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장현식,박철근,손은주,김은경,곽진영,문희정,윤정현 대한초음파의학회 2016 ULTRASONOGRAPHY Vol.35 No.2
Purpose: The goal of this study was to evaluate the clinicopathological and imaging features ofthyroid nodules surgically diagnosed as hyaline trabecular tumor (HTT), and to assess the role ofcytology and frozen sections (FS) in the diagnosis of HTT. Methods: This study included 21 thyroid nodules in 21 patients treated from August 2005 toMarch 2015 (mean age, 53.3 years) who were either diagnosed as HTT or had HTT suggestedas a possible diagnosis based on cytology, FS, or the final pathology report. Patients’ medicalrecords were retrospectively reviewed for cytopathologic results and outcomes during the courseof follow-up. Sonograms were reviewed and categorized. Results: Twelve nodules from 12 patients were surgically confirmed as HTT. Ultrasonography(US)-guided fine needle aspiration (FNA) was performed on 11 nodules, of which six (54.5%)were papillary thyroid carcinoma (PTC) or suspicious for PTC and three (27.3%) were HTT orsuspicious for HTT. Intraoperative FS suggested the possibility of HTT in seven nodules, of whichfour (57.1%) were confirmed as HTT. US-FNA suggested the diagnosis of HTT in 10 nodules,of which three (30.0%) were confirmed as HTT. Common US features of the 12 pathologicallyconfirmed cases of HTT were hypoechogenicity or marked hypoechogenicity (83.4%), absence ofcalcifications (91.7%), parallel shape (100.0%), presence of vascularity (75.0%), and probablebenignity (58.3%). Conclusion: HTT should be included in the differential diagnosis of solid tumors withhypoechogenicity or marked hypoechogenicity and otherwise benign US features that have beendiagnosed as PTC through cytology.