乾癬患者 臨床報告

吳恩英,朴惠宣,池鮮渶,具德謨 동의대학교 한의학연구소 2001 동의ㆍ경산 한의학 학술대회 Vol.5 No.-

A Reports were done on proriasis which were treated by medications of Sasang Constitution and Constitution-Acupunture in Dept. surgery, opthalmology &tolaryngology, college of Oriental Medicine, Kyungsan University, Pohang, Korea, from May 30. 2000 to JUN 30 2001. we gave score and checked involvement, plaque, erythematous popules, invasiveness according to psoriasis area and severity index. The results were as follows: 1. Sasang Constitution classification was Soyanggin 14(93.33%), Taeumgin 1(6.67%) in the 15 cases. Hyungbangsabaeksan is used in 9 cases(60%), Yanggeuksanhoatang is used in 3 cases(13.11%), Geopungchunggisan is used in 3 cases(20%), Hyungbangdojucksan is used in 1 case(6.57%). 2. In the 9 cases, we checked for over 4 weeks, clinical severity of involvement, plaque, total score(psoriasis area and severity index) was siginificantly decreased(p<05). clinical severity of erythematous popules, itching was decreased but lt is not siginificant(p>05). 3. The mean duration of treatmemt was 73.3 days, result of Excellent or Good improvement was showed on over 120 days. These resilts indicate that Sasang Constitution and Constitution-Acupuntuer treatment is effetive on psoriasis and the more study is needed.

복수과 진료 환자의 중복 처방에 대한 분석 및 평가

이지은,장혜경,오지영,유윤경,김현지,임숙인,연숙희,강진숙,최귀령 한국병원약사회 2003 병원약사회지 Vol.20 No.1

In an aging society, there is an increasing possibility of the duplication of the drugs given to patients because they take many kinds of drugs. Among the prescriptions given to the patients who was treated at multiple ambulatory clinics in St. Mary's hospital for one month of September, 2002, in which drugs that has identical or similar effects are prescribed, we analysed and evaluated them by patients' characteristics, kinds of medication, severity of side effects on a case by case basis. More, we assessed the potential additional costs. As a result of this study, the duplication rate turned out to be 6.69% and it was shown that the proportion of the elderly patients over 60 was high. The gastro-intestinal medications took up a large part and most of the cases showed that the danger caused by double taking of medicine was slight, but there were some examples in which the serious side effects were predicted. Expected additional costs were the average 11.349 won and it ranges from the minimum of 56 won to the maximum of 135,720 won. In conclusion, the management of drug histories of the patients who need the plural treatments is very important and the necessity of the individual and professional guidance of taking medicines for the elderly patients is emerged, too.

Change in Palliative Performance Scale (PPS) Predicts Survival in Patients with Terminal Cancer

Oh, Jee Hye,Lee, Yong Joo,Seo, Min Seok,Yoon, Jo Hi,Kim, Chul Min,Kang, Chung Korean Society for Hospice and Palliative Care 2017 한국호스피스.완화의료학회지 Vol.20 No.4

