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구강편평세포암종 세포주에서 유로키나제형 플라스미노젠 활성제 및 제일형 플라스미노젠 활성억제제 발현
유연상(Yeon Sang Yu),천윤권(Yun Gueon Cheon),박경주(Gyeong Ju Park),이종헌(Chong Heon Lee) 대한구강악안면병리학회 2010 대한구강악안면병리학회지 Vol.34 No.6
Tumor cell biological factors, such as urokinase plasminogen activator(uPA) and its inhibitor plasminogen activator inhibitor-1(PAI-1) play a role in tumor invasion, metastasis, and proliferation. These factors in patients with primary oral squamous cell carcinoma(Oral SCC) will be evaluated and correlated with clinicopathologic variables. However, relatively rarely has been known in oral squamous cell carcinoma in vivo and in vitro study. The purpose of this study were to investigate the protein expression of uPA and PAI-1 in oral SCC cell lines cell line compared to NHOK and to study migration and adhesion assay. All the cell lines were cultured under KBM bullet kit at 37℃ in a 5% CO2 incubator. We studied a possible association between cytosolic uPA and PA-1 concentrations in oral SCC cell line compared to NHOK using an enzyme-linked immunoassay(ELISA). Cell adhesion and migration assay were done in all the cell lines. In migration assay oral SCC cell lines were about 70 folds higher than NHOK. In adhesion assay oral SCC cell line were about 7-12 folds higher than NHOK. uPA cytosolic concentrations was about 15-19 folds and PAI-1 was 3 to 4.5 folds than that of NHOK. Both uPA and PAI-1 concentrations were correlated with migration and adhesion assay. High cytosolic concentrations of uPA and PAI-1 were correlated with migration and adhesion assay. It suggested that these markers might be specific for oral SCC cell line and these results would be contributed to treatment and prognosis of human oral squamous cell carcinoma.
차량 로드 휠의 복합축 평가 프로세스 구축을 통한 내구신뢰성 강건화 및 주행안정성 향상
정수식,유연상,김대성,Chung, Soo Sik,Yoo, Yoen Sang,Kim, Dae Sung 한국자동차안전학회 2016 자동차안전학회지 Vol.8 No.1
The steel road wheel on ventilation holes was cracked in the vehicle durability test. But the component durability test by uni-axial, CFT(Cornering Fatigue Test) and RFT(Radial Fatigue Test) had been satisfied. That is, the uni-axial component test could not forecast the crack of vehicle. Therefore this study developed the bi-axial test mode to reflect a vehicle condition(to reflect both vertical and lateral force simultaneously) based on real load data which was measured in Europe and China and developed CAE simulation too. It reproduced the cracks same as vehicle's and verified by bi-axial test machine in the LBF(Fraunhofer Institute for Structural Durability and System Reliability) durability research center in Germany. Finally this the durability CAE simulation by using HMC(Hyundai Motor Company)'s the bi-axial test mode predicts feasibly the steel wheel's durability performance before vehicle durability test.
신준탁(Jun Tak Shin),유연상(Yeon Sang Yoo),김성겸(Sung Kyeom Kim) 한국자동차공학회 2014 한국자동차공학회 학술대회 및 전시회 Vol.2014 No.11
There are several test modes (CFT, RFT, Impact Test) for aluminum wheel to prove its performance. HMC (Hyundai Motor Company) Chassis CAE Team has been developing wheel analysis which has been correlated with tests. The aluminum wheel material properties(Strength, Durability) which apply to CAE are gotten from specimen tests. Using Flow-Forming Process in manufacturing aluminum wheel is on the increase recently. According to studies and papers, aluminum wheel which apply to Flow-Forming Process has higher mechanical properties(Strength, Durability, Elongation etc.) than aluminum wheel which is not apply to. But, we have not gotten the durability material property in aluminum wheel which apply to Flow-Forming Process. Because, rim of aluminum wheel which apply to Flow-Forming Process is too thin to get the specimen. In this paper, to get the durability material property of aluminum wheel which apply to Flow-Forming Process, we propose the ‘Rim Specimen Test’ instead of common specimen test. From the results of ‘Rim Specimen Test’ and using CAE, we get the durability material property of aluminum wheel apply to Flow-Forming Process. Also, we are able to compare the durability material property of Flow-Forming Process and Non-Flow-Forming Process.
조준범,이종협,한진우,유연상,오혁준,Cho, Jun-Beom,Lee, Jong-Hyup,Han, Jin_Woo,You, Yeon-Sang,Oh, Hyok-Jun 대한전자공학회 2012 전자공학회논문지 Vol.50 No.8
주파수 옵셋 보상, 프레임 동기화, Timing Recovery를 포함하는 동기화는 모든 유/무선 통신 시스템에서 가장 중요한 신호 처리 블록이다. 대부분의 통신 시스템에서는 Training sequences 또는 프리앰블을 기반으로하는 동기화 방법이 사용된다. IEEE에서 제정한 802.11a/g/n의 무선랜 표준은 OFDM 시스템을 기반으로 한다. OFDM 시스템은 주파수와 타이밍 동기화 에러에 대해서 싱클캐리어 시스템보다 더 민감한 것으로 알려져 있다. 프레임의 시작점과 OFDM 심볼 및 훈련심볼의 시작점은 상관관계를 이용하여 추정될 수 있다. 상관관계를 처리 기능을 하는 블록은 일반적으로 많은 수의 곱셈기로 인하여 큰 복잡도를 갖게 된다. 본 논문에서는 IEEE 802.11a/g/n 시스템을 위한 훈련심볼 내의 심볼값이 반복되는 특성을 활용한 복잡도가 현저히 낮은 동기화 기법을 제안한다. 시뮬레이션과 구현결과 제안된 기법이 기존의 방법보다 성능저하는 없는 반면 훨씬 적은 복잡도를 갖는 결과를 보여준다. Synchronization including timing recovery, frequency offset compensation, and frame synchronization is most important signal processing block in all wireless/wired communication systems. In most communication systems, synchronization schemes based on training sequences or preambles are used. WLAN standards of 802.11a/g/n released by IEEE are based on OFDM systems. OFDM systems are known to be much more sensitive to frequency and timing synchronization errors than single carrier systems. A loss of orthogonality between the multiplexed subcarriers can result in severe performance degradations. The starting position of the frame and the beginning of the symbol and training symbol can be estimated using correlation methods. Correlation processing functionality is usually complex because of large number of multipliers in implementation especially when the reference signal is non-binary. In this paper, a simple correlation based synchronization scheme is proposed for IEEE 802.11a/g/n systems. Existing property of a periodicity in the training symbols are exploited. Simulation and implementation results show that the proposed method has much smaller complexity without any performance degradation than the existing schemes.