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Hur, W.,Park, M.,Lee, J.Y.,Kim, M.H.,Lee, S.H.,Park, C.G.,Kim, S.N.,Min, H.S.,Min, H.J.,Chai, J.H.,Lee, S.J.,Kim, S.,Choi, T.H.,Choy, Y.B. Elsevier Science Publishers 2016 Journal of controlled release Vol.222 No.-
<P>We prepared a bone plate enabled with the local, sustained release of alendronate, which is a drug known to inhibit osteoclast-mediated bone resorption and also expedite the bone-remodeling activity of osteoblasts. For this, we coated a bone plate already in clinical use (PLT-1031, Inion, Finland) with a blend of alendronate and a biocompatible polymer, azidobenzoic acid-modified chitosan (i.e., Az-CH) photo-crosslinked by UV irradiation. As we performed the in vitro drug release study, the drug was released from the coating at an average rate of 4.03 mu g/day for 63 days in a sustained manner. To examine the effect on bone regeneration, the plate was fixed on an 8 mm cranial critical size defect in living rats and the newly formed bone volume was quantitatively evaluated by micro-computed tomography (micro-CT) at scheduled times over 8 weeks. At week 8, the group implanted with the plate enabled with sustained delivery of alendronate showed a significantly higher volume of newly formed bone (52.78 +/- 6.84%) than the groups implanted with the plates without drug (23.6 +/- 3.81%) (p < 0.05). The plate enabled with alendronate delivery also exhibited good biocompatibility on H&E staining, which was comparable to the Inion plate already in clinical use. Therefore, we suggest that a bone plate enabled with local, sustained delivery of alendronate can be a promising system with the combined functionality of bone fixation and its expedited repair. (C) 2015 Elsevier B.V. All rights reserved.</P>
Lee, D-H,Kwon, J-S,Lee, H-J,Lee, Y-N,Hur, W,Hong, Y-H,Lee, J-B,Park, S-Y,Choi, I-S,Song, C-S Poultry Science Association, etc 2011 Poultry science Vol.90 No.5
<P>The frequent economic losses incurred with H9N2 low pathogenic avian influenza viruses (LPAI) infection have raised serious concerns for the poultry industry. A 1-dose regimen with inactivated H9N2 LPAI vaccine could not prevent vaccinated poultry from becoming infected and from shedding wild viruses. A study was conducted to determine whether a 2-dose regimen of inactivated H9N2 LPAI vaccine could enhance the immunologic response in chickens. Such gel-primed and mineral oil-boosted regimen has produced encouraging results associated with improved immune responses to an H9N2 LPAI. This strategy could be cost effective and helpful for preventing avian influenza virus in the poultry industry.</P>
ASXL2 promotes proliferation of breast cancer cells by linking ERα to histone methylation
Park, U-H,Kang, M-R,Kim, E-J,Kwon, Y-S,Hur, W,Yoon, S K,Song, B-J,Park, J H,Hwang, J-T,Jeong, J-C,Um, S-J Macmillan Publishers Limited 2016 Oncogene Vol.35 No.28
<P>Estrogen receptor alpha (ER alpha) has a pivotal role in breast carcinogenesis by associating with various cellular factors. Selective expression of additional sex comb-like 2 (ASXL2) in ER alpha-positive breast cancer cells prompted us to investigate its role in chromatin modification required for ERa activation and breast carcinogenesis. Here, we observed that ASXL2 interacts with ligand E2-bound ERa and mediates ERa activation. Chromatin immunoprecipitation-sequencing analysis supports a positive role of ASXL2 at ERa target gene promoters. ASXL2 forms a complex with histone methylation modifiers including LSD1, UTX and MLL2, which all are recruited to the E2-responsive genes via ASXL2 and regulate methylations at histone H3 lysine 4, 9 and 27. The preferential binding of the PHD finger of ASXL2 to the dimethylated H3 lysine 4 may account for its requirement for ERa activation. On ASXL2 depletion, the proliferative potential of MCF7 cells and tumor size of xenograft mice decreased. Together with our finding on the higher ASXL2 expression in ERa-positive patients, we propose that ASXL2 could be a novel prognostic marker in breast cancer.</P>
Hur, M.,Lee, J.Y.,Kang, W.S.,Lee, J.O.,Song, Y.-H.,Kim, S.J.,Kim, I.D. Elsevier 2016 THIN SOLID FILMS - Vol.619 No.-
<P><B>Abstract</B></P> <P>The effect of working gas on the properties of Al<SUB>2</SUB>O<SUB>3</SUB> films and SiO<SUB>x</SUB> interlayers was investigated in direct-type plasma-enhanced atomic layer deposition. The density of the Al<SUB>2</SUB>O<SUB>3</SUB> film was higher for Ar/O<SUB>2</SUB> plasma than for He/O<SUB>2</SUB> plasma, whereas the thicknesses of the Al<SUB>2</SUB>O<SUB>3</SUB> film and SiO<SUB>x</SUB> interlayer were greater for He/O<SUB>2</SUB> plasma than for Ar/O<SUB>2</SUB> plasma. For understanding these phenomena, the amounts of C– and H-containing impurities in the deposited Al<SUB>2</SUB>O<SUB>3</SUB> film were evaluated by using X-ray photoelectron spectroscopy (XPS). Further, differences between the plasma properties in He/O<SUB>2</SUB> and Ar/O<SUB>2</SUB> were analyzed using optical emission spectroscopy (OES); the consumption rate of O radicals and the production rate of H radicals were estimated from the time-resolved emission intensities for the O I and H<SUB>α</SUB> lines, respectively. The mechanisms underlying the working gas effect on the density of the Al<SUB>2</SUB>O<SUB>3</SUB> film, as well as the thicknesses of the Al<SUB>2</SUB>O<SUB>3</SUB> film and SiO<SUB>x</SUB> interlayer have also been discussed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The effect of working gas is investigated in direct-type plasma ALD. </LI> <LI> Ar/O<SUB>2</SUB> plasma yields a higher density and a smaller thickness of Al<SUB>2</SUB>O<SUB>3</SUB> films. </LI> <LI> SiO<SUB>x</SUB> interlayer thickness is larger for He/O<SUB>2</SUB> plasma. </LI> <LI> Mechanisms for these phenomena are discussed by analyzing the XPS and OES results. </LI> </UL> </P>
Fuzzy H-continuous Mappings and Fuzzy Strongly Closed Graphs
Hur, K.,Ahn, Y.S.,Ryou, J.H. Korean Institute of Intelligent Systems 2002 한국지능시스템학회논문지 Vol.12 No.6
We introduce the concepts of fuzzy H-continuity and fuzzy strongly closed graph, respectively and investigate some of their properties.
H∞최적 제어기법을 이용한 전력계통의 안정화에 관한 연구
정형환,이정필,허동렬,왕용필 東亞大學校 海洋資源硏究所 1998 硏究論文集 Vol.11 No.1
In this paper, we are considered various possible disturbance conditions in order to design controller, H ∞ optimal controller is successfully designed to control in such as situations. To do this, we are determined weighting function and design parameter γ to method of trial and error by Glover-Doyle algorithm. To compare with H∞-PSS and conventional-PSS which is applied in nominal system and load variations, the dynamic characteristics of H∞-PSS controller was verified which has a good response.