Fatal Breakthrough Mucormycosis in an Acute Myelogenous Leukemia Patient while on Posaconazole Prophylaxis

강승훈,김현선,배명남,김지혜,유지연,이관용,이동건,김희제 대한감염학회 2015 Infection and Chemotherapy Vol.47 No.1

Posaconazole is a new oral triazole with broad-spectrum antifungal activity. Posaconazole has also shown a significant advantageof preventing invasive fungal infection compared to fluconazole or itraconazole in patients with prolonged neutropenia. Indeed, posaconazole has been commonly used for antifungal prophylaxis in patients undergoing remission induction chemotherapyfor acute myelogenous leukemia or myelodysplastic syndrome. We experienced a case of fatal mucormycosis despiteposaconazole prophylaxis. To our knowledge, this is the first reported case of fatal breakthrough mucormycosis in a patientreceiving posaconazole prophylaxis during remission induction chemotherapy in Korea. This case demonstrated that breakthroughfungal infection can occurs in patients receiving posaconazole prophylaxis because of its limited activity against somemucorales.

Right aortic arch with aberrant Left subclavian artery and Kommerell`s diverticulum. Diagnosed with ancillary help of endoscopic ultrasound

강승훈,박낙순,류호상,김창덕,엄순호,전훈재,이홍식,진윤태,서연석,김용식,금보라 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.-

직접해법 기반의 FETI 알고리즘의 개선

강승훈,공두현,신상준,Kang, Seung-Hoon,Gong, DuHyun,Shin, SangJoon 한국전산구조공학회 2022 한국전산구조공학회논문집 Vol.35 No.5

본 논문은 직접해법 기반 FETI 알고리즘의 개선 방안을 제시하였다. 개선 대상은 FETI-local로, 해당 알고리즘은 국부 Lagrange 승수를 통해 부영역 간 경계 문제를 정의한다. 부영역 경계 강성 및 하중 계산 단계의 경우, 전체 역행렬 계산 등 과도한 비용을 요구했던 기존 알고리즘을 Boolean 행렬 특성을 활용한 선택적 역행렬 성분 계산으로 개선하였다. 전역 경계 행렬식 계산 단계의 경우, 기존 단일 프로세서 연산을 다중 프론탈 기법 기반 병렬 연산으로 대체하였다. 제시된 FETI-local 알고리즘의 성능 개선은 64만 자유도 수치 예제를 통해 검증되었으며, 기존 대비 최대 97.8%의 계산 시간 감소가 달성되었다. 또한, 기존 대비 안정적이고 개선된 확장성이 가속 지표를 통해 확인되었다. 추가로, 432만 자유도의 대용량 계산 성능 비교가 제시된 알고리즘과 상용 프로그램인 ANSYS 간에 수행되었다. 그 결과, 계산 시간 측면에선 ANSYS가 우수하였으나, 프로세서 수에 따른 가속 성능 증가율 측면에선 제시된 알고리즘이 우수한 것이 확인되었다. This paper presents an improved computational framework for the direct-solution-based finite element tearing and interconnecting (FETI) algorithm. The FETI-local algorithm is further improved herein, and localized Lagrange multipliers are used to define the interface among its subdomains. Selective inverse entry computation, using a property of the Boolean matrix, is employed for the computation of the subdomain interface stiffness and load, in which the original FETI-local algorithm requires a full matrix inverse computation of a high computational cost. In the global interface computation step, the original serial computation is replaced by a parallel multi-frontal method. The performance of the improved FETI-local algorithm was evaluated using a numerical example with 64 million degrees of freedom (DOFs). The computational time was reduced by up to 97.8% compared to that of the original algorithm. In addition, further stable and improved scalability was obtained in terms of a speed-up indicator. Furthermore, a performance comparison was conducted to evaluate the differences between the proposed algorithm and commercial software ANSYS using a large-scale computation with 432 million DOFs. Although ANSYS is superior in terms of computational time, the proposed algorithm has an advantage in terms of the speed-up increase per processor increase.

