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RISS 인기검색어
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- 저자 : ( Ji Yoon Choo ) (검색결과 78 건)
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주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4
Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)
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노인 인구에서 신경인지기능저하와 혈청 지질농도와의 상관성
유영선,최석주,정성수,김지은,윤성욱,전동욱,백준형,박성우,이정구,추일한,김영훈 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.6
Objectives : In this study, the authors evaluated the correlation between eurocognitive impairments and serum lipids levels among Korean elderly over the age of 65. Methods : A total of 609 elderly individuals participated in this study. Screening for cognitive impairments were carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). There were 197 subjects above 1.5SD Of MMSE- KC and they were evaluated using the Korean versions of the Consortium to Establish a Registry for Alzheimer's Disease (AD) (CERAD-KC) and Geriatric Depression Scale (GDS-K). Results : There was a correlation between old age/low levels of education and AD (p<0.05, P<0.01). There was an inverse correlation between the serum level of total cholesterol and the word list recognition test scores. The serum levels of LDL cholesterol were inversely correlated with the scores on the constructional praxis test, word list recall test and word list recognition test. Inverse correlations between the serum level of triglyceride and scores on the word list recall test and word list recognition test were also observed. Conclusion : There were inverse correlations between the serum levels of lipids and language/memory function in subjects with AD.
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( Ji Yoon Choo ),( Ji Hyun Lee ),( Jun Young Lee ),( Young Min Park ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Cutaneous vasculitis is an inflammatory process of vessels whose diagnosis is based on the histologic evidence of endothelial damage. However, random selection of the biopsy site from lesions can’t always promise to confirm vasculitis. Objectives: To determine the dermoscopic features of ‘true vasculitis’ which may facilitate to select the optimal biopsy site. Methods: From the histopathologic data base of recent 2 years, 27 biopsy-proven cases with dermoscopic imagesavailable were finally included in this study. These cases were divided into two groups; ‘vasculitis’ or ‘vasculopathy’ group according to the histopathologic criteria for ‘true vasculitis’. Nine specimens fulfilled the standard criteria of vasculitis (‘vasculitis’ group) and 18 specimens who failed to satisfy the criteria were included in ‘vasculopathy’ group. We compared the dermoscopic images between two groups. Results: Whitish blotch was shown in 6 cases (75.0%) of ‘vasculitis’ group, whereas that in 2 (15.8%) of ‘vasculopathy’ group (P=0.006). Mottled purpuric pattern, orange-brown background, and purpuric globules were demonstrated in 100%, 66.7%, 55.6%, respectively, of ‘vasculitis’ cases, and in 83.3%, 77.8%, 50.0%, respectively, of ‘vasculopathy’ cases (P=0.495, 0.653, 1.0, respectively). Conclusion: Our results suggest the whitish blotch is the most helpful dermoscopic finding of true vasculitis to select the optimal biopsy site.
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A rare case of adenoid basal cell carcinoma
( Ji Yoon Choo ),( Ju Hee Han ),( Ji Hyun Lee ),( Young Min Park ),( Jun Young Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Adenoid type basal cell carcinoma (BCC) is rare histopathological variant accounting 5.9 % of all BCC. Clinically, adenoid BCC present as pigmented and nonpigmented nodule or ulcer without any site predilection. Herein, we report on a case of adenoid BCC occurring in unusual site. A 77-year-old female presented with a pruritic, 2cm-sized, skin-colored to brownish mass with telangiectasia on the trunk since childhood. She had no past history or family history of skin cancer. At dermoscopic examination we observed vascular pattern with linear-irregular vessels, multiple blue-gray dots and ovoid nests. The histopathological examination showed a multiple cyst-like structures with proliferation of basaloid cells that extended into the dermis. In the center of the cyst-like enlarged structure, the basaloid cells showed slightly enlarged, hyperchromatic nuclei and scanty cytoplasm. Immunohistochemical staining for CEA, EMA and S-100 was negative and P63 and Ki-67 was positive. After no evidence of distant metastasis was confirmed, wide excision was done.
