위내시경 검사환자에 대한 정신의학적 연구 : BDI와 STAI를 중심으로

신동균,조숙행,이성근 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.6

The authors studied the emotinal status of the medical outpatient who underwent gastroscopy for gastrointestinal complaints by means of BDI(Beck Depression Inventory) and STAI(State-Trait Anxiety Inventory). Also, the authors compared the degree of anxiety and depression according to each factors of demographic and other data which might influence emotional status. The subjects were 674 patients who underwent gastroscopy at Guro Hospital, College of Medicine, Korea University. from March 1 to September 30, 1986. The results are as follows : 1) There were no statistically significant differences in BDI and STAI between the negative group and positive group, and between the ulcer group and gastritis group. 2) There were no statistically significant differences in BDI and STAI between the gastric ulcer group and duodenal ulcer group, and among the chronic superficial group and erosive gastritis group and atrophic gastritis group. In atrophic gastritis group, there was no statistically significant difference in BDI and T-A among patients with mild, moderate or severe pathology. But in S-A, patients with severe pathology showed higher degree of anxiety than patients with mild or moderate pathology. 3) 25% of the positive group and 13% of the ulcer group and 23% of the gastritis group were rated as depressed by BDI(a score of 21 was used as criterion). 4) In the negative group, according to sex, there was significant difference in BDI and STAI. According to economic state, there was significant difference in BDI, but not in STAI. According to sleep pattern, there were significant difference in BDI and S-A, but not in T-A. 5) In the ulcer group, according to sex, education level, and sleep pattern, there were significant differences in BDI and S-A, but not in T-A. According to economic state, there was significant differences in T-A, but not in BDI or S-A. 6) In the gastritis group, according to age, there was significant differences in BDI but not in STAI. According to marital state, there was significant differences in BDI and T-A, but not in S-A. According to sex, economic state, educational level, early parental death, and sleep pattern, there was significant differences in BDI and STAI.

한국인 환자에서 Vancomycin의 집단약동학 (Population Pharmacokinetics)에 관한 연구

유경상,배균섭,이주연,조주연,장인진,신상구,신완균 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

서방형 Diltiazem제제의 개발을 위한 약동학/약력학적 특성 검토

유경상,배균섭,조주연,장인진,신상구 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

CAE 응용설계 기법을 이용한 클램프 척(Clamp chuck)의 금형설계 개선에 관한 연구

신명균,허용정,강성남 호서대학교 반도체제조장비국산화연구센터 2000 학술대회 자료집 Vol.2000 No.1

사출성형에 관한 연구는 오랜 역사를 가지고 있으며 공정 시뮬레이션을 위한 상용화된 CAE 프로그램을 포함하여 많은 연구가 진행되는 분야중의 하나이다 그러나 다양한 고분자 재료의 성질, 금형의 복잡한 형상 및 성형조건 등의 변화로 인해 금형설계 및 제작 그리고 사출성형시 상당한 어려움을 겪게 된다. 사출성형 공정에서는 금형온도, 플라스틱 재료, 냉각수, 보압과 사출압 등의 여러 가지 공정변수가 있어 현장전문가의 경험에 의해 사출금형의 제작이 이루어지는 경우가 보통이다. 이와 같은 경험에 의한 금형 제작은 상당한 납기지연과 노동집약적인 방식으로 흘러가게 된다. 금형 제작시 가장 고려해야 될 사항 중의 하나는 사출성형품의 수축이다. 사출성형에서 용융수지는 냉각, 고화하면서 수축하는데 성형품 치수를 유지하기 위해서는 수축하는만큼 금형의 치수를 보정하여야 한다. 이 수축률은 사용수지의 종류와 성형품 트기, 살두께 등에 따라 다르다. 또 동일한 수지일 경우에도 성형조건에 따라 변화하고 특히 배향성을 가진 수지는 유동방향에 따라서도 변화가 있다. 즉, 금형의 온도가 높으면 수축률은 증가하고 사출압력이 높으면 감소한다. 또한 살두께가 두껍고 길이가 길 때 수축률은 증가한다. 방향성이 있는 수지는 유동방향에 대하여 직각방향에서 가장 적다. 특히 방향성이 현저한 HDP에서는 유동방향에 따라 수축차가 크므로 성형할 때 변형을 일으키는 경우가 많다. 일반적으로 PE, PP, PA와 같은 결정성 수지는 PS, SAN, ABS 등의 비결정성 수지보다 수축률이 크다. 본 연구에서는 한조산업사에서 제작한 '클램프 척' 금형 제작과정에서 성형품의 수축으로 인한 금형의 치수보정에 있어서의 문제점을 유동해석 전용 CAE 프로그램인 C-mold를 사용하여 해석하고 평가하였다. 그리하여 현장 전문가가 경험적으로 여러 번의 시행착오를 거쳐 완성된 금형을 제작하던 기존의 방법보다 체계적이고 합리적이며 또한 신속하게 문제를 해결함으로써 궁극적으로 금형설계 및 제작 기간을 단축하고자 한다.

