http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Taha Barkaoui,Selma Hamimed,Houda Bellamine,Insaf Bankaji,Noomene Sleimi,Ahmed Landoulsi 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.11
The aim of this study was to explore the possible protective mechanisms and to determine the antioxidant capacity of phenolic compounds extracted from Plantago albicans against lead acetate-induced hepatic injury. High performance liquid chromatography-photo diode array/electrospray ionization-mass spectrometry (HPLC-PDA/ESI-MS) assay was used to identify the P. albicans extract phenolic compounds. Animals received 100 mg of lead acetate/kg of body weight (bw) in the drinking water for a period of 30 days. The other groups of rats were orally administered with silymarin (300 mg/kg bw) or the P. albicans extract at two doses (100 and 300 mg/kg of bw), once daily, by gastric gavage for the same time. The P. albicans exhibited high total phenolic, flavonoid, and anthocyanin contents. The antioxidant in vitro activity demonstrated that the P. albicans exhibits an important effect against deleterious reactive species. The in vivo results showed that P. albicans prevented the lead acetate-induced significant changes on serum and liver lipid levels. In contrast, P. albicans succeeded in improving the biochemical parameters of serum and liver bringing them closer to the normal values of the control group. It also significantly promoted (P < .05) pro-inflammatory cytokines (TNF-α, IL-6, and NF-κB) in the liver of the experimental animals. The evaluated sample with HPLC-PDA/ESI-MS method showed to contain 10 dominant polyphenols, 2 hydroxycinnamic acids (p-coumaric acid and chlorogenic acids), 4 flavones (Apigenin, Luteolin, Cirsiliol, and Luteolin-7-O-rutinoside), and an anthocyanin (cyanidin-3-glucoside). Hence, it can be concluded that P. albicans could be a potent source of health-beneficial phytochemicals providing a novel therapy to protect liver against lead exposure.
이현숙(Hyunsook Lee),이준구(Joongoo Lee),김진철(Jinchul Kim),오재호(Jaeho Oh),장영미(Youngmi Jang),김미혜(Meehye Kim) 한국식품과학회 2011 한국식품과학회지 Vol.43 No.6
본 연구는 국내/수입 유통되는 식품과 건강기능식품의 발기부전치료제 및 그 유사물질 혼입 농도를 모니터링하고, 그 결과를 바탕으로 식품의 안전성을 확보하고자 하였다. 전국에서 유통중인 식품 및 건강기능식품 총 226건을 구입하고 24종의 발기 부전치료제 및 그 유사물질을 HPLC/PDA 및 LC-ESI-MS-MS를 이용하여 분석하였다. 고체 및 액체 시료의 전처리는 메탄올을 이용하여 추출하였다. 식품 및 건강기능식품 시료에서 확립된 시험법을 이용하여 식품과 건강기능식품 226건을 수거하여 모니터링한 결과, 5건의 성기능 표방 제품에서 acethylvardenafil, sildenafil, tadalafil이 검출되었다. 분석 결과, 검출량은 acethylvardenafil이 1종에서 21,476 ㎎/㎏(15 ㎎/capsule)이었으며, sildenafil이 2종에서 각각 52,778 ㎎/㎏(29 ㎎/capsule), 71,535 ㎎/㎏ (48 ㎎/capsule)이었고, tadalafil이 4종에서 9,772 ㎎/㎏(6 ㎎/capsule) -55,545 ㎎/㎏ (33 ㎎/capsule)이었다. 따라서 식품 및 건강기능식품 중의 발기부전치료제 및 그 유사물질에 대한 지속적인 실태조사가 요구된다. This study was conducted to monitor the concentrations of 24 anti-impotence drugs and their analogues in various foods and dietary supplements, with the aim of ensuring the safety of the foods and supplements. The measurements were done in 226 samples using high performance liquid chromatography/photodiode array detector (HPLC/PDA) and liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Five male sexual function enhancing products have been detected as follows: acethylvardenafil (21,476 ㎎/㎏; 15 ㎎/capsule from one sample), sildenafil (52,778 ㎎/㎏, 29 ㎎/capsule in one sample; 71,535 ㎎/㎏, 48 ㎎/capsule in one sample), and tadalafil (9,772-55,545 ㎎/㎏, 6-33 ㎎/capsule in four samples). A sustainable monitoring of anti-impotence drugs and their analogues in various foods and dietary supplement is recommended.
Quanjun Yang,Xiaolan Cui,Bin Wu,Yujing Shi,Xiaowei Du,Mingsong Fan,Zhaolin Sun,Chenggang Huang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.1
Bioassay-guided fractionation of extracts from Fructus Gardeniae led to analysis of its bioactive natural products. After infection by influenza virus strain A/FM/1/47-MA in vivo,antiviral activity of the extracts were investigated. The target fraction was orally administered to rats and blood was collected. High-performance liquid chromatography coupled with photo diode array detector and electrospray ion trap multiple-stage tandem mass spectrometry was applied to screen the compounds absorbed into the blood. A structural characterization based on the retention time, ultraviolet spectra, parent ions and fragmentation ions was performed. Thirteen compounds were confirmed or tentatively identified. This provides an accurate profile of the composition of bioactive compounds responsible for the anti-influenza properties.