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A case of Vogt-Koyanagi-Harada (VKH) syndrome with alopecia universalis in an adolescent girl
( Ji Yoon Choo ),( Young Hoon Yoon ),( Ji Hyun Lee ),( Young Min Park ),( Jun Young Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Vogt-Koyanagi-Harada (VKH) syndrome is a rare systemic disorder and an idiopathic autoimmune disease characterized by panuveitis in association with cutaneous, neurologic, and auditory abnormalities. It usually affects darker-pigmented individuals, especially members of the Asian, Indian, and Latin races. Women are more affected than men (2:1), and the peak incidence is seen in the third or fourth decade of life. It is rarely seen in children, with one study indicating that only 3% of all VKH cases are observed in childhood. The cutaneous features are alopecia and vitiligo or poliosis, dependent upon the site of melanocyte location. Alopecia usually appears as discrete, alopecic patches around the head. However, in our knowledge, only a few cases have been reported diffuse hair loss and only one previous case has been reported alopecia universalis with VKH syndrome. A 13-year-old woman presented with asymptomatic, diffuse hair loss and depigmented patches on the scalp since 1 year ago. She had been suffered total hair loss on the whole body after 2 months. She had uveitis, meningitis and tinnitus for several years, but no family history. According to clinical manifestation, diagnosis of VKH disease was established. Herein, we report a rare case of VKH syndrome with alopecia universalis in an adolescent period.
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( Ji Yoon Choo ),( Han Mi Jung ),( Ji Hyun Lee ),( Tae Yoon Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Stucco keratosis (STK) clinically presents as typical whiteor white-grey warty papules having a diameter of only a few millimeters. STK preferentially occurs in older patients on the extensor surfaces of the forearm and lower legs and dorsal aspects of the hands and feet. The distribution of the lesion suggests a possible involvement of lifetime ultraviolet (UV) exposure. They usually appear in large numbers, often more than 100. The lesion could be removed by curettage or gentle scraping. STK generally shows up at age 40 years and older, with the higher prevalence in males up to four times. STK is not inherited genetically in contrast with acrokeratosis verruciformis of Hopf, which is similar to STK clinically and pathologically. A 68 years-old man presented asymptomatic, multiple, whitish, small, verrucous scaly papules on the extremities for several months. The lesions were small in size (from 2mm to 5mm), and increased in number gradually. He had a past medical history of Leriche’s syndrome and prostate cancer with no familial history of any skin diseases. Skin biopsy was done on his rt. dorsum of hand. The histopathologic findings showed diffuse hyperkeratosis, papillomatosis and peaked church-spire acanthosis in epidermis, and sparse perivascular lymphohistocytic infiltration in upper dermis. The clinical and pathological findings were consistent with STK. We report a case of Stucco keratosis as a rare case.
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( Yoon Jae Jeon ),( Ji Yoon Choo ),( Jin Hee Kang ),( Jin A Kim ),( Woo Seok Jeon ),( Tae Yoon Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Rhododendron brachycarpum has been used in a traditional oriental medicine for the treatment of skin diseases such as psoriasis and eczema. In human innate immune defense, TLR7 is highly expressed in some skin diseases, such as psoriasis. Objectives: In this study, we demonstrated whether rhododendrin isolated from Rhododendron brachycarpum could inhibit TLR7 signaling-mediated skin inflammation. We showed that TLR7 is expressed on the differentiated normal human epidermal keratinocytes induced by calcium, and rhododendrin could inhibit imiquimod-induced NF- B activation and the expression of TNF- , IL-6 in normal human epidermal keratinocytes. Methods: To explore the inhibitory effect of rhododendrin on skin inflammation in vivo, we pretreated the rhododendrin in mouse skin followed by imiquimod treatment. Results: The result showed that imiquimod-induced increase in skin thickness was inhibited in a dose-dependent manner by treatment with rhododendrin and major induced inflammatory cytokines and chemokines, such as IL-17, CCL20 and IL-6 were reduced by the treatment with rhododendrin. We also demonstrated that rhododendrin could inhibit IL-23-induced psoriasis-like skin inflammation. Conclusion: These results suggest that rhododendrin has an anti-inflammatory effect on the skin inflammation and imply that it has therapeutic potentials for the skin inflammatory diseases, such as psoriasis.
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