손바닥선인장의 방사선 방호 효과

신태균,김성호 제주대학교 생명과학연구소 1998 제주생명과학연구 Vol.1 No.-

제주특산 손바닥 선인장의 방사선 방호 효과를 확인 하기 위하여 선인장을 투여한 마우스에 방사선을 다양한 방법으로 조사한 후 소장움 생존(고선량 방사선, 12Gy), 조혈세포 생존(중등도선량 방사선, 6.5Gy), appotosis 형성(저선량 방사선, 2Gy) 실험법을 적용하여 관찰하였다. 방사선조사전 선인장을 투여한 실험군(경구투여: 음수 ml당 2mg 씩 7일간, 복강내주사 : 마리당 1mg 씩 방사선조사 24시간전)에서 소장움의 생존율 및 endogenous spleen colony의 형성정도에는 통계적으로 유의성 있는 차이는 관찰되지 않았다. 그러나 소장움에서의 apoptotic cell의 발생율은 선인장 투여군에서 유의성 있는 억제를 보았다. 이상의 결과는 선인장이 방사선방호 식품으로의 사용 가능성을 제시하였다. To examine the radioprotective effect of prickly pear(Opuntia ficus) sampled in Cheju, we studied crypt survival of intestine, endogenous spleen colony and colony and apoptosis in irradiated mice with or without intraperitoneal injection of prickly pear extract. Although the survival of crypt of intestine and endogenous spleen colony formation induced by radiation was not affected by the pretreatment of prickly pear extract, the frequency of radiation-induced apoptosis in intestinal crypt cells was significantly reduced by pretreatment of prickly pear extract. These findings suggest that prickly pear in part have a potential to protect irradiation through unknown mechanism.

장애,비장애인 휠체어 농구선수의 유산소 능력

김성수,이동희,황부근,신말순,배종진,윤진환,지용석,안희구 한국특수체육학회 2002 한국특수체육학회지 Vol.10 No.2

The purpose of this study was to analyzed the aerobic capacity of disability· able-bodied wheelchair basketball players. Cardiorespiratory parameters were measured during graded maximal exercise test. Exercise time, HRpeak, oxygen uptake(VO_2, L·min^-1, ml·min^-1·kg^-1), carbon dioxide production(VCO_2, L·min^-1), ventilation(L·min^-1) were examined in disability national elite male wheelchair basketball at letes(DA, N = 10), able-bodied wheelchair basketball athletes(AA, N = 10). All data were expressed in means and standard deviation. Exercise time, HRpeak, oxygen uptake, carbon dioxide production, ventilation were not different between groups. In conclusion, aerobic capacity of disability national elite male wheelchair basketball athletes is the same able-bodied wheelchair basketball athletes. These finding suggest that chronic wheelchair basketball training produce local adaptations in the functional upper body musculature.

췌장암 환자에서 알코올 내장신경 신경파괴블럭 후 발생한 간염

이상은,최석환,김영환,임세훈,이정한,이근무,정순호,최영균,김영재,신치만 인제대학교 2008 仁濟醫學 Vol.29 No.-

Splanchnic neurolytic block(SNB) with alcohol improves the management of pancreatic cancer pain. Adverse effects of alcohol SNB which include regional pain, hypotension, diarrhea, and acute alcohol intoxication are common, but acute hepatitis caused by alcohol neurolytic block is rare. A 63-year-old patient with pancreatic head cancer and liver metastasis had complete pain relief after both retrocrural tansdiscal SNB with 100% alcohol 10 ml. But, 1 day later, liver function test showed a high elevation in the aspartate aminotransferase (AST, 2182 IU/L) and alanine aminotransferase (ALT, 1807 IU/L). The patient had slight jaundice, general weakness, chilling, nausea and vomiting after SNB. Both AST and ALT decreased to 46 and 119 IU/L within 10 days with only supportive therapy. But, 19 days later, the patient died due to pneumonia. Our case illustrates the importance of clinical surveillance especially in patient with hepatic disease after alcohol SNB.

