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Priscilla Rose Prasath,Justine K. James,Ananya Ruth Samuel,Christine Suniti Bhat,Mutharasi Paramasivan 한국상담학회 2023 Journal of Asia Pacific counseling Vol.13 No.2
This study used a cross-sectional survey design to examine the moderating role of psychological capital (PsyCap) on the association between psychological distress (depression, anxiety, and stress) and well-being among 387 college students in India. PsyCap refers to an individual’s positive psychological state of development that is comprised of hope, efficacy, resilience, and optimism. There was a negative association between psychological distress and well-being, whereas a positive association was found between PsyCap and well-being. As hypothesized, PsyCap moderated the association between psychological distress and well-being. The PsyCap components of hope, efficacy, resilience, and optimism each acted as a moderator in the association between psychological distress and well-being. The practical implications of enhancing PsyCap to positively affect well-being and reduce psychological distress in college students are provided through the lens of positive psychology.
Tristan James Sim,Rose Mardie Pacia,고영수 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.9
N1 -(3-(trimethoxysilyl)propyl)-1,3-propanediamine (2NS-P), a diaminosilane having a propyl spacer between the two amino groups was successfully synthesized, and a CO2 adsorbent functionalized with 2NS-P was prepared via impregnation of it into silica. The adsorption performance and stability of 2NS-P/Kona95 were examined and compared to that of N1 -(3-(trimethoxysilyl)propyl)ethane-1,2-diamine (2NS)/Kona95 having an ethyl spacer. 2NS-P/Kona95 exhibited better CO2 adsorption capacity and CO2/N efficiency. The adsorbents were subjected to ten cycles of temperature swing adsorption (TSA), demonstrating that stability of 2NS-P/Kona95 was better than that of 2NS/Kona95. The spent 2NS-P/Kona95 showed the absence of cyclic urea formation in FT-IR spectrum, explaining the better stability of 2NS-P/Kona95 than 2NS/Kona95.
Hasson Denise C.,Mohan Shruthi,Rose James E.,Merrill Kyle A.,Goldstein Stuart L.,Benoit Stefanie W.,Varnell Charles D. 대한진단검사의학회 2024 Annals of Laboratory Medicine Vol.44 No.1
Background: Abnormal serum magnesium (Mg) concentrations are common and associated with worse mortality in kidney-transplant recipients. Many kidney and transplant-related factors affect Mg homeostasis. The concentration of the active form, ionized Mg (iMg), is not measured clinically, and total Mg (tMg) and iMg correlations have conflicted. We hypothesized that iMg and tMg concentrations show poor categorical agreement (i.e., low, normal, and high) in kidney-transplant recipients but that ionized calcium (iCa) correlates with iMg. Methods: We retrospectively evaluated hypomagnesemia in kidney-transplant recipients over a 2-yr period. We prospectively collected blood at 0–28 days post-transplant to measure correlations between iMg and iCa/tMg. iMg and iCa concentrations in the reference ranges of 0.44–0.65 and 1.0–1.3 mmol/L, respectively, were considered normal. Fisher’s exact test and unweighted kappa statistics revealed category agreements. Pearson’s correlation coefficients and linear regression measured correlations. Results: Among 58 retrospective kidney-transplant recipients, 54 (93%) had tMg<0.66 mmol/L, 28/58 (48%) received Mg supplementation, and 20/28 (71%) had tacrolimus dose adjustments during supplementation. In 13 prospective transplant recipients (N=43 samples), iMg and tMg showed strong category agreement (P=0.0003) and correlation (r=0.71, P<0.001), whereas iMg and iCa did not (P=0.7; r=–0.25, P=0.103, respectively). Conclusions: tMg and iMg exhibited strong correlation following kidney transplantation. However, iCa may not be an accurate surrogate for iMg. Determining the effect of Mg supplementation and the Mg concentration where supplementation is clinically necessary are important next steps.
( Jeong Heon Lee ),( Jie Zhang ),( Lourdes Flores ),( James C Rose ),( G Angela Massmann ),( Jorge P Figueroa ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
The aim of the present study was to ascertain, in vivo, the contribution of the endothelin system to the development of hypertension in the adult offspring and the signaling pathway involved. Pregnant sheep were treated with two doses of betamethasone (n = 23) or vehicle (n = 22) at 80 days (~0.55) gestation and allowed to deliver at term. Adult sheep were chronically instrumented under general anesthesia to place vascular catheters and a femoral artery flow probe. Blood pressure and flow were recorded continuously, and femoral artery vascular resistance was calculated before and during administration of endothelin 1 (ET-1). Selective blockers (dantrolene, BQ123, niacinamide) or saline were administered simultaneously. Betamethasone-exposed animals exhibited a significant elevation in mean blood pressure (female: 98 ± 1.8 vs. 92 ± 2.1; males: 97 ± 3.4 vs. 90 ± 2.3; mmHg; p<0.05). ET-1 elicited a significant increase in blood pressure (F = 56.4; p< 0.001) and in vascular resistance (F = 44.3; p< 0.001) in all groups. A betamethasone effect in the vascular resistance response to ET-1 (F = 25.7; p< 0.001) was present in females only, and the effect was partially blunted by niacinamide (F = 6.6; p< 0.01). Combined administration of niacinamide and BQ123, as well as of dantrolene abolished the betamethasone effect on vascular resistance. No significant differences in mRNA expression of ETA or ETB in endothelial or smooth muscle cells of resistance-size arteries were observed. We conclude that the betamethasone effect on vascular resistance is mediated by an enhanced response to ET-1 through ETA receptor via the cyclic ADPR/ryanodine pathway.