공정거래위원회의 디지털증거 수집의 적법성 강화 방안

강승훈 한국경쟁법학회 2019 競爭法硏究 Vol.39 No.-

Due to the development and advancement of information technology, a object of administrative investigation is rapidly being replaced by digital evidence from material things. In response to this situation, several administrative agencies with authority to conduct administrative investigation have set up procedures and standards for collecting digital evidence, and have established an organization dedicated to the related tasks. The Fair Trade Commission(FTC) is a collegiate governmental authorities that independently conducts affairs under Monopoly Regulation and Fair Trade Act(MRFTA) through the investigation and deliberation of the violation of MRFTA. It declares itself to be in violation of the law and has the authority to impose fines and prosecute prosecutions. FTC has expanded the scope of investigation through the collection of digital evidence in order to detect cases of law violations more efficiently in case processing procedures. Due to the characteristic of digital evidence, collecting digital evidence for administrative investigations is more likely to infringe on the rights and freedoms of the people than the investigations of material things. Therefore, the conduct should be controlled according to lawful and due process. This study started with the consciousness of the issue of whether FTC's digital evidence collection procedure is operated through due process of law. As a result, it can be raised under the existing laws and related regulations, I recognized the problem as follows. First, under the current legal system, the procedure of collecting digital evidence by FTC is judged to be in violation of the due process principle guaranteed by the Constitution because it is not conducted in accordance with a legal basis. Second, considering that FTC has a role as the first instance court, the point that examine of evidence for digital evidence presented in the deliberation process of FTC is not practically achieved can be contrary to the constitutional principle of guaranteeing the right of access to courts. Recognizing these problems, I suggest to strengthen the legitimacy of the digital evidence collection process of FTC as follows. First, the essentials of the legal basis for collecting digital evidence of FTC should be enacted as laws. Second, the FTC's deliberation procedure should strengthen the procedures for examine of evidence for digital evidence. The purpose of this paper is to verify the meaning and nature of the digital evidence collection activities of FTC and to provide the procedural requirements and procedural procedures. As a result it is meaningful that the legality of FTC enforcement is strengthened.

Recent advances in in vivo genotoxicity testing: prediction of carcinogenic potential using comet and micronucleus assay in animal models

강승훈,권지영,이종권,서영록 대한암예방학회 2013 Journal of cancer prevention Vol.18 No.4

Genotoxic events have been known as crucial step in the initiation of cancer. To assess the risk of cancer, genotoxicity assays, including comet, micronucleus (MN), chromosomal aberration, bacterial reverse, and sister chromatid exchange assay, can be performed. Compared with in vitro genotoxicity assay, in vivo genotoxicity assay has been used to verify in vitro assay result and definitely provide biological significance for certain organs or cell types. The comet assay can detect DNA strand breaks as markers of genotoxicity. Methods of the in vivo comet assay have been established by Japanese Center for the Validation of Alternative Methods (JaCVAM) validation studies depending on tissue and sample types. The MN can be initiated by segregation error and lagging acentric chromosome fragment. Methods of the in vivo MN assay have been established by Organization for Economic Co-operation and Development (OECD) test guidelines and many studies. Combining the in vivo comet and MN assay has been regarded as useful methodology for evaluating genetic damage, and it has been used in the assessment of potential carcinogenicity by complementarily presenting two distinct endpoints of the in vivo genotoxicity individual test. Few studies have investigated the quantitative relation between in vivo genotoxicity results and carcinogenicity. Extensive studies emphasizes that positive correlation is detectable. This review summarizes the results of the in vivo comet and MN assays that have investigated the genotoxicity of carcinogens as classified by the International Agency for Research on Cancer (IARC) carcinogenicity database. As a result, these genotoxicity data may provide meaningful information for the assessment of potential carcinogenicity and for implementation in the prevention of cancer.

