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Lidia Morales,Nuria Acero,Antonio Galán,Carmen Perez-García,Luis Fernando Alguacil,Dolores Muñoz-Mingarro 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.9
Tynanthus panurensis (Bureau) Sanwith (Bignoniaceae) is a liana vine used in traditional Amazonian medicine as a tonic and energizer as well as a treatment for rheumatism. These traditional indications prompted this study of the antioxidant and anti-inflammatory activities of T. panurensis bark extract (ETP). Phytochemical analysis of ETP showed the presence of saponins and a high concentration of phenols and flavonoids. A battery of in vitro tests revealed that the extract has free radical–scavenging antioxidant properties and reduces microsomal lipid peroxidation, uric acid synthesis, and tumor necrosis factor-α production. The anti-inflammatory properties of ETP were further confirmed in vivo in a rat carrageenan edema model, in which the extract exhibited a potent activity. These results support the idea that T. panurensis bark extract could be beneficial for treating inflammation and are in agreement with one of the main traditional uses of this plant.
Oh, Chan-Ho,Kim, Nam-Seok,Yang, Jae-Heon,Lee, Hyun-Jin,Yang, Seok-Won,Park, Sae-Rom,So, Un-Ki,Bae, Jin-Beom,Eun, Jae-Soon,Jeon, Hoon,Lim, Jong-Pil,Kwon, Jin,Kim, Young-Suk,Shin, Tae-Yong,Kim, Dae-Keun 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.4
Three compounds were isolated from the ethyl acetate soluble fraction of the methanolic extract of the leaves of Catalpa ovata (Bignoniaceae) through repeated column chromatography. We investigated the effects of these compounds on T cell-mediated responses for tumor surveillance and proliferation in U937, HL60, and Molt-4 leukemia cells. Compounds 1-3 inhibited proliferation of those cells in a dose-dependent manner. Compound 3 showed mild effect in Molt-4 cell cytotoxicity. Compound 3 enhanced gene expressions of p53 and IL-4, but decreased IL-2 and IFN-${\gamma}$ genes in Molt-4 cell. Our findings indicate that compound 3 may enhance T cell-mediated immune responses and anticancer properties.
Jacaranda cuspidifolia Mart. (Bignoniaceae) as an Antibacterial Agent
Ana Lu´cia A. Arruda,Carla J.B. Vieira,Daniella G. Sousa,Regilene F. Oliveira,Rachel O. Castilho 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.12
This study evaluated, in vitro, the antimicrobial activity of the hexane extract (JCHE), methanol extract (JCME),and chloroform fraction (JCCF) of bark from Jacaranda cuspidifolia Mart. (Family Bignoniaceae), a Brazilian medicinal plant,traditionally used as anti-syphilis and anti-gonorrhea treatment. The antimicrobial activity was evaluated using the disc diffusion method followed by the determination of minimum inhibitory concentration (MIC) values. JCHE was not active against the bacteria evaluated. JCME presented antibacterial activity against Streptococcus pyogenes, Staphylococcus aureus, and Neisseria gonorrhoeae with MIC values of 16.3mg/mL, 9.1mg/mL, and 25.2mg/mL, respectively. JCCF was active against Staphylococcus epidermidis, S. aureus, Proteus mirabilis, Serratia marcescens, S. pyogenes, Enterobacter aerogenes, and N. gonorrhoeae with MIC values of 18.3mg/mL, 9.3mg/mL, 6.3mg/mL, 6.1mg/mL, 9.2mg/mL, 6.2mg/mL, and 25.2mg/mL,respectively. Phytochemical analysis of JCME and JCCF gave positive results for saponins, coumarins, flavonoids, tannins,quinones, alkaloids, triterpenes, and steroids. Verbascoside was isolated and identified as a major peak in JCME and JCCF highperformance liquid chromatography fingerprints and might contribute to the observed antimicrobial activity.
Dong-Hyun Kim,Kyung-Min Han,정인식,김대근,김성훈,권병목,정태숙,Mi-Hyun Park,Eun-Mi Ahn,백남인 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.5
The flower of Campsis grandiflora K. Schum. was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O. From the EtOAc fraction, seven triterpenoids were isolated through the repeated silica gel, ODS column chromatographies and preparative HPLC. From the result of physico-chemical data including NMR, MS and IR, the chemical structures of the compounds were determined as 3β-hydroxyolean-12-en-28- oic acid (oleanolic acid, 1), 3β-hydroxyurs-12-en-28-oic acid (ursolic acid, 2), 3β-hydroxyurs- 12-en-28-al (ursolic aldehyde, 3), 2α,3β- dihydroxyolean-12-en-28-oic acid (maslinic acid, 4), 2α,3β-dihydroxyurs-12-en-28-oic acid (corosolic acid, 5), 3β,23-dihydroxyurs-12-en-28-oic acid (23-hydroxyursolic acid, 6) and 2α,3β,23-trihydroxyolean-12-en-28-oic acid (arjunolic acid, 7). These teriterpenoids were isolated for the first time from this plant. Also, compounds 4, 5, 6, and 7 revealed relatively high hACAT-1 inhibitory activity with the value of 46.2±1.1, 46.7±0.9, 41.5±1.3 and 60.8±1.1% at the concentration of 100 µg/mL, respectively.
