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Jesu C. Ferreira-Ju´nior,Lucia M. Conserva,Rosangela P. Lyra Lemos,Genilda C. de Omena-Neta,Araken Cavalcante-Neto,Emiliano Barreto 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
The antinociceptive activity of icariside E4, adihydrobenzofuran-type lignan isolated from Tabebuiaroseo-alba (Ridley) Sandwith (Bignoniaceae) bark, wasevaluated in mice by using chemical and thermal models ofnociception. Intraperitoneal (i.p.) administration of crude T. roseo-alba bark extract and its methanol fraction inhibitedacetic acid-induced abdominal constriction in mice. Furthermore,i.p. administration of 0.1, 1, and 10 mg/kg oficariside E4 reduced the number of writhes evoked by aceticacid injection by 46.9, 82.3, and 66.6 %, respectively. Icariside E4 administration had no effect in the first phase ofthe formalin test, but it reduced nociceptive behavior in thesecond phase as indicated by a reduction in the licking time. Icariside E4 did not modify thermal nociception in the hotplatetest model, suggesting that it had a peripheral antinociceptiveaction. The antinociceptive effect of icariside E4 inthe writhing test was reversed by pre-administration ofglibenclamide, but not of naloxone, atropine, yohimbine, orhaloperidol. Together, these results indicated that theantinociceptive activity of icariside E4 from T. roseo-alba inmodels of chemical pain occurred through ATP-sensitiveK? channel-dependent mechanisms.