소아의 상완골 원위부 과간 골절

이우석,정환용,김우식,김용찬,전택수,김남현,김규태 대한골절학회 2004 대한골절학회지 Vol.17 No.4

상완골 원위부 과간 골절은 소아에서는 매우 드물게 발생되는 골절로 대부분 주관절의 굴곡상태로 주관절 후방부에 직접적인 충격에 의해 발생하는 것으로 보고되고 있다. 전위가 없거나 경미한 경우 도수적 정복술 혹은 도수적 정복술 후 경피적 핀고정술을 시행하며, 전위가 심한 골절이거나 도수적 정복술이 불가능한 경우 관혈적 정복술 후 핀고정술을 시행하는 것으로 알려져 있다. 저자들은 전위된 상완골 원위부 과간 골절 환아 2예에서 각각 도수적 정복술과 관혈적 정복술 후 K 강선 고정술을 시행하여 만족한 결과를 얻었기에 보고하는 바이다. Intercondylar fractures of the distal humerus are very rare in children. The pattern of the fracture would suggest that the mechanism of injury involves a fall directly on the flexed elbow. Most agree that the undisplaced fracture can be managed conservatively. With increasing displacement and comminution, the opinions tend to differ. We suggest that closed reduction with percutaneous K wire pinning and open reduction with percutaneous K wire pinning offer a satisfactory methods by which to treat displaced intercondylar fracture in children.

한국산 수산물의 방사능 오염도에 관한 연구

金又俊,李昌男,丁奎珍 여수대학교 1998 論文集 Vol.13 No.2

This study was carried out to investigate the of radioactivity of Iodine-131, cesium-134 and cesium-137 with the purpose of preserving the health and sanitation of the public in marine product of Korea. In the contacts of radioactivity of marine products collected from East sea of Korea, 131I was detected only 137Cs contents were at 0.07∼0.63 Bq/Kg range. 134Cs was not detected in all used sample, In products collected from west sea of Korea, 131I was detected at 0.72 Bq/Kg value at only spotted halibut and 137content were at 0.08∼0.29 Bq/Kg range in sample of five Species. In samples collected from south sea of Korea, detecting range of 131I was 0.01∼1.19 Bq/Kg in Glue plant and white shrimp, and 137Cs was detected at 0.14 Bq/Kg in putter and sea cuccmbers respectively. But these nuclides in South sea of Korea were detected at lower rate than that of the other coasts of Korea. From the result of this study, radioactive contents in marine products of Korea. The content of radioactivity in all used samples were naturale ones.

실험적 종양 모델에서의 자기공명영상과 조직학적 소견의 비교 연구

신규호,서진석,양우익,김남현 中央醫學社 1999 中央醫學 Vol.64 No.1

결락이 있는 3×3 교차설계법에서의 생물학적 동등성시험

임남규,김정일 대전대학교 기초과학연구소 2000 自然科學 Vol.11 No.2

최근 동일한 유효 성분을 가지면서 용량 혹은 형식만이 다른 제제의 개발이 증가되고 이에 따라 두 제제 이상에 대한 생물학적 동등성 시험의 필요성이 제기되고 있다. 중앙약심은 한 회사에서 개발된 제품으로서 동일한 유효성분을 함유하고 용량만이 다른 두 시험제제에 대하여 동시에 시험을 행할 경우에 3×3 교차설계법에 의한 생물학적 동등성 시험을 인정하기로 하였다. 이에 이영주 등 (1998)은 온단세트론 제제에 대한 생물학적 동등성시험에서 3×3 교차설계법을 적용하였다. 그러나 오현숙 등(1999)에 의하면 3×3 교차설계법에서 각각 순서에 피험자의 수가 다르거나 실험 중에 결락(dropout)되는 피험자가 발생하는 경우에는 일반적인 통계적 방법을 적용하기 어려웠다. 이에 본 연구에서는 이러한 경우에 제제효과의 추론과 생물학적 동등성 시험에 대한 통계적 방법에 대해 논의하였다. In recent years, the generic drug products which provide the same therapeutic effect with an innovator drug product have become very popular in pharmacokinetic area. Since assessing bioequivalence of a generic drug with the innovator is required prior to distribution in markets, bioavailablity/bioequivalence studies in comparing several generic drugs simultaneously with the innovator is highly interested. In such circumstance, the Korean Drug Administration announces officially the partial acceptance regulation for the bioequivalence with the results from a 3 x 3 crossover designs when the generic drugs which contain same active ingredients and are produced by a same company are compared with the innovator in an experiment. Lee et a1.(1998), motivated from this new policy, try to assess hioequivalence of Ondensetron drugs using the 3 X 3 latin squares. In bioavailability and bioequivalence studies, the observed data set from a 3 x 3 cross-over design is unbalanced so that standard statistical methods for a cross-over design may not apply drectly. For drug and period effects, we propose a method based on differences of the observations that eliminates the random subject effects and thus does not require any distributional condition on the random subject effects.

