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- 저자 : ( In Ao Cho ) (검색결과 8 건)
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Modified Shirodkar Procedure in Emergency Cervical Cerclage
( In Ao Cho ),( Wan Ju Kim ),( Yoon Kyoung Lee ),( Jin Sook Seok ),( In Young Choi ),( Ji Hye Lee ),( Jeong Kyu Shin ),( Won Jun Choi ),( Soon Ae Lee ),( Jong Hak Lee ),( Won Young Paik ),( Ji Kwon Pa 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-
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Ao, X.,Meng, Q.W.,Yan, L.,Kim, H.J.,Hong, S.M.,Cho, J.H.,Kim, I.H. Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.12
Two experiments with growing pigs were conducted to investigate the effects of two distinct multienzyme preparations on nutrient digestibility, growth performance and blood profiles. In Exp. 1, a total of 96 pigs ($29.7{\pm}0.69\;kg$) were utilized in a 42-day performance and digestibility trial using four dietary treatments: CON (control diet), ENDO (control+0.10% Endopower), NSPase1 (control+0.10% NSPase) and NSPase2 (control+0.20% NSPase). Endopower was a commercial multienzyme preparation which contained ${\alpha}$-galactosidase, galactomannase, xylanase and ${\beta}$-glucanase. NSPase mainly contained ${\alpha}$-1,6-${\beta}$-galactosidase, ${\beta}$-1,4-mannanase and ${\beta}$-1,4-mannosidase. There were six replication pens per treatment with four pigs per pen. Pigs fed NSPase1 diet had a higher ADG (p<0.05) and G:F (p<0.05) than those fed the control diet. There were no significant differences in growth performance among the multienzyme treatments (p>0.05). Compared with CON, apparent digestibility of DM was increased (p<0.05) by ENDO treatment. N digestibility was improved (p<0.05) in response to multienzyme treatments during the experimental period. Blood urea nitrogen (BUN) was higher (p<0.05) in ENDO treatment than in CON and NSPase1 treatments at the end of the experiment, while the glucose level improved (p<0.05) due to ENDO and NSPase2 treatments. In Exp. 2, four ileal-cannulated, growing barrows ($20.17{\pm}1.31\;kg$) were housed in individual metabolism crates and randomly assigned to 1of 4 treatments (same as Exp. 1) within a $4{\times}4$ Latin square design. Enzyme supplementations improved the majority of apparent ileal amino acid digestibilities (p<0.05). It is concluded that the supplementation of NSPase1 improved growth performance as well as N digestibility and partially improved apparent ileal amino acid digestibility in growing pigs fed a diet based on corn and soybean meal.
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( Ao Xuan Zhen ),( Mei Jing Piao ),( Yu Jae Hyun ),( Kyoung Ah Kang ),( Yea Seong Ryu ),( Suk Ju Cho ),( Hee Kyoung Kang ),( Young Sang Koh ),( Mee Jung Ahn ),( Tae Hoon Kim ),( Jin Won Hyun ) 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.4
Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis via oxidative stress, particulate matter 2.5 (PM<sub>2.5</sub>) was shown to trigger excessive production of reactive oxygen species. In this study, we observed that UVB radiation and PM<sub>2.5</sub> severely damaged human HaCaT keratinocytes, disrupting cellular DNA, lipids, and proteins and causing mitochondrial depolarization. Purpurogallin protected HaCaT cells from apoptosis induced by UVB radiation and/or PM<sub>2.5</sub>. Furthermore, purpurogallin effectively modulates the pro-apoptotic and anti-apoptotic proteins under UVB irradiation via caspase signaling pathways. Additionally, purpurogallin reduced apoptosis via MAPK signaling pathways, as demonstrated using MAPK-p38, ERK, and JNK inhibitors. These results indicate that purpurogallin possesses antioxidant effects and protects cells from damage and apoptosis induced by UVB radiation and PM<sub>2.5</sub>.
