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형개연교탕합가미지황탕(荊芥連翹湯合加味地黃湯)으로 호전된 객혈을 호소하는 기관지확장증 환자 1례
도하윤,김재효,유창환,김의중,김관일,이범준,정희재,Do, Ha-yoon,Kim, Jae-hyo,Yu, Chang-hwan,Kim, Eui-joong,Kim, Kwan-il,Lee, Beom-joon,Jung, Hee-jae 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4
Objective: This case report describes the treatment of hemoptysis in a bronchiectasis patient with Hyunggaeyungyo-tang plus Gamijihwang-tang. Methods: The hemoptysis in this patient was suspected to result from bronchiectasis, which was diagnosed with a chest CT at another hospital. She was treated with a herbal medicine, Hyunggaeyungyo-tang, plus Gamijihwang-tang. The effectiveness of the treatment was evaluated by measuring the amount of hemoptysis and by a visual analogue scale (VAS) to determine the patient's quality of life. Results: After administration of Hyunggaeyungyo-tang plus Gamijihwang-tang, the severity of hemoptysis decreased, based on the amount of hemoptysis and the VAS scores. Conclusions: Hyunggaeyungyo-tang plus Gamijihwang-tang is a potent therapeutic agent for the treatment of hemoptysis.
천식환자 허실변증과 객담 cytokine 및 특성 비교분석
도하윤,유창환,강성우,김관일,이범준,정희재 대한한방내과학회 2019 大韓韓方內科學會誌 Vol.40 No.4
Objective: The aims of this study were to analyze the deficiency-excess pattern identification (虛實辨證) and compare it to the sputum cytokines of asthma patients. Method: 50 asthma patients who met the inclusion and exclusion criteria were included in this study. They were divided into two groups: deficiency and excess syndrome groups. Sputum examinations were performed including TNF-α, Interleukin (IL)-4, IL-5, IL-10, and IL-13. The Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA), the Visual Analog Scale(VAS), and heart rate variability (HRV) were also measured. We also conducted laboratory tests, including the hematological indexes. Results: Based on the pattern identification, 50 asthma patients can be divided into two categories of groups: the deficiency syndrome group (N=24) and the excess syndrome group (N=26). In the analysis of sputum cytokines, although the TNF-α, IL-4 and IL-13 were at a higher level in the deficient pattern group than in the excess pattern group, it was insignificantly different. There was a negative correlation in the analysis of QLQAKA and VAS. In the analysis of HRV, although the mean value of VLF, LF, and HF in the deficiency syndrome group was higher than in the excess syndrome group, it was insignificantly different. There was no significant difference in the hematological tests between the deficiency and the excess syndrome group. The mean value of the IgE in the blood tests was five times greater than the reference value. Conclusion: The cytokines of sputum including TNF-α, IL-4, IL-5, IL-10, and IL-13 were indifferent statistically. Reinforcing the healthy and eliminating the pathogenic factors should be considered.
한약 치료를 통해 비용종(Nasal polyp)이 소실된 부비동염 환자 치험 증례 1례
유창환,도하윤,강성우,노지애,김관일,이범준,정희재 대한한방내과학회 2019 大韓韓方內科學會誌 Vol.40 No.5
Objective: The purpose of this case study was to report the effect of Korean medicine treatment on a patient diagnosed with a nasal polyp. Methods: A 62-year-old female patient with a nasal polyp visited the clinic sixteen times from September 11th, 2018 to December 18th, 2018. The patient was treated with Eunhwayeongyo-tang, Haeyeol-tang, Hongsamkyungok-go extract, and acupuncture during the treatment period. We evaluated the improvement of symptoms by nasoendoscopy. Results: After the Korean medicine treatment, the nasal polyp was completely eradicated. Hyperemia of the nasal mucous membrane and rhinorrhea were also relieved. Conclusion: The study findings suggested that Korean medicine treatment (Eunhwayeongyo-tang, Haeyeol-tang, and Hongsamkyungok-go extract, and acupuncture) might be effective for treatment of patients diagnosed with nasal polyps.
김재효,방연희,도하윤,안준모,김관일,이범준,정승기,정희재,Kim, Jae-hyo,Bhang, Yeon-hee,Do, Ha-yoon,Ahn, Jun-mo,Kim, Kwan-il,Lee, Beom-joon,Jung, Sung-ki,Jung, Hee-jae 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.1
Objective: The purpose of this study was to develop a standard tool for pattern identification of radiation pneumonitis. Methods: Textbooks, published studies, and references with comments about patterns were reviewed. Through the Delphi method, we determined pattern identifications based on advice from a committee of experts composed of 13 Korean respiratory internal medicine professors. Results: Using the Delphi method, four pattern identifications were chosen: Qi Deficiency (氣虛), Yin Deficiency (陰虛), Heat Toxin (熱毒), and Phlegm Dampness (痰濕). The tool was developed in a question-and-answer format with 35 questions. Conclusions: A pattern identification tool that can discriminate the patterns of radiation pneumonitis for standardized diagnosis was developed through expert consultation. Further study of its validity and reliability is necessary.