목적: Palliative Performance Scale (PPS)는 진행성 암환자에서 널리 사용되는 예후도구이다. PPS 측정이 생존에 대한 예측을 의미하지만, 연속적인 PPS 측정에 대한 유용성은 추가적인 연구가 필요하다. 본 연구에서는 완화 병동에 입원한 진행성 암환자를 대상으로 PPS score의 변화와 생존간의 연관성에 대해 진행한 연구이다. 방법: 2010년 1월부터 2012년 12월까지 서울성모병원 완화의학과에 입원한 환자 606에 대한 의무기록을 통하여 입원 당일의 PPS score와 입원 3일째의 PPS score 그리고, 두 score의 차이를 측정하여 점수의 변화와 생존간의 관련성을 분석하였다. 결과: PPS score의 변화와 생존과는 통계적으로 유의한 관련이 있었다. PPS score의 변화가 30% 이하인 군과 비교하였을 때, 30% 초과된 군에서 hazard ratio가 2.66(95% CI 2.19~3.22)로 확인되었다. 입원 3일째 PPS score가 30% 이하인 경우 독립적으로 생존에 대한 예측이 가능하였으며, PPS score 30% 초과된 군과 비교했을 때 hazard ratio는 1.67 (95% CI 1.38~2.02)로 확인되었다. 입원 당시의 PPS score는 생존과 독립적인 관련성은 없었다. 결론: 후향적으로 의무기록 분석을 통해 이루어진 본 연구에서 30% 이상의 PPS score 변화는 입원중인 말기 암환자의 생존과의 관련이 확인되었다. 입원 당시의 PPS score는 생존을 예측하지 못했다. PPS score의 변화는 말기암환자에서 단일 PPS score 측정보다 더 민감한 지표일 수 있다. 차후 더 많은 환자들에서 이에 대한 다기관, 전향적 연구가 필요하다. Purpose: The Palliative Performance Scale (PPS) is a widely used prognostic tool in patients with advanced cancer. This study examines the association between changes in PPS score and survival in patients with advanced cancer. Methods: We identified a cohort of 606 inpatients who died at a Korean university hospital's hospice/palliative care center. For each patient, the PPS score was measured twice according to a standard procedure: 1) upon admission, and 2) three days after admission (D3). "Change on D3" was defined as a difference between initial PPS and PPS on D3. We used a Cox regression modeling approach to explore the association between this score change and survival. Results: The changes in scores were associated with survival. A score change of >30% yielded a hazard ratio for death of 2.66 (95% CI 2.19~3.22), compared to a score change of ${\leq}30%$. PPS of ${\leq}30$ on D3 also independently predicted survival, with a hazard ratio of 1.67 (95% CI 1.38~2.02) compared to PPS of >30. Conclusion: A change of over 30% in PPS appears to predict survival in hospitalized patients with terminal cancer, even after adjustment for confounders. Changes in PPS may be a more sensitive indicator of impending death than a single PPS measured on the day of admission in terminal cancer patients. Further prospective study is needed to examine this important finding in other populations.

An Analysis of Pre-Service Teachers` Reflective Thinking for Tasks on Polar Coordinates

( Hye Mi Oh ),( Jee Hyun Park ),( Oh Nam Kwon ) 한국수학교육학회 2013 수학교육 학술지 Vol.2013 No.-

It is the first time that there is a subject, advanced mathematics in the 2009 revised high school curriculum. Therefore it is posing a challenge to the teachers who are teaching it. At the advanced level, it is important for learners to reflect on their mental mathematical activities. This research analysed pre-service secondary teachers` reflective thinking in solving the tasks specific for the teaching and learning of polar coordinates. We report how and through what process mathematical tasks that can create disequilibrium for preservice secondary teachers enable reflective thinking and expand pre-service secondary teachers` thoughts and recognition of defining reflective thinking in looking back on one`s problem solving and thinking processes.

An Analysis of Pre-Service Teachers` Reflective Think-ing for Tasks on Polar Coordinates

( Hye Mi Oh ),( Jee Hyun Park ),( Oh Nam Kwon ) 한국수학교육학회 2013 수학교육연구 Vol.17 No.2

It is the first time that there is a subject, advanced mathematics in the 2009 revised high school curriculum. Therefore it is posing a challenge to the teachers who are teaching it. At the advanced level, it is important for learners to reflect on their mental mathematical activities. This research analysed pre-service secondary teachers` reflective thinking in solving the tasks specific for the teaching and learning of polar coordinates. We report how and through what process mathematical tasks that can create disequilibrium for pre-service secondary teachers enable reflective thinking and expand pre-service secondary teachers` thoughts and recognition of defining reflective thinking in looking back on one`s problem solving and thinking processes.

Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth

( Jee Hye Oh ),( Kwan Ho Jeong ),( Jung Eun Kim ),( Hoon Kang ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.2

Background: The ceramide is known to play an important role in the formation of intracellular lipids, and play a crucial role as a barrier for skin and hair cuticle. Recent study has revealed that ceramide has potential effect on hair growth in a mouse model. However, the role of ceramide in human dermal papilla cells (hDPCs) known to play an important role in hair growth is not well understood yet. Objective: The goal of this study was to investigate the effect of synthetic ceramides (oleyl and stearyl ceramides) on hair growth using hDPCs. Methods: hDPCs were treated with synthesized ceramides. hDPCs viability was evaluated by MTT assay. The expression of hair growth related factors were investigated by western blot, real-time polymerase chain reaction and growth factor array. The expression of β-catenin was confirmed by immunofluorescence. Results: Treatment with ceramides increased the expression of proteins affecting cell proliferation such as Bcl-2, BAX, phosphorylated-ERK and Cyclin D1. Also, ceramides treatment were increased the expression of several growth factors, including epidermal growth factor family, and promote the expression of Wnt/β-catenin and BMP2/4 signaling. Conclusion: Our data suggest that synthetic ceramides stimulates hair growth by induction proliferation of hDPCs via modulation of Wnt/β -catenin and BMP2/4 signaling. (Ann Dermatol 31(2) 164∼174, 2019)