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Ao, X.,Kim, H.J.,Meng, Q.W.,Yan, L.,Cho, J.H.,Kim, I.H. Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.11
Two experiments were conducted to evaluate the effects of diet complexity and fermented soy protein on growth performance and amino acid digestibility. In Exp. 1, a total of 120 crossbred weanling pigs ($5.68{\pm}0.80\;kg$ BW) were randomly allocated into 4 treatments. Each treatment had 6 replicate pens comprising 5 pigs in each replicate. Experimental diets consisted of simple (soybean meal as protein source) and complex (soybean meal, rice protein concentrate, potato protein concentrate and fish meal as protein sources) diets; each diet contained 0 or 5% fermented soy protein (FSP), respectively. Dietary treatments included: i) simple diet; ii) simple diet with 5% FSP; iii) complex diet; iv) complex diet with 5% FSP. Pigs were provided each experimental diet for 20 d (phase 1) and then fed the same common diet for 10 d (phase 2). During days 0-10, pigs fed FSP diets had greater ADG than those fed non-FSP diets (p<0.05). G/F in FSP treatments was significantly higher than that in non-FSP treatments (p<0.05) from days 0 to 10. Throughout the overall period, G/F was greater in FSP treatments compared with non-FSP treatments (p<0.05). On d 10, N digestibility was higher in pigs fed FSP diets than in those fed non-FSP diets (p<0.05). Diet complexity did not affect growth performance and nutrient digestibility (p>0.05) in this experiment. In Exp 2, 12 ileal-cannulated, weanling barrows were housed in individual metabolism crates and randomly assigned to 1 of 4 treatments (same as Exp. 1) by using a $4{\times}4$ Latin square design. Among the essential amino acids, apparent ileal digestibility (AID) of Met and Val were increased in pigs fed FSP diets compared with those fed non-FSP diets (p<0.05). AID of Met, Phe and total essential amino acids were higher in pigs fed complex diets than in those fed simple diets (p<0.05). Among the non-essential amino acids, AID of Ala in FSP treatments was greater than that in non-FSP treatments (p<0.05). In addition, Asp, Cys, Glu, Pro, Ser and total non-essential amino acid digestibilities in pigs fed complex diets were higher compared with those fed simple diets (p<0.05). Interaction was observed in AID of Met, Asp and Pro. In conclusion, these results indicated that feeding of 5% FSP to nursery pigs improved feed efficiency and AID of amino acids, and diet complexity did not maximize the growth performance of pigs in the subsequent phase.
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Meng, Q.W.,Yan, L.,Ao, X.,Jang, H.D.,Cho, J.H.,Kim, I.H. Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.11
This study was conducted to evaluate the effects of dietary supplementation with chito-oligosccharide (COS) on egg production, nutrient digestibility, egg quality and blood profiles in laying hens. A total of 240 Hy-line Brown laying hens were randomly allocated into one of the following 5 dietary treatments: i) CON, basal diet; ii) ANT, basal diet+44 mg/kg avilamycin; iii) COS0.2, basal diet+200 mg/kg COS; iv) COS0.4, basal diet+400 mg/kg COS; v) ANTCOS, basal diet+200 mg/kg COS+22 mg/kg avilamycin. The experiment lasted for 6 wk. No change in egg weight (p>0.05) was observed during the trial period. Egg production in ANTCOS treatment was improved (p<0.05) when compared to CON during weeks 4-6. The birds in the COS0.2, COS0.4 and ANTCOS groups had higher (p<0.05) Haugh unit than those fed CON and ANT diets at the end of the $6^{th}$ wk. The apparent digestibility of nitrogen in CON group was lower (p<0.05) than in other treatments. The white blood cell (WBC) concentration of birds in the COS0.4 and ANTCOS group was higher (p<0.05) than that of birds in other groups at the end of the $6^{th}$ wk. In addition, the differences of WBC counts between the beginning and end of the experiment in COS0.4 and ANTCOS groups were higher (p<0.05) than in CON and ANT groups. At the end of the experiment, the birds fed ANTCOS diet showed higher (p<0.05) total blood protein concentration than those fed CON or ANT diets. In conclusion, dietary supplementation of COS appeared to increase egg production and quality by increasing nutrient digestibility. Additionally, COS improved WBC and total protein concentration.
