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Development of Intelligent Power Wheelchair Assisting for Frail Elderly People on Daily Life
Atsuhiro Nakamura,Gen Obayashi,Yasunari Fujimoto,Osamu Nitta,Toru Yamaguchi 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
Recently, the number of elderly people increases in Japan, and the development of welfare apparatus having the effect of minimizing care is required. In this research, authors develop Intelligent Power Wheelchair along with minimizing care needs for frail elderly people. This Intelligent Power Wheelchair features the four functions ; approach function by human gesture recognition, standing up assistance, walking assistance, and operation assistance by posture recognition. And it shows experiments which three assistances function in useful.
Calcitonin induces connective tissue growth factor through ERK1/2 signaling in renal tubular cells
Misa Nakamura,Takashi Ozaki,Aiko Ishii,Masayoshi Konishi,Yuji Tsubota,Toru Furui,Hayato Tsuda,Ichiro Mori,Kiichiro Ota,Kennichi Kakudo 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.5
Calcitonin (CT), a polypeptide hormone, plays important roles in a variety of physiological processes. CT has been used clinically to treat osteoporosis and humoral hypercalcemia of malignancy. In order to clarify the pharmacological effects of CT in the kidney, we identified potential downstream genes induced by CT in the renal cells. Using a cDNA subtraction hybridization method, we identified connective tissue growth factor (CTGF) as a CT-induced gene in the porcine renal cell line, LLC-PK1. Furthermore, we found that CT-mediated induction of the gene was not inhibited by cycloheximide, which suggests that CTGF gene was not induced by an increased synthesis of regulating proteins. Therefore, CTGF is an immediate early gene. We further demonstrated that the regulation of CTGF gene expression by CT involved the ERK1/2 pathway, because PD98059, a MEK1 inhibitor, partially inhibited the mRNA expression of CTGF induced by CT. CT-induced CTGF protein expression was also observed in vivo. Our present findings suggest that CT induces the transcription of CTGF through ERK1/2 phosphorylation. We also identified twelve other genes induced by CT that, like CTGF, were related to wound healing. These results suggest that CT may have an effect on renal differentiation and wound healing in the kidney. Calcitonin (CT), a polypeptide hormone, plays important roles in a variety of physiological processes. CT has been used clinically to treat osteoporosis and humoral hypercalcemia of malignancy. In order to clarify the pharmacological effects of CT in the kidney, we identified potential downstream genes induced by CT in the renal cells. Using a cDNA subtraction hybridization method, we identified connective tissue growth factor (CTGF) as a CT-induced gene in the porcine renal cell line, LLC-PK1. Furthermore, we found that CT-mediated induction of the gene was not inhibited by cycloheximide, which suggests that CTGF gene was not induced by an increased synthesis of regulating proteins. Therefore, CTGF is an immediate early gene. We further demonstrated that the regulation of CTGF gene expression by CT involved the ERK1/2 pathway, because PD98059, a MEK1 inhibitor, partially inhibited the mRNA expression of CTGF induced by CT. CT-induced CTGF protein expression was also observed in vivo. Our present findings suggest that CT induces the transcription of CTGF through ERK1/2 phosphorylation. We also identified twelve other genes induced by CT that, like CTGF, were related to wound healing. These results suggest that CT may have an effect on renal differentiation and wound healing in the kidney.
Electron compound nature in a surface atomic layer of a two-dimensional hexagonal lattice
Matsuda, Iwao,Nakamura, Fumitaka,Kubo, Keisuke,Hirahara, Toru,Yamazaki, Shiro,Choi, Won Hoon,Yeom, Han Woong,Narita, Hisashi,Fukaya, Yuki,Hashimoto, Mie,Kawasuso, Atsuo,Ono, Masanori,Hasegawa, Yukio,H American Physical Society 2010 Physical review. B, Condensed matter and materials Vol.82 No.16
( Masaki Kuwatani ),( Toru Nakamura ),( Tsuyoshi Hayashi ),( Yasutoshi Kimura ),( Michihiro Ono ),( Masayo Motoya ),( Koji Imai ),( Keisuke Yamakita ),( Takuma Goto ),( Kuniyuki Takahashi ),( Hiroyuki 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2020 Gut and Liver Vol.14 No.2
Neoadjuvant chemotherapy/neoadjuvant chemoradiotherapy (NAC/NACRT) can be performed in patients with pancreatic cancer to improve survival. We aimed to clarify the clinical outcomes of biliary drainage with a metal stent (MS) or a plastic stent (PS) during NAC/NACRT. Between October 2013 and April 2016, 96 patients with pancreatic cancer were registered for NAC/NACRT. Of these, 29 patients who underwent biliary drainage with MS or PS before NAC/NACRT and a subsequent pancreatoduodenectomy were retrospectively analyzed with regard to patient characteristics, preoperative recurrent biliary obstruction rate, NAC/NACRT delay or discontinuation rate, and operative characteristics. The median age of the patients was 67 years. NAC and NACRT were performed in 14 and 15 patients, respectively, and MS and PS were used in 17 and 12 patients, respectively. Recurrent biliary obstruction occurred in 6% and 83% of the patients in the MS and PS groups, respectively (p<0.001). NAC/NACRT delay was observed in 35% and 50% of the patients in the MS and PS groups, respectively (p=0.680). NAC/NACRT discontinuation was observed in 12% and 17% of the patients in the MS and PS groups, respectively (p=1.000). The operative time in the MS group tended to be longer than that in the PS group (625 minutes vs 497 minutes, p=0.051), and the operative blood loss volumes and postoperative adverse event rates were not different between the two groups. MS was better than PS from the viewpoint of preventing recurrent biliary obstruction, although MS was similar to PS with regards to perioperative outcomes. (Gut Liver 2020;14:269-273)