Heo, Jeong,Reid, Tony,Ruo, Leyo,Breitbach, Caroline J,Rose, Steven,Bloomston, Mark,Cho, Mong,Lim, Ho Yeong,Chung, Hyun Cheol,Kim, Chang Won,Burke, James,Lencioni, Riccardo,Hickman, Theresa,Moon, Anne Nature Publishing Group, a division of Macmillan P 2013 Nature medicine Vol.19 No.3
Oncolytic viruses and active immunotherapeutics have complementary mechanisms of action (MOA) that are both self amplifying in tumors, yet the impact of dose on subject outcome is unclear. JX-594 (Pexa-Vec) is an oncolytic and immunotherapeutic vaccinia virus. To determine the optimal JX-594 dose in subjects with advanced hepatocellular carcinoma (HCC), we conducted a randomized phase 2 dose-finding trial (n = 30). Radiologists infused low- or high-dose JX-594 into liver tumors (days 1, 15 and 29); infusions resulted in acute detectable intravascular JX-594 genomes. Objective intrahepatic Modified Response Evaluation Criteria in Solid Tumors (mRECIST) (15%) and Choi (62%) response rates and intrahepatic disease control (50%) were equivalent in injected and distant noninjected tumors at both doses. JX-594 replication and granulocyte-macrophage colony-stimulating factor (GM-CSF) expression preceded the induction of anticancer immunity. In contrast to tumor response rate and immune endpoints, subject survival duration was significantly related to dose (median survival of 14.1 months compared to 6.7 months on the high and low dose, respectively; hazard ratio 0.39; P = 0.020). JX-594 demonstrated oncolytic and immunotherapy MOA, tumor responses and dose-related survival in individuals with HCC.
Brian Kenneth E. Eduarte,Nicole Andrey Acosta,Jenela Pauline Lumanlan,Jhevia E. agnampo,Diana Rose Medrano,Kaori Ann B. Vicente,James Patrick C. Picar ASCONS 2019 IJBSA Vol.1 No.1
Background/Objectives: The fire related injuries such as burns are one of the main problems of the community. It is because of the insufficient ideas in wound healing and lack of financial capabilities resulting into self-medication. Methods/Statistical analysis: In this study, the researchers will prepare an ointment from milkfish skin and scale added to soft paraffin in 70 C until it congeals. The milkfish is known having high content of riboflavin and vitamin B complex that is a big impact to fasten the first-degree burn healing process. The milkfish skin and scales are also to be extracted using Gamma Irradiation as a manner of sterilization and for preservation of collagen and vitamin B content. The experimental rats will be induced of burn wounds by 5 seconds in the back part using cylindrical heat steel to be associated in 100C boiling water which will be treated with the prepared ointment. The epithelialization times, wound contraction and histological examination will be observed and the data recorded is to be analyzed using one-way ANOVA and repeated measures. Findings: This study deals with scientific experimentation to identify the potential of Milkfish skin and scale in wound healing. Improvements/Applications: If proven effective, it may be utilized as an alternative wound healing agent.
Hot Populations in M87 Globular Clusters
Sohn, Sangmo T.,O'Connell, Robert W.,Kundu, Arunav,Landsman, Wayne B.,Burstein, David,Bohlin, Ralph C.,Frogel, Jay A.,Rose, James A. American Institute of Physics 2006 The Astronomical journal Vol.131 No.2
<P>To explore the production of UV-bright stars in old, metal-rich populations like those in elliptical galaxies, we have obtained Hubble Space Telescope (HST) Space Telescope Imaging Spectrograph far- and near-UV photometry of globular clusters (GCs) in four fields in the giant elliptical (gE) galaxy M87. To a limit of m<SUB>FUV</SUB> ~ 25 we detect a total of 66 GCs in common with the deep HST optical-band study of Kundu et al. Despite strong overlap in V- and I-band properties, the M87 GCs have UV-optical properties that are distinct from clusters in the Milky Way and in M31. M87 clusters, especially metal-poor ones, produce larger hot horizontal-branch populations than do Milky Way analogs. In color plots including the near-UV band, the M87 clusters appear to represent an extension of the Milky Way sequence. Cluster mass is probably not a factor in these distinctions. The most metal-rich M87 GCs in our sample are near solar metallicity and overlap the local E galaxy sample in estimated Mg<SUB>2</SUB> line indices. Nonetheless, the clusters produce much more UV light at a given Mg<SUB>2</SUB>, being up to 1 mag bluer than any gE galaxy in (FUV - V) color. The M87 GCs do not appear to represent a transition between Milky Way-type clusters and E galaxies. The differences are in the correct sense if the clusters are significantly older than the E galaxies.</P><P>Comparisons with Galactic open clusters indicate that the hot stars lie on the extreme horizontal branch, rather than being blue stragglers, and that the extreme horizontal branch becomes well populated for ages ≳5 Gyr. Existing model grids for clusters do not match the observations well, due to poorly understood giant branch mass loss or perhaps high helium abundances. We find that 41 of our UV detections have no optical-band counterparts. Most appear to be UV-bright background galaxies seen through M87. Eleven near-UV variable sources detected at only one epoch in the central field are probably classical novae. Two recurrent variable sources have no obvious explanation but could be related to activity in the relativistic jet.</P>