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소적건비환과립(消積健脾丸顆粒)이 흰쥐의 위운동성(胃運動性)에 미치는 영향
홍종희,김진성,류봉하,윤상협,Hong, Jong-Hee,Kim, Jin-Sung,Ryu, Bong-Ha,Yoon, Sang-Hyub 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.1
Background & Objective : The herbal medicine Sojukgunbihwan granule has been used for the treatment of functional dyspepsia, generally categorized as a gastric dysmotility disease. However, its mechanisms are not yet well known. Therefore, the effects of Sojukgunbihwan granules on gastric motility in rats was investigated. Methods : The myoelectrical activity of the gastric smooth muscle was recorded by a bipolar electrode placed at the gastric antrum of rats. The contractile waves were measured for 30 minutes before and after intragastric administration of each solution(normal saline, Pyungwisan 40mg/kg, Sojukgunbihwan granules 60mg/kg) and expressed as the motility index. Gastric emptying was measured by the number of glass beads expelled from the stomach(containing one hundred 1mm glass beads) within an hour after glass beads and test drugs(normal saline, Pyungwisan 40mg/kg, Pyungwisan 120mg/kg, Sojukgunbihwan granules 60mg/kg, Sojukgunbihwan granules 180mg/kg) were administered. In another series of experiments to evaluate the mechanisms of Sojukgunbihwan granules under delayed conditions, the rats were treated with atropine sulfate(1 mg/kg, s.c.), cisplatin(10mg/kg, i.p.), and NAME($N^G$-nitro-L-arginine methyl ester, 75mg/kg, s.c.) respectively. Results : Intragastric administration of Sojukgunbihwan granules increased the myoelectrical activity significantly, gastric motility index rose 25%, and gastric emptying of glass beads was significantly enhanced over a period of 60minutes. Under the delayed gastric emptying induced by atropine sulfate, cisplatin, and NAME, Sojukgunbihwan granules aggravated gastric emptying in the atropine sulfate($5.71{\pm}3.45\;vs\;3.71{\pm}4.42$) and cisplatin($13.86{\pm}3.53\;vs\;5.14{\pm}5.05$, p<0.01) treated groups, but enhanced gastric emptying in the NAME treated group($5.00{\pm}3.21\;vs\;11.71{\pm}5.65$, p<0.05). Conclusions : Results suggest that Sojukgunbihwan granules stimulate gastric motility through cholinergic and 5-hydroxytryptamine 3 receptors. Results are indicative of Sojukgunbihwan as an especially effective remedy in dysmotility-like functional dyspepsia with impaired reservoir functions such as gastric adaptive relaxation.
한방 치료로 호전을 보인 흉선종을 동반한 중증 근무력증 환자 1례
홍종희,박재우,김진석,전우현,조남희,오수완,김진성,류봉하,류기원 대한한방성인병학회 2000 韓方成人病學會誌 Vol.6 No.1
Myasthenia Gravis is an autoimmune disorder characterized by fluctuating muscle weakness and fatigue of different muscle groups. Diagnostic tests include use of anticholinesterase agents(Tensilon test), curare test, repetitive nerve stimulation, acetylcholine-receptor antibody assay and single fiber electromyography. Medical therapy includes use of anticholinesterase agents, immunotherapy, plasmapheresis and thymectomy. We report a case of Myasthenia Gravis diagnosed by acetylcholine-receptor antibody assay, EMG and thymoma on the chest-CT. The major clinical symptoms were low back pain, waddling gait, weight loss and fatigue. This patient was diagnosed as Wea Jeung(위증) and treated by Herbal-medication based on the differentiation of syndromes. As we treated, some of his symptoms were improved.
消癌去痰益氣湯의 cyclophosphamide 부작용 형성 억제효과
홍종희,류기원,류봉하,윤상협,김진성 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-
Object : It is well known that modern chemotherapy against cancer has side effcts to a living body, especially hemopoietic and immunologial disfunctions. However, there are no effctive ways to reduce them.Recently, traditonal Korean herb medicine has been repoted to have some biological modifying responses. Therefore, we hypothesized that additional application of herb medicine during chemotherapy is more effective to reduce its side effects. While we were studying the effects, we have observed the inhibitory effect of Soamgudamikgitang on formation of side effects derived from Cyclophosphamide, it has been used in clinical practice at Kyung Hee Medicd Center.Methods : We injected 200㎎/㎏ of Cyclophosphamide, one time, to an experimental group, consisting of ten mice. We divided them into eight groups: normal, CPX, SAKT 2㎎, SAKT 10㎎, SAKT 50㎎, SAKI 2㎎+CPX, SAKT 10㎎+CPX, SAKT 50㎎+CPX. We injeted Soamgudamikgitang seven days, five days, three days, and one day before we injected CPX. One day, three days, and five days after CPX injection, we injected Soamgudamikgitang again and then killed all the mice.The parameters determined in this experiment were daily body weight liver and spleen weight, RBC, WBC, and platelet for hemopoietic dysfunction and AST, ALT for hepatotoxicity, BUN, creatine for renal toxcity, Iymphocyte proliferation activity and lymphocyte subsets for immunological toxvity.Results : We have found that Soamgdamikgitang has inhibitory effects on the formation of Cyclophosphamide 's side effects. Significant differences between the group, which contained Cyclophosphamide, and the other group, which contains Cyclophosphamide and 2, 10, 50㎎ of Soamgudamikgitang respectively were observed. Platelets(2㎎ of Soamgudamikgitang, p<O.05 ;10㎎, p<0.Ol ;50㎎, p<0.001), liver weight(SOw p.001), spieen weight(10mg, p<0.05), AST(all groups, p<0.01), ALT(2㎎, p<001 ;10㎎, p<O.05 ;50㎎, p<0.01), BUN(2㎎, p<0.01 ;50㎎, p<0.05). Althought immunological in both lymphocyte proliferation and its subsets were not observed, which shows that Soamgudamikgilang has a strong effect on T cell activities Conclusions : From the above results, we can expect that the combined therapy of Soamgudamikgitang and Cyclophosphamide is more effective for treating cancer Patients.
홍종희(Jong-Heui Hong),임영철(Young-Chul Lim),임진규(Jin-Kyu Lim),정기훈(Gi-Hoon Jung),김익환(Ick-Hwan Kim),최재승(Jae-Seung Choi),하영호(Yeong-Ho Ha),서대화(Dae-wha Seo) 한국정보과학회 2004 한국정보과학회 학술발표논문집 Vol.31 No.2Ⅲ
본 논문은 디지털 TV에 접목하는 멀티미디어 부가기능 모듈 내의 영상출력 처리부 개발에 관한 것이다. 이 영상 출력 처리부는 영상데이터 처리부로부터의 저 프레임의 HD영상 입력을 TV 시스템에서 사용가능한 60 프레임의 HD영상으로 출력하는 기능을 수행한다. 이렇게 함으로써 기존 시스템의 영상 처리부에서 60 프레임의 영상 출력을 위해 사용한 프로세서 성능을 제안된 시스템에서는 저 프레임 영상 출력에 해당하는 정도로 줄여줄 수 있으며 이는 시스템의 비용 절감 및 다양한 부가기능 추가로 연결 되어질 수 있다.