TDI 노출 작업자에서 직업성천식 및 항체반응

김덕인 ( Deok In Kim ),김형렬 ( Hyoung Ryoul Kim ),박해심 ( Hae Sim Park ),박신구 ( Sin Gu Park ),임종한 ( Jong Han Leem ),노재훈 ( Jae Hoon Roh ),김정구 ( Jeong Goo Kim ),윤병갑 ( Byeong Kab Yoon ),김철우 ( Cheol Woo Kim ) 대한천식알레르기학회 2005 천식 및 알레르기 Vol.25 No.4

Background: Toluene diisocyanate (TDI) is known to be the most common cause of occupational asthma (OA) in Korea. Although TDI can elicit humoral immune responses including specific-IgE (sIgE) and specific-IgG (sIgG) responses, the exact role of these immune responses has not been clearly clarified yet. Objective: This study was carried out to estimate the prevalence of TDI-induced OA, and to evaluate the clinical significance of TDI-related humoral immune responses in currently TDI-exposed workers. Method: Questionnaire interview for respiratory symptoms was conducted to 170 workers with direct exposure to TDI (exposed group). After screening survey, workers with suspected occupational asthma were selected for methacholine and TDI bronchial provocation tests (BPTs). Serum sIgG and sIgE antibodies to TDI-HSA conjugate, and sIgG to cytokeratin (CK) 8, 18, and 19 were detected by enzyme-linked immunosorbent assay in 170 exposed workers, and compared with 61 unexposed workers in the same workplace (unexposed group) and 75 unexposed healthy controls(healthy control group). Result: Eleven (6.9%) among 170 workers complained symptoms of OA, and 7 of 11 symptomatic workers showed positive airway hyperresponsiveness to methacholine (4.1%). One worker with spray-painting job was confirmed as having TDI-induced asthma by showing positive responses to both methacholine and TDI BPTs. The prevalence of sIgG to TDI-HSA conjugate was significantly higher in TDI-exposed workers (10.1%) than in unexposed workers (0%) and healthy control (2.7%). However, no significant difference was noted between symptomatic (18.2%) and asymptomatic workers (9.5%) among the exposed group. The prevalences of sIgE to TDI-HSA conjugate and sIgG to CK 8, 18, 19 were not significantly different between the three groups. Conclusion: The prevalence of TDI-induced OA was noted to 0.58% in the current working environments. The clinical significance of TDI-induced humoral immune responses may be clarified by further prospective studies. (Korean J Asthma Allergy Clin Immunol 2005;25:276-283)

경계성 인격장애 환자의 마음헤아리기치료 효과 : 중간분석에 대한 예비보고

최선우(Sun-Woo Choi),김종선(Jong-Sun Kim),김민경(Min-Kyeong Kim),박해인(Hae-In Park),오욱진(Uk-jin Oh),석정호(Jeong-Ho Seok) 대한신경정신의학회 2020 신경정신의학 Vol.59 No.1

Objectives The treatment of borderline personality disorder (BPD) in Korea has been based mainly on individual psychopharmacotherapy and psychotherapy. No quantitative study has examined the effectiveness of group psychotherapy for patients with BPD in Korea. In the present study, the mentalization-based treatment (MBT) program developed from the Anna Freud Center in London was conducted in the author’s hospital. This article presents the results of a preliminary analysis of the treatment effects of the Korean MBT for BPD. Methods The recruited subjects are patients diagnosed with BPD at Gangnam Severance Hospital. A psychological assessment was conducted at baseline and every six months during the treatment. Statistical analysis was performed using the data of 62 people at the baseline assessment, and the treatment effectiveness was analyzed with the data from 21 people who participated in the treatment group over six months. Results Borderline personality features were positively correlated with depressive symptoms, anxious attachment, avoidant attachment, and novelty seeking trait, and negatively correlated with self-directedness. After the 12-month treatment, the depressive symptoms and self-disclosure scores were improved significantly. In addition, the self-directedness, cooperativeness factor scores of the temperament and character inventory, and the self-regulation ability score of the resilience scale were also improved significantly. Conclusion This study suggests that the Korean MBT can improve depressive symptoms and induce positive changes in personality functioning. Although the number of people who continued MBT over 12 months was very small due to the high dropout rate, this study is the first quantitative study on the effects of the Korean MBT for BPD patients.

