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A Study on Prevalence and Risk Factors for Varicose Veins in Nurses at a University Hospital
윤명자,김영기,강동묵,김종은,하원춘,정갑열,최현우 한국산업안전보건공단 산업안전보건연구원 2018 Safety and health at work Vol.9 No.1
Background: Lower-limb varicose veins (VVs) are common and known to have a higher prevalence among people who work in occupations requiring prolonged standing. In the Republic of Korea, however, VV-related occupational factors have seldom been examined. This study was conducted to assess the prevalence of VVs among nurses, an occupational group considered to be at high risk of VVs, and determine the occupational risk factors of prolonged standing. Methods: Between March and August 2014, a questionnaire survey coupled with Doppler ultrasonography was conducted on the nurses working at a university hospital. Results: A total of 414 nurses participated in the survey and diagnostic testing. From the survey analysis and test results, the prevalence of VVs in nurses was estimated to be 16.18%. Significant factors for venous reflux were age [odds ratio (OR) ¼ 1.06, 95% confidence interval (CI) ¼ 1.03e1.10], pregnancy (OR ¼ 2.15, 95% CI ¼ 1.17e3.94), and delivery (OR ¼ 2.02, 95% CI ¼ 1.08e3.78). The statistical significance of these factors was verified after risk adjustment for sociodemographic factors (OR ¼ 3.40, 95% CI ¼ 1.27e9.09). Conclusion: Factors significantly associated with venous reflux were increasing age and prolonged working hours ( 4 hours) in a standing position (OR ¼ 2.80, 95% CI ¼ 1.08e7.25), even after risk adjustment for sociodemographic factors. This study is significant in that an objective diagnosis of VVs preceded the analysis of the risk factors for VV incidence, thus verifying objectively that VVs are associated with occupations requiring prolonged hours of working in a standing position.
윤명자,김연하,김형진,송제호,유동희,설정덕,소홍섭,박래길,전호성 한의병리학회 2009 동의생리병리학회지 Vol.23 No.6
Coptidis rhizoma (huanglian) is an herb that is widely used in traditional Chinese medicine that has recently been shown to possess anticancer activity. However, the molecular mechanism underlying the anticancer effects of this herb is poorly understood. In this study, we investigated the anticancer activity of a combination of CR extract and arsenic trioxide, as well as the apoptotic pathway associated with its mechanism of action in human lung cancer H157 cells. Combined treatment of H157 cells with CR extract and arsenic trioxide resulted in significant apoptotic death. In addition, combined treatment with CR extract and arsenic trioxide acted in concert to induce a loss of mitochondrial membrane potential (ΔΨ), the release of cytochrome c from mitochondria, and an increase in the expression of pro-apoptotic p53 and Bax protein, which resulted in activation of caspases and apoptosis. CR extract combined with arsenic trioxide also increased the lipid peroxidation, mRNA expression of DR4 and DR5 and caspase-8 activity. These data indicate that combined treatment with CR extract and arsenic trioxide enhanced apoptotic cell death in H157 cells through diverse pathways, including mitochondrial dysfunction and death receptors, particularly DR4 and DR5. Thus, this treatment may be an effective from of chemotherapy.
Takayasu`s disease(무맥증, pulseless disease)의 마취례
윤명자,전세웅 대한마취과학회 1970 Korean Journal of Anesthesiology Vol.3 No.1
A case of anesthesia for a patient of $quot;pulaeless disease$quot; (Takayasu's disease) was reported. During her general anesthesia, blood pressure was measured at the femoral artery by auscultatory method. There are numerous problems to evaluate the result of indrect measurements of arterial blood pressure obtained by auscultatory method. For accurate measurements of blood preasure, the relationship between the circumference of the arm and the blood preasure should be considered, which was emphasized by Ragan and Bordley. The auscultatory method of blood preasure measurement wsa reviewed.
유아기 부모의 자녀가치가 부모 공동양육과 가족 상호작용을 매개로 행복감에 미치는 자기-상대방 효과
윤명자,제경숙,김병만 한국열린유아교육학회 2023 열린유아교육연구 Vol.28 No.6
This study attempted to confirm the relationships between parents' child value, co-parenting, and family interaction, which affect parents' happiness in the home. The study used 889 parent data pairs obtained from the seventh iteration of the Korea Childcare Policy Institute's Child Panel Survey. The data verified the research model's suitability for assessing self-relative effects, using SPSS 24.0 and AMOS 24.0. The main research results, specifically descriptive statistics and the normality of the parents' child value, confirmed the relatedness of parental co-parenting, family interaction, and happiness. The main results on the self-effect and counterpart effect arising from the mediating effect of parental co-parenting and family interaction were found to derive from the effect of parents' child value on happiness. This study has significant implications as basic data for creating a healthy parenting environment in early childhood. 본 연구는 가정 내 아버지와 어머니 각각의 행복감에 영향을 미치는 부모의 자녀가치, 공동양육, 가족 상호작용의 관계를 확인하고자 하였다. 본 연구는 한국육아정책연구소의 아동패널조사 7차년도 자료를 활용하여 889쌍의 부모 자료를 사용하였다. 자료는 SPSS 24.0과 AMOS 24.0 프로그램을 이용하여 자기-상대방효과에 대한연구모형의 적합도와 모형을 검증하였다. 본 연구의 주요 연구결과를 통해 부모의자녀가치, 부모 공동양육, 가족 상호작용, 행복감의 정도 및 정규성을 확인하였다. 이후 부모의 자녀가치가 행복감에 미치는 영향에서 부모 공동양육과 가족 상호작용의 매개효과에 의한 자기효과 및 상대방효과에 대한 주요 결과를 도출하였다. 본 연구는 유아기 자녀의 건강한 양육환경 제공을 위한 기초자료로 유의미한 시사점을 제공하였다.