심포지엄 : 개원준비 ABC ; 피부과의사로 개원하기 A to Z (초)

강승훈 대한피부과학회 2009 초록집 Vol.47 No.20

Right aortic arch with aberrant left subclavian artery and Kommerell`s diverticulum. Diagnosed with ancillary help of endoscopic ultrasound

강승훈,박낙순,류호상,김창덕,엄순호,전훈재,이홍식,진윤태,서연석,김용식,금보라 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1

Dysphagia resulting from esophageal compression by anomalous aortic arch vessels is not common, often overlooked without every single effort to find out the reason. In case that endoscopy or barium swallow to evaluate dysphagia shows extrinsic esophageal compression, the next step like EUS, CT or MR imaging is generally considered to evaluate the cause of compression. CT or MR imaging is very excellent to figure out the correlation between the esophagus and its surrounding structure. But the anomaly of aortic arch is frequently ignored in review of CT or MR imaging with little attention to vascular structure because it is a very rare etiology of dysphagia. Herein, we report a case in which EUS and 3D-CT were used to establish the diagnosis of dysphagia due to congenital vascular anomaly, right aortic arch with aberrant left subclavian artery with Kommerell`s diverticulum.

Strain effects on phase transitions in transition metal dichalcogenides

강승훈,권영균 한국물리학회 2019 Current Applied Physics Vol.19 No.6

We perform density functional theory calculation to investigate the structural and electronic properties of various two-dimensional transition metal dichalcogenides, MX2 (M=Ti, V, Cr, Zr, Nb, Mo, Hf, Ta, or W, and X=S or Se), and their strain-induced phase transitions. We evaluate the relative stability and the activation barrier between the octahedral-T and the trigonal-H phases of each MX2. It is found that the equilibrium and phase transition characteristics of MX2 can be classified by the group to which its metal element M belongs in the periodic table. MX2 with M in the group 4 (Ti, Zr, or Hf), forms an octahedral-T phase, while that with an M in the group 6 (Cr, Mo, or W) does a trigonal-H phase. On the other hand, MX2 with M in the group 5 (V, Nb, or Ta), which is in-between the groups 4 and 6, may form either phase with a similar stability. It is also found that their electronic structures are strongly correlated to the structural configurations: mostly metallic in the T phase, while semiconducting in the H phase, although there are some exceptions. We also explore the effects of an applied stress and find for some MX2 materials that the resultant strain, either tensile or compressive, may induce a structural phase transition by reducing the transition energy barrier, which is, in some cases, accompanied by its metal-insulator transition.

예쁜꼬마선충 동물 모델 기반 신약 스크리닝 기계 · 바이오 융합 기술

강승훈,신용운,임승은,최신식 대한기계학회 2023 기계저널 Vol.63 No.6

교각 안정화 운동이 몸통 근육의 근활성도와 근활성도 비에 미치는 영향

강승훈,이수영 기독보건학회 2014 전인건강과학회지 Vol.4 No.2

The purpose of this study was to investigate both relative muscle activity levels and ratios of local to global muscle activity, during bridging stabilization exercises. Twenty-fours healthy students volunteered to participate in this study. Subjects were required to complete the following four exercises: exercise 1, bridging position exercise: exercise 2, bridging position exercise with right leg lift exercise: exercise 3, bridging position exercise with right leg lift and hip/knee 0°∼90° flexion: exercise 4, bridging position exercise with right leg lift and swiss ball under leg, hip 0°∼30° abduction. Surface EMG signals were recorded from internal oblique (IO), rectus abdominal (RA), multifidus (MF), erecter spinae (ES) muscle during the exercises. RMS (root mean square) from selected trunk muscle was normalized by maximum voluntary isometric contraction (MVIC). One-way repeated of ANOVA with post-hoc Bonferroni`s correction was used to compare the differences in the muscle activity levels and ratios according to the types of exercise. The results of these muscles activites are as follows: The EMG activities of the muscles in exercise 2 showed significantly higher than those of muscle in exercise 1, 3, 4 (p<.05). The results of these muscles activity ratios are as follows: During all bridging exercises, the ratio of the IO/RA was very high due to relatively minimal activity of the rectus abdominis (RA). The relative muscle activity and the ratio of the back muscle demonstrated similar activity levels for all exercise. This study suggests that bridging exercise with leg lift is the most effective in lumbar bridging stabilization exercise. Also we provide useful information that will inform future studies on how bridging stabilization exercise affects muscle activity levels and ratios of local to global muscle activity.