Takashi Yokoyama,Masaru Nakamura,Junichi Tatami,Toru Wakihara,Takeshi Meguro 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.5
Preparation of cubic spinel-type oxides, Mn(1.75−1.25X)Co2.5XNi1.25(1−X)O4 (0 ≤X≤ 0.6), and their electrical properties were investigated. The starting oxides, containing metals with a prescribed molar ratio, were heated to 1400℃ and held for 3 h in argon. The sintered bodies were cooled to 800 oC and then oxidized for 48 h in air to convert them into a cubic spinel structure. The electrical conductivities of the sintered bodies were confirmed to increase exponentially with an increase in the temperature, indicating that they have intrinsic NTC thermistor characteristics. In the region of 0 ≤ X≤ 0.4, the electrical conductivity increased with an increase in X and decreased with an increase in X in the region of 0.4 < X ≤ 0.6. The concentration of Mn4+ in the octahedral sites of the spinel structure was considered to be larger than that of Mn3+ because the sintered bodies were n-type semiconducting. The electrical conduction of the oxides prepared in this study was concluded to be controlled by a small polaron hopping mechanism. Preparation of cubic spinel-type oxides, Mn(1.75−1.25X)Co2.5XNi1.25(1−X)O4 (0 ≤X≤ 0.6), and their electrical properties were investigated. The starting oxides, containing metals with a prescribed molar ratio, were heated to 1400℃ and held for 3 h in argon. The sintered bodies were cooled to 800 oC and then oxidized for 48 h in air to convert them into a cubic spinel structure. The electrical conductivities of the sintered bodies were confirmed to increase exponentially with an increase in the temperature, indicating that they have intrinsic NTC thermistor characteristics. In the region of 0 ≤ X≤ 0.4, the electrical conductivity increased with an increase in X and decreased with an increase in X in the region of 0.4 < X ≤ 0.6. The concentration of Mn4+ in the octahedral sites of the spinel structure was considered to be larger than that of Mn3+ because the sintered bodies were n-type semiconducting. The electrical conduction of the oxides prepared in this study was concluded to be controlled by a small polaron hopping mechanism.
Role of Interfacial B Impurity in the Magnetocrystalline Anisotropy at MgO/Fe Interface
Koji Hotta,Kohji Nakamura,Toru Akiyama,Tomonori Ito 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
The structural stability and the magnetocrystalline anisotropy (MCA) at MgO/Fe(001) interfaceswith the incorporation of interfacial B atoms were investigated by using first-principles calculations. Total energy calculations predicted that the B atoms favored segregating to the interface. Thecalculated MCA energy for an ideal abrupt MgO/Fe interface (with no B atom) indicated that themagnetization strongly favored pointing along the perpendicular direction. However, when B atomswere incorporated at the MgO/Fe interfaces, the perpendicular MCA almost disappeared.
Magnetism and Multiplets in Fe-phthalocyanine Molecules
Yukie Kitaoka,Kohji Nakamura,Toru Akiyama,Tomonori Ito,M. Weinert,A. J. Freeman 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
Magnetism and multiplets for Fe-phthalocyanine molecules were investigated based on the constraintdensity functional theory (DFT) by imposing a density matrix constraint on the d-orbitaloccupation numbers. We demonstrate that for a single FePc molecule, there are three stationarystates of multiplets, 3Eg, 3A2g, and 3B2g, and that the magnetic anisotropy (MA) strongly dependson the multiplet structures. The ground state of the 3A2g obtained from the constraint DFT totalenergy calculations has planar MA, with the spin moments pointing along the molecule’s planardirection. The columnar stacking structure for α-FePc, with the ground state of the 3Eg, showsplanar MA.
Structural and Elastic Properties of the Magnetic Shape Memory Ni2MnGa1−xInx Alloy
Fumiya Kitanishi,Kohji Nakamura,Toru Akiyama,Tomonori Ito 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
The structural and the elastic properties of the magnetic shape memory Ni2MnGa1−xInx (x 0.25) alloy were investigated from first principles calculations within the generalized gradient approximationby using the full-potential linearized augmented plane-wave method and the Connolly-Williams cluster expansion method. The calculated lattice constant and bulk modulus have analmost linear dependence on the In composition x, where the former increases and the latter decreaseswhen x increases. In contrast, the calculated shear modulus, C0 = (C11 − C12)/2, of thedisordered state, which shows a nonlinear dependence on x, indicates that a deviation from thestoichiometric composition Ni2MnGa (x = 0) enhances the elastic tetragonal anisotropy.