자가 슬개건과 자가 슬괵건을 이용한 전방십자인대 재건술의 비교

최성욱,오인석,김려섭,김명구,배주한,박해봉,Choi, Sung-Wook,Oh, In-Suk,Kim, Ryuh-Sup,Kim, Myung-Ku,Bae, Joo-Han,Park, Hae-Bong 대한관절경학회 2008 대한관절경학회지 Vol.12 No.1

Purpose: The purpose of this study is to compare the results of the arthroscopic reconstruction of ACL using autologous hamstring tendon and autologous bone-patellar tendon-bone. Materials and Methods: From January, 2000 to December, 2004, 120 patients underwent arthroscopic ACL reconstruction using autologous hamstring tendon(60 cases) and autologous bone-patellar tendon-bone(BPTB)(60 cases). The mean followed up period of hamstring tendon group was 42 months(range $24{\sim}69$ months) and patellar tendon group was 52 months(range $24{\sim}84$ months). At the time of the final follow up, sixty patients in each group were evaluated the results of physical examination, activity level, patients' satisfaction, functional status, and objective anteriror stability using KT-2000 arthrometer. Results: At the time of the final follow up we compared the two groups who had ACL reconstruction using either autologous hamstring tendon or BPTB, and the final results of the Lachman test showed negative, or mildly positive in 85%(51 cases) of the hamstring tendon group and 90%(54 cases) of the BPTB group. Pivot shift test indicated positive in both groups, 8%(5 cases) and 5%(3 cases) respectively and showed no statistically significant difference. The evaluation of the anterior laxity using the KT-2000 arthrometer revealed no significant difference in the hamstring and BPTB groups: differences less than 3 mm compared to the healthy side were 85%(51 cases) and 90%(54 cases)(p>0.05). The Lysholm score improved from a preoperative score of 51 to a postoperative score of 79.1 in the hamstring groups and from 52 to 82.2 in the BPTB groups. According to the IKDC rating system, 87%(52 cases) were normal or near normal in the hamstring group. In the BPTB group, 83%(50 cases) were normal or near normal. The Tegner score for the hamstring groups was 4.8 preoperatively and 7.1 at the final follow up, and the Tegner score for the BPTB groups was 4.5 preoperatively and 7.3 after the last follow-up. The anterior knee pain was found in 7%(4 cases) in the hamstring tendon group and 10%(6 cases) in the patellar tendon group. Conclusion: Arthroscopic ACL reconstruction using both the autologous hamstring tendon and the patellar tendon during their mid term follow up period demonstrated excellent results. However, the final results during their last follow up showed no statistically significant difference between the two groups. 목적: 자가 슬괵건과 자가 슬개건을 이용한 관절경적 전방 십자 인대 재건술의 결과를 비교하였다. 대상 및 방법: 2000년 1월부터 2004년 12월까지 자가 슬괵건과 자가 슬개건을 이용하여 전방 십자인대 재건술을 시행한 각각 60명의 환자군을 대상으로 하였다. 추시기간은 슬건 군은 평균 42개월(범위$24{\sim}69$개월)이였으며 슬개건 군은 평균 51개월(범위 $24{\sim}84$개월)이었다. 술 전과 최종 추시에 이학적 검사로 수술 전 후 관절운동범위를 측정하였으며, Lachman 검사 및 pivot shift 검사를 실시하였다. 환자의 활동도와 만족도, 기능적 상태는 전방 슬관절 통증 여부, Lysholm 점수, IKDC 활동도 등급, Tegner 활동도 점수를 조사하였으며 KT-2000 arthrometer를 이용하여 전방 안정성을 객관적으로 평가하였다. 결과: 최종 추시점에서 자가 슬괵건과 슬개건을 이용하여 관절경적 전방 십자 인대 재건술을 시행한 군들 간의 비교에서, Lachman 검사는 음성 또는 경도의 양성이 각각 51예(85%)와 54예(90%)였으며, Pivot shift 검사에서는 각각 5예(8%)와 3예(5%)에서 양성으로 양군 모두 차이가 없었다.(p>0.05) 최종 추시시 KT-2000 검사에서 건측과 비교한 최대 도수 전방 전위차는 3 mm미만이 각각 51예(85%), 54예(90%)였다. Lysholm 점수는 슬괵건군은 평균 51.0점에서 평균 79.1점으로, 슬개건 군은 평균 52점에서 평균 82.2점으로 호전되었으며, IKDC 활동도 등급은 술후 각각 52예(87%)와 50예(83%)에서 정상 또는 거의 정상 소견을 보였다. Tegner 활동도 검사도 슬괵건 군에서 평균 4.8점에서 평균 7.1점으로, 슬개건 군은 평균 4.5점에서 평균 7.3점으로 호전되었다. 또한 전방 슬관절 동통은 슬괵건군 4예(7%), 슬개건군 6예(10%)에서 관찰되었다. 결론: 자가 슬괵건 또는 자가 슬개건을 이용한 관절경적 전방 십자 인대 재건술 후 추시 결과, 두 군 모두 우수한 결과를 보였으나 두 군 간에 최종 추시시의 결과는 통계적으로 유의한 차이가 없었다.

