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- 저자 : Emiliano Barreto (검색결과 2 건)
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Antinociceptive Activity of Aqueous Extract of Bowdichia virgilioides in Mice
Juliane P. Silva,Renato S. Rodarte,Andrea S. Calheiros,Cristiane Z. Souza,Fabio C. Amendoeira,Marco A. Martins,Patrı´cia Machado R. Silva,Valber S. Frutuoso,Emiliano Barreto 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.2
Bowdichia virgilioides Kunth (Family Fabaceae) is a plant that is distributed widely in the tropical and subtropical regions of the world. In the northeast region of Brazil, where B. virgilioides is called “sucupira-preta,” the stem bark is used in folk medicine to treatment of inflammatory and painful diseases. This study aimed to evaluate the antinociceptive activity of the aqueous extract of the dried stem bark of B. virgilioides. The aqueous extract of B. virgilioides in doses of 50, 100, 200, and 400mg/kg was administered orally 1 hour prior to pain induction. Only the doses of 200 and 400mg/kg produced an inhibition by 61% and 74%, respectively, in the number of abdominal writhings induced by acetic acid. This antinociceptive effect was not reversed by pretreatment with naloxone, indicating that the effect is not associated with the activation of opioid receptors. In the formalin test, using the two highest doses, the extract had no effect in the first phase but produced an analgesic effect on the second phase with the inhibition of licking time (P<.001). In the hot plate test, no effect was seen at the dose of 400mg/㎏ p.o. Our findings show that B. virgilioides contains pharmacologically active constituents that possess antinociceptive activity justifying its popular therapeutic use in treating conditions associated with the painful conditions.
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Jesu C. Ferreira-Ju´nior,Lucia M. Conserva,Rosangela P. Lyra Lemos,Genilda C. de Omena-Neta,Araken Cavalcante-Neto,Emiliano Barreto 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
The antinociceptive activity of icariside E4, adihydrobenzofuran-type lignan isolated from Tabebuiaroseo-alba (Ridley) Sandwith (Bignoniaceae) bark, wasevaluated in mice by using chemical and thermal models ofnociception. Intraperitoneal (i.p.) administration of crude T. roseo-alba bark extract and its methanol fraction inhibitedacetic acid-induced abdominal constriction in mice. Furthermore,i.p. administration of 0.1, 1, and 10 mg/kg oficariside E4 reduced the number of writhes evoked by aceticacid injection by 46.9, 82.3, and 66.6 %, respectively. Icariside E4 administration had no effect in the first phase ofthe formalin test, but it reduced nociceptive behavior in thesecond phase as indicated by a reduction in the licking time. Icariside E4 did not modify thermal nociception in the hotplatetest model, suggesting that it had a peripheral antinociceptiveaction. The antinociceptive effect of icariside E4 inthe writhing test was reversed by pre-administration ofglibenclamide, but not of naloxone, atropine, yohimbine, orhaloperidol. Together, these results indicated that theantinociceptive activity of icariside E4 from T. roseo-alba inmodels of chemical pain occurred through ATP-sensitiveK? channel-dependent mechanisms.
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