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박인식,안상현,정재만,강윤호,이해풍,서귀문,홍용기,김호현,김진택 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.7 No.2
본 연구는 긴볼레기말 추출물의 항고지혈증 효과를 조사하기 위해 ICR 생쥐에 TritonWR-1339(TX) 복강주사로 인위적인 고지혈증을 유발시킨 후 긴볼레기말 추출물(30㎎/㎏)를 복강주사하여 시간의 경과에 따른 간세포내에서의 지방 축적 변화를 조직화학적으로 관찰하였다. TX 주사후 그물구조의 세포질출 가진 간세포가 간엽 전체에서 관찰되었고, 일부 간소엽에서는 간세포 손상으로 인한 간세포판 소실이 나타났다. 또한 간세포내 지방축척도 증가하여 전체 간소엽의 간세포에서 지방의 과출현을 확인 할 수 있었고, 지방의 크기도 대조군에 비해 증가된 것으로 관찰되었다. 그러나 긴볼레기말 추출물 주사군에서는 그물구조의 세포질을 가진 간세포의 수가 TX 주사군에 비해 감소되었고, 대부분의 간소엽에서 정상적인 간세포판의 배열을 확인할 수 있었다. 간세포내의 지방 축적과 크기도 감소된 경향으로 관찰되었다. 이상의 결과로 볼 때 해조류 긴볼레기말 추출물은 고지혈증이 유발된 생쥐 간세포 내에서의 과도한 지방축적을 감소시키는 항고지혈증 효과를 하는 것으로 사료된다. Hepatic tissues of ICR mouse were intraperitoneally injeced with Colpomenia bullosa(CB) Extract after Triton WR-1339(TX) injection were observed to investigate the antihyperlipermic effect of CB extract for hyperlipidemic hepatic tissue caused by destruction of lipid metabolism. The hepatic tissues were obtained at hour-24, 48, and 72 after TX injection with CB extract treatment. And then these specimen were fixed in 10% neutral buffer solution and were cryocut. The tissue stained by H&E for general morphology and sudan black B for lipid distribution. The increase of hepatocyte having rneshlike cytoplasm were shown in all hepatic lobules after TX injection and the hepatic plates were disappeared in the region of meshlike hepatocyte aggregation, But the hepatocyte having meshlike cytoplasm were disappeared and hapatic plate were rearranged in CB extract injected mouse. The number of blue black colored lipid drop in hepatic cytoplasm of mouse injected with TX were increased and the size of lipid drop were enlarged. But the number of lipid drop in hepatic cytoplasm of mouse treated CB extract were decreased and the size of lipid drop were diminished. As results indicated that the accumulation of lipid drop caused by TX injection were mitigated by the antihyperlipidermic effect of CB extract.
Moon, Chang-Kiu,Chung, Jin-Ho,Choi, Seong-Soo,Lee, Soo-Hwan,Hwang, Gwi-Seo,Park, Kwang-Sik,Mock, Myung-Soo,Kim, Seong-Gon,Kim, Ji-Young The Pharmaceutical Society of Korea 1988 Archives of Pharmacal Research Vol.11 No.2
Effects of brazilin on the blood viscosity and erythrocyte deformability were investigated in alloxan induced diabetic rats. By the treatment to alloxan induced diabetic rats, enhancement of erythrocyte deformability was observed. In the in vitro study on the erythrocyte deformability, brazilin showed statistically significant improving effects on the erythrocyte deformability. At the concentrations of $10^3$ M of brazilin, erythrocyte deformability was compared with those of hematoxylin, pentoxifyline and prednisolone.
Effect of Hematoxylin on Glucose Metabolism in Soleus Muscle of Streptozotocin-Induced Diabetic Rats
Moon, Chang-Kju,Chung, Yi-Sook,Hwang, Gwi-Seo The Korean Society of Food Hygiene and Safety 1992 한국식품위생안전성학회지 Vol.7 No.1
천연 색소성분의 하나인 hematoxylin은 Streptozotocin으로 유도한 당뇨병쥐에서 혈당강하 효과를 나타내는 것으로 관찰되었으며, 이때 혈중 insulin치에는 영향을 미치지 않았다. 혈당강하기전 연구의 일환으로 당뇨병쥐의 soleuo muscle에서의 포도당 대사에 미치는 영향을 검토한 결과 in vivo 및 in vitro 실험 모두에서 대사능이 증가되었고 이는 포도당대사 과정에서의 insulin 작용의 강화와 glycgen 합성의 증가에 기인하는 것으로 추정된다. Hypoglycemic effect of hematoxylin was observed in streptozotocin-induced diabetic rats, of which plasma insulin levels were not affected. Investigation of hypoglycemic mechanism showed that hematoxylin stimulated glucose oxidation and glycogen synthesis in soleus muscle from diabetic rats in both basal and insulin stimulated state.