뇌컴퓨터접속(BCI) 무경험자에 대한 EEG-BCI 알고리즘 성능평가

김진권,강대훈,이영범,정희교,이인수,박해대,김은주,이명호,Kim, Jin-Kwon,Kang, Dae-Hun,Lee, Young-Bum,Jung, Hee-Gyo,Lee, In-Su,Park, Hae-Dae,Kim, Eun-Ju,Lee, Myoung-Ho 대한의용생체공학회 2009 의공학회지 Vol.30 No.5

The Performance research about EEG-BCI algorithm in BCI-naive subjects is very important for evaluating the applicability to the public. We analyzed the result of the performance evaluation experiment about the EEG-BCI algorithm in BCI-naive subjects on three different aspects. The EEG-BCI algorithm used in this paper is composed of the common spatial pattern(CSP) and the least square linear classifier. CSP is used for obtaining the characteristic of event related desynchronization, and the least square linear classifier classifies the motor imagery EEG data of the left hand or right hand. The performance evaluation experiments about EEG-BCI algorithm is conducted for 40 men and women whose age are 23.87${\pm}$2.47. The performance evaluation about EEG-BCI algorithm in BCI-naive subjects is analyzed in terms of the accuracy, the relation between the information transfer rate and the accuracy, and the performance changes when the different types of cue were used in the training session and testing session. On the result of experiment, BCI-naive group has about 20% subjects whose accuracy exceed 0.7. And this results of the accuracy were not effected significantly by the types of cue. The Information transfer rate is in the inverse proportion to the accuracy. And the accuracy shows the severe deterioration when the motor imagery is less then 2 seconds.

가상현실기법을 활용한 정신건강교육 및 기술훈련 프로그램의 우울증상 회복 및 자살위험성 감소 효과

김민지(MinJea Kim),최선우(Sun-Woo Choi),문선영(SunYoung Moon),박해인(Hae-In Park),황희경(HeeKyung Hwang),김민경(Min-Kyeong Kim),석정호(Jeong-Ho Seok) 대한신경정신의학회 2020 신경정신의학 Vol.59 No.1

Objectives To compare the clinical effectiveness of the virtual reality (VR) programs in assessing psychosocial problems, improving symptoms, and reducing suicide risk in depressive patients with those of pharmacotherapy. Methods Thirty-six patients were recruited with depression in the treatment group and 22 participants in the healthy control group through internet advertisements between November 2018 and March 2019. Participants in the treatment group were allocated randomly at a 1:1 ratio to either the VR group or pharmacotherapy group. At the baseline, all participants were assessed with a comprehensive battery for their psychological characteristics by structured scales using VR technologies. Assessments of patients in the treatment group were repeated four weeks after therapeutic intervention. The primary outcome measures were the Korean Version of Quick Inventory of Depressive Symptomatology-Self-Report and suicidality scales of the Korean Mini International Neuropsychiatric interview. The borderline personality (Personality Assessment Inventory–Borderline Features Scale) and resilience (Korean Resilience Questionnaire) were also evaluated. Results Twenty-four depressive patients completed the treatment, and the final assessment was conducted after four weeks of treatment. In the initial assessment, the patient group showed significantly higher depressive symptoms, suicidality, borderline personality trait, and lower resilience than healthy control group. After the four-week therapeutic interventions, the VR group showed significant improvement in depression, suicidality, borderline personality trait, and resilience. In addition, there was no significant difference in the treatment efficacy between the VR group and the pharmacotherapy group. Conclusion In this study, the VR treatment program has clear benefits for emotional distress and reducing suicidality in depressive patients. Evidence-based VR treatments may show new clinical potential for depressive disorder.

