( Chin Kook Rhee ),( Sunghoon Park ),( Chang Youl Lee ),( Seong Yong Lim ),( Seung Hun Jang ),( Yo 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.1

Background/Aims: Hypoxemia in chronic obstructive pulmonary disease (COPD) leads to reduced ability to exercise, decreased quality of life, and, eventually, increased mortality. Home oxygen therapy in patients with severe COPD reduces distress symptoms and mortality rates. However, there have been few studies on physicians’ prescription behavior toward home oxygen therapy. Therefore, we investigated the respiratory specialists’ perspective on home oxygen therapy. Methods: In this cross-sectional, study, a questionnaire was completed by 30 pulmonary specialists who worked in tertiary hospitals and prescribed home oxygen therapy. The questionnaire consisted of 28 items, including 15 items on oxygen prescription for outpatients, four for inpatients, and nine on service improvement. Results: All physicians were prescribing less than 2 L/min of oxygen for either 24 (n = 10, 33.3%) or 15 hours (n = 9, 30.3%). All (n = 30) used pulse oximetry, 26 (86.7%) analyzed arterial blood gas. Thirteen physicians had imposed restrictions and recommended oxygen use only during exercise or sleep. Sixteen (53.3%) physicians were educating their patients about home oxygen therapy. Furthermore, physicians prescribed home oxygen to patients that did not fit the typical criteria for long-term oxygen therapy, with 30 prescribing it for acute relief and 17 for patients with borderline hypoxemia. Conclusions: This study identified the prescription pattern of home oxygen therapy in Korea. Respiratory physicians prescribe home oxygen therapy to hypoxemic COPD patients for at least 15 hours/day, and at a rate of less than 2 L/ min. More research is needed to provide evidence for establishing policies on oxygen therapy in COPD patients.

Clinical significance of insulin-Like growth factor-1 receptor expression in stage 1 non-small-cell Lung cancer: immunohistochemical analysis

( Chang Youl Lee ),( Jeong Hee Jeon ),( Hyung Jung Kim ),( Dong Hwan Shin ),( Tae Woong Roh ),( Chul Min Ahn ),( Yoon Soo Chang ) 대한내과학회 2008 The Korean Journal of Internal Medicine Vol.23 No.3

Background/Aims: The insulin-like growth factor (IGF) system has been implicated in tumor growth, invasion, and metastasis. However, reports on the IGF-1 receptor (IGF-1R) based on radioimmunoassays are conflicting, and its prognostic implications in non-small-cell lung cancer (NSCLC) are still controversial. Methods: Seventy-one paraffin-embedded tissue sections from stage I NSCLC patients were stained using a mouse monoclonal antibody against human IGF-1R. Results: The intensity and frequency of IGF-1R expression on the membrane and cytoplasm of cancer cells was evaluated and scored using a semiquantitative system. IGF-1R expression was detected in nine of 71 (12.7%) cases. No significant relationship was found between clinical/histopathological parameters and IGF-1R expression. None of the patients whose tumor expressed IGF-1R had experienced distant metastasis or cancer-related death, although the difference did not reach statistical significance. Conclusions: We conclude that IGF-1R expression may not be a major prognostic factor for stage I NSCLC.

The impact of short-term acute heat stress on the rumen microbiome of Hanwoo steers

( Youl Chang Baek ),( Hyuck Choi ),( Jinyoung Jeong ),( Sung Dae Lee ),( Min Ji Kim ),( Seul Lee ),( Sang Yun Ji ),( Minseok Kim ) 한국축산학회(구 한국동물자원과학회) 2020 한국축산학회지 Vol.62 No.2

Heat stress negatively affects cattle productivity by reducing feed intake. In the present study, we assessed if the rumen microbiome composition of Hanwoo steers was altered by exposure to heat stress. Rumen samples were collected from four Hanwoo steers that were individually housed in climate-controlled chambers with 60% humidity and environmental temperatures of: 1) 15℃ (0-day group), 2) 35℃ for 3 days (3-day group), and 3) 35℃ for 6 days (6-day group). The total community DNA of samples was extracted, and 997,843 bacterial and 1,508,770 archaeal sequences were analyzed using next-generation sequencing. Assessment of the relative abundances revealed 15 major phyla of which Bacteroidetes was found to be the most dominant. After 3 days of heat stress exposure there were no significant changes in the rumen microbiome composition, except for a decrease in the Planctomycetes. However, after 6 days of heat stress exposure, we found that the relative abundance of fibrolytic Ruminococcaceae had decreased while that of lactate-producing Lactobacillaceae and amylolytic Prevotella and Ruminobacter had increased. The normal rumen microbiome of Hanwoo cattle was shown to be disrupted after 6 days of heat stress, which led to the decrease in fibrolytic bacteria that are sensitive to low pH and the increase in both lactate-producing and amylolytic bacteria. We have demonstrated that the microbiome composition of the rumen is affected by acute heat stress. Our findings may contribute to the development of different feeding strategies to restore heat stress-induced disruption of the rumen microbiome

