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한국인 쯔쯔가무시병 환자에서 사이토카인 유전자의 다양성 조사
장우임,김수연,위성헌,김태규 대한감염학회 2010 감염과 화학요법 Vol.42 No.1
Background: Scrub typhus is caused by Orientia tsutsugamushi and can become severe and potentially life-threatening. It is suggested that specific host factors can modify the host response during O. tsutsugamushi infection. It is known that susceptibility and outcome of infectious disease are associated with genetic polymorphisms of some cytokines. Materials and Methods: Peripheral blood of 144 patients who were diagnosed with scrub typhus and of 311 unrelated healthy subjects were collected. A diagnosis of scrub typhus was made upon demonstration of a fourfold rise in antibody titer to O. tsutsugamushi in paired serum specimens in an indirect immunofluorescent (IFA) test. Genomic DNAs were extracted from peripheral mononuclear cells and genotypings for IL-1 (-511C/T), IL-1β (+3953T/C), IL-2 (-330T/G), IL-4 (-590C/T), IL-4R(-1902G/A), IL-10 (-1082G/A), IL-10 (-819C/T), TNF-α (-238G/A) and TNF-α (-308G/A) were performed simultaneously using PCR-SSP (sequence specific polymorphisms) assay. Results: The frequency of IL-1 (-511T/T) (OR=0.53, P<0.01) and IL-2 (-330T/T) (OR=0.56, P<0.01) were significantly decreased, but that of IL-2(-330G/G) (OR=4.49, P<0.01) was increased, in the scrub typhus patients compared to the healthy controls. And, there were no statistically significant differences in the genetic polymorphisms of IL-4 (-590C/T), IL-4Rα (-1902G/A), IL-10 (-1082G/A), IL-10 (-819C/T), TNF-α (-238G/A), TNF-α (-308G/A) genes, in the scrub typhus patients compared to the unrelated healthy controls. Conclusions: Cytokine polymorphisms in the IL-1 (-511T/T) and the IL-2 genes may influence the host response to O. tsutsugamushi.
최영호,서홍주,임영혁,김정중,박성강,이석기,임진수,김은규 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2
Pulmonary blastoma is a very rare primary neoplasm of the lung. We experienced a case of pulmonary blastoma in a 40 years old man. The mediobasal segmentectomy of the right lower lobe was performed. The patient was discharge on the postoperative days 6. There is no evidence of recurrence or metastasis on followup study during 7 months period after operation.
농촌인구에서의 대사증후군의 특징과 비만 관련 인자와의 연관성
임수 ( Im Su ),권경훈 ( Kwon Gyeong Hun ),김은주 ( Kim Eun Ju ),임덕상 ( Im Deog Sang ),임효진 ( Im Hyo Jin ),조성일 ( Jo Seong Il ),이윤용 ( Lee Yun Yong ),박경수 ( Park Gyeong Su ),이홍규 ( Lee Hong Gyu ) 한국지질동맥경화학회(구 한국지질학회) 2002 韓國脂質學會誌 Vol.12 No.4
Objective: Metabolic syndrome is a loosely defined state characterized by insulin resistance, which includes phenotypes of glucose intolerance, abdominal obesity, dyslipidemia and hypertension. However, there is no internationally agreed definition for th
폐암 및 결핵성 흉막염에서 Vascular Endothelial Growth Factor의 임상적 의의
임병국 ( Im Byeong Gug ),오윤정 ( O Yun Jeong ),신승수 ( Sin Seung Su ),이규성 ( Lee Gyu Seong ),박광주 ( Park Gwang Ju ),황성철 ( Hwang Seong Cheol ),이이형 ( Lee I Hyeong ),최진혁 ( Choe Jin Hyeog ),임호영 ( Im Ho Yeong ) 대한결핵 및 호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.50 No.2
자발적 복강내 출혈로 사망한 P-ANCA 양성 소혈관염
임성호 ( Im Seong Ho ),이규백 ( Lee Gyu Baeg ),박범준 ( Park Beom Jun ),김현승 ( Kim Hyeon Seung ),박은미 ( Park Eun Mi ),김지연 ( Kim Ji Yeon ),김향 ( Kim Hyang ),임시영 ( Im Si Yeong ),정은철 ( Jeong Eun Cheol ),이영래 ( Lee Ye 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.6
P-ANCA small vessel vasculitis is multisystemic disease, especially frequently involving the kidney. Diagnosis is delayed because it`s non-specific clinical manifestation. Recently ANCA becomes available tools for diagnosis of vasculitis. Infection and gastrointestinal complications are relatively common in vasculitis. But spontaneous rupture of gastrointestinal artery is a rare complication. A 61-year-old housewife was admitted due to poor oral intake, weight loss and microscopic hematuria. Renal biopsy showed an extensive necrotizing glomerulonephritis, consistent with Wegener`s granulomatosis or microscopic polyangitis. Serum test showed positive for P-ANCA. Despite steroid therapy, she expired due to spontaneous rupture of right gastroepiploic artery.
조갑진균증의 임상 양상 및 원인균 동정 (1999-2002)
임성욱 ( Im Seong Ug ),서무규 ( Seo Mu Gyu ),하경임 ( Ha Gyeong Im ) 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.1
N/A Background: Although there have been many studies about tinea unguium, few studies about etiologic agents including nondermatophytic molds and yeasts in onychomycosis have been reported in Korea. Objective: The purpose of the study was to investigate the recent clinical features and identification of etiologic agents in onychomycosis. Methods: In the 3-year period 1999-2002, we reviewed five hundred ninty nine patients with onychomycosis in retrospectively. The etiologic agents were identified by cultures on Sabouraud`s dextrose agar with and without cycloheximide. The identification of yeasts based on the results of culture, germ tube test, and biochemical API system tests. Nondermatophytic molds or yeasts isolated were considered as pathogens when the presence of fungal elements was identified at direct microscopy and follow-up specimen yielding cultures showed the same fungi. Results: Of the five hundred ninty nine patients presenting with onychomycosis, 92.5% were toenail onychomycosis, 5.5% fingernail onychomycosis, and 2.0% onychomycosis in both toenails and fingernails. Among the age groups, the incidence rate was highest in the fifth decade(22.0%). The ratio of male to female patients was 1.1:1. Distal subungual onychomycosis(96.1%) was the most common clinical type of onychomycosis. In the toenail onychomycosis, dermatophytes were most frequently isolated(81.9%), followed by yeasts(11.7%), and nondermatophytic molds(6.4%). Tricho-phyton rubrum was the most frequently isolated agent. In the fingemail onychomycosis, yeasts were mostly isolated(48.2%), followed by dermatophytes(44.4%), and nondermatophytic molds(7.4%). Conclusion: Because of the increase in onychomycosis by nondermatophytic molds and yeasts, we suggest the need of a careful mycological examination in patients with onychomycosis. (Korean J Dermatol 2004;42(1):53~60)