고추의 부위별 카벤다짐과 클로르피리포스의 잔류 양상

박해인(Hae-In Park),황재문(Jae-Moon Hwang),김병수(Byung-Soo Kim),이미경(Mi-Gyeong Lee),최영욱(Young-Wook Choi),이민호(Min-Ho Lee),정은정(Jeong-Eun Jeong),김정한(Jeong-Han Kim) 한국농약과학회 2011 농약과학회지 Vol.15 No.3

업사이클 브랜드 패션가방제품의 표현 특성 연구

박해인(Hae-In Park),곽태기(Tai-Gi Kwak) 한국의상디자인학회 2017 한국의상디자인학회지 Vol.19 No.2

무인항공기 제어용 통신 방식 : Laurent Decomposition 수신 기술

박해인(Park Hae In),조용수(Cho Yong Soo),김희욱(Kim Hee Wook),안재영(Ahn Jae Young) 한국통신학회 2015 한국통신학회 학술대회논문집 Vol.2015 No.11

청주 성안길 가로경관의 변천에 관한 연구-1992. 3~2001. 3 스케치도 비교 분석-

박해인(Park Hae-In),김태영(Kim Tai-Young) 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

The purpose of this study is to find the transitional process of streetscape as the sketch-drawings drawn between 1992 and 2001 years. The following results is obtained:<br/> 1) The number of the grocery shop is decreasing, the dress shops are getting larger and the facade is changing as a use of shop.<br/> 2) When classifying the facade, the result shows that the opening size of the current building that built in the 1980's was large and it shows the wall of 1992 years is changing the function of the wall to the wall as the show-windows in 2001.<br/> 3) The new building's features are to changed the reinforced concrete-structure to the steel structure and used the materials which can renovate a building.

대학생의 용서신념과 용서행동간 불일치와 분노의 관계에서 완벽주의의 조절효과

박해인 ( Hae In Park ),김향숙 ( Hyang Sook Kim ) 서강대학교 학생생활상담연구소 2016 人間理解 Vol.37 No.2

용서(forgiveness)가 대인간 갈등에서 치료적 기제로 사용되려면 심리내적 측면과 대인관계적 측면을 아울러야 하나, 때로는 내적 경험과 행동이 불일치하는 경우도 있다. 본 연구에서는 용서신념과 용서행동간의 불일치가 개인의 심리적 부적응에 미치는 영향을 분노를 중심으로 살펴보았고, 이러한 역기능적 영향을 조절하는 변인으로서 완벽주의의 역할을 검증하고자 하였다. 서울 시내 S 대학에 재학 중인 대학생 430명을 대상으로 용서신념척도, 한국인 용서척도, 한국판 상태분노 척도 및 다차원적 완벽주의 척도로 구성된 설문을 실시하였으며, 성실하게 응답을 완료한 399명의 자료로 중다회귀분석을 실시하였다. 용서에 대한 신념은 긍정적이나 용서하지 못하는 용서실패가 분노를 설명하였으며, 이는 완벽주의 수준에 의해 조절되었다. 반면 용서에 대한 긍정적 신념을 동반하지 않은 채 용서행동을 하는 경우에는 예상과는 달리 분노 감정이 줄어들었으며, 완벽주의와의 상호작용은 확인되지 않았다. 본 연구는 용서에 대한 신념이 긍정적임에도 용서하는데 곤란을 겪으며 심리적 고통을 호소하는 경우에 치료적 초점이 될 수 있는 부적응적 정서와 그 영향을 조절하는 내담자의 성격특성을 탐색하였다는 점에서 의의를 찾을 수 있다. 마지막으로 본 연구의 한계 및 후속 연구에 대한 제안을 논의하였다. The discrepancy between one`s inner-experience and behavior in the forgiving process can compromise the effectiveness of therapeutic intervention focused on forgiving other people`s misbehavior. ≪e present study investigated the impacts of the discordance between forgiveness belief and behavior on psychological maladjustment focusing on anger. In addition, the moderating role of perfectionism was explored. For this purpose, the forgiveness-belief scale, forgiveness scale, state anger scale and multi-dimensional perfectionism scale were administered to 430 college students. Multiple regression analysis revealed that `forgiveness failure` explained a large portion of the variability in anger and this process was moderated by perfectionism. However, for false forgiveness, the moderating effect was not found. Finally, implications and limitation of the study were discussed with suggestions for future research.