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Activatable Polymersome for Oral Delivery of Vaccines
Yurim AHN,Seojin KIM,Minse KIM,Jaewon CHOI,Jiyeon PARK,HakSeon KIM,Hyun-Ouk KIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Vaccination is widely regarded as the only exit strategy for emerging, re-emerging viral diseases currently spreading around the world. Vaccines are important as the only way to defend our bodies from viral diseases. Accordingly, it is necessary to study a delivery system that can increase the efficiency of a vaccine to prevent a threatening emerging, re-emerging viral diseases. In this study, we produced Activatable polymersome, a vaccine formulation for oral administration that has its own driving force according to the in vivo environment using nanostructures. We confirmed the synthesis and effectiveness of Activatable polymersome using DLS, TEM and CLSM. In addition, the stability of this polymersome was evaluated over several months. These polymersome have a driving force by generating hydrogen gas in the intestinal environment, as well as releasing an inherent vaccine. Therefore, this system is a vaccine formulation for oral administration and can lead to an efficient immune response by resolving a feeling of resistance to pain and maximizing the activation of mucosal immunity. Therefore, our study can be developed as an efficient vaccine delivery platform using in vivo environment.
스팀 절감량 예측을 위한 흑액 다중 효용 증발 공정 모델 개발
김유림 ( Yurim Kim ),임종훈 ( Jonghun Lim ),최영렬 ( Yeongryeol Choi ),김태복 ( Taebok Kim ),박한신 ( Hansin Park ),조형태 ( Hyungtae Cho ),김정환 ( Junghwan Kim ) 한국화학공학회 2022 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.60 No.1
본 연구에서는 흑액 증발공정에 소비되는 스팀의 절감량을 예측하기 위해 증발기 수에 따른 다중 효용 증발공정 모델을 개발하였다. 개발한 공정 모델은 흑액의 예열 및 증발 과정으로 구성되어 있고, 스팀 사용량을 예측하기 위해 가상의 재비기가 추가되었다. 시뮬레이션 결과, 2중 효용 증발기에서 스팀 사용량은 48.9% 감소하였고, 증발기 수가 증가함에 따라 스팀 사용량이 감소하여 8중 효용 증발기에서 최대 76.5% 감소함을 확인하였다. 시뮬레이션 결과를 증발기 수에 따른 포화증기의 잠열 회수량, 스팀 사용량, 각 증발기의 포화증기 생산량으로 분석하여 최적의 증발기 수 도출을 위한 방안을 제시하였다. This study developed the black liquor evaporation process models using the multiple-effect-evaporator according to the number of effects to predict steam consumption. The developed models were divided into the black liquor preheating and evaporation processes, and a virtual reboiler was added to predict steam consumption. In simulation results, the steam consumption in the double-effect-evaporator was decreased by 48.9 %, and as the number of effects increased, the steam consumption was decreased. Finally, the steam consumption in the octuple-effectevaporator was decreased by 61.2 %. Also, this study suggests a strategy for deriving the optimal number of effects in the process by analyzing the latent heat recovered from the saturated vapor produced in the multiple-effect-evaporator and the amount of saturated vapor produced by each effect.
High Velocity Impact Characteristics of Shear Thickening Fluid Impregnated Kevlar Fabric
Yurim Park,Abrar H. Baluch,YunHo Kim,Chun-Gon Kim 한국항공우주학회 2013 International Journal of Aeronautical and Space Sc Vol.14 No.2
The development of high performance fabrics have advanced body armor technology and improved ballistic performance while maintaining flexibility. Utilization of the shear thickening phenomenon exhibited by Shear Thickening Fluids (STF) has allowed further enhancement without hindering flexibility of the fabric through a process of impregnation. The effect of STF impregnation on the ballistic performance of fabrics has been studied for impact velocities below 700 m/s. Studies of STF-impregnated fabrics for high velocity impacts, which would provide a transition to significantly higher velocity ranges, are lacking. This study aims to investigate the effect of STF impregnation on the high velocity impact characteristics of Kevlar fabric by effectively dispersing silica nanoparticles in a suspension, impregnating Kevlar fabrics, and performing high velocity impact experiments with projectile velocities in the range of 1 ㎞/s to compare the post impact characteristics between neat Kevlar and impregnated Kevlar fabrics. 100 ㎚ diameter silica nanoparticles were dispersed using a homogenizer and sonicator in a solution of polyethylene glycol (PEG) and diluted with methanol for effective impregnation to Kevlar fabric, and the methanol was evaporated in a heat oven. High velocity impact of STF-impregnated Kevlar fabric revealed differences in the post impact rear formation compared to neat Kevlar.