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Therapeutic mechanisms and beneficial effects of non-antidiabetic drugs in chronic liver diseases
Han Ah Lee,Young Chang,Pil Soo Sung,Eileen L. Yoon,Hye Won Lee,Jeong-Ju Yoo,Young-Sun Lee,Jihyun An,Do Seon Song,Young Youn Cho,Seung Up Kim,Yoon Jun Kim 대한간학회 2022 Clinical and Molecular Hepatology(대한간학회지) Vol.28 No.3
The global burden of chronic liver disease (CLD) is substantial. Due to the limited indication of and accessibility to antiviral therapy in viral hepatitis and lack of effective pharmacological treatment in nonalcoholic fatty liver disease, the beneficial effects of antidiabetics and non–antidiabetics in clinical practice have been continuously investigated in patients with CLD. In this narrative review, we focused on non-antidiabetic drugs, including ursodeoxycholic acid, silymarin, dimethyl- 4,4’-dimethoxy-5,6,5’,6’-dimethylenedixoybiphenyl-2,2’-dicarboxylate, L-ornithine L-aspartate, branched chain amino acids, statin, probiotics, vitamin E, and aspirin, and summarized their beneficial effects in CLD. Based on the antioxidant, anti-inflammatory properties, and regulatory functions in glucose or lipid metabolism, several non–antidiabetic drugs have shown beneficial effects in improving liver histology, aminotransferase level, and metabolic parameters and reducing risks of hepatocellular carcinoma and mortality, without significant safety concerns, in patients with CLD. Although the effect as the centerpiece management in patients with CLD is not robust, the use of these non-antidiabetic drugs might be potentially beneficial as an adjuvant or combined treatment strategy.
Gülşah Uslu,Uğur İnan 대한치과보존학회 2019 Restorative Dentistry & Endodontics Vol.44 No.2
Objectives: The aim of this study was to investigate the effect of glide path preparation with PathFile and ProGlider nickel-titanium (NiTi) files on the cyclic fatigue resistance of WaveOne NiTi files. Materials and Methods: Forty-four WaveOne Primary files were used and divided into four groups (n = 11). In the first group (0 WaveOne), the WaveOne Primary files served as a control group and were not used on acrylic blocks. In the 1 WaveOne Group, acrylic blocks were prepared using only WaveOne Primary files, and in the PF+WaveOne group and PG+WaveOne groups, acrylic blocks were first prepared with PathFile or ProGlider NiTi files, respectively, followed by the use of WaveOne Primary files. All the WaveOne Primary files were then subjected to cyclic fatigue testing. The number of cycles to failure was calculated and the data were statistically analyzed using one-way analysis of variance (ANOVA) and the Tukey honest significant difference multiple-comparison test at a 5% significance level. Results: The highest number of cycles to failure was found in the control group, and the lowest numbers were found in the 1 WaveOne group and the PF+WaveOne group. Significant differences were found among the 1 WaveOne, PF+WaveOne, and control groups (p < 0.05). No statistically significant differences were found between the PG+WaveOne group and the other three groups (p > 0.05). Conclusion: Glide path preparation with NiTi rotary files did not affect the cyclic fatigue resistance of WaveOne Primary files used on acrylic blocks.
Association between Parkinson’s Disease and Helicobacter Pylori
Gülşah C¸amcıa,Sıdıka Oğuzb 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.2
Helicobacter pylori (HP) is a common infection of the gastrointestinal system that is usually related to peptic ulcers. However, recent studies have revealed relationships between HP and many other diseases. Although the exact mechanism is unknown, HP can prevent the absorption of certain drugs. A high prevalence of HP has been found in patients with Parkinson’s disease, and this bacterium causes motor fluctuations by affecting the absorption of levodopa, which is the main drug used to treat Parkinson’s disease. Eradicating HP from patients with Parkinson’s disease by applying antibiotic treatment will increase the absorption of levodopa and decrease their motor fluctuations.
Thermal Characteristics, Mechanical and Comfort Properties of Heat-Protective Textiles
Gülşah Pamuk,Berna Cüreklibatır Encan,Esra Zeynep Yıldız 한국섬유공학회 2023 Fibers and polymers Vol.24 No.12
Specially developed protective textiles are the greatest armor for people who are exposed to high heat or struggle against flames in their working environment. When the protective clothing worn is constantly exposed to these conditions, changes in their performance can be observed over time. Therefore, in this article, the effects of wetting on breaking, tearing, and seam strength are comparatively examined. A total of five fabrics used in the study were chosen from among the inherently heat-protective blends that are widely used commercially. Extensive research was conducted by combining different techniques such as differential scanning calorimeter and thermogravimetric analysis to characterize their thermal behavior. People working in high temperatures or firefighting often exhibit intense physical activity while performing their jobs, and the comfort of the protective clothing worn becomes even more important due to the adverse conditions of the environment they are in. For this reason, as a part of the study, parameters affecting thermo-physiological comfort such as air permeability, water vapor permeability, and thermal resistance were discussed for heat-protective fabrics selected within the scope of the work. Also, these comfort parameters are examined in terms of variables such as fabric weight, fabric structure, and fiber blend ratio. Based on the results of the study, it appears that the fabrics used are suitable for workwear at temperatures up to about 300 degrees. It is recommended that woven fabrics be chosen when strength is the primary concern, while knitted fabrics are ideal when comfort is the priority.
