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Masaru Hashimoto,Tomoki Houda,Rito Furuchi,Hiroki Nakano,Kiyomi Okamoto,Toru Sakai 한국물리학회 2023 새물리 Vol.73 No.12
The magnetization process of the S = 1=2 distorted diamond quantum spin chain with the Ising-like anisotropic ferromagnetic interaction is investigated using the numerical diagonalization method. Two kinds of wide magnetization plateaux are found at 1=3 of the saturation magnetization based on the Haldane-like mechanism and the Néel-like mechanism, respectively. Apart from the magnetization plateaux, there appear the conventional Tomonaga-Luttinger liquid (TLL) phase and the two-magnon TLL phase. The latter phase is composed of the nematic TLL phase and the SDW TLL phase. The phase diagram with respect to the ferromagnetic interaction anisotropy parameter versus the magnetization is presented.
Toru Sakai,Masaru Hashimoto,Tomoki Houda,Rito Furuchi,Hiroki Nakano,Kiyomi Okamoto,Kouichi Okunishi 한국물리학회 2023 새물리 Vol.73 No.12
The magnetization process of the S = 1=2 ferromagnetic and antiferromagnetic bond-alternating chain with competing anisotropies is investigated using the numerical diagonalization of finite-size systems. It is found that when the easy-plane and easy-axis anisotropies are introduced at the ferromagnetic and antiferromagnetic bonds, respectively, the system possibly exhibits the 1/2 magnetization plateau with the spontaneous translational symmetry breaking. The phase diagrams with respect to the two anisotropies are presented.
Shinji Okabayashi,Taku Kobayashi,Eiko Saito,Takahiko Toyonaga,Ryo Ozaki,Shintaro Sagami,Masaru Nakano,Junichi Tanaka,Keiji Yagisawa,Satoshi Kuronuma,Osamu Takeuchi,Toshifumi Hibi 대한장연구학회 2019 Intestinal Research Vol.17 No.2
Background/Aims: The pharmacokinetics of tacrolimus (TAC) is known to be largely influenced by single-nucleotide polymorphisms (SNPs) in CYP3A5. Patients starting TAC require careful dose adjustment, owing to the wide range of optimal dosages, depending on their CYP3A5 expression status. Here, we evaluated whether individualization of TAC dosages based on CYP3A5 SNPs would improve its therapeutic efficacy in ulcerative colitis. Methods: Twenty-one patients were prospectively treated, with their initial dosage adjusted according to their CYP3A5 status (0.1, 0.15, and 0.2 mg/kg/day for CYP3A5*3/*3, CYP3A5*1/*3, and CYP3A5*1/*1, respectively). Their clinical outcomes were compared with those of patients treated with a fixed dose (0.1 mg/kg/day). Results: The first blood trough level of CYP3A5 expressors, CYP3A5*1/*3 or CYP3A5*1/*1, and the overall rate in achieving the target blood trough level within a week in the individualized-dose group were significantly higher than those in the fixed-dose group (5.15±2.33 ng/mL vs. 9.63±0.79 ng/mL, P=0.035 and 12.5% vs. 66.7%, P=0.01). The remission rate at 2 weeks in the expressors was as high as that in the nonexpressors, CYP3A5*3/*3, in the individualized-dose group. Conclusions: Individualized TAC treatment is effective against ulcerative colitis regardless of the CYP3A5 genotype. (Intest Res 2019;17:218-226)