Moon, Chang-Kiu,Lee, Soo-Hwan,Park, Kwang-Sik,Hwang, Gwi-Seo,Mock, Myung-Soo,Chung, Dong-Seok,Kim, Dae-Dok,Min, Seok-Ki The Pharmaceutical Society of Korea 1987 Archives of Pharmacal Research Vol.10 No.4
The effects of butylated hydroxyanisole and butylated hydroxytoluene on the immune status in normal male were evaluated. They exhibited significant decrease in the circulating leukocyte counts. Relative spleen and thymus weights were slightly decreased, but not stratistically significant. These were, however, significant liver hypertrophies in theier exposed mice. Splenic IgM PFCs per one million cells in 1/20 LD50 BHA and BHT exposed mice were significantly reduced IgM PFCs per spleen were similar tothose of control, except in 1/20 LD50 BHA exposed mice, where they were significantly suppressed. The precise nature of the inhibition is not clear. Direct cytotoxicity is not responsible for the depressed antibody response, even following relatively high doses of them, because the changes in spleen cellularity are not significant. Both substances, however, did not show any effects on the arthus reaction and delayed hypersensitivity reaction induced by heat aggreagted bovine serum albumin, and in vivo phagocytosis of colloidal carbon. In the light of the present results, in vivo antibody response as well as in vitro, may be sensitive to BHA of the present results, in vivo antibody response as well as in vitro, amy be sensitie to BHA and BHT. Further elucidation of the precise nature of antibody suppression in their exposed mice, is warranted.
Moon, Chang-Kiu,Chung, Jin-Ho,Lee, You-Mie,Lee, Soo-Hwan,Hwang, Gwi-Seo,Park, Kwang-Sik,Mock, Myung-Soo,Kim, Seong-Gon,Ahn, Young-Soo,Ann, Jeong-Hee The Pharmaceutical Society of Korea 1988 Archives of Pharmacal Research Vol.11 No.2
Impaired erythrocyte deformability was considered to paly an important role in microcirculatory disturbances. We recently confirmed that the brazilin, the main active principle of Caesalpinia sappan, enhanced activity of erythrocyte deformability and reduced blood viscosity. In this study, we examined the effects of brazilin on three biochemical parameters (ATP, 2, 3-diphosphoglycerate, and calcium) which influenced erythrocyte deformability. Treatment with barzilin increased erythrocyte deformability and ATP concentrations in streptozotocin-induced diabetic rats. Concentrations of 2, 3-diphosphoglycerate and calcium in diabetic rats following brazilin administration were decreased significantly compared to those of diabetic control rats. The results suggest that brazilin have a potential effect to improve rheological abnormalities in diabetes.
Hwang, Gwi-Seo,Kim, Ji-Young,Chang, Tong-Shin,Jeon, Sun-Duck,So, Dhong-Su,Moon, Chang-Kiu The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.6
Brazilin [7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol] inhibited thrombin-, collagen- and ADP-induced aggregation of washed rat platelets. T hrombin- and collagen-induced ATP release were also inhibited by brazilin in a concentration-dependent manner. Brazilin inhibited the formation of platelet thromboxane $A_2$ caused by thrombin, whereas it had no effect on the prostaglandin $D_2$ formation. Brazilin inhibited $^3H$-arachidonic acid liberation from membrane phospholipids of thrombin-stimulated platelets. Brazilin inhibited the rise of intracellular free calcium caused by thrombin. These results indicate that the inhibition of phospholipase ($PLA_2$) activity and [$[Ca^{2+}]_1$ elevation might be at least a part of antiplatelet mechanism of brazilin.