몽골 바양노르 벽화묘와 복고을돌묘 출토 용과 비잔틴 금화 연구
박아림 ( Park Ah-rim ),L.에르덴볼드 ( Erdenebold L. ),낸시S.스타인하트 ( Steinhardt Nancy S. ) 중앙아시아학회 2017 中央아시아硏究 Vol.22 No.1
This paper examined the tomb figurines and Byzantine golden coins discovered from the Bayannuur tomb and Pugu Yitu Tomb located in Mongolia. The scientific analysis on the tomb figurines and the lime plasters of the murals shows the Bayannuur Tomb can be dated to 670±70 or 680±100CE. The Byzantine coins cannot be the definite evidence to decide the date of the tomb, but similar Byzantine golden coin imitations discovered from other regions can help us determine the cultural exchanges among those regions where the same kind of Byzantine coins. Tomb figurines from the two tombs resemble to those figurines found in the early Tang tombs located in the Xi`an, Shaanxi which might tell us strong evidence of Tang Chinese influence on the region. However, in terms of materials, techniques, and pigments, there are certainly different features from those in the Central Plain region. Especially, they are more similar to those from the Astana tomb complex in Turfan, Xinjiang which appear to have a close relation with sculptures and murals in Central Asia. Thus, the tomb figurines from the Bayannuur Tomb and Pugu Yitu Tomb should be considered not only in the context of Tang Chinese tombs but also with sculptures and paintings of Central Asia About 40 gold coins from the Bayannuur Tomb are quite different from examples found in China in the number, techniques, and burial practice. Those tombs where Byzantine coins were buried also yielded many interesting burial objects related to Central Asia. It might tell us about the background of the tomb occupant, and the regional transmission process of such Central Asian objects, and the possible location of such workshop. Therefore, the burial objects and the burial practice shown in those tombs can shed a light on the understanding of the cultural background of a tomb occupant of the Bayannuur Tomb as well of the cultural interaction along the Steppe route.
Palanikumar, L.,Choi, Eun Seong,Oh, Jun Yong,Park, Soo Ah,Choi, Huyeon,Kim, Kibeom,Kim, Chaekyu,Ryu, Ja-Hyoung American Chemical Society 2018 Biomacromolecules Vol.19 No.7
<P>Current drug delivery systems are hampered by poor delivery to tumors, in part reflecting poor encapsulation stability of nanocarriers. Although nanocarriers such as polymeric micelles have high colloidal stability and do not aggregate or precipitate in bulk solution, nanocarriers with low encapsulation stability can lose their cargo during circulation in blood due to interactions with blood cells, cellular membranes, serum proteins, and other biomacromolecules. The resulting premature drug release from carriers limits the therapeutic efficacy at target sites. Herein, we report a simple and robust technique to improve encapsulation stability of drug delivery systems. Specifically, we show that installation of disulfide cross-linked noncovalent polymer gatekeepers onto mesoporous silica nanoparticles with a high loading capacity for hydrophobic drugs enhances <I>in vivo</I> therapeutic efficacy by preventing premature release of cargo. Subsequent release of drug cargos was triggered by cleavage of disulfide cross-linking by glutathione, leading to improved antitumor activity of doxoroubicin in mice. These findings provide novel insights into the development of nanocarriers with high encapsulation stability and improved <I>in vivo</I> therapeutic efficacy.</P> [FIG OMISSION]</BR>
Kim, Ah-Na,Kim, Hyun-Jin,Chun, Jiyeon,Heo, Ho Jin,Kerr, William L.,Choi, Sung-Gil Elsevier 2018 FOOD SCIENCE AND TECHNOLOGY -ZURICH- Vol.89 No.-
<P>The effect of storage temperature on the degradation of total phenolic content (TPC) and antioxidant activity in hardy kiwifruit (Actinidia arguta) puree was investigated at temperatures of 5, 15, 25, and 45 degrees C for 72 h. An increase in the storage temperature resulted in a decrease in the TPC and antioxidant activity of hardy kiwi puree over time. The degradation of total phenolic content and antioxidant activity followed a first-order kinetic model and the kinetic parameters such as k, t(1/2), Q(10), and Ea were calculated. The k and t(1/2) values decreased with increasing storage temperature and the Q(10) values for TPC and antioxidant activity were 1.43 and 1.43, respectively. These results indicated strong dependence on temperature of phenolic content and antioxidant activity in hardy kiwi puree. The Ea for the degradation of TPC and antioxidant activity in hardy kiwi puree were 28.15 and 29.07 kJ/mol, respectively. Major phenolic compounds in hardy kiwi identified by UPLC-Q-TOF MS were epicatechin, procyanidin B type, procyanidin timers, catechin, chlorogenic acid, and isoquercetin. These compounds were degraded with increase in storage temperature and time. This result is consistent with kinetic studies on phenolic content and antioxidant activity.</P>