http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Joung Ah Park ),( Gi Dae Kim ),( Jung Hoon Cha ),( Hye Lim Kim ),( Eun Suk Choi ),( Eun Sun Jung ),( Seung Kew Yoon ),( Seh Hoon Oh ),( Si Hyun Bae ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.4
Mesenchymal stem cells (MSCs) derived from various human tissues, including amnion (AM) from the placenta and bone marrow (BM), have been known to differentiate into multi-lineages and mesodermal cell lines. Few comparative studies have reported their potential for hepatogenic differentiation using an in vitro culture system and it remains unclear if their therapeutic potential in an animal model also depends on this differentiation. The pur-pose of this study was to compare the hepatogenic differentiation capacity of AM- and BM-derived MSCs, and toevaluate their antifibrotic efficacy after direct transplantation into a bile duct-ligated rat model of liver fibrosis. The proliferation of AM-MSCs derived from placenta was higher than that of BM-MSCs. Differentiated hepatocyte-like cells changed in morphology, expressed hepatocyte-specific genes, and demonstrated functional activities. Differ-entiated AM- and BM-derived hepatocyte-like cells were directly transplanted into rat livers suffering from hepaticfibrosis due to bile duct ligation. Liver tissues were analyzed at one and two weeks post-transplantation. Albumin expression was increased in rats one week after transplanting AM- and BM-derived hepatocyte-like cells. And, col-lagen deposition decreased compared with the control group. These results contribute to our understanding of the antifibrotic effects of AM- and BM-derived hepatocyte-like cells on liver disease and their ability to undergo hepato-genic differentiation. AM- and BM-derived MSCs may be a source of cells for liver regeneration and may providea foundation for the development of novel cell therapies.
( Young Ah Park ),( Jae Sun Uhm ),( Tae Hoon Kim ),( Han Cheol Lee ),( Jun Beom Park ),( Jin Kyu Park ),( Bo Young Joung ),( Hui Nam Pak ),( Moon Hyoung Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: In patients with sick sinus syndrome (SSS) or atrioventricular block (AVB), hypertension can be uncontrollable due to the compensatory increase of sympathetic tone. The aim of this study was to elucidate changes of blood pressure (BP) before and after pacemaker implantation. Methods: We retrospectively reviewed the medical record of patients who underwent pacemaker implantation from January 2010 through December 2013 in one center, who were diagnosed with hypertension and taking antihypertensive drugs before pacemaker implantation. Results: A total of 58 patients met the eligible criteria, and they showed signifi cant decreases of systolic BP (143.5±17.3mmHg vs 127.1±13.7mmHg, p<0.001) and mean BP (120.0±14.1mmHg vs 69.4±12.1mmHg, p=0.001) after 3 months of pacemaker implantation. The systolic BP of 36 patients (68.4%) and mean BP of 34 patients (59.6%) were decreased after 3 months of implantation compared to the initial systolic BP and mean BP. The tendency of BP decrease were more obvious in patients with borderline to high initial systolic BP. However, the BP in normotensive patients were increased over time (% of patients with decreased BP, 31.8% vs 82.9%, p<0.001 after 3 months). The reduction of BP in patients with borderline and high initial systolic BP persisted after 9 months of follow up compared with baseline BP (Difference of systolic BP, 22.1 ± 3.7mmHg, p<0.001, difference of mean BP, 15.7 ± 3.0mmHg, p<0.001). The fi nding was independent of the cause of pacemaker implantation (SSS vs AVB 54.8% vs 73.1%, p=0.179 at discharge, 58.1% vs 61.5%, p=1.00 after 3 months). The number of antihypertensive drugs before implantation was not signifi cantly different from that after implantation (before implantation vs after implantation 1.6±0.7, 1.6±0.6, p=0.568). Conclusions: Pacemaker implantation can be helpful for blood pressure control in patients with hypertension and SSS or AVB.
Seon Ah Park,Hua Yin,Janardhan P. Bhattarai,Soo Joung Park,Seong Kyu Han KOREAN ACADAMY OF ORAL BIOLOGY 2009 International Journal of Oral Biology Vol.34 No.4
Somatostatin (SST) is a known neuromodulator of the central nervous system. The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) receives many thinmyelinated Aδ-fiber and unmyelinated C primary afferent fibers and is involved in nociceptive processing. Many studies have demonstrated that SST plays a pivotal role in pain modulation in the spinal cord. However, little is yet known about the direct effects of SST on the SG neurons of the Vc in adult mice. In our present study, we investigated the direct membrane effects of SST and a type 2 SST receptor agonist, seglitide (SEG), on the SG neurons of the Vc using a gramicidin-perforated current clamp in adult mice. The majority (53%, n = 27/51) of the adult SG neurons were hyperpolarized by SST (300 nM) but no differences were found in the hyperpolarization response rate between males and females. When SST was applied successively, the second response was smaller (76 ± 9.5%, n = 19), suggesting that SST receptors are desensitized by repeated application. SST-induced hyperpolarization was also maintained under conditions where presynaptic events were blocked (75 ± 1.0%, n = 5), suggesting that this neuromodulator exerts direct effects upon postsynaptic SG neurons. SEG was further found to induce membrane hyperpolarization of the SG neurons of the Vc. These results collectively demonstrate that SST inhibits the SG neuronal activities of the Vc in adult mice with no gender bias, and that these effects are mediated via a type 2 SST receptor, suggesting that this is a potential target for orofacial pain modulation.