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Kang, Kyoung Ah,Piao, Mei Jing,Hyun, Yu Jae,Zhen, Ao Xuan,Cho, Suk Ju,Ahn, Mee Jung,Yi, Joo Mi,Hyun, Jin Won Nature Publishing Group UK 2019 Experimental and molecular medicine Vol.51 No.4
<▼1><P>Luteolin, a dietary flavone, modulates various signaling pathways involved in carcinogenesis. In this study, we investigated the molecular mechanism that underlies the apoptotic effects of luteolin mediated by DNA demethylation of the nuclear factor erythroid 2-related factor 2 (Nrf2) promoter and the interaction of Nrf2 and p53, a tumor suppressor, in human colon cancer cells. Luteolin increased the expression of apoptosis-related proteins and antioxidant enzymes. In DNA methylation, luteolin inhibited the expression of DNA methyltransferases, a transcription repressor, and increased the expression and activity of ten-eleven translocation (TET) DNA demethylases, a transcription activator. Methyl-specific polymerase chain reaction and bisulfite genomic sequencing indicated that luteolin decreased the methylation of the Nrf2 promoter region, which corresponded to the increased mRNA expression of Nrf2. In addition, luteolin increased TET1 binding to the Nrf2 promoter, as determined using a chromatin immunoprecipitation (ChIP) assay. TET1 knockdown decreased the percentages of luteolin-treated cells in sub-G<SUB>1</SUB> phase and cells with fragmented nuclei. Furthermore, complex formation between p53 and Nrf2 was involved in the apoptotic effects of luteolin. These results provide insight into the mechanism that underlies the anticancer effects of luteolin on colon cancer, which involve the upregulation of Nrf2 and its interaction with the tumor suppressor.</P></▼1><▼2><P><B>Cancer: Cell-killing plant compound exerts antioxidant effects</B></P><P>A molecule found in fruits, vegetables and herbs helps kill colon cancer cells by activating a master regulator of detoxifying enzymes. Jin Won Hyun from Jeju National University School of Medicine in South Korea and colleagues treated human colon cancer cells with luteolin, a molecule that occurs naturally in many food plants. They showed that luteolin increased the levels of proteins involved in cell death and antioxidant responses by causing DNA-modifying enzymes to strip suppressive chemical markers off the gene encoding Nrf2, a protein that regulates antioxidant effects. Nrf2 levels subsequently increased and the protein interacted with the tumor suppressor p53 to facilitate destruction of the colon cancer cells. The findings offer a mechanistic basis for using luteolin to help prevent and treat cancer.</P></▼2>
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3,4-Dicaffeoylquinic acid protects human keratinocytes against environmental oxidative damage
Hyun, Yu Jae,Piao, Mei Jing,Kang, Kyoung Ah,Ryu, Yea Seong,Zhen, Ao Xuan,Cho, Suk Ju,Kang, Hee Kyoung,Koh, Young Sang,Ahn, Mee Jung,Kim, Tae Hoon,Hyun, Jin Won Elsevier 2019 Journal of Functional Foods Vol.52 No.-
<P><B>Abstract</B></P> <P>Skin is exposed to several harmful environmental effects including ultraviolet B (UVB) and air pollution, the most harmful component of which is particulate matter (PM). Damaging effects of UVB and PM include the generation of cellular reactive oxygen species (ROS), lipid peroxidation, protein carbonylation, DNA damage, and apoptosis. A compound with the potential to protect the skin against environmental oxidative damage is 3,4-dicaffeoylquinic acid (DQA), an antioxidant found in plant matter, including the coffee bean. In this study, we investigated the protective effects of DQA against UVB- and PM-induced oxidative cell damage in cultured human keratinocytes (HaCaT). We demonstrated that UVB, and PM with a diameter <2.5 µm (PM<SUB>2.5</SUB>), induced cellular damage via oxidative stress, and this was mitigated by the antioxidative action of DQA.</P> <P><B>Highlights</B></P> <P> <UL> <LI> DQA scavenged environmental UVB and PM<SUB>2.5</SUB>-induced intracellular ROS. </LI> <LI> DQA treatment attenuated environmental oxidative stressed-skin cellular modifications and apoptotic cell death. </LI> <LI> FFO may be developed as a functional food against environmental oxidative stress-induced skin damage. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Exposure of UVB or PM<SUB>2.5</SUB> increased intracellular ROS and induced oxidative stress in HaCaT cells. DQA protects against UVB or PM<SUB>2.5</SUB>-indeced oxidative damage. In addition, it protects against UVB-induced apoptosis through inhibiting activation MAPKs.</P> <P>[DISPLAY OMISSION]</P>
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