상관계수검정에서 Score 검정

이은구,김정일,임남규 대전대학교 기초과학연구소 1996 自然科學 Vol.7 No.2

단순상관계수는 두변수간의 선형적인 연관관계를 나타내는 모수이다. 즉, 이는 두변수에 대해 얻어진 값들이 선형함수를 나타내는 직선의 주변에 어느정도 집중되어 있는지를 의미한다. 이러한 단순상관계수를 어느정도 집중되어 있는지를 측정함을 의미한다. 이러한 단순상관수를 검정함에 있어서 귀무가설이 ρ가 0일때는 표본상관계수 R의 함수가 t-분포를 따름을 이용하여 그 기각역을 구하였고, ρ가 0이 아닐 때에는 Fisher(1921)의 근사검정방법인 z-검정을 이용하였다. 그러나 본 연구는 상관계수검정을 Cox & Hinkley(1974)가 제안한 근사검정방법인 Score 검정에 응용하여 모의실험방법으로 위의 검정방법들과 비교하였다. The simple correlation coefficient is a statistical parametor for concerning linear relationship between two random variables. It measures the degree of concentration in samples around a linear function. When we test null hypothesis ρ=0, we derive critical regions based on the fact that the function of sample correlation coefficient follows t-distribution. On the other hand, if the null hypothesis ρ=ρo(≠0) we may use Fisher's z-test(1921). In this article we have applied score test (Cox & Hinkley (1974)) to testing correlation. We have compared the powers of score test with those of t-test and Fisher's z-test with respect to the method of simulation.

口腔領域에 發生한 囊腫에 關한 臨床 및 統計學的 硏究

李春根,金圭植,南日祐,申相澈 醫藥係社 1954 綜合 醫學 Vol.11 No.12

齒根囊腫에 關한 臨床 및 統計學的 硏究

李春根,金圭植,南日祐,河正洙 中央醫學社 1967 中央醫學 Vol.12 No.1

We have studied on clinical and statistical studies of periodontal cysts developed from 46 patients. The results were obtained as follows, 1) Periodontal cysts are more frequent in females (52.17%) than that in males (47.83%). 2) Predominant ages are third decade (34.78 % ), fifth decade (23. 91 % ), second decade and fourth decade (each other 17.39%) and sixth decade (6.52 %) in the orders. 3) In the etiological teeth of periodontal cysts, the upper central and lateral incisors, lower first and second molars are prevalent. 4) periodontal cysts are more frequent in maxilla (70 %) than that in mandible (30%). The predominant region of periodontal cysts are anterior region of maxilla and molar region of mandible. 5) The 46 periodontal cysts have been treated by means of direct enucleation technique of cyst walls in 43 cases and apicoectomy in 3 cases.