Investigation of Resolution Enhancement by Using Interferometric Immersion Lithography with a Lloyd Mirror

Jee-Hye You,Hye-Keun Oh,Seung-Wook Park,Young-Min Kang 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.6

The minimum feature size of semiconductor devices will be smaller and smaller because of the increasing demand for high integration of such devices. The resolution limit of an optical lithography system is described by Rayleigh's criterion. While it is hard to achieve a small critical dimension by reducing the illumination wavelength and the processing-dependent factors, the critical dimension can be reduced by increasing the refractive index of the material between the lens and the wafer. We have used an interferometric immersion lithography system. This system uses a Lloyd mirror for interference between the 1st and the -1st diffraction order and deionized water with a refractive index of 1.437 at 193 nm. The experimental result showed that immersion lithography, compared to conventional dry lithography, improved not only the resolution but also the depth of focus. The simulation result confirmed this behavior, showing a larger depth of focus for immersion compared to dry lithography. Also, the linewidth with immersion lithography was smaller than the linewidth with dry lithography.

Position Shift Analysis in Resist Reflow Process for Sub-50 nm Contact Hole

You, Jee-Hye,Park, Joonwoo,Park, Joon-Min,Jeong, Heejun,Hong, Joo-Yoo,Oh, Hye-Keun IOP Publishing 2009 Japanese journal of applied physics Vol.48 No.r9

한국인 다낭난소증후군 여성에서 Peroxisome Proliferator-activated Receptor-γ (PPARγ) 유전자다형성

오지영 ( Jee Young Oh ),이혜진 ( Hye Jin Lee ),홍영선 ( Young Sun Hong ),성연아 ( Yeon Ah Sung ),정혜원 ( Hye Won Chung ) 대한당뇨병학회 2007 Diabetes and Metabolism Journal Vol.31 No.6

Serum C-Reactive Protein Levels in Normal-Weight Polycystic Ovary Syndrome

( Ji Young Oh ),( Ji Ah Lee ),( Hye Jin Lee ),( Jee Young Oh ),( Yeon Ah Sung ),( Hye Won Chung ) 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.4

Background/Aims: Serum levels of highly sensitive C-reactive protein (hsCRP), a vascular inflammatory marker, may predict the development of cardiovascular disease (CVD) and type 2 diabetes. Women with polycystic ovary syndrome (PCOS) are at greater risk for type 2 diabetes and CVD. The aim of this study was to compare hsCRP levels between normal weight women with PCOS and controls with a normal menstrual cycle and to determine the factors associated with serum hsCRP levels. Methods: Thirty-nine lean PCOS patients and 24 healthy, regular cycling women were enrolled in this study. We performed anthropometric measurements, fat computed tomography (CT), and blood sampling to determine blood chemistry and levels of hsCRP, gonadotropins, testosterone, and sex-hormone binding globulin. We also conducted 75-g oral glucose-tolerance test and euglycemic hyperinsulinemic clamp to assess insulin sensitivity. Results: Serum hsCRP concentrations were higher in women with PCOS than in women with regular mensturation. However, this difference was no longer significant after adjusting for body mass index (BMI). hsCRP levels were correlated with waist circumference (r=0.46, p<0.01), BMI (r=0.46, p<0.01), visceral fat area (r=0.45, p<0.01), and systolic (r=0.42, p<0.05) and diastolic blood pressure (r=0.39, p<0.05). hsCRP also tended to be negatively associated with insulin-mediated glucose uptake (IMGU) (r=-0.31, p=0.07). A multiple regression analysis revealed that BMI (β=0.29, p<0.05), systolic blood pressure (β=0.39, p<0.01), and IMGU (β=-0.31, p<0.05) predicted serum hsCRP levels in women with PCOS. Conclusions: PCOS by itself does not seem to be associated with increased hsCRP levels, whereas known CVD risk factors affect serum hsCRP levels in PCOS. (Korean J Intern Med 2009;24:350-355)