극단 저체중 신생아에서의 동맥관 개존증 결찰술을 위한 진정맥 마취 경험 2례

최영균,고명진,이상은,조광래,김영환,임세훈,이정한,이근무,정순호,김영재,신치만 仁濟大學校 白病院 2010 仁濟醫學 Vol.31 No.-

Running title: Cases of anesthesia for extremely low birth weight infant. Extremely low birth weight infants (birth weight < 1000 g) are prone to various morbidities such as respiratory distress syndrome, intraventricular hemorrhage, periventricular leukomalacia, patent ductus arteriosus, necrotizing enterocolitis and retinopathy. To accomplish successful anesthetic management, many precautions must be continuously taken during the operation. First, inspired oxygen concentration should be adjusted to avoid oxygen toxicity. Second, body temperature must be maintained adequately. Third, hemodynamic parameters should be kept stable. We report 2 cases of successful anesthetic management for extremely low birth weight infant who underwent ligation of patent ductus arteriosus at the neonatal intensive care unit.

Rocuronium의 애별투여방법이 모지내전근의 이완에 미치는 영향

최영균,김승수,이원진,조광래,이상은,김영환,임세훈,이정한,이근무,정순호,김영재,신치만 인제대학교 2009 仁濟醫學 Vol.30 No.-

Objective : There are controversies in pnmmg technique of rocuronium whether it can or can't shorten the onset time. We want to compare the effects of two different priming doses and intervals of rocuronium. Materials and Methods : After giving propofol, 50 patients were randomly assigned to 5 groups. Group I received a placebo, followed 3 min later by rocuronium 0.6 mg/kg. Priming doses and intervals of Group II, Ill, N, V were 0.06 rng/kg and 2 min, 0.12 mg/kg and 2 min, 0.06 rug/kg and 3 min, 0.12 mg/kg and 3 min, respectively. Total dose of rocuronium was 0.6mg/kg. Train of four (TOF) count or ratio and 1st twitch height of TOF (T1) were monitored with 15 secondsintervals. TOF ratio of each groups just before bolus injection, duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were compared. Results : Duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were decreased in priming groups compared to Group 1 (P < 0.01) In group V, significant depression of TOF ratio just before bolus injection was seen (P < 0.05). Conclusion : Priming technique with rocuronium is effective method to shorten the onset of neuromuscular block. But priming dose of rocuronium itself could cause hypoxia and aspiration in awake patients and should be used carefully. Priming dose of rocuronium 0.06 mg/kg and 2 minutes interval maybe relatively safe method.

Ciprofloxacin 제제의 생물학적 동등성에 관한 연구

최철희,신재국,신완균,유호진,이경훈,정원석,장인진,신상구 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1

국내 시판중인 ciprofloxacin 제제인 Citopcin®(250㎎ tablet)의 동등성을 검토하기 위해 제조원인 Bayer사의 Citopcin®(250㎎ tablet)를 기준제제로 하여 18명의 건강한 남성 피험자를 대상으로 500㎎ 1회 교차 경구 투여후 약동학적 성상을 분석비교한 결과는 다음과 같다. 시험제제의 생체 이용율의 지표인 AUC, C_(mao), T_(max) 및 MRT들의 평균치는 백분율차이에 있어 모든 기준제제 지표의 ± 20% 이내였으며, 이들 생체 이용율 지표들은 분산분석 검정에서 차이를 인지할 수 없었다.생체 이용율 지표들의 기준제제에 대한 백분율 90% 대칭 신뢰구간 검토시 모든 경수들에서 ± 20% 이내의 조건을 만족하였으며 AUC의 경우에는 대칭형 신뢰구간으로 변환시 95% 신뢰구간에서도 동등성의 조건을 만족하였다, 이상의 시험결과로 시험제제인 Citopcin®은 기준제제인 Ciprobay®와 생물학적 동등한 제제로 판단되었다. The pharmacokinetics of ciprofloxacin was studied for the evaluation of the bioequivalence of the generic ciproflocacin products. Two single doses of 500㎎ each of ciprofloxacin(Ciprobay® 250㎎ tablet as a reference compound and Citopcin® 250㎎ tablet s a test compound) were administered orally to ighteen male volunteers in a balanced, randomized crossover design. Pek plasma levels of ciprofloxacin were observed about 1 hour after the doses and the peak concentrations of both products were similar(Ciprobay®, 3.18㎍/㎖; Citopcin®, 2.89㎍/㎖). The values of other pharmacokinetic parameter of ciprofloxacin computed for Ciprobay® are presented in that order: AUC=13.53:12.47㎍·h/㎖, T_(max)=1.28:1.14 hours; MRT=5.30:5.08 hours; t_(1/2)β=3.65:3.47 hours. No satistically significant, differences were detected when AUC and the other parameters were compared with the method of ANOVA. Using the criteria of 90% confidence interval for the assessment of bioequivalence al the parameters were acceptable. The products were found to be equivalent on the premise that no significant difference was detected when the relevant pharmacokinetic parameters were compared, and the confidence limit analysis showed acceptable results.