Considerations and Protocols in Virtual Surgical Planning of Reconstructive Surgery for More Accurate and Esthetic Neomandible with Deep Circumflex Iliac Artery Free Flap

Kim, Nam-Kyoo,Kim, Hyun Young,Kim, Hyung Jun,Cha, In-Ho,Nam, Woong Korean Association of Maxillofacial Plastic and Re 2014 Maxillofacial Plastic Reconstructive Surgery Vol.36 No.4

Purpose: The reconstruction of mandibular defects poses many difficulties due to the unique, complex shape of the mandible and the temporomandibular joints. With development of microvascular anastomosis, free tissue transplantation techniques, such as deep circumflex iliac artery (DCIA) flap and fibular free flap (FFF), were developed. The DCIA offers good quality and quantity of bone tissue for mandibular segmental defect and implant for dental rehabilitation. Virtual surgical planning (VSP) and stereolithography-guided osteotomy are currently successfully applied in three-dimensional mandibular reconstruction, but most use FFF. There are only a few articles on reconstruction with the DCIA that assess the postoperative results. Methods: Three patients admitted during a five month period (April of 2013 to August of 2013) underwent resection of mandible and DCIA musculo-osseous reconstruction using a VSP and stereolithographic modeling and assessment of outcomes included technical accuracy, esthetic contour, and functional outcomes. Results: This technique yielded iliac bone segment with excellent apposition and duplication of the preoperative plan. Flap survival was 100 percent and all patients maintained preoperative occlusion and contour. Conclusion: Based on our experience, we offer considerations and logically consistent protocols by classification of mandibular defects, and demonstrate the benefits in VSP and stereolithographic modeling of mandibular reconstructive surgery with DCIA flap.

Alveolar bone necrosis and spontaneous tooth exfoliation associated with trigeminal herpes zoster: a report of three cases

Nam-Kyoo Kim,Bong Chul Kim,Jung-woo Nam,Hyung Jun Kim 대한구강악안면외과학회 2012 대한구강악안면외과학회지 Vol.38 No.3

Herpes zoster is a viral infection caused by the reactivation of the varicella zoster virus, an infection most commonly affecting the thoracolumbar trunk. Herpes Zoster Infection (HZI) may affect the cranial nerves, most frequently the trigeminal. HZI of the trigeminal nerve distribution network manifests as multiple, painful vesicular eruptions of the skin and mucosa which are innervated by the infected nerves. Oral vesicles usually appear after the skin manifestations. The vesicles rupture and coalesce, leaving mucosal erosions without subsequent scarring in most cases. The worst complication of HZI is post-herpetic neuralgia; other complications include facial scarring, motor nerve palsy and optic neuropathy. Osteonecrosis with spontaneous exfoliation of the teeth is an uncommon complication associated with HZI of the trigeminal nerve. We report several cases of osteomyelitis appearing on the mandible, caused by HZI, and triggering osteonecrosis or spontaneous tooth exfoliation.

Anti-apoptotic Effect of Bojungbangam-tang Ethanol Extract on Cisplatin-Induced Apoptosis in Rat Mesangial Cells

Kim, Nam-Su,Ju, Sung-Min,Kwon, Young-Dal,Shin, Byung-Cheul,Ahn, Kyoo-Seok,Kim, Sung-Hoon,Song, Yung-Sun,Jeon, Byung-Hun The Physiological Society of Korean Medicine and T 2006 동의생리병리학회지 Vol.20 No.6

Cisplatin is a anti-neoplastic agent which is commonly used for the treatment of solid tumor. Cisplatin activates multiple signal transduction pathways involved in the stress-induced apoptosis in a variety of cell types. Cytotoxicity of cisplatin was detected in rat mesangial cells and the value of $IC_{50}$ is about 20 ${\mu}M$. The treatment of cisplatin to rat mesangial cells showed the apoptotic bodies and DNA fragmentation. The activation of caspase-3, -8, and -9 and proteolytic cleavage of PARP were observed in the rat mesangial cells treated time-dependently with cisplatin. The activation of ERK, p38 and JNK was also observed in the apoptosis induced by cisplatin in rat mesangial cells. The ethanol extract of Bojungbangam-tang (EBJT), a new hergal prescription composed of nine crude drugs, inhibited cisplatin-induced apoptosis in rat mesangial cells. EBJT reduced sub-G1 peak (apoptotic peak) in cisplatin-treated rat mesangial cells. The cisplatin-induced ERK and JNK activation in rat mesangial cells were blocked by EBJT, but EBJT had no effect on p38 activation. Taken together, these results con suggest that EBJT prevents cisplatin-induced apoptotic cell death in rat mesangial cells through inhibition of ERK and JNK activation.