방연희,김재효,도하윤,김미아,김관일,이범준,정희재 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.6
Objectives: The aim of this observational study was to identify and analyze the patterns to compare the characteristics of asthma patients. Methods: The subjects were 40 asthma patients who had satisfied the inclusion and exclusion criteria. They were divided into deficiency syndrome and excess syndrome groups, and cold syndrome and heat syndrome groups. Their quality of life was measured by the quality of life questionnaire for adult Korean asthmatics (QLQAKA) and VAS. Heart rate variability (HRV) was measured, and the degree of obesity was evaluated by body mass index (BMI). Hematological, biochemical, and immunoglobulin (Ig) E laboratory tests were included. Results: Based on pattern identification, the 40 asthma patients could be divided into two categories of groups: 1) the deficiency syndrome (N=18) and the excess syndrome (N=22) groups: 2) the cold syndrome (N=35) and the heat syndrome (N=5) groups. The mean value of HF differed significantly between the deficiency and excess syndrome groups. The mean value of IgE in blood tests of asthmatics was greater than four times the reference value. For BMI, the subjects were classified into three groups: normal weight (N=12), overweight (N=12), and obese (N=16). Conclusions: Development of a more accurate asthma-specific pattern identification tool could play a crucial role in asthma control. In addition, good control of asthma can improve the quality of life. Obesity is one of the factors associated with asthma exacerbation.
시경반하탕(보험제제)을 통한 기관지확장증 환자의 관리 1례
김재효,방연희,도하윤,유창환,김관일,이범준,정희재 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.3
Objective: This case reports the management of a patient with bronchiectasis treated with Sikyungbanha-tang, an herbal extract covered by national health insurance. Methods: Twice a year, the patient was treated for a 30-day period with the herbal extract Sikyungbanha-tang. History-taking and a chest X-ray (CXR) were used to evaluate the effects. Results: Following treatment with herbal medicine, the patient’s complaints of symptoms decreased, and improvement was shown on CXR. Conclusions: Sikyungbanha-tang in herbal extract form in insured herbal extracts has effects on the management of bronchiectasis patients.
오적산합생맥산(五積散合生脈散)으로 호전된 위식도 역류에 의한 만성기침 환자 3례
이준환,방연희,김재효,도하윤,김관일,정희재,이범준,Lee, Jun-Hwan,Bhang, Yeon-Hee,Kim, Jae-Hyo,Do, Ha-Yoon,Kim, Kwan-Il,Jung, Hee-Jae,Lee, Beom-Joon 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.4
Objectives: Gastro-esophageal reflux-induced chronic cough is not easy to diagnose and treat. In this study, three patients diagnosed with this disease were treated with Ojeok-san plus Saengmaek-san. Methods: Three patients with chronic cough, suspected to be gastro-esophageal and reflux-based, were diagnosed according to symptoms and abdominal examinations. They were treated with the herbal medicine, Ojeok-san plus Saengmaek-san. To evaluate the effectiveness of the treatment, a visual analogue scale (VAS) for measuring the severity of a cough and the Korean version of the Leicester Cough Questionnaire (LCQ-K) were used to determine the patients' quality of life. Results: After administration of Ojeok-san plus Saengmaek-san, the severity of the patients' coughing decreased based on VAS scores and quality of life improved based on LCQ-K scores for all patients. Conclusions: Ojeok-san plus Saengmaek-san is a potent therapeutic agent for gastro-esophageal reflux-induced chronic cough.
김재학,강도영,강민수,강보라,강은별,강진석,고예진,고휘형,곽재영,구현정,권서연,기유미,김가연,김경묵,김경훈,김규리,김동현,김민우,김민채,김성호,김세윤,김시라,김신형,김영준,김종현,김지수,남선우,도태윤,도하윤,문기역,민경록,박경근,박민영,박성민,박인우,박준규,박준한,박정건,박지은,박태기,배준형,변정욱,서세욱,서혜진,손강민,송창규,신혜진,신희연,문필동 셀메드 세포교정의약학회 2013 셀메드 (CellMed) Vol.3 No.3
Pharmacopuncture, or herbal acupuncture, is a new form of therapy derived from combinations of two traditional therapeutic methods, herbal medicine and acupuncture therapy. To compare the efficacy between dexamethasone-pharmacopuncture (DP) and dexamethasone-oral administration (DO), the effect of DP was investigated in murine models. Anti-anaphylactic effects of dexamethasone treatments were investigated in compound 48/80-induced systemic anaphylactic reaction, ear swelling response, and passive cutaneous anaphylaxis (PCA). DP treatment significantly inhibited the compound 48/80-induced systemic anaphylactic reaction, ear swelling response, and PCA. The effects between DP and DO were on a similar level. These results indicate that DP can be used as an alternative method for DO in case of emergency.