Association of Insulin Receptor Substrate-1 G972R Variant with Non-small Cell Lung Cancer Risk

( Chang Youl Lee ),( Chul Min Ahn ),( Jeong Hee Jeon ),( Hyung Jung Kim ),( Se Kyu Kim ),( Joon Chang ),( Sung Kyu Kim ),( Yoon Soo Chang ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.1

Background: The insulin receptor substrate-1 (IRS-1) is the primary docking molecule for the insulin-like growth factor I receptor (IGF-IR), and is required for activation of the phosphatidylinositol 3`-kinase (PI3K) pathway. IRS-1 activation of the (PI3K) pathway regulates IGF-mediated survival, enhancement of cellular motility and apoptosis. Therefore, we attempted to ascertain whether IRS-1 genetic variations affect an individual`s risk for non-small cell lung cancer (NSCLC). Methods: Two-hundred and eighteen subjects, either diagnosed with NSCLC or control subjects, were matched by age, gender and smoking status. Genomic DNA from each subject was amplified by PCR and analyzed according to the restriction fragment length polymorphism (RFLP) profile to detect the IRS-1 G972R polymorphism. Results: The frequencies of each polymorphic variation, in the control population, were as follows: GG=103 (94.5%) and GR=6 (5.5%); for the NSCLC subjects, the genotypic frequencies were as follows: GG=106 (97.2%) and GR=3 (2.8%). We could not demonstrate statistically significant differences in the genotypic distribution between the NSCLC and the control subjects (p=0.499, Fisher`s Exact test). The relative risk of NSCLC, associated with the IRS-1 G972R polymorphic variation, was 1.028 (95% CI; 0.63∼9.90). In addition, we found no differences between polymorphic variants with regard to the histological subtype of NSCLC. Conclusion: We did not observe any noteworthy differences in the frequency of the IRS-1 G972R polymorphism in NSCLC patients, compared to control subjects. These results suggest suggesting that, in our study population, the IRS-1 G972R polymorphism does may not appear to be associated with an increased risk of NSCLC.

In Vivo Assessment of Cosmetics and Developing Methods

( Min Youl Chang ),( Sang Wha Lee ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.1

Aged skin is characterized by a number of different signs, such as, wrinkles, dull skin, low skin elasticity, etc. Cosmetics are generally used to reduce such aging signs for healthy and beautiful skin. In order to properly express the functions of cosmetic products, objective evaluation methods must be established. Korea Food & Drug Administration regulates such laws regarding the efficacy of functional cosmetics (anti-wrinkle, skin whitening, SPF) and their proper expressions in advertisement. Recently, non-invasive imaging techniques have drawn great attention from researchers developing more objective evaluating methods. These methods include, in vivo confocal microscopy, multi-photon tomography, OCT, etc. Utilizing these advanced tools, our goal is to establish a more objective method for evaluating both the skin surface and inner skin.

