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Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9
구태영,이정준,김진수 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.6
Programmable nucleases, which include zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and RNA-guided engineered nucleases (RGENs) repurposed from the type II clustered, regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) system are now widely used for genome editing in higher eukaryotic cells and whole organisms, revolutionising almost every discipline in biological research, medicine, and biotechnology. All of these nucleases, however, induce off-target mutations at sites homologous in sequence with on-target sites, limiting their utility in many applications including gene or cell therapy. In this review, we compare methods for detecting nuclease off-target mutations. We also review methods for profiling genome-wide off-target effects and discuss how to reduce or avoid offtarget mutations.
New Dielectric Anomaly in DyMn2−xGaxO5
구태영,강선희,이해준,김일원,장태환,정윤희 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.6
We have studied the effect of Ga3+ substitution into the Mn3+ site in DyMn2O5 on its multiferroic charateristics. Crystallographic structural, thermal, dielectric and magnetic properties are measured and discussed in terms of the dilution of magnetic Mn3+ ions. Replacement of Mn3+ with Ga3+ changes the compound into a disordered multiferroic system and the colossal magnetodielectric effect observed in DyMn2O5 diappears quickly below x 0.1 in DyMn2−xGaxO5. However, as the content of Ga is increased above x 0.1, a new type of ferroelectric transition, identified by a peak in dielectric constant, can be obtained from the slowly varying dielectric background. Moreover, a remarkable enhancement of the dielectric constant at the ferroelectric transition temperature is continued, even up to the solubility limit of Ga (x 0.2). This observation suggests one possible channel for ferroelectricity in disordered multiferroic systems.
Growth of Epitaxial DyMn2O5 Thin Films and Their Magnetic Properties
구태영,강선희,김일원,정윤희,송종현 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.61 No.9
We grew highly qualified epitaxial DyMn<SUB>2</SUB>O<SUB>5</SUB> (DMO) thin films on an Nb-doped TiO<SUB>2</SUB>(110) single crystal substrate by using the pulsed laser deposition technique and studied their magnetic properties. Surface normal crystal direction was changed from DMO(002) to DMO(211) with increasing growth temperature from 750 ℃ to 950 ℃. Magnetic properties of the bulk-like were observed for the film grown at 950 ℃ while different behaviors from the bulk were observed for the film grown at 750 ℃. This alteration in the magnetic property is attributed to the structural deformation caused by the strain due to the substrate.
구태영,목우균,Koo, Tae-Young,Mok, Woo-Kyun 대한소아외과학회 2005 소아외과 Vol.11 No.1
Two cases of primary torsion of the greater omentum were described. The first patient was a 5-year-old boy who was admitted to the hospital because of severe abdominal pain for 1 day. The The clinical features were similar to perforated acute appendicitis. Laparotomy revealed a normal appendix and the greater omentum twisted around its pedicle. The second patient was a 7-year-old girl admitted to the hospital because of abdominal pain in right lower quadrant for 2 days. The clinical features? were that of acute appendicitis. Laparotomy revealed a normal appendix and primary torsion of greater omentum around its pedicle. In both cases, resection of twisted omentum and incidental appendectomy were done. The microscopic findings in two cases consisted of congestion and vascular hemorrhage. Both patients recovered uneventfully. Torsion of the greater omentum, therefore, may be added to the entities to consider in the differential diagnosis of acute appendicitis.
Resonant X-ray Scattering Study of Spinel Co2MnO4
구태영,Dae-Su Lee,송종현 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.10
X-ray resonant enhancement of the (200) crystallographically forbidden reflection in the inversecubic spinel Co2MnO4 single crystal is presented. Anisotropic X-ray scattering results near the Kabsorption edges of both Co and Mn ions observed in the azimuthal angle dependence are interpretedwith the anisotropic tensorial character of the X-ray susceptibility. Spectra calculations includingthe various electric multipole transition channels, such as dipole-dipole (E1-E1), dipole-quadrupole(E1-E2), and quadrupole-quadrupole (E2-E2), in two different polarization states of − and − are discussed and compared with the experimental data to determine the channel of majorcontribution in the resonant scattering intensity.