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Aging impairs vasodilatory responses in rats
김순열,박종택,Jae Kyun Park,이정수,최재찬 대한마취통증의학회 2011 Korean Journal of Anesthesiology Vol.61 No.6
Background: Aging causes profound changes of stiffness and compliance in the cardiovascular system, which contributes to decreased cardiovascular reserve. Mechanisms of the underlying endothelial vasodilator dysfunction in vasodilator signaling pathways may occur at multiple sites within any of these pathways. Methods: Age-related changes in the vasculature were investigated in adult young (3-6 months, Y) and old (26-29 month, O) Wistar rats (n = 6). The aortas were carefully dissected from the rat and cut into rings 1.5-2.0 mm in length to measure in vitro isometric tension. Vasorelaxant responses of aortic rings to acetylcholine (ACh), sodium nitroprusside (SNP) and P1075 were examined using Dose Response software (AD Instruments, Mountain View, CA). Results: Endothelium-dependent vasodilator function was impaired. The endothelium of aging rats impaired endothelial NO dependent vasodilation, but the machinery for vasodilation was not impaired. Conclusions: Age-related NO-mediated vasorelaxation in the aging endothelium was inhibited and appears to be major mechanism of vascular change and impaired vascular regulation.
김순열 한국공안행정학회 2001 한국공안행정학회보 Vol.11 No.-
이 연구는 국민생활 속에서 범죄예방활동에 대한 관심과 욕구는 다양하고 전문화된 양질의 치안서비스를 요구하게 되었다. 따라서, 경호경비안전산업은 고객인 수요자에게 대하여 범죄예방활동을 효율적으로 제공함으로써 각종범죄에 대한 피해를 사전에 예방해야 한다. 따라서, 민간경비업체가 인력경비와 기계경비를 원활하게 제공할 수 있도록 문제점을 도출하고 효율적인 활성화 방안을 제시하고자 하였다. The concerns and demands about crime-preventative activities in social life have increasingly raised much interest in various and specialized high-quality security services. Accordingly, guard-security safety industry must previously prevent any damages or injuries arising from many kinds of crimes by providing our customers with efficient measures for prevention of crime. Consequently, I would like to draw many problems that private security corporations can face, such as cost-efficiency of manpower and machinery, and then present effective activation scheme.
고양이에서 Galactosamine 에 의한 급성간부전이 Mivacurium의 근이완 작용에 미치는 영향
김순열,임현교,윤경봉,김천경 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.34 No.2
Background: Though the mivacurium is the short acting nondepolarizing neuromuscular blocking agent, the action duration of it is not prospected in condition of hepatic failure owing to its being metabolized by serum cholinesterase and other esterase produced in liver. The purpose of this study is to evaluate neuromuscular effect of the mivacurium in cats with acute hepatic failure. Methods: Six cats administrated only mivacurium are the control group, and six cats with acute hepatic failure by galactosamine hydrochloride are the experimental group. The force of the anterior tibialis muscle in response to supramaximal common peroneal nerve stimulations were recorded, the time intervals from mivacurium administration to attain 100% twitch depression (onset time), from mivacurium administration to recovery of 25% twitch tension(duration) and from 25% to 75% of twitch recovery (recovery index) were compared between the control group and the experimental group. Results: In experimental group, SGOT and SGPT prior to administration of galatosamine were 28.8±5.6(IU/L) and 43.0±7.9(IU/L), respectively, SGOT and SGPT in acute hepatic failure were 5004.0±8113.2(IU/L) and 3763.0±5416.4(IU/L), respectively, and there were significant differences between the control group and the experimental group. The action duration{47.6±18.0(min)} and the recovery time{7.7±3.7(min)} of mivacurium in the experimental group were more prolonged than the action duration{21.9±5.0(min)} and the recovery time{4.4±0.7(min)} of mivacurium in the control group. Conclusions: These results indicate that the hepatic failure can prolong the action duration and the recovery index of mivacurium, but the other factors affecting the action of mivacurium must be studied. (Korean J Anesthesiol 1998; 34: 266∼272)
김순열,박원환,이태균 동국대학교 경주대학 1994 東國論集 Vol.13 No.-
In order to investigate the effects of Gaeulsamutang on thrombosis and Vaginal bleeding, rats injected endotoxin into the caudal vein to make experimental thrombosis model were orally administrated solid extract of Gaeulsamultang 0.4㎖/200g, and then observed platelet, fiblinogen, prothrombin time and FDP level. The results were summarized as follows. 1. Platelet level was increased significantly in sample compared with the control group. 2. Fibrinogen level small increased in sample compared with the control group. 3. Prothrombin Time was decreased in sample compared with the control group. 4. FDP level was decreased in sample compared with the control group. According to the above results, it is considered that Gaeulsamultang has significant effects on Platelet level, Fibrinogen level, Prothrombin time and FDP level, therefore it is considered that Gaeulsamultang can be applied to the disease related to thrombosis.
만성골반통의 동서의학적 고찰 : 부인과 질환으로 중심으로
김순열 ( Soon Yeol Kim ),윤종원 ( Jong Won Yoon ) 동국대학교 한의학연구소 1996 東國韓醫學硏究所論文集 Vol.5 No.-
The purpose of this study was to generalize the conception of chronic pelvic pain(CPP)through the literature of oriental medicine and occidental medicine. The results are obtained as follows. First, chronic pelvic pain(pain of more than 6 months' duration) may include pain of gynecologic, gastroenterologic, urologic neurologic, and musculoskejetal origin. In this study, the etiologic of chronic pelvic pain may remain obscure and the relationship between certain types of pathologic, such as endometriosis or adhesions, and the pain response may be inconsistent and often inexplicable. Second, the causes of CPP through the literature of oriental medicine were reviewed as pains due to a wind-pathogen, a cold, disorder of Qi, disorder of blood stasis, a improper diet, disorder of fluid, and deficiency type etc... And the charateristic pains were concerned with a aching pain, a heavy pain, a distending pain, a pain due to mass in the abdoman, a pain likes pulling etc... The degree an4 classification of charateristic pains in current of time were dependent on subjective factors. Third, in oriental medicine, it wasn`t to be suggested concretely recognition of etiological factor in pain, But they recognised that facters were influenced by pain. For example, diretic peripheral demages were concerned with a blood stasis, a phlegm, a damp phlegm, heart, and the pains that were occurrenced by sevn emotions were concerned with a stagnancy of Qi or a stagnancy of liver-Qi.