4차 산업혁명에 따른 지능형 정보기술 산업의 경제적 효과 분석

최창열(Chang-Youl Choi),민윤지(Yun-Ji Min) 조선대학교 지식경영연구원 2020 기업과 혁신연구 Vol.43 No.3

본 연구는 한국의 지능형정보기술산업(ICT산업)을 대상으로 성장기여도와 경제적 효과에 대한 분석을 통해 지능형 정보기술로 인한 산업구조변화 및 경쟁력 강화를 위한 시사점을 제시하는데 목적이 있다. 연구는 성장기여도에 분석과 경제적 효과에 대한 분석으로 나누어 진행되었다. 성장기여도 모형은 연쇄시계열 성장기여도 방법을 사용하였으며 경제적 효과에 대한 분석은 산업연관분석을 사용하였다. 성장기여도 분석결과를 살펴보면 지능형정보통신 산업의 GDP 기여도 분석결과 대체적으로 높은 성장기여도를 나타냈으나 2013년 이후 금융위기 등의 여파로 감소추세를 보이는 것으로 나타났다. 지출 항목별 분석에서는 설비투자, 민간소비, 재화수출, 재화수입 자료를 기반으로 성장기여도를 추정하였다. 분석결과 연구대상 기간에서 설비투자 성장률와의 관계는 수치변화가 유사하게 나타나며 긍정적인 영향을 미친 것으로 나타났으나 그 효과는 미미한 수준으로 나타났다. 민간소비 부분은 2013년 이후 성장기여도가 지속적인 하락을 나타냈으며, 수출은 조사기간 연평균 8.9%의 성장기여도를 보이며 기여율이 높은 것으로 나타났다. 수입의 경우 2012년 이후 기여도가 둔화되는 추세이고, 수입성장률과 기여도가 동일한 방향성을 보이면서 수입이 감소하면 성장기여도에 부정적 영향을 미치는 것으로 나타났다. 경제적 효과는 창업효과, 부가가치효과, 고용효과를 분석하였다. 창업효과는 2009년 이후 사업체수 평균증가율이 4.4%라는 점을 고려하면 조사기간에 걸쳐 낮게 나타났다. 부가가치효과는 주로 제조업 부문의 자료를 기반으로 부가가치 창출효과를 분석하였다. 전반적으로 지능형정보통신 제조업의 부가가치 성장률은 제조업의 경기침체로 인해 감소하는 것으로 나타났다. The purpose of this study is to suggest implications for industrial change and competitiveness enhancement through analysis of growth contribution and economic effect of Korea"s intelligent information technology industry (ICT industry). This study was divided into analysis on growth contribution and analysis on economic effect. The growth contribution model was used by the chain time series growth contribution method, and the analysis of economic effects was conducted by industry-related analysis. The results of the analysis of growth contribution showed that the GDP contribution of the intelligent information and communication industry was generally high, but it showed a decline trend due to the financial crisis since 2013. In the analysis of expenditure items, growth contribution was estimated based on facility investment, private consumption, goods export, and goods import data. The results of the analysis showed that the relationship with the growth rate of facility investment in the period of study had a similar numerical change and had a positive effect, but the effect was insignificant. In the private consumption part, growth contribution has been steadily declining since 2013, and exports have a growth contribution of 8.9% per annum during the survey period. In the case of imports, the contribution has slowed since 2012, and the import growth rate and contribution have the same direction, and the decrease in imports has a negative impact on the growth contribution. The economic effects were analyzed by analyzing the start-up effect, value-added effect, and employment effect, and the start-up effect was low over the survey period considering that the average increase rate of the number of businesses since 2009 was 4.4%. The value added effect was analyzed based on the data of the manufacturing sector.Overall, the value added growth rate of intelligent information and communication manufacturing decreased due to the economic downturn of manufacturing industry.

Clinical significance of insulin-like growth factor-1 receptor expression in stage I non-small-cell lung cancer: immunohistochemical analysis

Lee, Chang Youl,Jeon, Jeong Hee,Kim, Hyung Jung,Shin, Dong Hwan,Roh, Tae Woong,Ahn, Chul Min,Chang, Yoon Soo The Korean Association of Internal Medicine 2008 The Korean Journal of Internal Medicine Vol.23 No.3

<P><B>Background/Aims</B></P><P>The insulin-like growth factor (IGF) system has been implicated in tumor growth, invasion, and metastasis. However, reports on the IGF-1 receptor (IGF-1R) based on radioimmunoassays are conflicting, and its prognostic implications in non-small-cell lung cancer (NSCLC) are still controversial.</P><P><B>Methods</B></P><P>Seventy-one paraffin-embedded tissue sections from stage I NSCLC patients were stained using a mouse monoclonal antibody against human IGF-1R.</P><P><B>Results</B></P><P>The intensity and frequency of IGF-1R expression on the membrane and cytoplasm of cancer cells was evaluated and scored using a semiquantitative system. IGF-1R expression was detected in nine of 71 (12.7%) cases. No significant relationship was found between clinical/histopathological parameters and IGF-1R expression. None of the patients whose tumor expressed IGF-1R had experienced distant metastasis or cancer-related death, although the difference did not reach statistical significance.</P><P><B>Conclusions</B></P><P>We conclude that IGF-1R expression may not be a major prognostic factor for stage I NSCLC.</P>

화장품과 보습제(Moisturizers) -작용기전에 따른 보습제의 종류-

장민열 ( Min Youl Chang ),김진준 ( Jin Jun Kim ),이천구 ( Cheon Koo Lee ) 한국피부장벽학회 2007 한국피부장벽학회지 Vol.9 No.1

The fundamental function of cosmetics is to give hydration and smoothness to the skin. To improve the moisturizing effect, many materials have been developed and many dermatological studies have been performed on the stratum corneum, in particalar. Nowadays, we understand that both natural moisturizing factors (NMF) and lipid barriers are very important in skin hydration. Also more important parameters are being studied for lipid biosynthesis and epidermal homeostasis. As the understanding of the skin increases, new cosmetic materials are developed. Recently, the following methods have been used to improve moisturizing of the skin in cosmetics: occlusive formulations to prevent evaporation; hygroscopic molecules; neutral, high-molecular-weight, water-binding polymers; supplement of NMF; and supplementing barrier lipids.