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( Jeong Seok Kim ),( Dok Hyun Yoon ),( In Keun Park ),( Shin Kim ),( Jung Sun Park ),( Sang Wook Lee ),( Joor Yung Huh ),( Chan Sik Park ),( Cheol Won Suh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Primary testicular diffuse large B-cell lymphoma (DLBCL) is a kind of rare but aggressive extranodal lymphoma. Relapse in central nervous system (CNS) is majorconcerns in the treatment of primary testicular DLBCL. However, the role of intrathecal prophylaxis is still controversial issue. Methods: We retrospectively reviewed the medical records of 14 patients with primary testicular DLBCL diagnosed between November 2000 and June 2012. We analyzed CNS relapse rate in the patients treated without intrathecal prophylaxis. Survival curves were estimated using the Kaplan-Meier method. Results: The median age at diagnosis was 57 years (range, 41-79 years). Unilateral testicular involvement was observed in 13 patients. Nine (64. 3%) patients were in stage I, 1 in stage II, and 4 in stage IV. The international prognostic index was low or low-intermediate risk in 12 patients, and high-intermediate risk in 2 patients. Thirteen patients underwent orchiectomy. All of the patients received systemic chemotherapy without intrathecal prophylaxis. And, prophylactic radiotherapy was administered to the contralateral testis in 12 patients. The median follow-up period of surviving patients was 39 months (10-139 months). Median overall survival had not been reached and median progression-free survival was 3. 8 years. Four patients experienced relapse, but CNS relapse was observed in only one patient (7. 1%) with stage IV disease at 27 months after a complete response. Conclusions: Even without intrathecal prophylaxis, the rate of relapse in the CNS appears not to be high in Korean patients with primary testicular DLBCL compared with prior reports.
연부조직의 말초신경상피암종의 세침흡인 - 1예 보고 -
박양순,옥순애,공경엽,최기영,허주영,유은실,이인철,Park, Yang-Soon,Oak, Soon-Ae,Gong, Gyung-Yub,Choe, Ghee-Young,Huh, Joor-Yung,Yu, Eun-Sil,Lee, In-Chul 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.1
Peripheral neuroepithelioma (PNE) of soft tissue is a malignant neuroectodermal tumor arising from peripheral (nonautonomic) nerve. It nay occur in both children and adults, and are highly aggressive neoplasms that rapidly give rise to metastatic disease and death. We exprienced a case of peripheral neuroepithelioma of soft tissue in the upper arm in a 18-year-old female. Cytologic features revealed small round cells with scanty cytoplasm occurring both singly and in clusters. The clusters frequently tended to form Homer-Wright rosettes. The cells had a round to oval nucleus with fine chromatin and inconspicuous nucleoli in a hemorrhagic background.
한은미,송동은,엄대운,최혜정,차희정,허주영,Han, Eun-Mee,Song, Dong-Eun,Eom, Dae-Un,Choi, Hye-Jeong,Cha, Hee-Jeong,Huh, Joor-Yung 대한세포병리학회 2006 대한세포병리학회지 Vol.17 No.2
In the investigation of superficial lymphadenopathy of unknown cause, fine needle aspiration (FNA) cytology plays an invaluable role. It enables the differentiation of benign lymphadenopathy from lymphoid and non-lymphoid malignancies, obviating the need for open biopsy, and allowing the triage of patients. Cytopathologists should be familiar with the typical FNA patterns of benign lymphadenopathy, and recognize and differentiate among categories. In a minority of cases of benign lymphadenopathy, FNA can render a specific diagnosis. Benign lymphadenopathies are generally categorized into reactive lymphoid hyperplasia (RLH), inflammatory or infectious processes, and benign lymphoproliferative disorders. RLH characteristically presents with a heterogeneous and polymorphous smear composed of normal cellular constituents of lymph nodes, in contrast with the homogeneous or monomorphic smear of most lymphomas. The caveat is that various malignant disorders may also present with polymorphous populations. It is also important to recognize thatbenign lymphoid smears may sometimes contain atypical cells that raise the suspicion of malignancy. Clinical information should always be the integral part of the diagnostic criteria in FNA of lymphadenopathy. If there is any doubt about the benign nature of the smear, it is prudent to suggest biopsy and ancillary studies.
( Sang Hyung Lee ),( Woo Jin Lee ),( Kwang Hee Won ),( Chong Hyun Won ),( Sung Eun Chang ),( Jee Ho Choi ),( Kee Chan Moon ),( Mi Woo Lee ),( Chan Sik Park ),( Joor Yung Huh ),( Cheol Won Suh ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: The relative frequency, clinical features, and survival outcomes of secondary cutaneous lymphoma remain poorly understood. Objectives: To determine the clinical characteristics and survival outcomes of secondary cutaneous lymphoma. Methods: The present retrospective cohort study included all 106 patients who presented with secondary cutaneous lymphoma. Patient medical records were reviewed to determine the clinical features, survival outcomes, and prognostic factors. Results: Secondary cutaneous lymphomas consisted of mature T-/NK-cell lymphomas (56%), mature B-cell lymphomas (35%), immature hematopoietic malignancies (8%), and Hodgkin lymphoma (1%). The lymphoma cell lineage did not significantly influence survival, even though T-/NK-cell lymphoma skin lesions were more extensive than B-cell lymphoma skin lesions. Prognostic factors that associated with poor survival were elevated lactate dehydrogenase at the time of initial staging, extranodal lymphoma, disseminated skin lesions, and an early (<6 months) development of skin lesions after the initial diagnosis. The two lymphoma cell lineages differed in terms of prognostic factors that influenced survival. Conclusion: Skin lesion characteristics such as time point of appearance and extent affect the survival outcomes of secondary cutaneous lymphoma. Cell lineage did not influence survival outcomes but the two lineages associated with different prognostic factors.
( Woo Jin Lee ),( Mi Hye Lee ),( Kwang Hee Won ),( Chong Hyun Won ),( Sung Eun Chang ),( Jee Ho Choi ),( Kee Chan Moon ),( Chan Sik Park ),( Joor Yung Huh ),( Cheolwon Suh ),( Mi Woo Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Differences in skin lesions and survival data for cutaneous diffuse large B-cell lymphoma (DLBCL) depending on primary tumor site are currently unknown. Objectives: We aimed to analyze the clinical features of skin lesions and survival outcomes of cutaneous DLBCL according to the primary tumor site. Methods: Forty-seven patients with cutaneous DLBCL were classified as primary cutaneous DLBCL or cutaneous DLBCL secondary to primary disease. Clinical features, survival outcomes, and prognostic factors were analyzed using patient medical records. Survival outcomes were analyzed using the Kaplan-Meier method and compared using the log-rank test. Results: Although skin lesion characteristics did not significantly differ between groups, secondary cutaneous DLBCL more commonly presented disseminated skin lesions that involved multiple anatomical sites. Primary cutaneous DLBCL demonstrated a less aggressive clinical course and better survival outcomes than secondary cutaneous DLBCL. Disseminated skin lesions and a location on the leg significantly affected the prognosis of primary cutaneous DLBCL. The multiplicity of skin lesions and time point of cutaneous involvement were associated with prognosis in secondary cutaneous DLBCL Conclusion: Although the clinical features of skin lesions were similar regardless of subgroup, survival outcomes and prognostic factors differed depending on the primary tumor site of cutaneous DLBCL.