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이윤희,홍희현,임호영,윤영호 한국품질경영학회 2022 한국품질경영학회 학술대회 Vol.2022 No.2
화학무기로 사용되는 신경작용제는 고성능 미사일 대비 적은 비용으로 대량 생산이 가능하고 대량살상효과를 기대할 수 있어 가난한 나라의 핵무기라고 불릴 만큼 전술적 가치가 높다. 화학무기는 민간인을 포함한 대규모 살상 및 파괴를 유발하므로 화학무기금지협약(CWC)에 따라 화학무기를 개발, 생산, 획득 및 비축, 보유, 이전, 사용하는 것을 금지하고 있지만 북한은 화학무기금지협약(CWC)에 가입하지 않은 3개국(북한, 이집트, 남수단) 중 하나로 1980년대부터 화학무기를 생산하기 시작하여 2500톤 ~ 5000톤의 화학무기를 보유하고 있을 것으로 추정된다. 이에 따라 우리 나라는 신경작용제에 대한 방호 및 해독체계를 공고히 할 필요성이 있으나, 현재 보유하고 있는 신경작용제 해독체계는 1987년 개발된 해독제 키트(KMARK-1)로 치명적인 뇌손상을 방지할 수 없다는 한계가 있어 추가적인 해독체계 개발 필요성이 제기되고 있다. 본 연구는 신경작용제 해독체계 기술 동향을 분석하여 현재 운용되고 있는 신경작용제 해독체계의 문제점을 파악하고 향후 발전 방향을 살펴보고자 한다.
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조영,Cho, Young 한국군사과학기술학회 2011 한국군사과학기술학회지 Vol.14 No.5
Nerve agents are irreversible inhibitors of the cholinesterase enzyme. Exposure causes a progression of toxic signs, including hypersecretions, fasciculations, tremor, convulsions, respiratory distress, epileptiform seizures, brain injuries and death. A combined regimen of prophylaxis and therapy is the most effective medical countermeasure for dealing with the threat of nerve agent poisoning to military personnel. In this paper, the author investigated the updated technologies regarding various pre- and post-treatment drugs for nerve agents detoxification which are under development in several countries including Korea. Some characteristics of active ingredients in the formulations of drugs, their action mechanisms, and effectiveness were analyzed. Additionally, part of experimental data on the transdermal patch studied in ADD using beagle dogs was introduced.
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이근우,안서연,허병일,Lee, Keunwoo,An, Seoyeon,Hur, Byungil 한국군사과학기술학회 2016 한국군사과학기술학회지 Vol.19 No.1
The US Army used MARK-1 composed of atropine autoinjector and 2-PAM autoinjector as a medical countermeasure against nerve agent poisoning. Recently, it has been being replaced by the ATNAA(Antidote Treatment Nerve Agent AutoInjector) for improvement the convenience in use and rapid detoxification effect. ATNAA(FDA approval, NDA 21-175, 2002. 1. 17) is a multi-chambered autoinjector that sequentially delivers atropine and 2-PAM through a single needle to allow Warfighters to survive against lethal exposure to nerve agents. In this paper, our group investigated the case of FDA approval of ATNAA in a point of the various data required by FDA guideline, thereby making it easy to meet the KFDA guideline for the approval of the prototype our group has been developed. The purpose of this study is to provide a reference for efficient research activities to minimize time and cost. Additionally, the purpose of this study is to provide a reference for the planning for the development of similar drug.
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Cu(II)-Chitosan Complex의 DFP 분해 반응 연구
계영식,정우영,김동욱,박양기,송시욱,정근홍,Kye, Young-Sik,Chung, Woo Yong,Kim, Dongwook,Park, Yangki,Song, Siuk,Jeong, Keunhong 한국군사과학기술학회 2012 한국군사과학기술학회지 Vol.15 No.5
In this study, we have proposed a novel decomposition agent composed of Cu(II) and soluble chitosan for organophosphorus chemical agents. Compared to the autohydrolysis, the soluble Cu(II)-Chitosan complex hydrolyzed DFP more effectively. Results show that soluble Cu(II)-Chitosan complex enhances the hydrolysis of DFP in 4~6 folds compared to the autohydrolysis of DFP in buffer solution. This study provides the possibility of using this soluble Cu(II)-Chitosan complex as the environmental friendly decomposition agent which can substitute current DS-2 decomposition agent.
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실험동물의 뇌파 측정에 의한 중추약물의 항경련효과 연구
조영,김왕수,허경행,Cho, Young,Kim, Wang-Soo,Hur, Gyeung-Haeng 한국군사과학기술학회 2013 한국군사과학기술학회지 Vol.16 No.2
Organophosphorus compounds are irreversible inhibitors of cholinesterase enzyme. Exposure causes a progression of toxic signs, including hypersecretion, tremor, convulsion, respiratory distress, epileptiform seizure, brain injuries and death. To protect brain injuries, administration of diazepam as a neuroprotectant is now considered essential for severely exposed nerve agent casualties. However, studies have shown diazepam to provide less than total protection against the neuropathological consequences of nerve agent exposure. In this context, extensive studies have been carried out to find out effective alternative drugs to protect brain from epileptiform seizures induced by organophosphate compounds intoxication. It has been reported that a combination of carbamate and anticholinergic or antiglutamatergic can be a very effective medical countermeasure in dealing with the threat of organophosphorous poisoning. In this study, experimental animals including rats and guinea pigs were implanted with microelectrodes on their brain sculls, and treated with various centrally acting drugs such as physostigmine and procyclidine prior to soman challenge, and then its electroencephalography(ECoG) was monitored to see anticonvulsant effects of the drugs. It was found that seizure activities in ECoG were not always in proportion to clinical signs induced by soman intoxication, and that combinative pretreatment with physostigmine plus procyclidine effectively stopped the seizures induced by organophosphorous poisoning.
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