Jesu C. Ferreira-Ju´nior,Lucia M. Conserva,Rosangela P. Lyra Lemos,Genilda C. de Omena-Neta,Araken Cavalcante-Neto,Emiliano Barreto 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
The antinociceptive activity of icariside E4, adihydrobenzofuran-type lignan isolated from Tabebuiaroseo-alba (Ridley) Sandwith (Bignoniaceae) bark, wasevaluated in mice by using chemical and thermal models ofnociception. Intraperitoneal (i.p.) administration of crude T. roseo-alba bark extract and its methanol fraction inhibitedacetic acid-induced abdominal constriction in mice. Furthermore,i.p. administration of 0.1, 1, and 10 mg/kg oficariside E4 reduced the number of writhes evoked by aceticacid injection by 46.9, 82.3, and 66.6 %, respectively. Icariside E4 administration had no effect in the first phase ofthe formalin test, but it reduced nociceptive behavior in thesecond phase as indicated by a reduction in the licking time. Icariside E4 did not modify thermal nociception in the hotplatetest model, suggesting that it had a peripheral antinociceptiveaction. The antinociceptive effect of icariside E4 inthe writhing test was reversed by pre-administration ofglibenclamide, but not of naloxone, atropine, yohimbine, orhaloperidol. Together, these results indicated that theantinociceptive activity of icariside E4 from T. roseo-alba inmodels of chemical pain occurred through ATP-sensitiveK? channel-dependent mechanisms.
The complete chloroplast genome of Campsis grandiflora (Bignoniaceae)
박종선,XIHONG 한국식물분류학회 2022 식물 분류학회지 Vol.52 No.3
Campsis grandiflora (Thunb.) K. Schum is an ornamental species with various useful biological effects. The chloroplast genome of C. grandiflora isolated in Korea is 154,293 bp long (GC ratio: 38.1%) and has four subregions: 84,121 bp of large single-copy (36.2%) and 18,521 bp of small single-copy (30.0%) regions are separated by 24,332 bp of inverted repeat (42.9%) regions including 132 genes (87 protein-coding genes, eight rRNAs, and 37 tRNAs). One single-nucleotide polymorphism and five insertion and deletion (INDEL) regions (40-bp in total) were identified, indicating a low level of intraspecific variation in the chloroplast genome. All five INDEL regions were linked to the repetitive sequences. Seventy-two normal simple sequence repeats (SSRs) and 47 extended SSRs were identified to develop molecular markers. The phylogenetic trees of 29 representative Bignoniaceae chloroplast genomes indicate that the tribe-level phylogenic relationship is congruent with the findings of previous studies.
High Frequency In Vitro Regeneration of Kigelia pinnata L. Via Organogenesis
Puthur, Jos T.,Thomas, T. Dennis 한국식물학회 2004 Journal of Plant Biology Vol.47 No.1
An effective and reproducible protocol for the micropropagation of Kigelia pinnata L through high frequency callus regeneration is described. Seeds were surface sterilized before culturing on Gamborgs basal medium (B5 medium). After two weeks the cotyledonary node along with a portion of the hypocotyl were carefully excised from well-developed embryos and subcultured on B5 medium supplemented with different concentrations of 2,4-D and BAP. The cultured cotyledonary node explants showed callus formation at the base of the lower cut end of the hypocotyl. This callus showed shoot initiation after two weeks of subculture on the regeneration medium supplemented with various concentrations of BAP alone or in combination with NAA. The highest number of shoot regeneration occurred on medium containing 5 μM BAP and 0.1 μM NAA. The optimum rooting of the regenerated shoots was observed on %B5 medium supplemented with 4 μM IBA. Micropropagated plants were successfully established in soil in field condition with a survival frequency of 100%.
Kim, Dong-Hyun,Han, Kyung-Min,Chung, In-Sik,Kim, Dae-Keun,Kim, Sung-Hoon,Kwon, Byoung-Mog,Jeong, Tae-Sook,Park, Mi-Hyun,Ahn, Eun-Mi,Baek, Nam-In The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.5
The flower of Campsis grandiflora K. Schum. Was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H$_2$O. From the EtO Ac fraction, seven triterpenoids were isolated through the repeated silica gel, ODS column chromatographies and preparative HPLC. From the result of physico- chemical data including NMR, MS and IR, the chemical structures of the compounds were determined as 3${\beta}$-hydroxyolean-12-en-28-oic acid (oleanolic acid, 1), 3${\beta}$-hydroxyurs-12-en-28-oic acid (ursolic acid, 2), 3${\beta}$-hydroxyurs-12-en-28-al (ursolic aldehyde, 3), 2${\alpha}$,3${\beta}$-dihydroxyolean-12-en-28-oic acid (maslinic acid, 4), 2${\alpha}$,3${\beta}$-dihydroxyurs-12-en-28-oic acid (corosolic acid, 5), 3${\beta}$,23-dihydroxyurs-12- en-28-oic acid (23-hydroxyursolic acid ,6) and 2${\alpha}$,3${\beta}$,23-trihydroxyolean-12-en-28- oic acid (arjunolic acid, 7). These teriterpenoids were isolated for the first time from this plant. Also, compounds 4, 5, 6, and 7 revealed relatively high hACAT-1 inhibitory activity with the value of 46.2${\pm}$1.1, 46.7${\pm}$0.9, 41.5${\pm}$1.3 and 60.8${\pm}$1.1% at the concentration of 100${\mu}$g/mL, respectively.
Phytochemical Study on Catalpa ovata
Young, Han-Suk,Kim, Min-Sun,Park, Hee-Juhn,Chung, Hae-Young,Choi, Jae-Sue The Pharmaceutical Society of Korea 1992 Archives of Pharmacal Research Vol.15 No.4
From the stem bark of Catalpa ovata, lupeol, 2(4-hydroxyphenyl)ethyl triacotanoate, a mixture of 9-hydroxy .alpha.-lapachone, 9-methoxy $\alpha$-lapachone, ferulic acid, 6-feruloyl catalpol, catalposide and 6'-feruloyl sucrose were isolated and identified.