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김형진,장선일,오기수,홍경환,김윤철,배현옥,윤용갑,정헌택,권태오,Kim Hyeong-Jin,Jang S.I.,Oh K,S.,Hong K.H.,Kim Y.C.,Pae H.O.,Yun Y.G.,Chung H.T.,Kwon T.O. 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.2
The fruiting bodies of Isaria japonica have been traditionally used in Korea to treat cancer. An apoptosis-inducing compound, 4-Acetyl-12, 13-epoxyl -9-trichothecene-3, I5-diol (AETD), was isolated from the methanol extract of fruiting bodies of Isaria japonica Yasuda by bioassay -guided fractionation. The apoptosis of murine bladder cancer cell line (NBT-Ⅱ) by the compound was accessed by propidium iodide staining flow cytometric analysis, and apoptosis-inducing activity at $IC_{50}$ concentration (5 nmol/L) was further confirmed by a nuclear morphological change, a ladder pattern of DNA fragmentation, and an activation of caspase-3. These results indicate that AETD induces apoptosis of NBT-Ⅱ cells via expression of caspase-3.
두 가지 배광을 갖는 LED 횡단보도 조명장치에 관한 연구
김형진,이동규,곽준섭,Kim, Hyeong Jin,Lee, Dong Kyu,Kwak, Joon Seop 한국전기전자재료학회 2014 전기전자재료학회논문지 Vol.27 No.9
Recently, LED lighting fixtures for crosswalk become popular in order to recognize the pedestrians at crosswalk, which can enhance the safety of the pedestrian at crosswalk. However, there are several problems related to the LED lighting fixtures for crosswalk, such as a lot of energy consumption due to a constant illumination during night and glaring of pedestrians at the opposite side of crosswalk. In this study, in order to overcome these problems, we have investigated a novel LED lighting fixture for crosswalk, which has two modules with different angles ($60^{\circ}$, $120^{\circ}$). Illuminance of min and max at four-line city street crosswalk shown 50 Lux, 125 Lux, respectively. Illuminance of min and max at eight-line city street crosswalk shown 150 Lux, 200 Lux, respectively. Simulation investigation was optimized design using optical program. Prototype was verified measurement by goniometer system.